Assays of cephalosporin antibiotics administered prophylactically in open heart surgery. Determination of serum and tissue levels before, during and after cardiopulmonary bypass.

Abstract:

:Twenty-eight patients who underwent open-heart surgery were divided into three groups, each of which received a different antibiotic from the cephalosporin series (cephalotin, cefazolin or cefamandole) in order to prevent infection. All antibiotics were given via intravenous infusion in a dosage of 2 g prior to surgery. To clarify the question of antibacterial activity under operative conditions with the cardiopulmonary bypass, the serum and tissue levels were determined before, during and after the surgical procedure. The effectiveness of the cephalosporins against bacteria most frequently encountered in open-heart surgery was demonstrated and substantiated by the serum and tissue concentrations. It became apparent that, in view of the favorable serum and tissue levels during and after the cardiopulmonary bypass, cefamandole should be considered the antibiotic of choice in preventing infections during open-heart surgery.

journal_name

Infection

journal_title

Infection

authors

Eigel P,Tschirkov A,Satter P,Knothe H

doi

10.1007/BF01641087

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

23-8

issue

1

eissn

0300-8126

issn

1439-0973

journal_volume

6

pub_type

杂志文章
  • Pharmacokinetics of ampicillin, sulbactam and cefotiam in patients undergoing orthopedic surgery.

    abstract::As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very simil...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01713160

    authors: Wildfeuer A,Mallwitz J,Gotthardt H,Hille E,Gruber H,Dahmen G,Pfaff G,Göbel C

    更新日期:1997-07-01 00:00:00

  • An outbreak of rubella aboard a ship of the German Navy.

    abstract:BACKGROUND:During May and June 1996, an outbreak of rubella occurred offshore aboard a ship of the German Navy. The outbreak spread among 330 crew members over a period of 9 weeks, ending 2 days after the ship's return. This is the first detailed epidemiological investigation of a rubella outbreak on a ship, describing...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-003-3048-y

    authors: Ziebold C,Hassenpflug B,Wegner-Bröse H,Wegner K,Schmitt HJ

    更新日期:2003-06-01 00:00:00

  • Hospitalization rates for complicated and uncomplicated chickenpox in a poorly vaccined pediatric population.

    abstract:BACKGROUND:A retrospective study was conducted to provide epidemiological data on hospitalization for complicated and uncomplicated chickenpox in a pediatric population. METHODS:The study analyzed hospitalization cases for chickenpox, among all the 31 Tuscan hospitals, during the period 1997-2003. RESULTS:Globally, 6...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6248-z

    authors: Bonsignori F,Chiappini E,Frenos S,Peraldo M,Galli L,de Martino M

    更新日期:2007-12-01 00:00:00

  • [Enoxacin concentration in bone tissue].

    abstract::For successful treatment of bacterial osteomyelitis the administered antibiotic must reach sufficiently high concentrations in bone tissues. Therefore concentrations of enoxacin in bone in ten patients requiring hip surgery were measured. To prevent a postoperative infection, 400 mg enoxacin b.i.d. for two days were a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643632

    authors: Adam D,Weismeier K,Sörgel F,Zürcher J

    更新日期:1989-01-01 00:00:00

  • Investigation of Rickettsia conorii antibodies in the Antalya area.

    abstract::Mediterranean spotted fever, caused by Rickettsia conorii, is a tick-borne infection. Serum samples for screening R. conorii antibodies of professionally exposed persons in the Antalya region, on the Mediterranean coast of Turkey, were analyzed. R. conorii IgG antibodies were detected in 13 of 98 (13.3%) serum samples...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02771845

    authors: Vural T,Ergin C,Sayin F

    更新日期:1998-05-01 00:00:00

  • Tuberculous meningitis in adults: review of 61 cases.

    abstract:BACKGROUND:Tuberculosis is still a major cause of serious illness in developing countries. The objective of this study was to assess the clinical, laboratory, radiological and prognostic features of tuberculous meningitis (TBM) in immuncompetent adult patients. PATIENTS AND METHODS:Sixty-one patients with confirmed or...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-003-3179-1

    authors: Sütlaş PN,Unal A,Forta H,Senol S,Kirbaş D

    更新日期:2003-12-01 00:00:00

  • Guidelines for medical research in children.

    abstract::Nearly everyone agrees that violations in research occur. Nobody knows how often. But if Pediatrics is to progress children must be the subjects of research carried out in an acceptable way. The following guidelines should be followed in childhood experimentation: (1) Research should not be done on children if the sam...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01645562

    authors: Papadatos CJ

    更新日期:1989-11-01 00:00:00

  • Comparative in vitro antibacterial activity of seven semi-synthetic penicillins against aerobic gram-negative bacteria and enterococci.

    abstract::The MICs and MBCs of mecillinam, ticarcillin, mezlocillin, azlocillin and piperacillin were determined by the microdilution method in liquid medium using 700 strains of gram-negative bacilli and enterococci isolated from pathological sources and classified as a function of their sensitivity to ampicillin and carbenici...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640683

    authors: Thabaut A,Durosoir JL,Saliou P

    更新日期:1982-01-01 00:00:00

  • [Comparison of the adverse effect profile of different substances such as penicillins, tetracyclines, sulfonamides and quinolones].

    abstract::The penicillins, the tetracyclines and the sulfonamides have often been used in the last few decades in spite of their well-known side effects. Hypersensitivity reactions to penicillins are among the most important adverse reactions in these antibiotics; in every case a careful medical history has to be taken before a...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01644730

    authors: Keller H

    更新日期:1991-01-01 00:00:00

  • [Escherichia coli o serotyping in different patient groups with urinary tract infections (author's transl)].

    abstract::Using 44 anti-O sera 789 Escherichia coli strains isolated from the urine of patients with urinary tract infections were typed. Of the 119 E. coli strains from the urine of children, 49.6% were O-typable; only 3.4% were rough strains. Of 357 strains from pregnant women, 47% were O-typable; 12.1% were rough strains. Th...

    journal_title:Infection

    pub_type: 杂志文章

    doi:

    authors: Budde E,Naumann G,Nimmich W,Straube E

    更新日期:1980-01-01 00:00:00

  • Mycobacterium avium-intracellulare pulmonary infection complicated by cutaneous leukocytoclastic vasculitis in a woman with anorexia nervosa.

    abstract::A 53-year-old Caucasian woman with a history of anorexia nervosa developed a bilateral lower extremity rash comprised of palpable red to violaceous, sub-centimeter papular lesions that increased in quantity rapidly. She also noted a 2-month history of non-productive cough. Imaging modalities revealed a thin-walled cav...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0574-0

    authors: Walsh TL,Baca V,Stalling SS,Natalie AA,Veldkamp PJ

    更新日期:2014-06-01 00:00:00

  • Antibacterial activity and kill kinetics of amoxicillin-clavulanic acid combinations against Escherichia coli and Klebsiella aerogenes.

    abstract::Combinations of amoxicillin and clavulanic acid were tested against 11 Escherichia coli strains and five Klebsiella aerogenes strains. Apart from one E. coli, the strains were highly resistant to amoxicillin due to beta-lactamase production. Synergy was demonstrated in all strains by agar dilution. Synergy was detecte...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641359

    authors: Fuglesang JE,Bergan T

    更新日期:1983-11-01 00:00:00

  • Alpha-hemolytic streptococci: a major pathogen of iatrogenic meningitis following lumbar puncture. Case reports and a review of the literature.

    abstract::Iatrogenic meningitis following lumbar puncture is a rare complication of myelography, spinal anesthesia, intrathecal chemotherapy, and epidural anesthesia. Sporadic cases and clusters of iatrogenic meningitis have been reported after intrathecal therapy, but most incidental cases are reported after myelography. Four ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01780647

    authors: Schneeberger PM,Janssen M,Voss A

    更新日期:1996-01-01 00:00:00

  • A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe.

    abstract::ATRIPLA is licensed for use only in HIV-positive persons whose viral loads <50 for ≥ 3 months. We investigated the use of ATRIPLA as first-line antiretroviral therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations when initiating first...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0630-4

    authors: Mocroft A,Reiss P,Rakhmanova A,Banhegyi D,Phillips AN,De Wit S,Ristola M,Lundgren JD,Grarup J,Kirk O,EuroSIDA in EuroCOORD.

    更新日期:2014-08-01 00:00:00

  • Antiviral therapy of varicella-zoster virus infection in immunocompromised children--a prospective randomized study of aciclovir versus brivudin.

    abstract::Both aciclovir and brivudin are effective in the treatment of immunocompromised children with varicella-zoster virus infection. To determine which drug is preferable, a prospective randomized trial aciclovir vs. brivudin was conducted. Forty-three immunocompromised children were randomly assigned to receive aciclovir ...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01726449

    authors: Heidl M,Scholz H,Dörffel W,Hermann J

    更新日期:1991-11-01 00:00:00

  • Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease.

    abstract::Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filam...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0724-7

    authors: Shigemura T,Nakazawa Y,Amano Y,Sudo A,Watanabe M,Kobayashi M,Kobayashi N,Koike K,Agematsu K,Nishimura K

    更新日期:2015-06-01 00:00:00

  • Isolation of mycoplasma species from infertile patients: an epidemiological contribution.

    abstract::In this study the presence of Mycoplasma species in patients suffering from infertility was examined. 41 women and 37 men were examined, including 31 couples, and ten single women and six single men. Samples of vaginal and cervical mucus were taken from each woman, and samples of seminal fluid from each man. Identific...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642082

    authors: Brenciaglia MI,Cipriani P,Lilli D,Lorino G,Mancini C,Sangnier C

    更新日期:1977-01-01 00:00:00

  • Prevalence of anti-HCV and risk factors for hepatitis C virus infection in healthy pregnant women.

    abstract::The prevalence of anti-HCV antibodies and the risk factors for HCV infection were assessed in 5,672 pregnant women living in North Italy. All reactive sera were confirmed by RIBA-2 test. Anti-HCV positive pregnant women together with an anti-HCV negative control group, were interviewed by standardised questionnaire to...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01715541

    authors: Marranconi F,Fabris P,Stecca C,Zampieri L,Bettini MC,Di Fabrizio N,de Lalla F

    更新日期:1994-09-01 00:00:00

  • Prevention of borreliosis in persons bitten by infected ticks.

    abstract::A study on prevention of borreliosis in humans bitten by infected ticks was performed in 1992-1994 in the Perm' region of Russia. Adult Ixodes persulcatus ticks were removed from the study subjects, and live preparations made from the material obtained from the gut of each tick were microscopically analyzed (up to 250...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01713337

    authors: Korenberg EI,Vorobyeva NN,Moskvitina HG,Gorban' LYa

    更新日期:1996-03-01 00:00:00

  • IFN-alpha: therapeutic options in HIV and HIV/HCV, HIV/HBV dual infection.

    abstract::The antiviral effects of interferon-alpha (IFN-alpha) are well documented for the treatment of hepatitis B or C infections, whereas antiretroviral effects for treatment of HIV-1 infection have been investigated up to now only in small-sized preclinical studies. New preclinical and clinical data on IFN-alpha for HIV, H...

    journal_title:Infection

    pub_type:

    doi:

    authors: Jablonowski H

    更新日期:2003-03-01 00:00:00

  • New aspects on the pathophysiology of wound infection and wound healing--the problem of lowered oxygen pressure in the tissue.

    abstract::There is a correlation between tissue oxygen tension, incidence of infection and disturbance of wound healing. Scientific investigations in recent years have documented that infection and tissue repair are processes consuming oxygen. Animal experiments have shown that oxygenation of the tissue is essential for the eli...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01660413

    authors: Kühne HH,Ullmann U,Kühne FW

    更新日期:1985-03-01 00:00:00

  • Pharmacokinetics of quinolone derivatives in the prostate.

    abstract::The pharmacokinetics of six quinolone derivatives were investigated in the human and dog prostate. The possible therapeutic applications of these findings are discussed. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643687

    authors: Madsen PO,Aagaard J

    更新日期:1991-01-01 00:00:00

  • Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis.

    abstract:BACKGROUND:The diagnostic value of admission serum levels of procalcitonin (PCT) and C-reactive protein (CRP) as indicators of the etiology and prognosis was prospectively investigated. PATIENTS:96 patients, 50-85 years of age, treated in the hospital for community-acquired pneumonia (CAP). RESULTS:On admission, all ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050049

    authors: Hedlund J,Hansson LO

    更新日期:2000-03-01 00:00:00

  • Infection in immunodepressed patients. The approach to diagnosis and treatment.

    abstract::Infection is an important cause of death in patients receiving cytostatic drugs or with any other impairment of host resistance. Such infections are frequently due to opportunist micro-organisms usually belonging to the endogenous flora of the patient. It is often difficult to obtain an exact diagnosis of the cause an...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642766

    authors: Nauta EH,van Furth R

    更新日期:1975-01-01 00:00:00

  • In vitro activity of second and third generation cephalosporins against ampicillin susceptible and resistant haemophilus influenzae.

    abstract::One hundred seventy-five clinical isolates of Haemophilus influenzae (including 74 beta-lactamase-producing strains) were examined for susceptibility to ampicillin, cefonicid, cefamandole, cefuroxime and cefotaxime. Cefonicid and cefamandole exhibited similar activity against ampicillin-susceptible strains (MIC90 = 0....

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645075

    authors: Burns JL,Wong K,Smith AL

    更新日期:1988-09-01 00:00:00

  • Guillain-Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c.

    abstract::In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (P...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0448-5

    authors: Scharn N,Ganzenmueller T,Wenzel JJ,Dengler R,Heim A,Wegner F

    更新日期:2014-02-01 00:00:00

  • Prevalence of hepatitis B virus markers among Polish urban alcoholics.

    abstract::124 consecutive patients (mean age: 41.1 years; range: 20-63 years) attending an outpatient alcoholic clinic were tested for the presence of markers of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), thes...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644546

    authors: Laskus T,Lupa E,Szczutowska E,Babiuch L

    更新日期:1988-01-01 00:00:00

  • Cefetamet pivoxil: bacteriostatic and bactericidal activity of the free acid against 355 gram-negative rods.

    abstract::The in vitro activity of the free acid of cefetamet pivoxil (Ro 15-8075) was tested against 355 clinical isolates, namely enteropathogenic bacteria, glucose non-fermentative gram-negative rods (excluding Pseudomonas aeruginosa) and Legionella pneumophila. Ceftriaxone was included in the study as reference compound. Al...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644102

    authors: Hohl P,von Graevenitz A,Zollinger-Iten J

    更新日期:1988-05-01 00:00:00

  • Anti-V3 loop spectrotype in HIV-infected individuals during zidovudine therapy.

    abstract::In order to investigate the role played by zidovudine (ZDV) as immune modulator, particularly on B-cell response, the anti-V3 loop spectrotype in 115 sera from 26 HIV-infected individuals was evaluated, prior to and during treatment with ZDV, by isoelectric focusing and reverse blotting (IEF-RB), a technique useful fo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01781097

    authors: Biselli R,Del Bono V,Anselmo M,Canessa A,Mazzarello G,D'Amelio R,Bassetti D

    更新日期:1996-05-01 00:00:00

  • [A microbiological method for the rapid determination of antibiotic concentrations during therapy].

    abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62° C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the te...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642093

    authors: Wahlig H

    更新日期:1977-06-01 00:00:00