Cytomegalovirus infection in newborns and their family members: polymerase chain reaction analysis of isolates.

Abstract:

:Polymerase chain reaction (PCR) analysis with primers for the pp65, a-sequence, glycoprotein B, and major immediate early genes of human cytomegalovirus (CMV) was used to study five congenitally-infected infants and their CMV-infected family members. Family members excreting CMV included three mothers and two siblings. The PCR results indicated that the CMV strain excreted by each infant was indistinguishable from that excreted by the corresponding family member. By contrast, the molecular profiles of the CMV strains were distinct between families, indicating that the PCR algorithm described in this study is a useful method for analyzing CMV strains.

journal_name

Infection

journal_title

Infection

authors

Souza IE,Gregg A,Pfab D,Dawson JD,Benson P,O'Neill ME,Murph JR,Petheram SJ,Bale JF Jr

doi

10.1007/BF02113601

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

144-9

issue

3

eissn

0300-8126

issn

1439-0973

journal_volume

25

pub_type

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