Abstract:
:In an experimental infection caused by Listeria monocytogenes in mice a considerable enhancement (90-fold) of the therapeutic activity of ampicillin resulting from liposomal encapsulation was observed. The mechanism by which liposomes improved the therapeutic index of ampicillin in this infection appeared to be an increased delivery of the antibiotic to the site of infection, i.e. the liver and spleen. Substantial amounts of liposomal ampicillin were recovered from isolated Kupffer cells, the target cells of L. monocytogenes after intravenous inoculation. In addition, in studies on the survival of L. monocytogenes within murine peritoneal macrophages in vitro it was found that liposomal encapsulation of ampicillin resulted in an increased availability of the antibiotic for the intracellular bacteria: liposomal ampicillin killed 90% of the intracellular bacteria, whereas a similar concentration of free ampicillin plus empty liposomes had no effect upon the intracellular bacteria.
journal_name
Infectionjournal_title
Infectionauthors
Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FHdoi
10.1007/BF01639742subject
Has Abstractpub_date
1988-01-01 00:00:00pages
S165-70eissn
0300-8126issn
1439-0973journal_volume
16 Suppl 2pub_type
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