Influence of aminopenicillins on bacterial growth kinetics in vitro in comparison with the antibacterial effect in vivo.

Abstract:

:To quantify the relative antibacterial efficacy of beta-lactam antibiotics in vitro, a mathematical description of bacterial growth was developed. Curves of growth in the presence of the antibiotic are expressed as quadratic functions of time, with initial growth rate (ko) and rate of change of growth (a) as concentration dependant variables. For these variables the concentration-effect slopes were not parallel; therefore the potency ratio varied between 1 (at about 2 mg/l) and 2 (at higher concentrations). The relative efficacy in vivo was expressed as a potency ratio with regard to the number of bacteria in an infected thigh muscle in mice. The potency ratio was 1.5, which is between the limits of the in vitro results.

journal_name

Infection

journal_title

Infection

authors

Mattie H,van der Voet GB

doi

10.1007/BF01659765

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

S434-7

eissn

0300-8126

issn

1439-0973

journal_volume

7 Suppl 5

pub_type

杂志文章
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    abstract::Circulatory secretory non-pancreatic phospholipase A2 (snp-PLA2) was measured prospectively at the onset (day 0) of severe sepsis in 52 patients as well as on day 1 and 2 in 25 patients, in order to answer two questions: 1) does the snp-PLA2 plasma concentration differ according to the type and severity of infection? ...

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    pub_type: 杂志文章

    doi:10.1007/BF01713312

    authors: Guidet B,Piot O,Masliah J,Barakett V,Maury E,Bereziat G,Offenstadt G

    更新日期:1996-03-01 00:00:00

  • Epidemiological study of tuberculosis in Palermo, Italy: IS6110 fingerprinting of Mycobacterium tuberculosis strains isolated in the years 1994-1998.

    abstract::In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050036

    authors: Nastasi A,Mammina C

    更新日期:1999-11-01 00:00:00

  • Serum and sputum antibiotic levels after ampicillin, amoxycillin and bacampicillin chronic bronchitis patients.

    abstract::Serum and sputum concentrations of ampicillin or amoxycillin were measured in patients admitted to hospital for acute exacerbations of chronic bronchitis with purulent sputum. Mean peak serum levels of nearly 12 mg/l were found after 1600 mg bacampicillin (mean peak level in sputum 0.85 mg/l). The serum and sputum con...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01659773

    authors: Davies B,Maesen F

    更新日期:1979-01-01 00:00:00

  • Release of TNF alpha and IL6 from human monocytes infected with Mycobacterium kansasii: a comparison to Mycobacterium avium.

    abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of B-lymphocytes. Mycobacterium avium has been shown to stimulate the release of TNF alpha and IL6 fro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01715538

    authors: Stauffer F,Petrow EP,Burgmann H,Graninger W,Georgopoulos A

    更新日期:1994-09-01 00:00:00

  • The potential impact of biomarker-guided triage decisions for patients with urinary tract infections.

    abstract:OBJECTIVES:Current guidelines provide limited evidence as to which patients with urinary tract infection (UTI) require hospitalisation. We evaluated the currently used triage routine and tested whether a set of criteria including biomarkers like proadrenomedullin (proADM) and urea have the potential to improve triage d...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0423-1

    authors: Litke A,Bossart R,Regez K,Schild U,Guglielmetti M,Conca A,Schäfer P,Reutlinger B,Mueller B,Albrich WC

    更新日期:2013-08-01 00:00:00

  • ELISA for antibodies to lipid A, lipopolysaccharides and other hydrophobic antigens.

    abstract::A simple, sensitive and rapid ELISA method for the quantification and characterization of antibodies to lipid A has been developed, which can also be applied to other hydrophobic antigens. For coating, antigens were applied to the wells of ELISA plates as solutions in a mixture of chloroform and ethanol 1:9 (v/v), and...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650719

    authors: Freudenberg MA,Fomsgaard A,Mitov I,Galanos C

    更新日期:1989-09-01 00:00:00

  • Comparative trial of trimethoprim and co-trimoxazole in recurrent urinary infections.

    abstract::Eighty-nine patients with a history of recurrent urinary infection who required immediate treatment for significant bacteriuria were treated with either trimethoprim (300 mg at night) or with the standard course of co-trimoxazole (two tablets 12-hourly) for seven days. Cure rates one week after the end of treatment we...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01640874

    authors: Brumfitt W,Hamilton-Miller JM,Ludlam H,Damjanovic V,Gargan R

    更新日期:1982-09-01 00:00:00

  • Guillain-Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c.

    abstract::In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (P...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0448-5

    authors: Scharn N,Ganzenmueller T,Wenzel JJ,Dengler R,Heim A,Wegner F

    更新日期:2014-02-01 00:00:00

  • Thrombocytosis associated with acute osteomyelitis.

    abstract::Thrombocytosis is rarely observed during infection. We are describing a patient with acute osteomyelitis and bacteremia who developed thrombocytosis. In the patient described the platelet count paralleled the activity of the infection and the response to therapy. The causes of thrombocytosis and its implications are b...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645220

    authors: Robey C,Chmel H

    更新日期:1984-11-01 00:00:00

  • Passive immunization against cytomegalovirus in allograft recipients. The Rotterdam Heart Transplant Program experience.

    abstract::We analyzed the results of passive immunization against CMV in 146 heart transplant recipients. The 65 seronegative recipients were prophylactically treated with anti-CMV immunoglobulins during and after the operation. Twenty-nine of these 65 patients received a seropositive donor heart. CMV infection occurred in 21/6...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01728886

    authors: Balk AH,Weimar W,Rothbarth PH,Meeter K,Metselaar HJ,Mochtar B,Simoons ML

    更新日期:1993-07-01 00:00:00

  • Clinical evaluation of the antifungal effect of sertraline in the treatment of cryptococcal meningitis in HIV patients: a single Mexican center experience.

    abstract:PURPOSE:Cryptococcal meningitis is a potentially fatal fungal infection associated with a significant attributable morbidity and mortality, especially among HIV/AIDS patients. The first-line therapy for the treatment of this clinical entity is the combinatory therapy of amphotericin B plus flucytosine. However, the hig...

    journal_title:Infection

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s15010-017-1059-3

    authors: Villanueva-Lozano H,Treviño-Rangel RJ,González GM,Hernández-Rodríguez PA,Camacho-Ortiz A,Castillo-Reyna L,Galindo-Alvarado SG,Martínez-Reséndez MF

    更新日期:2018-02-01 00:00:00

  • In vitro activity, pharmacokinetics, clinical safety and therapeutic efficacy of enoxacin in the treatment of patients with complicated urinary tract infections.

    abstract::Minimal inhibitory concentrations (MIC) of enoxacin, nalidixic acid, pipemidic acid, norfloxacin, ciprofloxacin, ofloxacin and pefloxacin against isolates from 400 urological in-patients with complicated urinary tract infections (UTI) were determined by means of an agar dilution technique (10(4) cfu, multipointer). 28...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01667215

    authors: Naber KG,Sörgel F,Gutzler F,Bartosik-Wich B

    更新日期:1985-09-01 00:00:00

  • Rotavirus epidemiology and vaccine demand: considering Bangladesh chapter through the book of global disease burden.

    abstract:BACKGROUND:Rotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged < 5 years die from rotavirus-related diarrhoeal diseases. Though these infections are vaccine-preventable, the vast majority of children in low-income countries suffer from the infect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-1082-4

    authors: Mahmud-Al-Rafat A,Muktadir A,Muktadir H,Karim M,Maheshwari A,Ahasan MM

    更新日期:2018-02-01 00:00:00

  • Comparison in a laboratory model between the performance of a urinary closed system bag with double non-return valve and that of a single valve system.

    abstract:BACKGROUND:Catheter-associated urinary tract infection is the most common nosocomial infection in clinical settings. For bacteria ascending to the bladder the most common route is the extraluminal, but the intraluminal route also plays a role. For this reason, we compared two urinary closed system bags (CSB), one with ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-5626-2

    authors: Wenzler-Röttele S,Dettenkofer M,Schmidt-Eisenlohr E,Gregersen A,Schulte-Mönting J,Tvede M

    更新日期:2006-08-01 00:00:00

  • [Escherichia coli o serotyping in different patient groups with urinary tract infections (author's transl)].

    abstract::Using 44 anti-O sera 789 Escherichia coli strains isolated from the urine of patients with urinary tract infections were typed. Of the 119 E. coli strains from the urine of children, 49.6% were O-typable; only 3.4% were rough strains. Of 357 strains from pregnant women, 47% were O-typable; 12.1% were rough strains. Th...

    journal_title:Infection

    pub_type: 杂志文章

    doi:

    authors: Budde E,Naumann G,Nimmich W,Straube E

    更新日期:1980-01-01 00:00:00

  • Early experience with remdesivir in SARS-CoV-2 pneumonia.

    abstract::At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200 mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01448-x

    authors: Durante-Mangoni E,Andini R,Bertolino L,Mele F,Florio LL,Murino P,Corcione A,Zampino R

    更新日期:2020-10-01 00:00:00

  • Localized pulmonary infection associated with Mycobacterium tilburgii in an HIV-infected patient.

    abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-4118-0

    authors: Kolditz M,Halank M,Spornraft-Ragaller P,Schmidt H,Höffken G

    更新日期:2005-08-01 00:00:00

  • Effect of dexamethasone and pentoxifylline in combination with amoxicillin in the treatment of penicillin-insensitive pneumococcal pneumonia in guinea pigs.

    abstract::A fatal guinea pig model of pneumococcal pneumonia was developed in order to evaluate the efficacy of amoxicillin combined with either pentoxifylline or dexamethasone. Parameters assessed were survival time and lung changes (alterations, bacterial colony counts, inducible nitric oxide synthase [iNOS] and cyclooxygenas...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2098-x

    authors: Parra A,García-Olmos M,Nieto E,García-Calvo G,Ponte C,Soriano F

    更新日期:2002-06-01 00:00:00

  • Visceral manifestation of cat scratch disease in children. A consequence of altered immunological state?

    abstract::A 12-year-old girl with a 2-month history of fever and abdominal pain was admitted to our hospital. Ultrasound and CT scans of the abdomen showed multiple hypoechoic lesions of liver and spleen. Screening for zoonosis revealed high positive titers to Bartonella henselae. T-cell deficiency was demonstrated and remained...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s150100050059

    authors: Kahr A,Kerbl R,Gschwandtner K,Heinzl B,Lackner H,Schwinger W,Stünzner D,Lindbichler F,Urban EC

    更新日期:2000-03-01 00:00:00

  • Escherichia coli isolated from babies delivered by caesarean section and their environment.

    abstract::The sources from which eight Caesarean section babies acquired E. coli are described and the probable routes by which the organisms reached the babies are outlined. Suggestions are made concerning the control of the spread of E. coli in premature nurseries and during outbreaks of E. coli gastroenteritis. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01638940

    authors: Lennox-King SM,O'Farrell SM,Bettelheim KA,Shooter RA

    更新日期:1976-01-01 00:00:00

  • Cefodizime given once daily for the treatment of upper urinary tract infections and complicated lower urinary tract infections.

    abstract::The efficacy of cefodizime (CDZ) in upper urinary tract infections (UUTI) and complicated lower urinary tract infections (LUTI) was assessed by analysis of the combined results of five clinical trials. Doses of CDZ 1 g i.m. daily, 1 x 2 g i.v. or i.m. and 2 x 2 g i.v. were investigated; comparative agents were cefurox...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01709945

    authors: Hofstetter AG

    更新日期:1992-01-01 00:00:00

  • Safety and immunogenicity of early vaccination with two doses of tetravalent measles-mumps-rubella-varicella (MMRV) vaccine in healthy children from 9 months of age.

    abstract:BACKGROUND:This open, randomized, controlled study [208136/018] assessed the safety and immunogenicity of early vaccination with an experimental tetravalent measles-mumps-rubella-varicella (MMRV) vaccine (GlaxoSmithKline Biologicals) compared to concomitant administration of separate licensed MMR (Priorix) and varicell...

    journal_title:Infection

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s15010-007-6337-z

    authors: Goh P,Lim FS,Han HH,Willems P

    更新日期:2007-10-01 00:00:00

  • Abdominal wall phlebitis due to Prevotella bivia following renal transplantation in a patient with an occluded inferior vena cava.

    abstract::Pre-existing occlusion of the inferior vena cava may complicate renal transplantation. Suppurative abdominal wall phlebitis following renal transplantation was diagnosed in a patient with pre-existing thrombosis of the inferior vena cava of unknown cause. The phlebitis developed in the subcutaneous collateral veins of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0335-5

    authors: Janssen S,van Donselaar-van der Pant KA,van der Weerd NC,Develter W,Bemelman FJ,Grobusch MP,Idu MM,Ten Berge IJ

    更新日期:2013-02-01 00:00:00

  • Prevalence of antibodies to human herpesviruses and hepatitis B virus in patients at different stages of human immunodeficiency virus (HIV) infection.

    abstract::The results of antibody assays for viruses of the herpes group (HSV, EBV, VZV and CMV) and for hepatitis B virus (HBV) were retrospectively evaluated in 439 HIV-seropositive patients classified into different stages of HIV infection. The prevalence of specific IgG, IgM and IgA antibodies in these groups was compared w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643233

    authors: Enzensberger R,Braun W,July C,Helm EB,Doerr HW

    更新日期:1991-05-01 00:00:00

  • A new cytokine release assay: a simple approach to monitor the immune status of HIV-infected patients.

    abstract:PURPOSE:To test a new assay based on an ex vivo cytokine release from whole blood for the monitoring of immune changes in human immunodeficiency virus (HIV)-infected patients. METHODS:A pilot study of outpatients with HIV infection (n = 9) at a large academic hospital who were divided into three groups: HIV-infected p...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0445-8

    authors: Kaufmann I,Draenert R,Gruber M,Feuerecker M,Roider J,Choukèr A

    更新日期:2013-06-01 00:00:00

  • Screening for Chlamydia trachomatis in military personnel by urine testing.

    abstract::In order to determine the infection rate of Chlamydia trachomatis in young males in Austria an epidemiological study was performed on 335 male Austrian soldiers attending the military hospital for a health check-up procedure. Three hundred twenty-nine (98.2%) of the screened males were clinically asymptomatic. Chlamyd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644946

    authors: Stary A,Steyrer K,Heller-Vitouch C,Müller I,Mårdh PA

    更新日期:1991-07-01 00:00:00

  • Femoral osteomyelitis due to Aspergillus nidulans in a patient with chronic granulomatous disease.

    abstract::13 cases of osteomyelitis caused by Aspergillus nidulans have been previously reported in patients with chronic granulomatous disease (CGD). All of them have been associated with simultaneous pulmonary infection and have had an extremely poor outcome. We report an unusual case of femoral osteomyelitis due to A. nidula...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2167-1

    authors: Dotis J,Panagopoulou P,Filioti J,Winn R,Toptsis C,Panteliadis C,Roilides E

    更新日期:2003-03-01 00:00:00

  • Low transmission rate of 2009 H1N1 Influenza during a long-distance bus trip.

    abstract:BACKGROUND:Current data on the risk of transmission of 2009 H1N1 Influenza in public transportation systems (e.g., public trains, busses, airplanes) are conflicting. The main transmission route of this virus is thought to be via droplets, but airborne transmission has not been completely ruled out. METHODS:This is a c...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0084-x

    authors: Piso RJ,Albrecht Y,Handschin P,Bassetti S

    更新日期:2011-04-01 00:00:00

  • Clearance of Candida colonizing the urinary bladder by a two-day amphotericin B irrigation.

    abstract::The minimum duration of continuous amphotericin B irrigation (50 mg/liter/day) required to clear the candida colonizing the urinary bladder was investigated. Eleven in vitro experiments revealed a consistent candidicidal effect within 48 hours with 25 and 5 mg/l of amphotericin B concentrations attainable in the bladd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647004

    authors: Hsu CC,Ukleja B

    更新日期:1990-09-01 00:00:00

  • Ageing with HIV: a multidisciplinary review.

    abstract:INTRODUCTION:After the introduction of highly active antiretroviral treatment, the course of HIV infection turned into a chronic disease and most of HIV-positive patients will soon be over 50 years old. MATERIAL AND METHODS:This paper reviews the multiple aspects that physicians have to face while taking care of HIV-p...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-015-0795-5

    authors: Calcagno A,Nozza S,Muss C,Celesia BM,Carli F,Piconi S,De Socio GV,Cattelan AM,Orofino G,Ripamonti D,Riva A,Di Perri G

    更新日期:2015-10-01 00:00:00