Abstract:
PURPOSE:Cryptococcal meningitis is a potentially fatal fungal infection associated with a significant attributable morbidity and mortality, especially among HIV/AIDS patients. The first-line therapy for the treatment of this clinical entity is the combinatory therapy of amphotericin B plus flucytosine. However, the high cost, toxic effects, and limited repertoire of effective antifungal drugs have led to the investigation of novel molecules. This is a prospective, double-blinded, and randomized study performed in a Mexican tertiary care center to evaluate the antifungal activity of sertraline in the treatment of cryptococcal meningitis in HIV patients. METHODS:During June 2015-December 2016, patients were recruited and included in one of two study groups: group A was given standard antifungal treatment plus sertraline 200 mg/day, while group B was given standard antifungal plus placebo. Lumbar punctures were performed on days 0, 7, and 14 of the study, and cryptococcal antigenemia and quantitative fungal culture in cerebrospinal fluid at each time point were evaluated to measure the rate of fungal clearance. RESULTS:The fungal loads and cryptococcal antigenemia titers showed a marked tendency to decrease by day 14 in both groups. Otherwise, group B exhibited a slightly higher nonstatistical rate of fungal clearance (-0.2868 ± 0.08275 log CFU/ml/day) than group A (-0.2496 ± 0.08340 log CFU/ml/day). CONCLUSIONS:A statistical difference between study groups was not found. This is the first study in Latin America that reports the experience of using sertraline as an adjuvant in the antifungal management of cryptococcal meningitis in HIV patients.
journal_name
Infectionjournal_title
Infectionauthors
Villanueva-Lozano H,Treviño-Rangel RJ,González GM,Hernández-Rodríguez PA,Camacho-Ortiz A,Castillo-Reyna L,Galindo-Alvarado SG,Martínez-Reséndez MFdoi
10.1007/s15010-017-1059-3subject
Has Abstractpub_date
2018-02-01 00:00:00pages
25-30issue
1eissn
0300-8126issn
1439-0973pii
10.1007/s15010-017-1059-3journal_volume
46pub_type
杂志文章,随机对照试验相关文献
INFECTION文献大全abstract::The sources from which eight Caesarean section babies acquired E. coli are described and the probable routes by which the organisms reached the babies are outlined. Suggestions are made concerning the control of the spread of E. coli in premature nurseries and during outbreaks of E. coli gastroenteritis. ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01638940
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1007-2
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS:Anti...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-0998-z
更新日期:2017-08-01 00:00:00
abstract::The MICs and MBCs of mecillinam, ticarcillin, mezlocillin, azlocillin and piperacillin were determined by the microdilution method in liquid medium using 700 strains of gram-negative bacilli and enterococci isolated from pathological sources and classified as a function of their sensitivity to ampicillin and carbenici...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640683
更新日期:1982-01-01 00:00:00
abstract::Lower urinary tract infection is a common problem for women, and tends to be recurrent. It is not associated with significant long term morbidity. Optimal management for symptomatic infection is short course antimicrobial therapy. For women with frequent, symptomatic, recurrent infection a number of therapeutic option...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01643426
更新日期:1990-01-01 00:00:00
abstract::We studied the activity of cefotaxime both microbiologically and clinically. 138 blood cultures positive for gram-positive cocci were evaluated (90 strains of Staphylococcus aureus, 25 of Streptococcus faecalis, 13 of Streptococcus alpha and ten of Streptococcus mutans). Cefotaxime showed good activity against all str...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644230
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:Data on non-fermentative Gram-negative rods (NFGNR) bacteremia in children with malignancies are limited. The aim of this study was to present clinical picture, antimicrobial susceptibility pattern, risk factors for resistance and outcome in NFGNR bacteremia in children with cancer. METHODS:All episodes of NFG...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-0988-1
更新日期:2017-06-01 00:00:00
abstract::Satisfactory methods for the serodiagnosis of Chlamydia trachomatis have been widely discussed in recent years. Until a decade ago, the complement-fixation test measuring group-specific antibody was the most widely applied technique. However, despite showing relatively high diagnostic sensitivity in systemic chlamydia...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01640711
更新日期:1982-01-01 00:00:00
abstract::Since 1990 a relatively high number of cases of childhood tuberculosis has been observed in Austria, mainly occurring in the age-group of 0-4 years. Within this group most cases were registered in 1995. Since the beginning of 1995 the establishment of a lab-supported nationwide data collection system enables a more de...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02768752
更新日期:1998-01-01 00:00:00
abstract::A 97-year-old lady was hospitalized for left leg cellulitis. Comorbidity included hypertension and congestive heart failure. While in hospital, she developed a painless vesicular rash localized to the territory of the left trigeminal nerve (third branch), which evolved to pustules and crusts (Figure 1). A chickenpox-l...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-008-8287-5
更新日期:2009-04-01 00:00:00
abstract::Penetration of ciprofloxacin into human tonsils was studied following an intravenous infusion of 200 mg over 15 minutes to adult humans undergoing tonsillectomy. Samples were taken one-and-a-half to four hours after dosing. Generally, tissue levels exceeded corresponding serum concentrations by 50% (range of intraindi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01651152
更新日期:1984-09-01 00:00:00
abstract::The aminoglycosides play a central role in the treatment of infectious diseases caused by gram-negative bacteria. During the period of January to June 1984, 45 clinical specimens collected in our neonatal intensive care unit grew Enterobacter cloacae; 41 of them were gentamicin resistant. One neonate developed septice...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01646115
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS:After a literature review, five authors determined the barriers and facilitators to...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-018-1250-1
更新日期:2019-04-01 00:00:00
abstract::Infection is an important cause of death in patients receiving cytostatic drugs or with any other impairment of host resistance. Such infections are frequently due to opportunist micro-organisms usually belonging to the endogenous flora of the patient. It is often difficult to obtain an exact diagnosis of the cause an...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642766
更新日期:1975-01-01 00:00:00
abstract::For successful treatment of bacterial osteomyelitis the administered antibiotic must reach sufficiently high concentrations in bone tissues. Therefore concentrations of enoxacin in bone in ten patients requiring hip surgery were measured. To prevent a postoperative infection, 400 mg enoxacin b.i.d. for two days were a...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643632
更新日期:1989-01-01 00:00:00
abstract::The in vitro activity of clarithromycin alone and in combination with its primary human metabolite, 14-hydroxy-clarithromycin, was determined against 203 strains of Haemophilus influenzae. Microdilution broth MICs and MBCs of both clarithromycin and 14-hydroxy-clarithromycin were determined. The clarithromycin MIC50 w...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01704612
更新日期:1992-05-01 00:00:00
abstract::Circulatory secretory non-pancreatic phospholipase A2 (snp-PLA2) was measured prospectively at the onset (day 0) of severe sepsis in 52 patients as well as on day 1 and 2 in 25 patients, in order to answer two questions: 1) does the snp-PLA2 plasma concentration differ according to the type and severity of infection? ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01713312
更新日期:1996-03-01 00:00:00
abstract::Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of bleeding, co-administration of vitamin K has been advised. We reassessed the need for vitamin K use in a retrospective analysis of 50 patients undergoing urologic pro...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01704604
更新日期:1992-05-01 00:00:00
abstract::Using bDNA, the plasma viral load trend of HCV-infected patients undergoing IFN therapy was analyzed. Nine patients were enrolled, each assigned to one of three groups, based on IFN response as determined by ALT and AST level trend. HCV was genotyped using DEIA. Each patient's clinical stage was determined by liver bi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01743362
更新日期:1996-07-01 00:00:00
abstract::The clinical symptoms of urinary tract infections (UTI) are only rarely an indication of the presence of the disease in childhood. Of decisive importance for the detection of UTI is an appropriate investigation to determine whether there is significant bacteriuria. Since in a significant proportion of cases of UTI in ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659736
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:Limited data are available on immunologic responses to primary pandemic H1N1 (2009) vaccination in recipients of allogeneic hematopoietic stem cell transplantation (HSCT) recipients. In 2009 serologic responses to either pandemic H1N1 (2009) vaccine (n = 36) or pandemic H1N1 (2009) infection (n = 2) were studie...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0206-5
更新日期:2012-04-01 00:00:00
abstract::The activity of clarithromycin in combination with ethambutol and rifampicin was tested at concentrations achievable in serum against 20 strains of Mycobacterium avium complex. The combination of clarithromycin plus rifampicin showed inhibition of 11 of the strains and bactericidal synergism against seven of the strai...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645362
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:A retrospective study was conducted to provide epidemiological data on hospitalization for complicated and uncomplicated chickenpox in a pediatric population. METHODS:The study analyzed hospitalization cases for chickenpox, among all the 31 Tuscan hospitals, during the period 1997-2003. RESULTS:Globally, 6...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6248-z
更新日期:2007-12-01 00:00:00
abstract::In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100050036
更新日期:1999-11-01 00:00:00
abstract::The case of a 13-year-old girl with CVI is presented who required steroid treatment for myositis. After three weeks of treatment, the serum IgM level increased about ten-fold. Specific antibodies to vaccination antigens, which despite adequate vaccination were absent prior to any kind of treatment, could be synthesize...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643615
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:The PROGRESS Registry (Promoting Global Research Excellence in Severe Sepsis) was designed to provide comparative data reflecting everyday clinical practice, thereby allowing participating institutions to explore and benchmark medical interventions in severe sepsis. MATERIALS AND METHODS:PROGRESS was an int...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-008-8203-z
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients. METHODS:Data from SSI cases after glioblastoma surgeries between 2009 and...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01534-0
更新日期:2020-10-09 00:00:00
abstract::The natural decline of passively acquired maternal antibody titers and the influence of these antibodies on the efficacy of live, further attenuated measles vaccine were studied in 7 to 12 month old infants. Hemagglutination-inhibition (HI) antibody titers were determined in the pre- and postvaccination sera. HI antib...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642310
更新日期:1978-01-01 00:00:00
abstract::Many new species have been isolated from subgingival periodontal pockets, for example Wolinella recta and Bacteroides forsythus, reflecting better basic microbiological techniques. Other species were created from existing species as a result of better characterization methods, i.e. Bacteroides buccae and Bacteroides o...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01644027
更新日期:1989-05-01 00:00:00
abstract::Iatrogenic meningitis following lumbar puncture is a rare complication of myelography, spinal anesthesia, intrathecal chemotherapy, and epidural anesthesia. Sporadic cases and clusters of iatrogenic meningitis have been reported after intrathecal therapy, but most incidental cases are reported after myelography. Four ...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01780647
更新日期:1996-01-01 00:00:00