Neglected tropical diseases in Europe: rare diseases and orphan drugs?

abstract：:A 97-year-old lady was hospitalized for left leg cellulitis. Comorbidity included hypertension and congestive heart failure. While in hospital, she developed a painless vesicular rash localized to the territory of the left trigeminal nerve (third branch), which evolved to pustules and crusts (Figure 1). A chickenpox-l...

journal_title：Infection

authors： Capron J,Steichen O

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Recently, two excellent methods have been used for the diagnosis of Legionnaires' disease: urinary antigen detection and PCR. The purpose of the present study is to analyze and evaluate the sensitivity and specificity of three different urinary antigen detection kits as well as PCR. MATERIALS AND METHODS:A ...

journal_title：Infection

authors： Koide M,Higa F,Tateyama M,Nakasone I,Yamane N,Fujita J

更新日期：2006-10-01 00:00:00

abstract：:Clinical features of liver involvement due to Listeria monocytogenes infection in adults are rarely reported in literature. This is surprising, regarding the current opinion that the portal system is extensively involved in the first stages of pathogenesis in invasive L. monocytogenes disease. A literature search in t...

journal_title：Infection

authors： Scholing M,Schneeberger PM,van den Dries P,Drenth JP

更新日期：2007-06-01 00:00:00

abstract：:Antibiotic activity against common respiratory pathogens can be affected by the pH of the medium (in vitro) or the bodily fluid (in vivo) in which bacteria are present. The ionized fraction of an antibiotic is not able to efficiently penetrate bacterial or mammalian membranes, reducing the quantity of molecules able t...

journal_title：Infection

authors： Dalhoff A,Schubert S,Ullmann U

更新日期：2005-12-01 00:00:00

abstract：:A total of 208 patients underwent brain biopsy for presumptive herpes simplex encephalitis and were randomized to receive either vidarabine, vira-A, at 15 mg/kg/day, or acyclovir, at 30 mg/kg/day for ten days. 69 patients (33%) had biopsy-proven disease; 37 received vira-A and 32 acyclovir. With the exception of age, ...

journal_title：Infection

authors： Whitley RJ,Alford CA,Hirsch MS,Schooley RT,Luby JP,Aoki FY,Hanley D,Nahmias AJ,Soong SJ

更新日期：1987-01-01 00:00:00

abstract：:In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (P...

journal_title：Infection

authors： Scharn N,Ganzenmueller T,Wenzel JJ,Dengler R,Heim A,Wegner F

更新日期：2014-02-01 00:00:00

abstract：: ...

journal_title：Infection

authors： Bogner JR

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Current data on the risk of transmission of 2009 H1N1 Influenza in public transportation systems (e.g., public trains, busses, airplanes) are conflicting. The main transmission route of this virus is thought to be via droplets, but airborne transmission has not been completely ruled out. METHODS:This is a c...

journal_title：Infection

authors： Piso RJ,Albrecht Y,Handschin P,Bassetti S

更新日期：2011-04-01 00:00:00

abstract：:We report a unique case of sacral Capnocytophaga canimorsus abscess successfully treated with surgery and antibiotics. Close contact to a dog was assumed to be the most likely source of infection. Established risk factors for invasive C. canimorsus infection such as splenectomy, alcoholism or overt immunosuppression c...

journal_title：Infection

authors： Joswig H,Gers B,Dollenmaier G,Heilbronner R,Strahm C

更新日期：2015-04-01 00:00:00

abstract：:The serum half-life of cephacetrile and its penetration from the serum into the cerebrospinal fluid (CSF) was determined in 33 premature and full-term neonates. On an average the serum half-life was 3.6 hours in children with a birth weight above 1,500 g; in children with a birth weight below 1,500 g it was 5.1 hours....

journal_title：Infection

authors： Windorfer A,Gasteiger U

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Due to insufficient vaccination rates, measles outbreaks still pose a threat to public health in Germany. The purpose of this study was to identify risk factors for undervaccination against measles. PATIENTS AND METHODS:Datasets from two cross-sectional surveys were analyzed by logistic regression models. T...

journal_title：Infection

authors： Zucs AP,Crispin A,Eckl E,Weitkunat R,Schlipköter U

更新日期：2004-06-01 00:00:00

abstract：:To evaluate the diagnostic utility of C-reactive protein (CRP) for the detection of sepsis in bone marrow transplantation, CRP levels were analyzed after pretransplant conditioning and variably combined in septic, focal or viral infections with graft-versus-host disease (GvHD) in 64 bone marrow recipients. The CRP lev...

journal_title：Infection

authors： Rintala E,Remes K,Salmi TT,Koskinen P,Nikoskelainen J

更新日期：1997-11-01 00:00:00

abstract：:As highly active antiretroviral treatment (HAART) prolongs the life of HIV-infected individuals and reduces mortality associated with opportunistic infections, liver diseases have become a major challenge in the management of these patients. up to 45% of deaths of persons with HIV are related to endstage liver disease...

journal_title：Infection

authors： Horster S,Goebel FD

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). METHODS:Data were retrospectively collected from patients belonging to six referral hospitals in Italy between Janu...

journal_title：Infection

authors： Luzzati R,Merelli M,Ansaldi F,Rosin C,Azzini A,Cavinato S,Brugnaro P,Vedovelli C,Cattelan A,Marina B,Gatti G,Concia E,Bassetti M

更新日期：2016-12-01 00:00:00

abstract：:Cefotaxime is an effective antibiotic in lower respiratory tract infection caused by streptococci and staphylococci. There is a limited tendency to superinfections with Pseudomonas aeruginosa (1.5%) and there is a low incidence of side-effects. It is questionable whether there is really an urgent need for cefotaxime i...

journal_title：Infection

authors： Lode H,Glatzel PD

更新日期：1985-01-01 00:00:00

abstract：:Forty-six consecutive patients with pneumococcal meningitis were treated with cefotaxime (CTX). Ages ranged from 1-79 years: 29 adults, six adolescents, six children and five infants. Underlying diseases were found in 38 patients (82.6%). Twenty-six patients (56.5%) were admitted in coma. All isolates were sensitive t...

journal_title：Infection

authors： Lecour H,Seara A,Miranda AM,Cordeiro J

更新日期：1985-01-01 00:00:00

abstract：:The minimal inhibitory concentrations (MIC) of sulfamethoxazole and trimethoprim against 144 strains of obligately anaerobic bacteria were determined on supplemented Diagnostic Sensitivity Test (Oxoid) agar or broth. 58% of the strains were susceptible to sulfamethoxazole alone (MIC less than or equal to 16 micrograms...

journal_title：Infection

authors： Wüst J

更新日期：1980-01-01 00:00:00

abstract：:In order to assess the resistance profile for fosfomycin trometamol after several years of clinical use in Italy, this study has explored the susceptibility to fosfomycin and eight other antibacterial drugs of 6,021 strains isolated from 23,816 urines during 1990 in three teaching hospitals located in Genoa, Parma and...

journal_title：Infection

authors： Schito GC,Chezzi C,Nicoletti G,Moreddu M,Arcangeletti MC,Stefani S,Albini E,Del Bono GP

更新日期：1992-01-01 00:00:00

abstract：:To quantify the relative antibacterial efficacy of beta-lactam antibiotics in vitro, a mathematical description of bacterial growth was developed. Curves of growth in the presence of the antibiotic are expressed as quadratic functions of time, with initial growth rate (ko) and rate of change of growth (a) as concentra...

journal_title：Infection

authors： Mattie H,van der Voet GB

更新日期：1979-01-01 00:00:00

abstract：:Minimal inhibitory concentrations (MIC) of enoxacin, nalidixic acid, pipemidic acid, norfloxacin, ciprofloxacin, ofloxacin and pefloxacin against isolates from 400 urological in-patients with complicated urinary tract infections (UTI) were determined by means of an agar dilution technique (10(4) cfu, multipointer). 28...

journal_title：Infection

authors： Naber KG,Sörgel F,Gutzler F,Bartosik-Wich B

更新日期：1985-09-01 00:00:00

abstract：:The use of covered stents in an infected field is controversial. It is generally recommended that infected aneurysms be treated using autografts or allografts. We report a case of infected brachial pseudoaneurysms that developed after medical debridement of a methicillin-resistant Staphylococcus aureus (MRSA)-infected...

journal_title：Infection

authors： Kurimoto Y,Tsuchida Y,Saito J,Yama N,Narimatsu E,Asai Y

更新日期：2003-06-01 00:00:00

abstract：:In this article the cooperating partners of the ClinSurv HIV cohort were not listed in the acknowledgements. The correct paragraph appears below. ...

journal_title：Infection

authors： Stecher M,Schommers P,Schmidt D,Kollan C,Gunsenheimer-Bartmeyer B,Lehmann C,Platten M,Fätkenheuer G,Vehreschild JJ,ClinSurv Study Group.

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:This study aimed to describe the epidemiology of childhood group B streptococcus (GBS) disease including late late-onset disease (LLOD) and to clinically characterize recurrent cases and twin-sibling cases in Japan. METHODS:We collected information on infants (<1 year of age) with invasive GBS disease and inst...

journal_title：Infection

authors： Matsubara K,Hoshina K,Kondo M,Miyairi I,Yukitake Y,Ito Y,Minami K,Genkawa R

更新日期：2017-08-01 00:00:00

abstract：:Zinc was found to have profoundly different effects upon the infection of McCoy cells (mouse fibroblasts) by two strains of Chlamydia trachomatis dependent upon the time and concentration of zinc exposure. Radiolabeled zinc-65 became McCoy cell-associated in a manner independent of incubation temperature, but highly d...

journal_title：Infection

authors： Sugarman B,Agbor P

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) recurs in nearly one-third of patients who develop an initial infection. Recurrent CDI (RCDI) is associated with considerable morbidity, mortality, and cost. Treatment for RCDI has not been not well examined. METHODS:A systematic review. RESULTS:Sixty-four articles wer...

journal_title：Infection

authors： O'Horo JC,Jindai K,Kunzer B,Safdar N

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:To describe the influence of cardiac conduction tissue infection by Influenza A virus. METHODS AND RESULTS:A 54-year-old man with non-sustained ventricular tachycardia underwent noninvasive and invasive cardiac studies including left ventricular endomyocardial biopsy (LVEMB). Non-invasive studies showed normal...

journal_title：Infection

authors： Frustaci A,Petrosillo N,Ippolito G,Chimenti C

更新日期：2016-06-01 00:00:00

abstract：:In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of ...

journal_title：Infection

authors： Nastasi A,Mammina C

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad...

journal_title：Infection

authors： Lübbert C,Baars C,Dayakar A,Lippmann N,Rodloff AC,Kinzig M,Sörgel F

更新日期：2017-08-01 00:00:00

abstract：:In most cases of respiratory tract infection, antibiotic therapy has to be initiated before the results of microbiological examination are available. The four most common pathogens of acute exacerbations of chronic bronchitis are pneumococci, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. Pne...

journal_title：Infection

authors： Vogel F

更新日期：1993-01-01 00:00:00

abstract：:Raoultella planticola is a rare opportunistic pathogen usually invaded immunocompromised patients and sometimes even causes fatal infections. Recently, there is growing concern about the emergence of carbapenem resistance in this species. Here, we describe one case of hospital-acquired pneumonia due to a carbapenem-re...

journal_title：Infection

authors： Xu M,Xie W,Fu Y,Zhou H,Zhou J

更新日期：2015-04-01 00:00:00