Non-fermentative Gram-negative rods bacteremia in children with cancer: a 14-year single-center experience.

Abstract:

PURPOSE:Data on non-fermentative Gram-negative rods (NFGNR) bacteremia in children with malignancies are limited. The aim of this study was to present clinical picture, antimicrobial susceptibility pattern, risk factors for resistance and outcome in NFGNR bacteremia in children with cancer. METHODS:All episodes of NFGNR bacteremia occurring during 2001-2014 in children with cancer in a tertiary-care hospital were retrospectively analyzed. Pseudomonas and Acinetobacter spp. resistant to three or more antibiotic classes and all Stenotrophomonas maltophilia (SM) were defined as multidrug-resistant bacteria (MDR). RESULTS:A total of 80 children (44 males, 0.8-18 years, median 5 years) developed 107 episodes (116 pathogens) of NFGNR bacteremia; Pseudomonas aeruginosa (PA) (51; 43.9%), Acinetobacter baumannii (AB) (21, 18.1%), SM (18, 15.5%); and others (27, 25.2%). The rate of NFGNR bacteremia in children with certain solid tumors (e.g. sarcoma, 12/134 (9.0%)) was comparable to that of hematological malignancies (52/429 (12.2%). Focal infection and septic shock occurred in 16 (14.9%) and four (3.7%) episodes, respectively. Thirty (25.8%) of 116 NFGNR were MDR. The most significant predictors of bacteremia with MDR PA or AB were severe neutropenia (<100 cells/mm3; OR 7.8, p = 0.002), hospital-acquired (OR 16.9, p < 0.0001) and breakthrough (OR 11.2, p < 0.0001) infection. Infection with MDR bacteria was associated with inappropriate empirical therapy. The 30-day mortality was 3/107 (2.8%), all in neutropenic patients with hematological malignancies. CONCLUSIONS:NFGNR bacteremia can present with nonspecific signs or symptoms. MDR NFGNRs are common and compromise treatment options, but mortality is relatively low. Knowledge of local epidemiology, pattern and risk factors for resistance is important to guide empirical therapy.

journal_name

Infection

journal_title

Infection

authors

Averbuch D,Avaky C,Harit M,Stepensky P,Fried I,Ben-Ami T,Temper V,Peled Y,Troen H,Masarwa R,Abu Ahmad W,Weintraub M,Revel-Vilk S,Engelhard D

doi

10.1007/s15010-017-0988-1

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

327-334

issue

3

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-017-0988-1

journal_volume

45

pub_type

杂志文章
  • Prophylactic chemotherapy with fosfomycin trometamol during transurethral surgery and urological manoeuvres. Results of a multicentre study.

    abstract::The aim of the present open prospective study is to evaluate the efficacy and safety profile of fosfomycin trometamol in the chemoprophylaxis of urinary tract infections following transurethral diagnostic and/or therapeutic manoeuvres. 712 patients were enrolled in 72 urological surgical centres. All the enrolled pati...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF01643436

    authors: di Silverio F,Ferrone G,Carati L

    更新日期:1990-01-01 00:00:00

  • Release of TNF alpha and IL6 from human monocytes infected with Mycobacterium kansasii: a comparison to Mycobacterium avium.

    abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of B-lymphocytes. Mycobacterium avium has been shown to stimulate the release of TNF alpha and IL6 fro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01715538

    authors: Stauffer F,Petrow EP,Burgmann H,Graninger W,Georgopoulos A

    更新日期:1994-09-01 00:00:00

  • Epidemiology and clinical impact of glycopeptide resistance in Staphylococcus aureus.

    abstract::Staphylococcus aureus with resistance to glycopeptide antibiotics has been considered to be a rare cause of clinically relevant infections. A review of the current literature shows that this is indeed the case for infections caused by S. aureus with high-level resistance to vancomycin (VRSA), as only isolated cases ha...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-004-4124-7

    authors: Ruef C

    更新日期:2004-12-01 00:00:00

  • [Comparative study of cefaclor versus amoxicillin in urinary tract infections (author's transl)].

    abstract::In a comparative, prospective, open randomised clinical study, the efficacy and tolerance of cefaclor (3 x 500 mg) and amoxicillin (3 x 750 mg) in the treatment of urinary tract infection (UTI) were investigated and compared. A total of 110 patients (51 males and 59 females) age 10 to 83 years were treated for a perio...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01659750

    authors: Naber K,Kaldewey W

    更新日期:1979-01-01 00:00:00

  • Antiviral therapy of varicella-zoster virus infection in immunocompromised children--a prospective randomized study of aciclovir versus brivudin.

    abstract::Both aciclovir and brivudin are effective in the treatment of immunocompromised children with varicella-zoster virus infection. To determine which drug is preferable, a prospective randomized trial aciclovir vs. brivudin was conducted. Forty-three immunocompromised children were randomly assigned to receive aciclovir ...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01726449

    authors: Heidl M,Scholz H,Dörffel W,Hermann J

    更新日期:1991-11-01 00:00:00

  • Postoperative cauda syndrome caused by Staphylococcus aureus.

    abstract::Toxic shock syndrome (TSS) is a well-defined clinical syndrome attributed to certain exotoxins produced by Staphylococcus aureus. The acute episode is often characterized by a toxic encephalopathy, possibly caused by direct neurotoxicity of these exotoxins, although this mechanism has never been proven. We describe a ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01728901

    authors: Arend SM,Steenmeyer AV,Mosmans PC,Bijlmer HA,van't Wout JW

    更新日期:1993-07-01 00:00:00

  • Passive immunization against cytomegalovirus in allograft recipients. The Rotterdam Heart Transplant Program experience.

    abstract::We analyzed the results of passive immunization against CMV in 146 heart transplant recipients. The 65 seronegative recipients were prophylactically treated with anti-CMV immunoglobulins during and after the operation. Twenty-nine of these 65 patients received a seropositive donor heart. CMV infection occurred in 21/6...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01728886

    authors: Balk AH,Weimar W,Rothbarth PH,Meeter K,Metselaar HJ,Mochtar B,Simoons ML

    更新日期:1993-07-01 00:00:00

  • Pertussis complications in Germany--3 years of hospital-based surveillance during the introduction of acellular vaccines.

    abstract::Between 1 November 1993 and 31 October 1996, admissions to paediatric departments for Bordetella pertussis complications were reported to a nationwide, hospital-based active surveillance system. The case definition included pertussis complicated by pneumonia, apnoea requiring assisted ventilation, seizures, encephalop...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02962368

    authors: Herzig P,Hartmann C,Fischer D,Weil J,von Kries R,Giani G,Schroten H,Wirsing von König CH

    更新日期:1998-07-01 00:00:00

  • The optimal management of lower urinary tract infections.

    abstract::Lower urinary tract infection is a common problem for women, and tends to be recurrent. It is not associated with significant long term morbidity. Optimal management for symptomatic infection is short course antimicrobial therapy. For women with frequent, symptomatic, recurrent infection a number of therapeutic option...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01643426

    authors: Nicolle LE

    更新日期:1990-01-01 00:00:00

  • Legionella bozemanii, an elusive agent of fatal cavitary pneumonia.

    abstract::A 67-year-old patient died of Legionella bozemanii pneumonia with negative urinary antigen and negative serology. Cystic lesions in pneumonia of unknown origin should lead to the differential diagnosis of L. bozemanii infections. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6251-4

    authors: Widmer A,Hohl P,Dirnhofer S,Bassetti S,Marsch S,Frei R

    更新日期:2007-06-01 00:00:00

  • In vivo potentiation of polymorphonuclear leukocyte chemotaxis by clindamycin.

    abstract::Polymorphonuclear leukocyte (PMNL) chemotaxis was evaluated in ten healthy volunteers who had received 600 mg of clindamycin intramuscularly. Serum obtained 3 hours after the administration of clindamycin significantly increased PMNL chemotaxis. Serum obtained at 12 and 24 hours after the administration of the drug di...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01712455

    authors: Skoutelis AT,Lianou PE,Bassaris HP

    更新日期:1993-09-01 00:00:00

  • Seroprevalence of Chlamydia pneumoniae antibodies in a young adult population sample living in Verona. European Community Respiratory Health Survey (ECRHS) Verona.

    abstract:UNLABELLED:The aim of the study was to evaluate the prevalence of antibodies to Chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in Verona, Italy. IgG and IgM titers were measured by micro-immunofluorescence. IgG antibodies, greater or equal to 16, were found in 104/177 ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050009

    authors: Ferrari M,Poli A,Olivieri M,Tardivo S,Biasin C,Balestreri F,Dal Molin G,Lo Cascio V,Campello C

    更新日期:2000-01-01 00:00:00

  • IL-6 and TNF alpha release in association with neutrophil activation after cardiopulmonary bypass surgery.

    abstract::The serum IL-6 and TNF alpha response to cardiopulmonary bypass surgery was studied in 12 patients. Human neutrophil elastase was also measured in order to detect the presence of neutrophil activation. Peripheral venous blood samples were obtained before, during, and 1, 2, 3 and 6 days after surgery. Intra-operative s...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01780764

    authors: Holzheimer RG,Molloy RG,Görlach H,Wilkert S,Hehrlein F

    更新日期:1994-01-01 00:00:00

  • Correction to: Clinical management of ageing people living with HIV in Europe: the view of the care providers.

    abstract::The original version of this article unfortunately contained a mistake. ...

    journal_title:Infection

    pub_type: 已发布勘误

    doi:10.1007/s15010-020-01463-y

    authors: Boffito M,Ryom L,Spinner C,Martinez E,Behrens G,Rockstroh J,Hohenauer J,Lacombe K,Psichogyiou M,Voith N,Mallon P,Branco T,Svedhem V,dÁrminio Monforte A

    更新日期:2020-08-01 00:00:00

  • [Patient-oriented hospital hygiene (author's transl)].

    abstract::Primary objective of patient-oriented hospital hygiene is the reduction in frequency of the five most important nosocomial infections: urinary tract infection, wound infection, respiratory tract infection, sepsis and infection of the skin and subcutaneous tissue. The less the effect of individual measures on the rate ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639589

    authors: Daschner F

    更新日期:1980-01-01 00:00:00

  • Rufloxacin once daily in acute exacerbations of chronic bronchitis.

    abstract::In this open study the efficacy and tolerability of rufloxacin in a single dose of 400 mg the first day and 200 mg the nine consecutive days was studied in 26 patients with an acute exacerbation of chronic bronchitis. Twenty-two patients were evaluable for efficacy. Four patients stopped treatment prematurely after fi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644971

    authors: Dirksen M,Focht J,Boerema J

    更新日期:1991-07-01 00:00:00

  • Clinical significance and spread of fluoroquinolone resistant uropathogens in hospitalised urological patients.

    abstract::The minimum inhibitory concentrations (MIC) of ciprofloxacin were determined for 441 uropathogens from patients with complicated and/or hospital acquired urinary tract infections (UTI). None of the Enterobacteriaceae was resistant (MIC > or = 4 mg/l), but 21.7% of enterococci, 28.3% of Pseudomonas spp. and 38.5% of st...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01793576

    authors: Naber KG,Witte W,Bauernfeind A,Wiedemann B,Wagenlehner F,Klare I,Heisig P

    更新日期:1994-01-01 00:00:00

  • HHV6 meningoencephalitis sequelae in previously healthy children.

    abstract:INTRODUCTION:Human herpes virus 6 (HHV6) infection is a self-limiting illness occurring in early childhood. As with other herpes viruses, the encephalopathy associated with HHV6 is often attributable to the reactivation of a virus previously latent in human brain tissue. Previous reports on HHV6 encephalopathy dealt ma...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0295-9

    authors: Bozzola E,Krzysztofiak A,Bozzola M,Calcaterra V,Quondamcarlo A,Lancella L,Villani A

    更新日期:2012-10-01 00:00:00

  • Prolonged application of closed in-line suction catheters increases microbial colonization of the lower respiratory tract and bacterial growth on catheter surface.

    abstract:BACKGROUND:Microorganisms become attracted to polymer surfaces for a number of reasons including positive charge of biomaterial or concentration of nutrients on the biomaterial surface. Many bacteria additionally possess specific receptors for the interaction with extracellular host protein components that adhere on th...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s15010-002-3066-1

    authors: Freytag CC,Thies FL,König W,Welte T

    更新日期:2003-01-01 00:00:00

  • Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30 days: a retrospective before-and-after analysis.

    abstract:PURPOSE:Thoracoabdominal esophageal resection for malignant disease is frequently associated with pulmonary infection. Whether prolonged antibiotic prophylaxis beyond a single perioperative dose is advantageous in preventing pulmonary infection after thoracoabdominal esophagectomy remains unclear. METHODS:In this retr...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1160-2

    authors: Hochreiter M,Uhling M,Sisic L,Bruckner T,Heininger A,Hohn A,Ott K,Schmidt T,Berger MM,Richter DC,Büchler M,Weigand MA,Busch CJ

    更新日期:2018-10-01 00:00:00

  • Quantitative antibiotic use in hospitals: comparison of measurements, literature review, and recommendations for a standard of reporting.

    abstract:BACKGROUND:Reports on antibiotic use often lack complete definitions of the units of measurement, hampering the comparison of data between hospitals or hospital units. PATIENTS AND METHODS:To compare methods of measures of in-hospital antimicrobial use, we determined aggregate in-hospital consumption data at a tertiar...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-008-7462-z

    authors: Kuster SP,Ruef C,Ledergerber B,Hintermann A,Deplazes C,Neuber L,Weber R

    更新日期:2008-12-01 00:00:00

  • Soft-tissue infection secondary to cellulitis killed St. John of the Cross (1542-1591).

    abstract:PURPOSE:St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Here, an alternative diagnosis is proposed....

    journal_title:Infection

    pub_type: 历史文章,杂志文章

    doi:10.1007/s15010-017-1089-x

    authors: Bianucci R,Appenzeller O,Evans P,Charlier P,Perciaccante A

    更新日期:2018-04-01 00:00:00

  • Myocarditis in admitted patients with dengue fever.

    abstract:PURPOSE:Cardiac involvement in dengue fever is underdiagnosed due to low index of clinical suspicion and its contribution to hemodynamic instability in severe dengue is not well known. METHODS:A prospective observational study was conducted among admitted patients ≥ 14 years of age having confirmed dengue fever. Patie...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01500-w

    authors: Bhatt M,Soneja M,Farooqui FA,Singla P,Vikram NK,Biswas A,Roy A,Wig N

    更新日期:2020-12-01 00:00:00

  • Clearance of Candida colonizing the urinary bladder by a two-day amphotericin B irrigation.

    abstract::The minimum duration of continuous amphotericin B irrigation (50 mg/liter/day) required to clear the candida colonizing the urinary bladder was investigated. Eleven in vitro experiments revealed a consistent candidicidal effect within 48 hours with 25 and 5 mg/l of amphotericin B concentrations attainable in the bladd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647004

    authors: Hsu CC,Ukleja B

    更新日期:1990-09-01 00:00:00

  • Cryptococcus gattii meningoencephalitis in an immunocompetent person 13 months after exposure.

    abstract::A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-8211-z

    authors: Georgi A,Schneemann M,Tintelnot K,Calligaris-Maibach RC,Meyer S,Weber R,Bosshard PP

    更新日期:2009-08-01 00:00:00

  • [Parenteral cephalosporins for the treatment of lower respiratory tract infections].

    abstract::In most cases of respiratory tract infection, antibiotic therapy has to be initiated before the results of microbiological examination are available. The four most common pathogens of acute exacerbations of chronic bronchitis are pneumococci, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. Pne...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01710341

    authors: Vogel F

    更新日期:1993-01-01 00:00:00

  • Andrologic studies and sexual potency in chronic human brucellosis.

    abstract::A 100 male patients aged from 20 to 45 years were treated for chronic brucellosis. Sixty-eight complained of impaired sexual potency. The percentage of patients with sexual disorders increased parallel to the duration of the disease. Andrologic investigations comprised a study sexual history, physical examination of t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641469

    authors: Kassur B,Dziubek Z

    更新日期:1980-01-01 00:00:00

  • Chlamydial antigen detection in urine samples by immunofluorescence tests.

    abstract::To investigate the diagnostic value of a direct immunofluorescence test (DIF-test), urethral samples and first catch urine (FCU) from 153 male patients attending an outpatient clinic for sexually transmitted diseases (STD) were studied. Of the male patients, 40 (26.1%) had a positive urethral culture, 39 (25.5%) had a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01711077

    authors: Stary A,Genç M,Heller-Vitouch C,Mårdh PA

    更新日期:1992-03-01 00:00:00

  • The potential impact of biomarker-guided triage decisions for patients with urinary tract infections.

    abstract:OBJECTIVES:Current guidelines provide limited evidence as to which patients with urinary tract infection (UTI) require hospitalisation. We evaluated the currently used triage routine and tested whether a set of criteria including biomarkers like proadrenomedullin (proADM) and urea have the potential to improve triage d...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0423-1

    authors: Litke A,Bossart R,Regez K,Schild U,Guglielmetti M,Conca A,Schäfer P,Reutlinger B,Mueller B,Albrich WC

    更新日期:2013-08-01 00:00:00

  • Ventriculitis caused by Klebsiella pneumoniae successfully treated with pefloxacin in a neonate.

    abstract::Pefloxacin was applied to a newborn suffering from ventriculitis caused by Klebsiella pneumoniae after failure of routine antibiotics. Treatment was successful. Blood and CSF levels were high, thus documenting good CSF penetration. In addition to this case report, a review of the literature regarding seven neonates wi...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01716707

    authors: Linder N,Dagan R,Kuint J,Keler N,Keren G,Reichman B

    更新日期:1994-05-01 00:00:00