Abstract:
INTRODUCTION:Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking. CASE REPORT:We report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. The treatment was capable of rapidly inducing both HCV and HEV viral suppression. CONCLUSION:In conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.
journal_name
Infectionjournal_title
Infectionauthors
Biliotti E,Franchi C,Spaziante M,Garbuglia AR,Volpicelli L,Palazzo D,De Angelis M,Esvan R,Taliani Gdoi
10.1007/s15010-018-1168-7subject
Has Abstractpub_date
2018-10-01 00:00:00pages
725-727issue
5eissn
0300-8126issn
1439-0973pii
10.1007/s15010-018-1168-7journal_volume
46pub_type
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