Abstract：
:Ten patients about to undergo a colorectal operation lasting an average of three hours received 500 mg each of imipenem and cilastatin i.v. preoperatively. During the operation blood and tissue samples were taken in order to determine the serum kinetics of the substances as well as the levels of imipenem in the cutis, subcutis, fascia, muscle, parietal peritoneum and colon. The imipenem concentrations were measured by HPLC. The mean peak serum concentration was 26 mg/l, the mean half-life 55 min and the AUC 40 mg/l/h-1. The serum pharmacokinetics of imipenem was subject to substantially larger fluctuations in this patient group than in subjects or patients without surgery. Imipenem rapidly penetrates into tissue, with peak concentrations being reached after 10-25 min. The highest imipenem concentrations were found in the colon, the lowest in the cutis and subcutis. After 1 h a level of 8 mg/kg imipenem was still found in the colon. The concentrations were greater than 1 mg/kg in all tissues for more than 3 h p. a. and thus within this period exceeded the MICs of Escherichia coli and Bacteroides fragilis, the indicator organisms of intraabdominal infections.
journal_name
Infectionjournal_title
Infectionauthors
Erttmann M,Krausse R,Ullmann Udoi
10.1007/BF01646409subject
Has Abstractpub_date
1990-11-01 00:00:00pages
367-71issue
6eissn
0300-8126issn
1439-0973journal_volume
18pub_type
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