[Enoxacin concentration in bone tissue].

Abstract:

:For successful treatment of bacterial osteomyelitis the administered antibiotic must reach sufficiently high concentrations in bone tissues. Therefore concentrations of enoxacin in bone in ten patients requiring hip surgery were measured. To prevent a postoperative infection, 400 mg enoxacin b.i.d. for two days were administered. On an average 120 (90-210) min after the final dose samples of venous blood and bone tissue were taken. The bone pieces were divided into corticalis and spongiosa. Using a bio-assay-method the following concentrations were found: (mean +/- S.D.): serum 2.88 ( +/- 0.90) mg/l, corticalis 5.90 ( +/- 0.79) mg/kg, spongiosa 3.95 ( +/- 1.01) mg/kg. Thus enoxacin reaches higher levels in bone tissue than in serum.

journal_name

Infection

journal_title

Infection

authors

Adam D,Weismeier K,Sörgel F,Zürcher J

doi

10.1007/BF01643632

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S25-6

eissn

0300-8126

issn

1439-0973

journal_volume

17 Suppl 1

pub_type

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