Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review.

Abstract:

PURPOSE:There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS:We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment options for XDR NDM-producing Enterobacteriaceae. RESULTS:Infections caused by New Delhi beta-lactamase (NDM)-producing Enterobacteriaceae are becoming increasingly prevalent worldwide. The presence of the enzyme results in multidrug-resistant and extensively drug-resistant phenotypes which often pose a treatment challenge. Despite this challenge, case reports and series have demonstrated good clinical outcomes with numerous treatment options in comparison to infections due to KPC-producing Enterobacteriaceae. CONCLUSIONS:Further good-quality research focused on the treatment of NDM-producing Enterobacteriaceae is warranted.

journal_name

Infection

journal_title

Infection

authors

Chibabhai V,Nana T,Bosman N,Thomas T,Lowman W

doi

10.1007/s15010-017-1070-8

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

1-13

issue

1

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-017-1070-8

journal_volume

46

pub_type

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