Abstract:
:Twenty-eight patients who underwent open-heart surgery were divided into three groups, each of which received a different antibiotic from the cephalosporin series (cephalotin, cefazolin or cefamandole) in order to prevent infection. All antibiotics were given via intravenous infusion in a dosage of 2 g prior to surgery. To clarify the question of antibacterial activity under operative conditions with the cardiopulmonary bypass, the serum and tissue levels were determined before, during and after the surgical procedure. The effectiveness of the cephalosporins against bacteria most frequently encountered in open-heart surgery was demonstrated and substantiated by the serum and tissue concentrations. It became apparent that, in view of the favorable serum and tissue levels during and after the cardiopulmonary bypass, cefamandole should be considered the antibiotic of choice in preventing infections during open-heart surgery.
journal_name
Infectionjournal_title
Infectionauthors
Eigel P,Tschirkov A,Satter P,Knothe Hdoi
10.1007/BF01641087subject
Has Abstractpub_date
1978-01-01 00:00:00pages
23-8issue
1eissn
0300-8126issn
1439-0973journal_volume
6pub_type
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