Abstract:
:Eighty-nine patients with a history of recurrent urinary infection who required immediate treatment for significant bacteriuria were treated with either trimethoprim (300 mg at night) or with the standard course of co-trimoxazole (two tablets 12-hourly) for seven days. Cure rates one week after the end of treatment were 74.4% and 80.4%, respectively. During the following month the relapse rate was lower in the group given trimethoprim than among those who had received co-trimoxazole. Consequently, the cure rates six weeks after the start of treatment were 71.4% in the trimethoprim group and 58.5% in the co-trimoxazole group. These results suggest that in this type of patient, it may be possible to reduce the incidence of bacteriological relapse by giving antibiotics in larger doses and at less frequent intervals than are at present generally recommended.
journal_name
Infectionjournal_title
Infectionauthors
Brumfitt W,Hamilton-Miller JM,Ludlam H,Damjanovic V,Gargan Rdoi
10.1007/BF01640874subject
Has Abstractpub_date
1982-09-01 00:00:00pages
280-4issue
5eissn
0300-8126issn
1439-0973journal_volume
10pub_type
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