Abstract:
:The serum half-life of cephacetrile and its penetration from the serum into the cerebrospinal fluid (CSF) was determined in 33 premature and full-term neonates. On an average the serum half-life was 3.6 hours in children with a birth weight above 1,500 g; in children with a birth weight below 1,500 g it was 5.1 hours. The penetration volume of cephacetrile into CSF was higher and the rate of penetration faster in neonates with meningeal infections than in those without. The highest CSF concentrations were reached 2-4 hours after drug application (2.6-25.8 mcg/ml in infants with bacterial meningitis and 1.8-15.2 mcg/ml in infants without).
journal_name
Infectionjournal_title
Infectionauthors
Windorfer A,Gasteiger Udoi
10.1007/BF01640789subject
Has Abstractpub_date
1977-01-01 00:00:00pages
242-7issue
4eissn
0300-8126issn
1439-0973journal_volume
5pub_type
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