Abstract：
:Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of bleeding, co-administration of vitamin K has been advised. We reassessed the need for vitamin K use in a retrospective analysis of 50 patients undergoing urologic procedures and who had received cefoperazone for three days to prevent infection. Eleven of 50 patients were given vitamin K because of liver or renal disease. Prothrombin time was not elevated in any of the 50 patients analyzed. We conclude that routine use of vitamin K with cefoperazone for perioperative prophylaxis of infection may be unwarranted in patients without identified risk for bleeding.
journal_name
Infectionjournal_title
Infectionauthors
Rockoff SD,Blumenfrucht MJ,Irwin RJ Jr,Eng RHdoi
10.1007/BF01704604keywords:
subject
Has Abstractpub_date
1992-05-01 00:00:00pages
146-8issue
3eissn
0300-8126issn
1439-0973journal_volume
20pub_type
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