A retrospective analysis of weight changes in HIV-positive patients switching from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing treatment regimen in one German university hospital in 2015-2017.


PURPOSE:To determine whether changing from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing regimen is correlated with weight changes in a human immunodeficiency virus (HIV)-positive adult cohort. METHODS:Retrospective analysis was conducted of data gathered from routine care in a university hospital in Munich, Germany, between July 2015 and June 2017. Data from patients' charts were extracted and a two-step approach was applied. First, weight/BMI progression within 1 year after initiation of either TDF or TAF was compared. Subsequently, weight measurements within subjects changing from a TDF- to a TAF-containing antiretroviral regimen were analyzed by means of a repeated measurements general linear model. RESULTS:After 360 days of initiating TAF, patients showed a mean (± standard deviation) percentual weight increase of 3.17 ± 0.21, whereas after 360 days of initiating TDF, patients only showed a mean (± standard deviation) percentual weight increase of 0.55 ± 0.17. The repeated measurements general linear model for within-subjects design showed a statistically significant correlation in weight after changing from a TDF to a TAF containing antiretroviral regimen. The weight difference between the two measurements while on TDF was not statistically significant, but every measure after switching to TAF was significantly higher than the previous. CONCLUSION:Changing from a TDF- to a TAF-containing regimen is correlated with weight gain in this retrospectively analyzed real-world cohort in Munich, Germany.






Gomez M,Seybold U,Roider J,Härter G,Bogner JR




Has Abstract


2019-02-01 00:00:00














  • The binding of Chlamydia trachomatis and zinc to McCoy cells (mouse fibroblasts).

    abstract::Zinc was found to have profoundly different effects upon the infection of McCoy cells (mouse fibroblasts) by two strains of Chlamydia trachomatis dependent upon the time and concentration of zinc exposure. Radiolabeled zinc-65 became McCoy cell-associated in a manner independent of incubation temperature, but highly d...


    pub_type: 杂志文章


    authors: Sugarman B,Agbor P

    更新日期:1987-01-01 00:00:00

  • Clearance of Candida colonizing the urinary bladder by a two-day amphotericin B irrigation.

    abstract::The minimum duration of continuous amphotericin B irrigation (50 mg/liter/day) required to clear the candida colonizing the urinary bladder was investigated. Eleven in vitro experiments revealed a consistent candidicidal effect within 48 hours with 25 and 5 mg/l of amphotericin B concentrations attainable in the bladd...


    pub_type: 杂志文章


    authors: Hsu CC,Ukleja B

    更新日期:1990-09-01 00:00:00

  • Correction to: The diagnosis and treatment of urogenital schistosomiasis in Italy in a retrospective cohort of immigrants from Sub-Saharan Africa.

    abstract::The original version of this article unfortunately contained a mistake. The given name and family name of Filippo Parretti was transposed in the original publication. The correct name is as shown above. ...


    pub_type: 杂志文章,已发布勘误


    authors: Tilli M,Gobbi F,Rinaldi F,Testa J,Caligaris S,Magro P,Buonfrate D,Degani M,Minervini A,Carini M,Tuccio A,Sforza S,Gulletta M,Castelli F,Agostini S,Parretti F,Richter J,Olliaro P,Bisoffi Z,Bartoloni A,Zammarchi L

    更新日期:2019-06-01 00:00:00

  • Assays of cephalosporin antibiotics administered prophylactically in open heart surgery. Determination of serum and tissue levels before, during and after cardiopulmonary bypass.

    abstract::Twenty-eight patients who underwent open-heart surgery were divided into three groups, each of which received a different antibiotic from the cephalosporin series (cephalotin, cefazolin or cefamandole) in order to prevent infection. All antibiotics were given via intravenous infusion in a dosage of 2 g prior to surger...


    pub_type: 杂志文章


    authors: Eigel P,Tschirkov A,Satter P,Knothe H

    更新日期:1978-01-01 00:00:00

  • Clinical evaluation of the antifungal effect of sertraline in the treatment of cryptococcal meningitis in HIV patients: a single Mexican center experience.

    abstract:PURPOSE:Cryptococcal meningitis is a potentially fatal fungal infection associated with a significant attributable morbidity and mortality, especially among HIV/AIDS patients. The first-line therapy for the treatment of this clinical entity is the combinatory therapy of amphotericin B plus flucytosine. However, the hig...


    pub_type: 杂志文章,随机对照试验


    authors: Villanueva-Lozano H,Treviño-Rangel RJ,González GM,Hernández-Rodríguez PA,Camacho-Ortiz A,Castillo-Reyna L,Galindo-Alvarado SG,Martínez-Reséndez MF

    更新日期:2018-02-01 00:00:00

  • Clinical predictors for death in HIV-positive and HIV-negative tuberculosis patients in Guinea-Bissau.

    abstract:OBJECT:To assess easily monitored predictors for tuberculosis mortality. DESIGN:Risk factors for tuberculosis mortality were assessed during the 8-month treatment in 440 men and 269 women diagnosed with confirmed or presumed intrathoracic tuberculosis included prospectively in Guinea-Bissau from May 1996 to April 2001...


    pub_type: 杂志文章


    authors: Gustafson P,Gomes VF,Vieira CS,Samb B,Nauclér A,Aaby P,Lisse I

    更新日期:2007-04-01 00:00:00

  • IL-6 and TNF alpha release in association with neutrophil activation after cardiopulmonary bypass surgery.

    abstract::The serum IL-6 and TNF alpha response to cardiopulmonary bypass surgery was studied in 12 patients. Human neutrophil elastase was also measured in order to detect the presence of neutrophil activation. Peripheral venous blood samples were obtained before, during, and 1, 2, 3 and 6 days after surgery. Intra-operative s...


    pub_type: 杂志文章


    authors: Holzheimer RG,Molloy RG,Görlach H,Wilkert S,Hehrlein F

    更新日期:1994-01-01 00:00:00

  • Clinical significance and spread of fluoroquinolone resistant uropathogens in hospitalised urological patients.

    abstract::The minimum inhibitory concentrations (MIC) of ciprofloxacin were determined for 441 uropathogens from patients with complicated and/or hospital acquired urinary tract infections (UTI). None of the Enterobacteriaceae was resistant (MIC > or = 4 mg/l), but 21.7% of enterococci, 28.3% of Pseudomonas spp. and 38.5% of st...


    pub_type: 杂志文章


    authors: Naber KG,Witte W,Bauernfeind A,Wiedemann B,Wagenlehner F,Klare I,Heisig P

    更新日期:1994-01-01 00:00:00

  • Mycobacterium avium-intracellulare pulmonary infection complicated by cutaneous leukocytoclastic vasculitis in a woman with anorexia nervosa.

    abstract::A 53-year-old Caucasian woman with a history of anorexia nervosa developed a bilateral lower extremity rash comprised of palpable red to violaceous, sub-centimeter papular lesions that increased in quantity rapidly. She also noted a 2-month history of non-productive cough. Imaging modalities revealed a thin-walled cav...


    pub_type: 杂志文章


    authors: Walsh TL,Baca V,Stalling SS,Natalie AA,Veldkamp PJ

    更新日期:2014-06-01 00:00:00

  • A comparative study of the mannose-resistant and mannose-sensitive haemagglutinins of Escherichia coli isolated from urinary tract infections.

    abstract::The distribution of mannose-resistant (MRHA) and mannose-sensitive (MSHA) fimbrial haemagglutinins was examined in 482 strains of Escherichia coli isolated from 390 adult women and 45 pregnant mothers with a variety of urinary tract infections (UTI), and from 47 healthy controls. The proportion of MRHA strains was sig...


    pub_type: 杂志文章


    authors: Parry SH,Boonchai S,Abraham SN,Salter JM,Rooke DM,Simpson JM,Bint AJ,Sussman M

    更新日期:1983-03-01 00:00:00

  • Improvement of serological diagnosis of human cytomegalovirus infection in renal transplant recipients by testing for specific immunoglobulin E by ELISA.

    abstract::The kinetics of human cytomegalovirus (HCMV)-specific immunoglobulin E (IgE), M (IgM), A (IgA) and G (IgG) were studied in 421 sera obtained from 19 renal allograft recipients by enzyme-linked immunosorbent assay (ELISA). Cytomegalic inclusion disease (CID) occurred in 11 (57.9%) patients. HCMV infection was diagnosed...


    pub_type: 杂志文章


    authors: Weber B,Stemmler A,Ernst W,Scheuerman EH,Braun W,Doerr HW

    更新日期:1993-05-01 00:00:00

  • ELISA for antibodies to lipid A, lipopolysaccharides and other hydrophobic antigens.

    abstract::A simple, sensitive and rapid ELISA method for the quantification and characterization of antibodies to lipid A has been developed, which can also be applied to other hydrophobic antigens. For coating, antigens were applied to the wells of ELISA plates as solutions in a mixture of chloroform and ethanol 1:9 (v/v), and...


    pub_type: 杂志文章


    authors: Freudenberg MA,Fomsgaard A,Mitov I,Galanos C

    更新日期:1989-09-01 00:00:00

  • Development of sulphonamide-trimethoprim combinations for urinary tract infections. Part 2: Comparative pharmacokinetics of five sulphonamides.

    abstract::The pharmacokinetics and renal excretion of the sulphonamides sulphachloropyridazine, sulphadiazine, sulphaisodimidine, sulphamerazine, and sulphamethoxazole were investigated in a cross-over study with doses of 800 mg each. The serum half-life, urine levels, distribution volume, protein binding and potential antibact...


    pub_type: 杂志文章


    authors: Ortengren B,Fellner H,Bergan T

    更新日期:1979-01-01 00:00:00

  • HIV transmission by needle stick and eczematous lesion--three cases from Germany.

    abstract::Two cases of documented HIV-1 transmission by needle stick and one case of probable transmission by eczematous lesion in three nurses in Germany are reported in the period 1988 to 1991. In two of the cases the nurse knew of the AIDS status of the index patient. A review of the three cases reiterates the importance of ...


    pub_type: 杂志文章


    authors: Gürtler LG,Eberle J,Bader L

    更新日期:1993-01-01 00:00:00

  • Meningitis due to Micrococcus luteus.

    abstract::We are presenting a new case of meningitis due to the Micrococcus luteus species. This germ was isolated twice in eight days from the CSF of a 57-year old woman. The patient had a ventriculoperitoneal shunt implanted for hydrocephalus following a meningeal haemorrhage. Antibiotic therapy was efficient but the patient ...


    pub_type: 杂志文章


    authors: Fosse T,Peloux Y,Granthil C,Toga B,Bertrando J,Sethian M

    更新日期:1985-11-01 00:00:00

  • Cervical lymphadenitis--a rare case of focal listeriosis.

    abstract::Cervical lymphadenopathy is a condition with a broad differential diagnosis. Malignant tumors, allergic reactions, autoimmune diseases as well as various infectious agents can be the cause. We report the case of a 75-year-old man who had a cervical lymphadenopathy without symptoms of infection. The draining lymph node...


    pub_type: 杂志文章


    authors: Rosenthal R,Vogelbach P,Gasser M,Zimmerli W

    更新日期:2001-05-01 00:00:00

  • Occurrence of methicillin-resistant Staphylococcus aureus infections in German intensive care units.

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    pub_type: 杂志文章


    authors: Gastmeier P,Sohr D,Geffers C,Nassauer A,Dettenkofer M,Rüden H

    更新日期:2002-08-01 00:00:00

  • [A microbiological method for the rapid determination of antibiotic concentrations during therapy].

    abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62° C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the te...


    pub_type: 杂志文章


    authors: Wahlig H

    更新日期:1977-06-01 00:00:00

  • Thrombogenicity testing of central venous catheters in vitro.

    abstract::To date there have been no standard methods for assessing the thrombogenicity of central venous catheters. A procedure for testing the thrombogenicity of intravenous lines such as the silver-impregnated catheter by continuous blood flow in vitro was therefore developed. For this test, fresh blood was drawn from health...


    pub_type: 杂志文章


    authors: Böswald M,Lugauer S,Bechert T,Greil J,Regenfus A,Guggenbichler JP

    更新日期:1999-01-01 00:00:00

  • Seroprevalence of Chlamydia pneumoniae antibodies in a young adult population sample living in Verona. European Community Respiratory Health Survey (ECRHS) Verona.

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    pub_type: 杂志文章


    authors: Ferrari M,Poli A,Olivieri M,Tardivo S,Biasin C,Balestreri F,Dal Molin G,Lo Cascio V,Campello C

    更新日期:2000-01-01 00:00:00

  • Turicella otitidis and Corynebacterium auris: 20 years on.

    abstract::Turicella otitidis and Corynebacterium auris, described as new species 20 years ago, have been isolated mainly from the external ear canal and middle ear fluid. While their taxonomic position has been clearly established, their diagnosis in the routine laboratory is difficult. The question of their pathogenic potentia...


    pub_type: 杂志文章,评审


    authors: von Graevenitz A,Funke G

    更新日期:2014-02-01 00:00:00

  • Group B streptococcal disease in infants in the first year of life: a nationwide surveillance study in Japan, 2011-2015.

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    pub_type: 杂志文章


    authors: Matsubara K,Hoshina K,Kondo M,Miyairi I,Yukitake Y,Ito Y,Minami K,Genkawa R

    更新日期:2017-08-01 00:00:00

  • Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review.

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    pub_type: 杂志文章,评审


    authors: Johnson MG,Stout JE

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  • Mortality after bloodstream infections in allogeneic haematopoietic stem cell transplant (HSCT) recipients.

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    pub_type: 杂志文章


    authors: Mikulska M,Del Bono V,Bruzzi P,Raiola AM,Gualandi F,Van Lint MT,Bacigalupo A,Viscoli C

    更新日期:2012-06-01 00:00:00

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    pub_type: 杂志文章


    authors: van der Voort PH,van Roon EN,Kampinga GA,Boerma EC,Gerritsen RT,Egbers PH,Kuiper MA

    更新日期:2004-10-01 00:00:00

  • Prophylaxis of postoperative infections.

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    pub_type: 杂志文章,评审


    authors: Wittmann DH,Condon RE

    更新日期:1991-01-01 00:00:00

  • Six different strains of Neisseria meningitidis in a case with meningococcal sepsis and five contact persons in a boys' home.

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    pub_type: 杂志文章


    authors: Linde H,Glück T,Metz M,Reng C,Erlmeier S,Lehn N

    更新日期:2000-05-01 00:00:00

  • Thyroiditis due to Brucella melitensis--report of two cases.

    abstract::Two cases of thyroiditis due to Brucella melitensis are reported. Both occurred in foreigners working in Switzerland and presented with characteristic symptoms of thyroiditis which masked those of brucellosis. Cultures were diagnostic. One patient had concomitant thyroid malignancy. Both showed normal thyroid function...


    pub_type: 杂志文章


    authors: von Graevenitz A,Colla F

    更新日期:1990-05-01 00:00:00

  • Anaerobic microbiology in the NASA space program.

    abstract::After briefly reviewing the earlier methods used to monitor the microbial load of returned lunar material, the author reports the more accurate research on the ability of terrestrial organisms to grow under simulated Martian environments. The possible importance of anaerobic microbiology can readily be seen because of...


    pub_type: 杂志文章


    authors: Brewer JH

    更新日期:1980-01-01 00:00:00

  • Femoral osteomyelitis due to Aspergillus nidulans in a patient with chronic granulomatous disease.

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    pub_type: 杂志文章


    authors: Dotis J,Panagopoulou P,Filioti J,Winn R,Toptsis C,Panteliadis C,Roilides E

    更新日期:2003-03-01 00:00:00