Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin.

Abstract:

INTRODUCTION:Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking. CASE REPORT:We report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. The treatment was capable of rapidly inducing both HCV and HEV viral suppression. CONCLUSION:In conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.

journal_name

Infection

journal_title

Infection

authors

Biliotti E,Franchi C,Spaziante M,Garbuglia AR,Volpicelli L,Palazzo D,De Angelis M,Esvan R,Taliani G

doi

10.1007/s15010-018-1168-7

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

725-727

issue

5

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-018-1168-7

journal_volume

46

pub_type

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