Tuberculous meningitis in adults: review of 61 cases.

Abstract:

BACKGROUND:Tuberculosis is still a major cause of serious illness in developing countries. The objective of this study was to assess the clinical, laboratory, radiological and prognostic features of tuberculous meningitis (TBM) in immuncompetent adult patients. PATIENTS AND METHODS:Sixty-one patients with confirmed or presumed TBM seen over a 12-year period at the Neurology Department of Bakirköy Research and Training Hospital for Psychiatric and Neurological Disease, Istanbul, Turkey, were analyzed retrospectively. Patients were grouped according to the severity of meningitis on admission (stages I, II and III). They were also divided into two groups according to the presence of paradoxical response (progressive increase of lymphocytes or increase of polymorphonuclear cells instead of lymphocytes) in CSF samples. A combination of five antituberculosis drugs was used in the 1st month of treatment. Patients received antituberculosis therapy for at least 12 months. The outcome of the patients was defined on the basis of the 12-month Barthel index (BI) score (BI < 12 poor; BI >/= 12 good). For statistical analysis death was included in the poor outcome group. RESULTS:Paradoxical response in CSF findings was seen in 20 patients. There was no statistically significant difference between the outcome of the patients with and without CSF paradoxical response; however, new tuberculomas developed more frequently in the first group (p < 0.05). The overall mortality was 27.8%. Stage of disease was found to be independently associated with the 12-month outcome (OR 7.2; 95% CI 1.7-30.3, p = 0.007). CONCLUSION:In developing countries such as Turkey, tuberculosis is still an important public health issue. Early suspicion and appropriate long-term antituberculosis therapy together with corticosteroids may reduce mortality and morbidity in TBM patients.

journal_name

Infection

journal_title

Infection

authors

Sütlaş PN,Unal A,Forta H,Senol S,Kirbaş D

doi

10.1007/s15010-003-3179-1

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

387-91

issue

6

eissn

0300-8126

issn

1439-0973

journal_volume

31

pub_type

杂志文章,评审
  • Colistin and trimethoprim-sulfamethoxazole for the prevention of infection in patients with acute non-lymphocytic leukaemia. Decrease in the emergence of resistant bacteria.

    abstract::In a previous study we demonstrated that trimethoprim-sulfamethoxazole decreases the prevalence of infection in patients with severe granulocytopenia. However, treatment was accompanied by a relatively high incidence of multiresistant microorganisms. We therefore conducted this study to determine whether the addition ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641298

    authors: Rozenberg-Arska M,Dekker AW,Verhoef J

    更新日期:1983-05-01 00:00:00

  • SOFA and qSOFA usefulness for in-hospital death prediction of elderly patients admitted for suspected infection in internal medicine.

    abstract:PURPOSE:To reduce intensive care unit overcrowding and optimize resources, elderly patients affected by suspected infection with declining clinical conditions could be managed in internal medicine departments with stepdown beds. However, commonly used prognostic scores, as Sequential Organ Failure Assessment (SOFA) or ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01494-5

    authors: Falsetti L,Martino M,Zaccone V,Viticchi G,Raponi A,Moroncini G,Fioranelli A,di Pentima C,Martini A,Nitti C,Salvi A,Burattini M,Tarquinio N

    更新日期:2020-12-01 00:00:00

  • [Urinary tract infections in childhood (author's transl)].

    abstract::The clinical symptoms of urinary tract infections (UTI) are only rarely an indication of the presence of the disease in childhood. Of decisive importance for the detection of UTI is an appropriate investigation to determine whether there is significant bacteriuria. Since in a significant proportion of cases of UTI in ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01659736

    authors: Straub E

    更新日期:1979-01-01 00:00:00

  • The course of cryptococcal capsular polysaccharide antigenemia/human cryptococcal polysaccharide elimination kinetics.

    abstract::The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearan...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641291

    authors: Eng R,Chmel H,Corrado M,Smith SM

    更新日期:1983-05-01 00:00:00

  • [Altered bacterial periurethral flora in young girls with chronic, recurrent urinary tract infections? (author's transl)].

    abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640729

    authors: Hofmann K,Marget W,Belohradsky B

    更新日期:1981-01-01 00:00:00

  • Recommendations for the management of acute hepatitis B: position paper of the Italian Society for the Study of Infectious and Tropical Diseases (SIMIT).

    abstract:PURPOSE:To develop recommendations for the management of acute hepatitis B by the Italian Society for the Study of Infectious and Tropical Diseases. METHODS:Development of the recommendations divided into three levels of evidence according to the GRADE system: A (high), B (medium) and C (low experts opinion), together...

    journal_title:Infection

    pub_type: 杂志文章,实务指引,评审

    doi:10.1007/s15010-014-0642-0

    authors: Bruno R,Carosi G,Coppola N,Gaeta GB,Puoti M,Santantonio T,Taliani G,Armignacco O,Sagnelli E,Andreoni M,Angarano G,Di Perri G,D'Offizi G,Galli M,Rizzardini G,Italian Society for the Study of Infectious and Tropical Diseases.

    更新日期:2014-10-01 00:00:00

  • [Escherichia coli o serotyping in different patient groups with urinary tract infections (author's transl)].

    abstract::Using 44 anti-O sera 789 Escherichia coli strains isolated from the urine of patients with urinary tract infections were typed. Of the 119 E. coli strains from the urine of children, 49.6% were O-typable; only 3.4% were rough strains. Of 357 strains from pregnant women, 47% were O-typable; 12.1% were rough strains. Th...

    journal_title:Infection

    pub_type: 杂志文章

    doi:

    authors: Budde E,Naumann G,Nimmich W,Straube E

    更新日期:1980-01-01 00:00:00

  • Epidemiology of SARS-CoV-2.

    abstract:PURPOSE:SARS-CoV-2 is a recently emerged ß-coronavirus. Here we present the current knowledge on its epidemiologic features. METHODS:Non-systematic review. RESULTS:SARS-CoV-2 replicates in the upper and lower respiratory tract. It is mainly transmitted by droplets and aerosols from asymptomatic and symptomatic infect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-020-01531-3

    authors: Salzberger B,Buder F,Lampl B,Ehrenstein B,Hitzenbichler F,Holzmann T,Schmidt B,Hanses F

    更新日期:2020-10-08 00:00:00

  • In vitro testing of clarithromycin in combination with ethambutol and rifampicin against Mycobacterium avium complex.

    abstract::The activity of clarithromycin in combination with ethambutol and rifampicin was tested at concentrations achievable in serum against 20 strains of Mycobacterium avium complex. The combination of clarithromycin plus rifampicin showed inhibition of 11 of the strains and bactericidal synergism against seven of the strai...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645362

    authors: Stauffer F,Dörtbudak O,Lahonik E

    更新日期:1991-09-01 00:00:00

  • Legionella in two splenectomized patients. Coincidence or causal relationship?

    abstract::We describe two splenectomized patients admitted with pneumonia. The course in one was complicated by overwhelming multiorgan failure when the only indicative laboratory result was seropositivity for Legionella hackeliae and Legionella longbeachae. He was initially treated with ceftriaxone and roxithromycin, followed ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-3005-4

    authors: Gorelik O,Lazarovich Z,Boldur I,Almoznino-Sarafian D,Alon I,Modai D,Cohen N

    更新日期:2004-06-01 00:00:00

  • The integrity of latex gloves in clinical dental practice.

    abstract:BACKGROUND:The aim of the study was to assess the integrity of non-sterile latex gloves (Biogel Diagnostic (A), Biogel Dental (B), Gentle Skin (C) and Manufix (D)) in clinical dental practice. MATERIALS AND METHODS:After use, the gloves were collected and examined for perforations using the water inflation test accord...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100070011

    authors: Pitten FA,Herdemann G,Kramer A

    更新日期:2000-11-01 00:00:00

  • Haemophilus aphrophilus meningitis complicated by hydrocephalus in an immunocompetent adult.

    abstract::A case of meningitis due to an unusual organism, Haemophilus aphrophilus in an adult is described. In spite of rapid clearance of the organism from the cerebrospinal fluid with intravenous cefotaxime, fever persisted over 8 days of therapy and infection was complicated by hydrocephalus. H. aphrophilus meningitis is un...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02770846

    authors: Adeyemi-Doro FA,Hui AC,Ho FN,Ip M

    更新日期:1998-11-01 00:00:00

  • Serological biomarkers of candidemia: a retrospective evaluation of three assays.

    abstract:PURPOSE:Serologic testing allows for rapid detection of candidemia. More data are needed for the Virion\Serion ELISA antigen test (Ag), Hemkit Candida IHA antibody test (Ab), and Wako β-1,3-D-glucan assay (BDG). METHODS:Tests were performed on serum samples from 120 cases of culture-confirmed candidemia and 44 Candida...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1224-3

    authors: Dichtl K,Seybold U,Wagener J

    更新日期:2019-04-01 00:00:00

  • Low rate of clinical consequences derived from results of blood cultures obtained in an internal medicine emergency department.

    abstract:BACKGROUND:Blood cultures detect bacteremia in individual patients and help define local pathogen and resistance spectra. At the same time, the benefits of blood culture results in the management of individual patients -- and therefore their cost-effectiveness -- are disputed. PATIENTS AND METHODS:During 1 calendar ye...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-5065-5

    authors: Ehrenstein BP,Jarry T,Linde HJ,Schölmerich J,Glück T

    更新日期:2005-10-01 00:00:00

  • Infant tuberculosis in Austria--trend reversal since 1990?

    abstract::Since 1990 a relatively high number of cases of childhood tuberculosis has been observed in Austria, mainly occurring in the age-group of 0-4 years. Within this group most cases were registered in 1995. Since the beginning of 1995 the establishment of a lab-supported nationwide data collection system enables a more de...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02768752

    authors: Makristathis A,Stauffer F,Klein JP,Rotter ML,Wewalka G,Hirschl AM

    更新日期:1998-01-01 00:00:00

  • Clinical predictors for death in HIV-positive and HIV-negative tuberculosis patients in Guinea-Bissau.

    abstract:OBJECT:To assess easily monitored predictors for tuberculosis mortality. DESIGN:Risk factors for tuberculosis mortality were assessed during the 8-month treatment in 440 men and 269 women diagnosed with confirmed or presumed intrathoracic tuberculosis included prospectively in Guinea-Bissau from May 1996 to April 2001...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6090-3

    authors: Gustafson P,Gomes VF,Vieira CS,Samb B,Nauclér A,Aaby P,Lisse I

    更新日期:2007-04-01 00:00:00

  • An outbreak of rubella aboard a ship of the German Navy.

    abstract:BACKGROUND:During May and June 1996, an outbreak of rubella occurred offshore aboard a ship of the German Navy. The outbreak spread among 330 crew members over a period of 9 weeks, ending 2 days after the ship's return. This is the first detailed epidemiological investigation of a rubella outbreak on a ship, describing...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-003-3048-y

    authors: Ziebold C,Hassenpflug B,Wegner-Bröse H,Wegner K,Schmitt HJ

    更新日期:2003-06-01 00:00:00

  • Mother to child transmission of hepatitis B virus in the Philippines.

    abstract::A follow-up study of mother to infant transmission of hepatitis B virus was conducted in the Philippines between 1981 and 1983. The prevalence of HBsAg among 527 mothers was 8.5%. Overall, seven out of 17 (41.2%) infants born to HBsAg carrier mothers became HBsAg positive within the first 12 months of life. The risk o...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650707

    authors: Lingao AL,Torres NT,Muñoz N,Lansang MA,West SK,Bosch FX,Domingo EO

    更新日期:1989-09-01 00:00:00

  • Abdominal wall phlebitis due to Prevotella bivia following renal transplantation in a patient with an occluded inferior vena cava.

    abstract::Pre-existing occlusion of the inferior vena cava may complicate renal transplantation. Suppurative abdominal wall phlebitis following renal transplantation was diagnosed in a patient with pre-existing thrombosis of the inferior vena cava of unknown cause. The phlebitis developed in the subcutaneous collateral veins of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0335-5

    authors: Janssen S,van Donselaar-van der Pant KA,van der Weerd NC,Develter W,Bemelman FJ,Grobusch MP,Idu MM,Ten Berge IJ

    更新日期:2013-02-01 00:00:00

  • [Experimental study of the local application of silver sulfadiazine, cefsulodin and povidone-iodine in burns].

    abstract::Non-infected standardized burns and those contaminated experimentally with a constant number of organisms of a selected Pseudomonas aeruginosa strain underwent varying forms of treatment with silver sulfadiazine, cefsulodin cream and povidone iodine ointment. Wound healing was controlled by evaluating the wound area. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641022

    authors: Kaiser W,von der Lieth H,Potel J,Heymann H

    更新日期:1984-01-01 00:00:00

  • A comparative study of the mannose-resistant and mannose-sensitive haemagglutinins of Escherichia coli isolated from urinary tract infections.

    abstract::The distribution of mannose-resistant (MRHA) and mannose-sensitive (MSHA) fimbrial haemagglutinins was examined in 482 strains of Escherichia coli isolated from 390 adult women and 45 pregnant mothers with a variety of urinary tract infections (UTI), and from 47 healthy controls. The proportion of MRHA strains was sig...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641080

    authors: Parry SH,Boonchai S,Abraham SN,Salter JM,Rooke DM,Simpson JM,Bint AJ,Sussman M

    更新日期:1983-03-01 00:00:00

  • Operative management of intraabdominal infection.

    abstract::Surgical principles in the management of intraabdominal infection have remained constant. Rather, it is the application of these principles in selected cases that has varied. Judgement, therefore, becomes paramount for the surgeon. In selected cases multiple planned relaparotomies may be the most effective means of cl...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01726464

    authors: Aprahamian C,Wittmann DH

    更新日期:1991-11-01 00:00:00

  • Candidemia in intensive care unit patients: risk factors for mortality.

    abstract::Aim of this study was to evaluate whether risk factors which predict the development of candidemia may also predict death in ICU patients with candidemia. During an 8-year-period all ICU patients whose blood cultures yielded Candida species (n = 40) were retrospectively evaluated in a case-control fashion. The average...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02113499

    authors: Voss A,le Noble JL,Verduyn Lunel FM,Foudraine NA,Meis JF

    更新日期:1997-01-01 00:00:00

  • Cytomegalovirus infection in newborns and their family members: polymerase chain reaction analysis of isolates.

    abstract::Polymerase chain reaction (PCR) analysis with primers for the pp65, a-sequence, glycoprotein B, and major immediate early genes of human cytomegalovirus (CMV) was used to study five congenitally-infected infants and their CMV-infected family members. Family members excreting CMV included three mothers and two siblings...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02113601

    authors: Souza IE,Gregg A,Pfab D,Dawson JD,Benson P,O'Neill ME,Murph JR,Petheram SJ,Bale JF Jr

    更新日期:1997-05-01 00:00:00

  • New fluoroquinolones in lower respiratory tract infections and emerging patterns of pneumococcal resistance.

    abstract::The increasing resistance of Streptococcus pneumoniae, the most important community respiratory pathogen, to beta-lactams and other first-line antimicrobial agents usually employed for the empirical treatment of lower respiratory tract infections has led to the inclusion, in several current guidelines, of a fluoroquin...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-005-4102-8

    authors: Ferrara AM

    更新日期:2005-06-01 00:00:00

  • Clindamycin-induced hypersensitivity reaction.

    abstract::Drug-induced anaphylaxis is an unpredictable adverse reaction. Although it may occur with any medication, antibiotics induce more cases of anaphylaxis than any other medication class with most cases being induced by β-lactam antibiotics. Clindamycin is an antibiotic with good gram-positive and anaerobe coverage which ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0826-2

    authors: Bulloch MN,Baccas JT,Arnold S

    更新日期:2016-06-01 00:00:00

  • The incidence of fulminant hepatic failure in acute viral hepatitis in Taiwan: increased risk in patients with pre-existing HBsAg carrier state.

    abstract::The incidence of fulminant hepatitis in Taiwan was studied in a series of consecutive 523 patients with acute viral hepatitis including 11 with acute hepatitis A, 67 with acute hepatitis B, 124 with acute hepatitis NANB and 321 acute hepatitis in HBsAg carriers (patients who were HBsAg positive but anti-HBc IgM negati...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643385

    authors: Chu CM,Liaw YF

    更新日期:1990-07-01 00:00:00

  • Catheter-associated infections in urology: possible use of silver-impregnated catheters and the Erlanger silver catheter.

    abstract::Indwelling urinary catheters play a very important part in urology. However, their use is accompanied by a considerable increase in the risk of nosocomial urinary tract infections. The pathophysiological cause is ascribed to pathogens that adhere to the catheter surface, proliferate and produce a biofilm. In addition ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF02561624

    authors: Rösch W,Lugauer S

    更新日期:1999-01-01 00:00:00

  • Success of MRSA eradication in hospital routine: depends on compliance.

    abstract:BACKGROUND:To prevent transmission of MRSA, eradication by antiseptic washings and nasal ointment is recommended. There are few studies, which investigated the success of eradication of MRSA carriage during everyday clinical working conditions and results are controversial. We wanted to assess the effectiveness of MRSA...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6273-y

    authors: Hansen D,Patzke PI,Werfel U,Benner D,Brauksiepe A,Popp W

    更新日期:2007-06-01 00:00:00

  • Isolation of mycoplasma species from infertile patients: an epidemiological contribution.

    abstract::In this study the presence of Mycoplasma species in patients suffering from infertility was examined. 41 women and 37 men were examined, including 31 couples, and ten single women and six single men. Samples of vaginal and cervical mucus were taken from each woman, and samples of seminal fluid from each man. Identific...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642082

    authors: Brenciaglia MI,Cipriani P,Lilli D,Lorino G,Mancini C,Sangnier C

    更新日期:1977-01-01 00:00:00