In vivo potentiation of polymorphonuclear leukocyte chemotaxis by clindamycin.

Abstract:

:Polymorphonuclear leukocyte (PMNL) chemotaxis was evaluated in ten healthy volunteers who had received 600 mg of clindamycin intramuscularly. Serum obtained 3 hours after the administration of clindamycin significantly increased PMNL chemotaxis. Serum obtained at 12 and 24 hours after the administration of the drug did not induce significant increase in PMNL chemotaxis. The administration of clindamycin had no direct effect on the PMNLs in terms of their chemotactic activity. These results demonstrate serum-associated augmentation of PMNL chemotaxis by clindamycin in vivo which may be of potential clinical benefit in the outcome of infections.

journal_name

Infection

journal_title

Infection

authors

Skoutelis AT,Lianou PE,Bassaris HP

doi

10.1007/BF01712455

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

321-3

issue

5

eissn

0300-8126

issn

1439-0973

journal_volume

21

pub_type

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