Cryptococcus gattii meningoencephalitis in an immunocompetent person 13 months after exposure.

Abstract:

:A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.

journal_name

Infection

journal_title

Infection

authors

Georgi A,Schneemann M,Tintelnot K,Calligaris-Maibach RC,Meyer S,Weber R,Bosshard PP

doi

10.1007/s15010-008-8211-z

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

370-3

issue

4

eissn

0300-8126

issn

1439-0973

journal_volume

37

pub_type

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