Abstract:
PURPOSE:To describe the demographic, clinical, and microbiological profile of native vertebral osteomyelitis (NVO) in aged patients as compared to that of younger patients, to identify differences that could motivate changes in clinical management. METHODS:Retrospective, observational cohort study (1990-2015) including all adult patients with microbiologically confirmed NVO divided into 2 groups: aged (≥ 65 years) vs younger (18-64 years). RESULTS:247 patients included, 138 aged and 109 younger. Relative to younger patients, the aged had higher rates of healthcare-related infection (40.6 vs 25.7%, p = 0.014), previous known heart valve disease (29.7 vs 9.2%, p < 0.001), and concomitant infective endocarditis (38.4 vs 20.2%, p = 0.002). The groups showed similar rates of symptomatic spinal cord compression (14.5 vs 11.9%, p = 0.556) and paraspinal abscesses (62.3 vs 68.8%, p = 0.288) at presentation. There was a trend to lower spine surgery rates in the aged (11.6 vs 17.4%, p = 0.192). On univariate analysis, Staphylococcus aureus infection was associated with higher in-hospital mortality in aged (29%, OR 4.3, 95% CI 1.61-11.45). In-hospital mortality was higher among the aged (14.5 vs 6.4%, p = 0.044) as well as relapse rate due to treatment failure (3.4 vs 1%, p = 0.377). CONCLUSIONS:The findings underscore the importance of preventing healthcare-related infection and maintaining high clinical suspicion of infective endocarditis in aged NVO patients to implement proper management. S. aureus infection had a poorer prognosis in this population. As compared to younger patients, spinal surgery rates were slightly lower and overall prognosis poorer in the aged, despite similar rates of symptomatic spinal cord compression and abscesses at presentation.
journal_name
Infectionjournal_title
Infectionauthors
Aguilar-Company J,Pigrau C,Fernández-Hidalgo N,Rodríguez-Pardo D,Falcó V,Lung M,Pellisé F,Almirante Bdoi
10.1007/s15010-018-1177-6subject
Has Abstractpub_date
2018-10-01 00:00:00pages
679-686issue
5eissn
0300-8126issn
1439-0973pii
10.1007/s15010-018-1177-6journal_volume
46pub_type
杂志文章相关文献
INFECTION文献大全abstract::40 patients were given a single, short intravenous infusion of 4 g fosfomycin over a period of five to ten minutes. In 23 patients, the contents of the gall bladder were removed intra-operatively 30-105 minutes after the fosfomycin infusion. In 17 patients who had undergone cholecystectomy eight to ten days earlier, b...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640831
更新日期:1982-01-01 00:00:00
abstract::Fungal resistance is caused by an acquisition of intrinsically resistant species, by selection of resistant strains from a population or by mutation of an initially susceptible strain. According to different classes of antimycotics there are different resistance mechanisms: differences in the uptake mechanisms, drug t...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF02561673
更新日期:1999-01-01 00:00:00
abstract::The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (+/- SEM) concentration of 2.4 +/- 0.4 micrograms/ml ampicillin was found in the effusions a...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659775
更新日期:1979-01-01 00:00:00
abstract::The cephalosporins differ in the substituents attached at the 3 and/or 7 positions of the molecule. Very schematically, substitution at C3 mainly modifies the overall pharmacokinetic properties whereas substitution at position 7 influences the antibacterial characteristics. When using the more common "generation" syst...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01645535
更新日期:1991-01-01 00:00:00
abstract::The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641100
更新日期:1983-01-01 00:00:00
abstract::Penetration of ciprofloxacin into human tonsils was studied following an intravenous infusion of 200 mg over 15 minutes to adult humans undergoing tonsillectomy. Samples were taken one-and-a-half to four hours after dosing. Generally, tissue levels exceeded corresponding serum concentrations by 50% (range of intraindi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01651152
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:Due to insufficient vaccination rates, measles outbreaks still pose a threat to public health in Germany. The purpose of this study was to identify risk factors for undervaccination against measles. PATIENTS AND METHODS:Datasets from two cross-sectional surveys were analyzed by logistic regression models. T...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-004-3122-0
更新日期:2004-06-01 00:00:00
abstract::The serum IL-6 and TNF alpha response to cardiopulmonary bypass surgery was studied in 12 patients. Human neutrophil elastase was also measured in order to detect the presence of neutrophil activation. Peripheral venous blood samples were obtained before, during, and 1, 2, 3 and 6 days after surgery. Intra-operative s...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01780764
更新日期:1994-01-01 00:00:00
abstract::Streptococcus pyogenes rarely causes meningitis. A recent increase in the incidence and severity of diseases due to S. pyogenes has been observed worldwide, without an apparent increase in the incidence of S. pyogenes meningitis. However, more recently severe and fulminant cases of S. pyogenes meningitis have been rep...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1065-2
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:We examined lymphocyte apoptosis, activity of caspases-1, -3, -8 and -9 and the relationship between those two events and inflammation response in septic shock. MATERIALS AND METHODS:Blood samples were obtained within 24 h after diagnosis of septic shock from 16 patients to measure apoptosis, caspases-3, -8...
journal_title:Infection
pub_type: 信件
doi:10.1007/s15010-008-7070-y
更新日期:2008-10-01 00:00:00
abstract::The radiologic surveillance of smokers with low-dose CT scan has led to a significant surge of radiologic incidental findings, including the detection of early stages of pulmonary infections including nontuberculous mycobacteria (NTM). This causes a state of overdiagnosis and potential overtreatment of NTM lung diseas...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1232-3
更新日期:2018-12-01 00:00:00
abstract::ATRIPLA is licensed for use only in HIV-positive persons whose viral loads <50 for ≥ 3 months. We investigated the use of ATRIPLA as first-line antiretroviral therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations when initiating first...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-014-0630-4
更新日期:2014-08-01 00:00:00
abstract::The pharmacokinetics of six quinolone derivatives were investigated in the human and dog prostate. The possible therapeutic applications of these findings are discussed. ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643687
更新日期:1991-01-01 00:00:00
abstract::A 100 male patients aged from 20 to 45 years were treated for chronic brucellosis. Sixty-eight complained of impaired sexual potency. The percentage of patients with sexual disorders increased parallel to the duration of the disease. Andrologic investigations comprised a study sexual history, physical examination of t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641469
更新日期:1980-01-01 00:00:00
abstract::Association of renin-angiotensin system inhibitors with risk of death in patients with hypertension (HTN) and coronavirus disease 2019 (COVID-19) is not well characterized. The aim of this study was to evaluate the outcomes of patients with HTN and COVID-19 with respect to different chronic antihypertensive drug intak...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01550-0
更新日期:2020-11-22 00:00:00
abstract::A 24-year-old man presented with vague abdominal fullness and a mild epigastric dull pain for about 3 months was found to have a pancreatic head tumor at a medical center 2 months ago. He came to our hospital for further treatment. Ultrasonography, endoscopic retrograde cholangiopancreatography (ERCP) and abdominal co...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01739920
更新日期:1994-07-01 00:00:00
abstract:INTRODUCTION:In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0885-z
更新日期:2016-06-01 00:00:00
abstract::We studied the activity of cefotaxime both microbiologically and clinically. 138 blood cultures positive for gram-positive cocci were evaluated (90 strains of Staphylococcus aureus, 25 of Streptococcus faecalis, 13 of Streptococcus alpha and ten of Streptococcus mutans). Cefotaxime showed good activity against all str...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644230
更新日期:1985-01-01 00:00:00
abstract::Sera from 192 out-patient alcoholics attending a clinic for the treatment of alcoholism were tested for hepatitis B surface antigen (HBsAg) and for antibodies to HBsAg and to hepatitis B core antigen (HBcAg). Three sera (1.5%) were positive for HBsAg. Of the remaining 189 alcoholics, 29 (15%) were positive for one or ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641674
更新日期:1984-03-01 00:00:00
abstract:PURPOSE:SARS-CoV-2 is a recently emerged ß-coronavirus. Here we present the current knowledge on its epidemiologic features. METHODS:Non-systematic review. RESULTS:SARS-CoV-2 replicates in the upper and lower respiratory tract. It is mainly transmitted by droplets and aerosols from asymptomatic and symptomatic infect...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-020-01531-3
更新日期:2020-10-08 00:00:00
abstract:PURPOSE:In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition. METHODS:In the present study, the outbreak is described and risk factors fo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1103-3
更新日期:2018-02-01 00:00:00
abstract::The in vitro activity of clarithromycin alone and in combination with its primary human metabolite, 14-hydroxy-clarithromycin, was determined against 203 strains of Haemophilus influenzae. Microdilution broth MICs and MBCs of both clarithromycin and 14-hydroxy-clarithromycin were determined. The clarithromycin MIC50 w...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01704612
更新日期:1992-05-01 00:00:00
abstract::A microbiological analysis of 102 patients suffering from cystic fibrosis was conducted over a 22 month period. 20 microbial species with the following incidence were identified: Pseudomonas aeruginosa: 83.4%; Candida albicans: 29.4%; Staphylococcus aureus: 24.5%; Staphylococcus epidermidis: 11.8%; Haemophilus influen...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644137
更新日期:1987-07-01 00:00:00
abstract::Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640866
更新日期:1982-01-01 00:00:00
abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640729
更新日期:1981-01-01 00:00:00
abstract::The binding of the acylureidopenicillins azlocillin and mezlocillin to serum proteins was investigated by means of equilibrium dialysis and ultracentrifugation. The penicillin concentrations were determined by the agar diffusion test and by circular dichroism. The degree of binding is dependent on the penicillin conce...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641306
更新日期:1979-01-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. ...
journal_title:Infection
pub_type: 已发布勘误
doi:10.1007/s15010-020-01465-w
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The aim of the study was to evaluate the efficacy and safety of combined treatment with natural leukocyte interferon alpha (Alfaferone) plus ribavirin in patients with HCV-related cirrhosis. PATIENTS AND METHODS:Twenty-three patients (15 women, 8 men) aged 17-68 years hospitalized in 2005-2008 were included...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0135-3
更新日期:2011-10-01 00:00:00
abstract::Satisfactory methods for the serodiagnosis of Chlamydia trachomatis have been widely discussed in recent years. Until a decade ago, the complement-fixation test measuring group-specific antibody was the most widely applied technique. However, despite showing relatively high diagnostic sensitivity in systemic chlamydia...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01640711
更新日期:1982-01-01 00:00:00
abstract:PURPOSE:Differential diagnosis between acute viral and bacterial infection is an emerging common challenge for a physician in the emergency department. Serum C-reactive protein (CRP) is used to support diagnosis of bacterial infection, but in patients admitted with low CRP, its ability to discriminate between viral and...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-019-01383-6
更新日期:2020-04-01 00:00:00