Serological biomarkers of candidemia: a retrospective evaluation of three assays.


PURPOSE:Serologic testing allows for rapid detection of candidemia. More data are needed for the Virion\Serion ELISA antigen test (Ag), Hemkit Candida IHA antibody test (Ab), and Wako β-1,3-D-glucan assay (BDG). METHODS:Tests were performed on serum samples from 120 cases of culture-confirmed candidemia and 44 Candida-negative controls. Sensitivities and specificities of individual tests as well as combinations were assessed. RESULTS:The overall sensitivity of Ag, Ab, and Ag/Ab testing was 30, 40, and 54%, respectively, while in transplant patients it significantly dropped to 16, 26, and 40% (p = 0.02). For BDG testing it was 67%, both overall and in transplant patients. Especially Ag testing performed poorly among women ≤ 65 years with a significantly reduced sensitivity of 9% (p < 0.002). While the sensitivity of Ag/Ab testing was somewhat higher at 67% for C. albicans, it was significantly lower for non-albicans species at 42% (p = 0.006). The sensitivity of BDG testing for C. albicans and non-albicans species was not significantly different at 64 and 69%, respectively. Both Ag/Ab and BDG testing had a high specificity of 93%, for Ag testing it was 100%. Similar sensitivities were calculated for sera sampled on the day of and 4-6 days before sampling of positive blood cultures. CONCLUSIONS:Serological markers are valuable tools for the early diagnosis of candidemia. Ab, Ag, and BDG testing are all characterized by high specificity. The Wako BDG test is significantly more sensitive compared to combined Candida-Ag/Ab testing, particularly in the setting of non-albicans species and specific host factors.






Dichtl K,Seybold U,Wagener J




Has Abstract


2019-04-01 00:00:00














  • Mother to child transmission of hepatitis B virus in the Philippines.

    abstract::A follow-up study of mother to infant transmission of hepatitis B virus was conducted in the Philippines between 1981 and 1983. The prevalence of HBsAg among 527 mothers was 8.5%. Overall, seven out of 17 (41.2%) infants born to HBsAg carrier mothers became HBsAg positive within the first 12 months of life. The risk o...


    pub_type: 杂志文章


    authors: Lingao AL,Torres NT,Muñoz N,Lansang MA,West SK,Bosch FX,Domingo EO

    更新日期:1989-09-01 00:00:00

  • Risk factors for undervaccination against measles in a large sample of preschool children from rural Bavaria.

    abstract:BACKGROUND:Due to insufficient vaccination rates, measles outbreaks still pose a threat to public health in Germany. The purpose of this study was to identify risk factors for undervaccination against measles. PATIENTS AND METHODS:Datasets from two cross-sectional surveys were analyzed by logistic regression models. T...


    pub_type: 杂志文章


    authors: Zucs AP,Crispin A,Eckl E,Weitkunat R,Schlipköter U

    更新日期:2004-06-01 00:00:00

  • Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

    abstract:BACKGROUND:Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS:We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of...


    pub_type: 杂志文章


    authors: Anderson DJ,Murdoch DR,Sexton DJ,Reller LB,Stout JE,Cabell CH,Corey GR

    更新日期:2004-04-01 00:00:00

  • Development of sulphonamide-trimethoprim combinations for urinary tract infections. Part 2: Comparative pharmacokinetics of five sulphonamides.

    abstract::The pharmacokinetics and renal excretion of the sulphonamides sulphachloropyridazine, sulphadiazine, sulphaisodimidine, sulphamerazine, and sulphamethoxazole were investigated in a cross-over study with doses of 800 mg each. The serum half-life, urine levels, distribution volume, protein binding and potential antibact...


    pub_type: 杂志文章


    authors: Ortengren B,Fellner H,Bergan T

    更新日期:1979-01-01 00:00:00

  • [Pseudomonas aeruginosa immunoglobulin in experimental pneumonia].

    abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...


    pub_type: 杂志文章


    authors: Pennington JE,Pier GB

    更新日期:1987-01-01 00:00:00

  • Legionella in two splenectomized patients. Coincidence or causal relationship?

    abstract::We describe two splenectomized patients admitted with pneumonia. The course in one was complicated by overwhelming multiorgan failure when the only indicative laboratory result was seropositivity for Legionella hackeliae and Legionella longbeachae. He was initially treated with ceftriaxone and roxithromycin, followed ...


    pub_type: 杂志文章


    authors: Gorelik O,Lazarovich Z,Boldur I,Almoznino-Sarafian D,Alon I,Modai D,Cohen N

    更新日期:2004-06-01 00:00:00

  • Chlamydia trachomatis in andrologic patients--direct and indirect detection.

    abstract:BACKGROUND:Chlamydia trachomatis is considered to be the most common sexually transmitted disease in Germany. It is currently unclear whether chlamydial infection causes pathological conditions of the male accessory glands with consequences for male infertility. PATIENTS AND METHODS:Within the framework of several pro...


    pub_type: 杂志文章


    authors: Bollmann R,Engel S,Petzoldt R,Göbel UB

    更新日期:2001-05-01 00:00:00

  • Basis and results of therapy with Beta-lactam antibiotics in experimental infections.

    abstract::Experimental infections in animals and their chemotherapy are dependent on a variety of experimental conditions and parameters which may be themselves interrelated; the type and number of infecting organisms, the nature of the infection, the antibiotic chosen for therapy and its administration schedule can influence t...


    pub_type: 杂志文章


    authors: Rolinson GN

    更新日期:1980-01-01 00:00:00

  • Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis.

    abstract:BACKGROUND:The diagnostic value of admission serum levels of procalcitonin (PCT) and C-reactive protein (CRP) as indicators of the etiology and prognosis was prospectively investigated. PATIENTS:96 patients, 50-85 years of age, treated in the hospital for community-acquired pneumonia (CAP). RESULTS:On admission, all ...


    pub_type: 杂志文章


    authors: Hedlund J,Hansson LO

    更新日期:2000-03-01 00:00:00

  • The effects of pretransplant conditioning, graft-versus-host disease and sepsis on the CRP levels in bone marrow transplantation.

    abstract::To evaluate the diagnostic utility of C-reactive protein (CRP) for the detection of sepsis in bone marrow transplantation, CRP levels were analyzed after pretransplant conditioning and variably combined in septic, focal or viral infections with graft-versus-host disease (GvHD) in 64 bone marrow recipients. The CRP lev...


    pub_type: 杂志文章


    authors: Rintala E,Remes K,Salmi TT,Koskinen P,Nikoskelainen J

    更新日期:1997-11-01 00:00:00

  • Automated ribotyping and pulsed-field gel electrophoresis reveal a cluster of group A streptococci in intravenous drug abusers.

    abstract:BACKGROUND:In 1998, an unexpected increase of group A streptococci (GAS) in blood cultures was observed at our institution. MATERIALS AND METHODS:To determine whether they were from unrelated sporadic cases or attributable to a common source, all isolates were analyzed by pulsed-field gel electrophoresis (PFGE) and by...


    pub_type: 杂志文章


    authors: Brunner S,Fleisch F,Ruef C,Altwegg M

    更新日期:2000-09-01 00:00:00

  • Clinical characteristics and antibiotic susceptibility of viridans streptococcal bacteremia in children with febrile neutropenia.

    abstract:PURPOSE:This retrospective study was performed in order to investigate the clinical characteristics and antibiotic susceptibility of viridans streptococcal bacteremia (VSB) in febrile neutropenic children in the context of the increase in incidence and antibiotic resistance of VSB. METHODS:We conducted this study amon...


    pub_type: 杂志文章


    authors: Han SB,Bae EY,Lee JW,Lee DG,Chung NG,Jeong DC,Cho B,Kang JH,Kim HK

    更新日期:2013-10-01 00:00:00

  • [The antibacterial efficacy of cefaclor in routine testing of clinical material from two Berlin hospitals (author's transl)].

    abstract::The agar diffusion method was used to test the antibacterial efficacy of cefaclor against bacterial strains isolated routinely from patients in two hospitals in Berlin. A comparison was made with the efficacy of oxacillin, azlocillin, amikacin, gentamicin, ampicillin, co-trimoxazole, tetracycline, penicillin, cefazoli...


    pub_type: 杂志文章


    authors: Wagner J,Hahn H

    更新日期:1979-01-01 00:00:00

  • Epidemiology of MRSA.

    abstract::Staphylococcus aureus is recognized as one of the major causes of infections in humans occurring in both the community and the hospital. Up to now one of the most serious aspects as far as treatment of S. aureus infections is concerned is resistance to methicillin, which in clinical terms indicates resistance to all b...


    pub_type: 杂志文章,评审


    authors: Hryniewicz W

    更新日期:1999-01-01 00:00:00

  • Effect of aztreonam on the colon microflora in patients undergoing colorectal surgery.

    abstract::Aztreonam was given intravenously at a dose of 1 g at induction of anaesthesia, followed by subsequent doses of 1 g at eight hour intervals during 48 hours to 20 patients undergoing colorectal surgery. A series of serum and faecal specimens were taken for analysis of aztreonam concentrations. Tissue samples from the g...


    pub_type: 杂志文章


    authors: Kager L,Brismar B,Malmborg AS,Nord CE

    更新日期:1985-05-01 00:00:00

  • Guillain-Barré syndrome associated with Mycobacterium bovis lymphadenitis.

    abstract::Guillain-Barré syndrome (GBS) is an autoimmune disease that can be triggered by different infectious agents. Here we report the case of a 26-year-old Algerian woman who developed GBS associated with a Mycobacterium bovis cervical lymphadenitis. Following intravenous immunoglobulin therapy, the patient's neurologic sta...


    pub_type: 杂志文章


    authors: Vergnon-Miszczycha D,Suy F,Robert F,Carricajo A,Fresard A,Cazorla C,Guglielminotti C,Lucht F,Botelho-Nevers E

    更新日期:2015-10-01 00:00:00

  • The incidence of fulminant hepatic failure in acute viral hepatitis in Taiwan: increased risk in patients with pre-existing HBsAg carrier state.

    abstract::The incidence of fulminant hepatitis in Taiwan was studied in a series of consecutive 523 patients with acute viral hepatitis including 11 with acute hepatitis A, 67 with acute hepatitis B, 124 with acute hepatitis NANB and 321 acute hepatitis in HBsAg carriers (patients who were HBsAg positive but anti-HBc IgM negati...


    pub_type: 杂志文章


    authors: Chu CM,Liaw YF

    更新日期:1990-07-01 00:00:00

  • Controversies in the therapeutic approach to congenital cytomegalovirus infection.

    abstract::Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these child...


    pub_type: 杂志文章


    authors: Garrido-Barbero M,Arnaez J,Garcia-Alix A

    更新日期:2020-06-01 00:00:00

  • A retrospective analysis of weight changes in HIV-positive patients switching from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing treatment regimen in one German university hospital in 2015-2017.

    abstract:PURPOSE:To determine whether changing from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing regimen is correlated with weight changes in a human immunodeficiency virus (HIV)-positive adult cohort. METHODS:Retrospective analysis was conducted of data gathered from routine care...


    pub_type: 杂志文章


    authors: Gomez M,Seybold U,Roider J,Härter G,Bogner JR

    更新日期:2019-02-01 00:00:00

  • Specific anti cross-infection measures may help to prevent viral contamination of dental unit waterlines: a pilot study.

    abstract:BACKGROUND:In recent years, several reports have suggested, but never definitely demonstrated that dental units (DU) could be potential sources of viral cross-infections sustained by viral agents including HBV, HCV and HIV. This work aims at assessing the risk of HCV cross-infection by dental unit water lines (DUWLs). ...


    pub_type: 杂志文章


    authors: Artini M,Scoarughi GL,Papa R,Dolci G,De Luca M,Orsini G,Pappalardo S,Costerton JW,Selan L

    更新日期:2008-10-01 00:00:00

  • First report of chronic implant-related septic arthritis and osteomyelitis due to Kytococcus schroeteri and a review of human K. schroeteri infections.

    abstract::We report the first case of Kytococcus schroeteri implant-related septic arthritis and osteomyelitis, identified by phenotypic tests and 16S rRNA sequencing, which responded to implant removal and doxycycline. 16S rRNA sequencing was useful for the accurate and rapid identification of the organism as it exhibited thre...


    pub_type: 杂志文章


    authors: Chan JF,Wong SS,Leung SS,Fan RY,Ngan AH,To KK,Lau SK,Yuen KY,Woo PC

    更新日期:2012-10-01 00:00:00

  • Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections.

    abstract::Systemic enterococcal infections often lead to life-threatening disease. By analyzing the immune response of two patients with systemic enterococcal infections against enterococcal polysaccharide antigens, we found that both patients had antibodies against all four of the capsular serotypes identified to date. Antibod...


    pub_type: 杂志文章


    authors: Hufnagel M,Huebner J

    更新日期:2005-10-01 00:00:00

  • Hepatitis C virus infection: sexual or non-sexual transmission between spouses? A case report and review of the literature.

    abstract::The most efficient route of transmission of hepatitis C virus (HCV) infection is through contaminated blood. Sexual transmission or other close human contact could play a role in sporadic infections. We describe a case of acute hepatitis C progressing to chronic hepatitis over a follow-up of 4 years in a 44-year-old w...


    pub_type: 杂志文章,评审


    authors: Orlando R,Lirussi F

    更新日期:2007-12-01 00:00:00

  • Efficacy of clarithromycin in preventing viridans streptococcal bacteremia following autologous stem cell transplantation.

    abstract:BACKGROUND:In a study involving 200 patients, we previously found that 17.5% of patients developed viridans streptococcal (VS) bacteremia following autologous peripheral blood stem cell transplantation (aPBSCT) when ciprofloxacin or ciprofloxacin plus ampicillin was used for prophylaxis. PATIENTS AND METHODS:A retrosp...


    pub_type: 杂志文章


    authors: Naqvi B,Dorsky D,Ali SA,Feingold JM,Edwards RL,Bona RD,Clive J,Tutschka PJ,Bilgrami S

    更新日期:2001-08-01 00:00:00

  • Management of a Mycobacterium immunogenum infection of a peritoneal dialysis catheter site.

    abstract::Mycobacterium immunogenum is a member of the rapidly growing non-tuberculous mycobacteria and is a relatively new species identified within this group. An 81-year-old immune-competent male was diagnosed with M. immunogenum infection of his peritoneal dialysis catheter exit site and surrounding soft tissue. To our know...


    pub_type: 杂志文章


    authors: Shenoy A,El-Nahal W,Walker M,Chopra T,Townsend G,Heysell S,Eby J

    更新日期:2018-12-01 00:00:00

  • Temporofacial zygomycosis in a pregnant woman.

    abstract::A 38-year-old Omani woman, seven months pregnant, developed extensive zygomycosis involving maxillary and temporal bones. No evidence of any underlying immune deficiency was detected except that which may be attributed to pregnancy. After delivery the patient was treated with repeated courses of amphotericin B, which ...


    pub_type: 杂志文章


    authors: Buhl MR,Joseph TP,Snelling BE,Buhl L

    更新日期:1992-07-01 00:00:00

  • SOFA and qSOFA usefulness for in-hospital death prediction of elderly patients admitted for suspected infection in internal medicine.

    abstract:PURPOSE:To reduce intensive care unit overcrowding and optimize resources, elderly patients affected by suspected infection with declining clinical conditions could be managed in internal medicine departments with stepdown beds. However, commonly used prognostic scores, as Sequential Organ Failure Assessment (SOFA) or ...


    pub_type: 杂志文章


    authors: Falsetti L,Martino M,Zaccone V,Viticchi G,Raponi A,Moroncini G,Fioranelli A,di Pentima C,Martini A,Nitti C,Salvi A,Burattini M,Tarquinio N

    更新日期:2020-12-01 00:00:00

  • Women facing HIV. Key question on women with HIV infection: Italian consensus workshop.

    abstract::A panel of leading Italian specialists in infectious diseases, obstetrics and gynaecology met in a national consensus workshop on women facing HIV to review critical aspects and discuss recommendations for selected key questions on four issues: (1) women and highly active antiretroviral therapy (HAART): access to care...


    pub_type: 共识发展会议,杂志文章


    authors: Carosi G,Nasta P,Fiore S,Matteelli A,Cauda R,Ferrazzi E,Tamburrini E,Savasi V,Bini T,Ravizza M,Bucceri A,Vichi F,Murri R,Mazzotta F,d'Arminio Monforte A,Italian Working Group for the Women with HIV Management Guidelines.

    更新日期:2009-04-01 00:00:00

  • Serum levels of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), its soluble receptor sIL-1RII and C-reactive protein (CRP) in patients with Lyme arthritis.

    abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...


    pub_type: 杂志文章


    authors: Pietruczuk A,Swierzbińska R,Pancewicz S,Pietruczuk M,Hermanowska-Szpakowicz T

    更新日期:2006-06-01 00:00:00

  • Anaerobic microbiology in the NASA space program.

    abstract::After briefly reviewing the earlier methods used to monitor the microbial load of returned lunar material, the author reports the more accurate research on the ability of terrestrial organisms to grow under simulated Martian environments. The possible importance of anaerobic microbiology can readily be seen because of...


    pub_type: 杂志文章


    authors: Brewer JH

    更新日期:1980-01-01 00:00:00