Abstract:
PURPOSE:To determine whether changing from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing regimen is correlated with weight changes in a human immunodeficiency virus (HIV)-positive adult cohort. METHODS:Retrospective analysis was conducted of data gathered from routine care in a university hospital in Munich, Germany, between July 2015 and June 2017. Data from patients' charts were extracted and a two-step approach was applied. First, weight/BMI progression within 1 year after initiation of either TDF or TAF was compared. Subsequently, weight measurements within subjects changing from a TDF- to a TAF-containing antiretroviral regimen were analyzed by means of a repeated measurements general linear model. RESULTS:After 360 days of initiating TAF, patients showed a mean (± standard deviation) percentual weight increase of 3.17 ± 0.21, whereas after 360 days of initiating TDF, patients only showed a mean (± standard deviation) percentual weight increase of 0.55 ± 0.17. The repeated measurements general linear model for within-subjects design showed a statistically significant correlation in weight after changing from a TDF to a TAF containing antiretroviral regimen. The weight difference between the two measurements while on TDF was not statistically significant, but every measure after switching to TAF was significantly higher than the previous. CONCLUSION:Changing from a TDF- to a TAF-containing regimen is correlated with weight gain in this retrospectively analyzed real-world cohort in Munich, Germany.
journal_name
Infectionjournal_title
Infectionauthors
Gomez M,Seybold U,Roider J,Härter G,Bogner JRdoi
10.1007/s15010-018-1227-0subject
Has Abstractpub_date
2019-02-01 00:00:00pages
95-102issue
1eissn
0300-8126issn
1439-0973pii
10.1007/s15010-018-1227-0journal_volume
47pub_type
杂志文章相关文献
INFECTION文献大全abstract::A time-dependent degree of immunosuppression or immunostimulation which may be correlated to pharmacokinetic variables was obtained by administering a single dose of ofloxacin, norfloxacin, pipemidic and piromidic acid to healthy volunteers. The plasma samples collected before drug administration and then at various t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01661284
更新日期:1986-01-01 00:00:00
abstract::As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very simil...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713160
更新日期:1997-07-01 00:00:00
abstract::A panel of leading Italian specialists in infectious diseases, obstetrics and gynaecology met in a national consensus workshop on women facing HIV to review critical aspects and discuss recommendations for selected key questions on four issues: (1) women and highly active antiretroviral therapy (HAART): access to care...
journal_title:Infection
pub_type: 共识发展会议,杂志文章
doi:10.1007/s15010-008-7361-7
更新日期:2009-04-01 00:00:00
abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709952
更新日期:1992-01-01 00:00:00
abstract::Since 1990 a relatively high number of cases of childhood tuberculosis has been observed in Austria, mainly occurring in the age-group of 0-4 years. Within this group most cases were registered in 1995. Since the beginning of 1995 the establishment of a lab-supported nationwide data collection system enables a more de...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02768752
更新日期:1998-01-01 00:00:00
abstract::We analyzed the results of passive immunization against CMV in 146 heart transplant recipients. The 65 seronegative recipients were prophylactically treated with anti-CMV immunoglobulins during and after the operation. Twenty-nine of these 65 patients received a seropositive donor heart. CMV infection occurred in 21/6...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01728886
更新日期:1993-07-01 00:00:00
abstract:PURPOSE:This retrospective study was performed in order to investigate the clinical characteristics and antibiotic susceptibility of viridans streptococcal bacteremia (VSB) in febrile neutropenic children in the context of the increase in incidence and antibiotic resistance of VSB. METHODS:We conducted this study amon...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0470-7
更新日期:2013-10-01 00:00:00
abstract::Aim of this study was to evaluate whether risk factors which predict the development of candidemia may also predict death in ICU patients with candidemia. During an 8-year-period all ICU patients whose blood cultures yielded Candida species (n = 40) were retrospectively evaluated in a case-control fashion. The average...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02113499
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:SARS-COV-2 infection can develop into a multi-organ disease. Although pathophysiological mechanisms of COVID-19-associated myocardial injury have been studied throughout the pandemic course in 2019, its morphological characterisation is still unclear. With this study, we aimed to characterise echocardiographic ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01572-8
更新日期:2021-01-30 00:00:00
abstract:OBJECTIVES:We wanted to assess the diagnostic accuracy of urinary dipstick testing in excluding catheter-associated urinary tract infection (CAUTI) in intensive care unit (ICU) patients with fever or hypothermia. METHODS:This was a prospective observational cohort study in a medical-surgical ICU. Patients with new-ons...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-014-0612-6
更新日期:2014-08-01 00:00:00
abstract::A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle a...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-008-8211-z
更新日期:2009-08-01 00:00:00
abstract::To detect microorganisms in the blood it is necessary not only that the microbiologist uses reliable methods, but also that the clinician takes a sufficient number of blood samples at the right point in time using a correct method for drawing the blood. The best results are obtained if the blood sample is transferred ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01639113
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Low cerebrospinal fluid (CSF) glucose levels have been associated with sensorineural hearing loss (SNHL) in bacterial meningitis but systematic investigations are lacking. PATIENTS AND METHODS:A retrospective case control study was conducted comparing CSF glucose levels in 47 cases with and 145 controls wit...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-003-3208-0
更新日期:2003-08-01 00:00:00
abstract::In this article the cooperating partners of the ClinSurv HIV cohort were not listed in the acknowledgements. The correct paragraph appears below. ...
journal_title:Infection
pub_type: 杂志文章,已发布勘误
doi:10.1007/s15010-019-01281-x
更新日期:2019-04-01 00:00:00
abstract::Acinetobacter is one of the organisms responsible for nosocomial infections in intensive care, neurosurgery, burn and hemodialysis units. There are only a few reports on Acinetobacter infections in neonatal intensive care units. Over a 31 month period, nine cases of Acinetobacter sepsis occurred in our unit, with four...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01728921
更新日期:1993-11-01 00:00:00
abstract::Eighty-nine patients with a history of recurrent urinary infection who required immediate treatment for significant bacteriuria were treated with either trimethoprim (300 mg at night) or with the standard course of co-trimoxazole (two tablets 12-hourly) for seven days. Cure rates one week after the end of treatment we...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01640874
更新日期:1982-09-01 00:00:00
abstract:PURPOSE:High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1007-2
更新日期:2017-08-01 00:00:00
abstract::Staphylococcus aureus is recognized as one of the major causes of infections in humans occurring in both the community and the hospital. Up to now one of the most serious aspects as far as treatment of S. aureus infections is concerned is resistance to methicillin, which in clinical terms indicates resistance to all b...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF02561663
更新日期:1999-01-01 00:00:00
abstract::Q fever is an zoonosis caused by Coxiella burnetti, the clinical features of which are often nonspecific and self-limited. Involvement of the central nervous system is rare and is usually seen as a complication of endocarditis caused by this rickettsial organism in the chronic disease. Specific neurological manifestat...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645555
更新日期:1989-11-01 00:00:00
abstract::Association of renin-angiotensin system inhibitors with risk of death in patients with hypertension (HTN) and coronavirus disease 2019 (COVID-19) is not well characterized. The aim of this study was to evaluate the outcomes of patients with HTN and COVID-19 with respect to different chronic antihypertensive drug intak...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01550-0
更新日期:2020-11-22 00:00:00
abstract::Recently, important advances have been made in the immunodiagnosis of tuberculosis. New T cell interferon-gamma release assays (TIGRA) are more specific and more sensitive than the tuberculin skin test (TST) for the diagnosis of Mycobacterium tuberculosis (MTB) infection. However, like the TST, TIGRA are unable to dis...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-008-8089-9
更新日期:2008-12-01 00:00:00
abstract::Fusobacterium nucleatum is an anaerobic Gram-negative bacillus commensal to the human oropharynx and gastrointestinal tract which causes an array of human infection, yet it has never been associated with infection of prosthetic joints. We report the first case of prosthetic hip infection caused by F. nucleatum in a ma...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0197-2
更新日期:2012-06-01 00:00:00
abstract::A follow-up study of mother to infant transmission of hepatitis B virus was conducted in the Philippines between 1981 and 1983. The prevalence of HBsAg among 527 mothers was 8.5%. Overall, seven out of 17 (41.2%) infants born to HBsAg carrier mothers became HBsAg positive within the first 12 months of life. The risk o...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01650707
更新日期:1989-09-01 00:00:00
abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644192
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:Staphylococcus aureus frequently causes infections in outpatient and hospital settings and can present as a highly variable entity. Typical manifestations are endocarditis, osteoarticular infections or infection of implanted prostheses, intravascular devices or foreign bodies. A thorough diagnostic evaluat...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1221-6
更新日期:2019-04-01 00:00:00
abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62° C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the te...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642093
更新日期:1977-06-01 00:00:00
abstract::40 patients were given a single, short intravenous infusion of 4 g fosfomycin over a period of five to ten minutes. In 23 patients, the contents of the gall bladder were removed intra-operatively 30-105 minutes after the fosfomycin infusion. In 17 patients who had undergone cholecystectomy eight to ten days earlier, b...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640831
更新日期:1982-01-01 00:00:00
abstract::Cytomegalovirus (CMV) infection remains a common infection after solid-organ transplantation. In the general population CMV disease is associated with Guillain-Barre syndrome (GBS), an autoimmune disease leading to an acute peripheral neuropathy, in 1 of 1000 cases. Interestingly, GBS is a rarely observed complication...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-015-0819-1
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Although limited data exist on the efficacy and potential risk of synergistic aminoglycoside therapy for persistent Staphylococcus aureus bacteremia and endocarditis, aminoglycosides are frequently used in clinical practice. METHODS:As our study population, we included subjects fulfilling the modified Duke cri...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0189-2
更新日期:2011-12-01 00:00:00
abstract::The original version of this article unfortunately contained a mistake. In the author list, the first and last names were tagged incorrectly. The corrected author list is given above. ...
journal_title:Infection
pub_type: 已发布勘误
doi:10.1007/s15010-020-01490-9
更新日期:2020-10-01 00:00:00