Abstract：
:A fatal guinea pig model of pneumococcal pneumonia was developed in order to evaluate the efficacy of amoxicillin combined with either pentoxifylline or dexamethasone. Parameters assessed were survival time and lung changes (alterations, bacterial colony counts, inducible nitric oxide synthase [iNOS] and cyclooxygenase-2 [COX-2] protein expression). Animals receiving pentoxifylline (50 mg/kg) showed higher survival rates than controls (p < 0.05). Animals which received amoxicillin (50 mg/kg), alone or combined, showed significantly higher survival rates than controls (p < 0.05). Animals dying in spite of receiving amoxicillin alone or combined had lung colony counts significantly lower than those that did not receive the antibiotic (p < 0.001), but their lungs showed identical changes. The correlation between COX-2 protein expression and mortality was rather high (r = 0.75). The addition of either dexamethasone or pentoxifylline to amoxicillin improved neither survival rates nor lung pathology when compared with the antibiotic alone.
journal_name
Infectionjournal_title
Infectionauthors
Parra A,García-Olmos M,Nieto E,García-Calvo G,Ponte C,Soriano Fdoi
10.1007/s15010-002-2098-xkeywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
150-6issue
3eissn
0300-8126issn
1439-0973journal_volume
30pub_type
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