Abstract:
:In this review the pharmacokinetic properties of trimethoprim (TMP) and TMP/sulphonamide combinations are discussed. The concentration of both substances in the various body fluids and tissues differ considerably from the concentrations in blood due to the different distribution of TMP and sulphonamides in the body. As a rule the ratio of the concentration of TMP to sulphonamide is higher in most body fluids and secretions than in blood. If inflammation is present, the concentrations vary considerably. The pharmacokinetic data must be taken into account when making in vitro tests. At the site of inflammation a TMP/sulphonamide concentration factor of 1:0.5 to 1:4 can be expected in urine and of 1:2 to 1:5 in tissue.
journal_name
Infectionjournal_title
Infectionauthors
Reeves DS,Wilkinson PJdoi
10.1007/BF01639009subject
Has Abstractpub_date
1979-01-01 00:00:00pages
S330-41eissn
0300-8126issn
1439-0973journal_volume
7 Suppl 4pub_type
杂志文章,评审相关文献
INFECTION文献大全abstract::Tuberculous epididymitis is a rare entity associated with minor complications. We present two cases of tuberculous epididymitis associated with serious complications (bilateral psoas abscesses and Addison's disease with psoas abscess). A review of the literature disclosed six additional cases associated with serious c...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s150100050080
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:We analyzed the clinical manifestations and therapeutic outcomes of Klebsiella brain abscesses. PATIENTS AND METHODS:The clinical data of 15 patients with Klebsiella brain abscesses, retrospectively collected over a 14-year period, were studied. RESULTS:The 15 patients included 13 cases of Klebsiella pneum...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-0069-2
更新日期:2001-03-01 00:00:00
abstract:: ...
journal_title:Infection
pub_type: 社论
doi:10.1007/s15010-018-1228-z
更新日期:2018-12-01 00:00:00
abstract::Pneumopericardium, the presence of air in the pericardial space, is a rare disorder that is usually caused by trauma. We describe a patient given induction chemotherapy for acute myelogenous leukemia who developed pulmonary aspergillosis that resulted in pericarditis and pneumopericardium. He responded to antifungal t...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01739015
更新日期:1994-03-01 00:00:00
abstract::A case of meningitis due to an unusual organism, Haemophilus aphrophilus in an adult is described. In spite of rapid clearance of the organism from the cerebrospinal fluid with intravenous cefotaxime, fever persisted over 8 days of therapy and infection was complicated by hydrocephalus. H. aphrophilus meningitis is un...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02770846
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:It is routine practice to provide chemoprophylaxis for close contacts of a patient infected with meningococci. PATIENTS:When a 17-year-old boy living in a boys' home was admitted to the hospital with septic shock caused by Neisseria meningitidis, we immediately identified contact persons in the boys' home. ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100050070
更新日期:2000-05-01 00:00:00
abstract:PURPOSE:This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS:After a literature review, five authors determined the barriers and facilitators to...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-018-1250-1
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Screening for staphylococci among various patient populations has become important for appropriate therapeutic management and for control of nosocomial infections. The purpose of this study is to evaluate the in vitro sensitivity and specificity of a chromogenic agar medium, S. aureus ID (bioMérieux, France)...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-5094-8
更新日期:2006-04-01 00:00:00
abstract::We describe a 66-year-old woman hospitalized with fever, fatigue and hepatopathy. In her medical history arterial hypertension (treated with propranolol and lisinopril), diabetes mellitus type 2 (no treatment before admission) and a gout arthropathy were noted wherefore a therapy with allopurinol 300 mg per day has be...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6365-8
更新日期:2008-08-01 00:00:00
abstract::Eighty-nine patients with a history of recurrent urinary infection who required immediate treatment for significant bacteriuria were treated with either trimethoprim (300 mg at night) or with the standard course of co-trimoxazole (two tablets 12-hourly) for seven days. Cure rates one week after the end of treatment we...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01640874
更新日期:1982-09-01 00:00:00
abstract::Six hundred and fifteen Swedish soldiers (X = 24.9 years) serving with the UN forces in Cyprus were tested for antibody against hepatitis A (anti-HAV) before and after six months' service. Before the service, a high susceptibility to hepatitis A was found, as only 2.3% (14/615) had anti-HAV. In comparison, the prevale...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01648930
更新日期:1979-01-01 00:00:00
abstract::The antibacterial activities of two ureidopenicillins, azlocillin and mezlocillin, were compared with those of the alpha-carboxypenicillins, carbenicillin and ticarcillin, against a large number of gram-positive and gram-negative bacteria. All four penicillins were active against a wide range of bacteria including Pse...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641616
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:There is increasing evidence indicating an association between invasive non-typeable Haemophilus influenzae (NTHi) infection in pregnancy and early pregnancy loss. As the diagnosis relies on microbiological investigation of post-mortem placental and foetal samples, a significant proportion of NTHi-related pr...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-019-01359-6
更新日期:2020-04-01 00:00:00
abstract:PURPOSE:Invasive Mycobacterium marinum disease (tenosynovitis and osteomyelitis) may be an increasingly common manifestation of M. marinum infection that presents unique diagnostic and therapeutic challenges. We conducted a retrospective case series and literature review of M. marinum infection to better understand the...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-015-0776-8
更新日期:2015-12-01 00:00:00
abstract::The purpose of this study was to determine the effectiveness and tolerability of norfloxacin, cinoxacin and oxolinic acid in the treatment of urinary tract infections (UTI) in comparison to nalidixic acid. 125 patients were given the drugs in the appropriate doses for 10-14 days and 30 patients were treated for six we...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01645218
更新日期:1984-11-01 00:00:00
abstract::The Sporopachydermia cereana species lives in decaying stems of cactus and is exceptionally rare as a human pathogen. A 57-year-old man with therapy-refractory acute promyelocytic leukaemia developed severe neutropaenia. After about 3 weeks of micafungin used as prophylaxis, he developed high fever, multiple pulmonary...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-012-0402-y
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:To describe the influence of cardiac conduction tissue infection by Influenza A virus. METHODS AND RESULTS:A 54-year-old man with non-sustained ventricular tachycardia underwent noninvasive and invasive cardiac studies including left ventricular endomyocardial biopsy (LVEMB). Non-invasive studies showed normal...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0892-0
更新日期:2016-06-01 00:00:00
abstract::Material from 50 patients with purulent otitis media was investigated. All patients had undergone surgical operation. The results indicate that anaerobic non spore-forming bacteria, especially gram-negative rods of the family Bacteroidaceae, may play an important role in the aetiology of purulent otitis media. In a fu...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01639899
更新日期:1980-01-01 00:00:00
abstract::The in vitro activity of the free acid of cefetamet pivoxil (Ro 15-8075) was tested against 355 clinical isolates, namely enteropathogenic bacteria, glucose non-fermentative gram-negative rods (excluding Pseudomonas aeruginosa) and Legionella pneumophila. Ceftriaxone was included in the study as reference compound. Al...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644102
更新日期:1988-05-01 00:00:00
abstract::The clinical tolrance of 350 mg pivampicillin tablets was evaluated in 470 hospitalized patients in Denmark, Norway and Iceland. The tablets were given to 229 fasting patients and to 241 non-fasting patients at mealtime. Side-effects were reported in 44 patients (9.4%). Upper gastro intestinal disturbances occurred in...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01639105
更新日期:1977-01-01 00:00:00
abstract::Antibiotic activity against common respiratory pathogens can be affected by the pH of the medium (in vitro) or the bodily fluid (in vivo) in which bacteria are present. The ionized fraction of an antibiotic is not able to efficiently penetrate bacterial or mammalian membranes, reducing the quantity of molecules able t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-005-8206-y
更新日期:2005-12-01 00:00:00
abstract::The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearan...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641291
更新日期:1983-05-01 00:00:00
abstract::In this open study the efficacy and tolerability of rufloxacin in a single dose of 400 mg the first day and 200 mg the nine consecutive days was studied in 26 patients with an acute exacerbation of chronic bronchitis. Twenty-two patients were evaluable for efficacy. Four patients stopped treatment prematurely after fi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644971
更新日期:1991-07-01 00:00:00
abstract::In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (P...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0448-5
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jau...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2123-0
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival secretions from patients without ocular symptoms. METHODS:Conjunctival swabs were prospectively collected from laboratory-confirmed Coronavirus disease 2019 (COVID-19) patients without ocular symptoms for r...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01524-2
更新日期:2020-09-17 00:00:00
abstract::124 consecutive patients (mean age: 41.1 years; range: 20-63 years) attending an outpatient alcoholic clinic were tested for the presence of markers of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), thes...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644546
更新日期:1988-01-01 00:00:00
abstract::As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very simil...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713160
更新日期:1997-07-01 00:00:00
abstract::Serum and sputum concentrations of ampicillin or amoxycillin were measured in patients admitted to hospital for acute exacerbations of chronic bronchitis with purulent sputum. Mean peak serum levels of nearly 12 mg/l were found after 1600 mg bacampicillin (mean peak level in sputum 0.85 mg/l). The serum and sputum con...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659773
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:To test a new assay based on an ex vivo cytokine release from whole blood for the monitoring of immune changes in human immunodeficiency virus (HIV)-infected patients. METHODS:A pilot study of outpatients with HIV infection (n = 9) at a large academic hospital who were divided into three groups: HIV-infected p...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0445-8
更新日期:2013-06-01 00:00:00