Abstract:
:A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.
journal_name
Infectionjournal_title
Infectionauthors
Georgi A,Schneemann M,Tintelnot K,Calligaris-Maibach RC,Meyer S,Weber R,Bosshard PPdoi
10.1007/s15010-008-8211-zsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
370-3issue
4eissn
0300-8126issn
1439-0973journal_volume
37pub_type
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