Susceptibility of frequent urinary pathogens to fosfomycin trometamol and eight other antibiotics: results of an Italian multicenter survey.

Abstract:

:In order to assess the resistance profile for fosfomycin trometamol after several years of clinical use in Italy, this study has explored the susceptibility to fosfomycin and eight other antibacterial drugs of 6,021 strains isolated from 23,816 urines during 1990 in three teaching hospitals located in Genoa, Parma and Catania. Gram-negative strains, notably Escherichia coli (41.6%), were primarily involved. Amoxicillin was the least active compound with resistance in 41.4% of the isolates. Fosfomycin showed the lowest rate of resistance in both gram-negative (2.8%) and gram-positive (2.1%) pathogens. This was followed by norfloxacin with a resistance rate of 11.8% and netilmicin with 12.2%. These results indicate that fosfomycin-trometamol may continue to be used in single-dose treatment of urinary tract infections even in the absence of microbiological data since the prevalence of resistance to the drug is, at present, so low that therapeutic failure is highly improbable.

journal_name

Infection

journal_title

Infection

authors

Schito GC,Chezzi C,Nicoletti G,Moreddu M,Arcangeletti MC,Stefani S,Albini E,Del Bono GP

doi

10.1007/BF01710017

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

S291-5

eissn

0300-8126

issn

1439-0973

journal_volume

20 Suppl 4

pub_type

临床试验,杂志文章,多中心研究
  • The treatment of uncomplicated urinary tract infections with mezlocillin.

    abstract::Fourteen adult patients with uncomplicated urinary tract infections (UTI) caused by gram-negative and gram-positive bacteria were treated with 2 g mezlocillin daily by i. m. injection for an average of eight days. Clinical examinations were performed daily; bacteriological and laboratory controls (blood and urine) wer...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01640667

    authors: Coimbra F

    更新日期:1982-01-01 00:00:00

  • Brucellosis: difficulties in diagnosis and a report on 38 cases.

    abstract::We have reviewed 38 patients with brucellosis who were admitted to the Chaim Sheba Medical Center between 1955 and 1977, i.e. during a 23-year period. The clinical manifestations varied greatly. Diagnosis was easy when brucellosis was suspected, as in cases presenting with fever of unknown origin. In nine of the 38 ca...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641353

    authors: Samra Y,Shaked Y,Hertz M,Altman G

    更新日期:1983-11-01 00:00:00

  • [Fosfomycin concentrations in serum and bile (author's transl)].

    abstract::40 patients were given a single, short intravenous infusion of 4 g fosfomycin over a period of five to ten minutes. In 23 patients, the contents of the gall bladder were removed intra-operatively 30-105 minutes after the fosfomycin infusion. In 17 patients who had undergone cholecystectomy eight to ten days earlier, b...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640831

    authors: Müller O,Rückert U,Walter W,Haag R,Sauer W

    更新日期:1982-01-01 00:00:00

  • Infections in intraabdominal surgery. The EURESI Project. European Research Network on Surgical Infections.

    abstract::The situation of clinical research in Europe must be improved substantially according to statements of scientists, managers and politicians. The analysis of requirements is available; however, there are no indications that the conclusion of the analysis is being converted into actual facts. Government programs, althou...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02962265

    authors: Holzheimer RG

    更新日期:1998-09-01 00:00:00

  • Infection in immunodepressed patients. The approach to diagnosis and treatment.

    abstract::Infection is an important cause of death in patients receiving cytostatic drugs or with any other impairment of host resistance. Such infections are frequently due to opportunist micro-organisms usually belonging to the endogenous flora of the patient. It is often difficult to obtain an exact diagnosis of the cause an...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642766

    authors: Nauta EH,van Furth R

    更新日期:1975-01-01 00:00:00

  • Pharmacokinetics of quinolone derivatives in the prostate.

    abstract::The pharmacokinetics of six quinolone derivatives were investigated in the human and dog prostate. The possible therapeutic applications of these findings are discussed. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643687

    authors: Madsen PO,Aagaard J

    更新日期:1991-01-01 00:00:00

  • Effect of dexamethasone and pentoxifylline in combination with amoxicillin in the treatment of penicillin-insensitive pneumococcal pneumonia in guinea pigs.

    abstract::A fatal guinea pig model of pneumococcal pneumonia was developed in order to evaluate the efficacy of amoxicillin combined with either pentoxifylline or dexamethasone. Parameters assessed were survival time and lung changes (alterations, bacterial colony counts, inducible nitric oxide synthase [iNOS] and cyclooxygenas...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2098-x

    authors: Parra A,García-Olmos M,Nieto E,García-Calvo G,Ponte C,Soriano F

    更新日期:2002-06-01 00:00:00

  • [A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)].

    abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity...

    journal_title:Infection

    pub_type: 杂志文章

    doi:

    authors: Wahlig H

    更新日期:1977-01-01 00:00:00

  • Appendicitis followed by reactive arthritis in an HLA B27-positive man after infection with Yersinia enterocolitica, diagnosed by serotype specific antibodies and antibodies to Yersinia outer membrane proteins.

    abstract::A case of appendicitis followed by reactive arthritis in an HLA B27-positive, 29-year-old man after infection with Yersinia enterocolitica is reported. Infection with Y. enterocolitica was diagnosed by determination of serotype specific antibodies and antibodies to Yersinia outer membrane proteins. Bacteriological cul...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01720409

    authors: Ström H,Johansson C

    更新日期:1997-09-01 00:00:00

  • A prognostic score for postherpetic neuralgia in ambulatory patients.

    abstract::The main objective was to develop a scoring system for easy use by the physician in daily clinical practice in deciding the appropriate treatment for his herpes zoster patient. Data from 635 patients who did not receive antiviral therapy were included in this analysis. Of these, 131 developed postherpetic neuralgia (P...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02770836

    authors: Meister W,Neiss A,Gross G,Doerr HW,Höbel W,Malin JP,von Essen J,Reimann BY,Witke C,Wutzler P

    更新日期:1998-11-01 00:00:00

  • [Mezlocillin in the antibiotic therapy of severe bacterial infections in visceral surgery].

    abstract::Fifty-six patients suffering from severe and very severe bacterial infections received additional antibacterial treatment with mezlocillin following abdominal or chest surgery. There were 18 intestinal-peritoneal infections, 15 pleuropulmonary infections, seven patients with sepsis, six localized abscesses and ten pat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640656

    authors: Amgwerd R,Rauh G,Sonnabend W

    更新日期:1982-01-01 00:00:00

  • Studies on serum and cerebrospinal fluid levels of cephacetrile in neonates.

    abstract::The serum half-life of cephacetrile and its penetration from the serum into the cerebrospinal fluid (CSF) was determined in 33 premature and full-term neonates. On an average the serum half-life was 3.6 hours in children with a birth weight above 1,500 g; in children with a birth weight below 1,500 g it was 5.1 hours....

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640789

    authors: Windorfer A,Gasteiger U

    更新日期:1977-01-01 00:00:00

  • Six different strains of Neisseria meningitidis in a case with meningococcal sepsis and five contact persons in a boys' home.

    abstract:BACKGROUND:It is routine practice to provide chemoprophylaxis for close contacts of a patient infected with meningococci. PATIENTS:When a 17-year-old boy living in a boys' home was admitted to the hospital with septic shock caused by Neisseria meningitidis, we immediately identified contact persons in the boys' home. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050070

    authors: Linde H,Glück T,Metz M,Reng C,Erlmeier S,Lehn N

    更新日期:2000-05-01 00:00:00

  • A clinical evaluation of the tolerance to pivampicillin tablets.

    abstract::The clinical tolrance of 350 mg pivampicillin tablets was evaluated in 470 hospitalized patients in Denmark, Norway and Iceland. The tablets were given to 229 fasting patients and to 241 non-fasting patients at mealtime. Side-effects were reported in 44 patients (9.4%). Upper gastro intestinal disturbances occurred in...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01639105

    authors: Hey H,Medalen TJ,Molstad OM,Stokholm K

    更新日期:1977-01-01 00:00:00

  • Correlation between antibiotic consumption and resistance of bloodstream bacteria in a University Hospital in North Eastern Italy, 2008-2014.

    abstract:PURPOSE:The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS:Anti...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-0998-z

    authors: Mascarello M,Simonetti O,Knezevich A,Carniel LI,Monticelli J,Busetti M,Schincariol P,Torelli L,Luzzati R

    更新日期:2017-08-01 00:00:00

  • New aspects on the pathophysiology of wound infection and wound healing--the problem of lowered oxygen pressure in the tissue.

    abstract::There is a correlation between tissue oxygen tension, incidence of infection and disturbance of wound healing. Scientific investigations in recent years have documented that infection and tissue repair are processes consuming oxygen. Animal experiments have shown that oxygenation of the tissue is essential for the eli...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01660413

    authors: Kühne HH,Ullmann U,Kühne FW

    更新日期:1985-03-01 00:00:00

  • 'Lost in Nasal Space': Staphylococcus aureus sepsis associated with Nasal Handkerchief Packing.

    abstract:INTRODUCTION:Staphylococcus aureus frequently causes infections in outpatient and hospital settings and can present as a highly variable entity. Typical manifestations are endocarditis, osteoarticular infections or infection of implanted prostheses, intravascular devices or foreign bodies. A thorough diagnostic evaluat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1221-6

    authors: Koehler P,Jung N,Kochanek M,Lohneis P,Shimabukuro-Vornhagen A,Böll B

    更新日期:2019-04-01 00:00:00

  • Staphylococcus lugdunensis early prosthetic valve endocarditis in a young HIV positive patient.

    abstract::Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that causes skin and soft tissue infections and occasionally life threatening endocarditis of native valves. Prosthetic valve infection due to this pathogen is very rare and has not been described in HIV infected individuals. We report on the first case...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6029-8

    authors: Kourbeti IS,Alegakis DE,Roditakis GE,Samonis G

    更新日期:2007-02-01 00:00:00

  • Do antibody-coated bacteria prove bacterial prostatitis?

    abstract::Using the immunofluorescence technique in 187 patients with bacteriologically proven prostatitis according to the Meares-Stamey test demonstrated a significant amount of antibody-coated bacteria (ACB) in their ejaculates. The ACB test was useful to discriminate between chronic bacterial prostatitis and prostatodynia w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643684

    authors: Riedasch G,Möhring K,Ritz E

    更新日期:1991-01-01 00:00:00

  • Autoinfection as a cause of postpartum subdural empyema due to Mycoplasma hominis.

    abstract::Mycoplasma hominis is a commensal of the genitourinary tract, which is infrequently associated with urogenital infections. Extra-urogenital infections due to M. hominis are rare. Here, we report an unusual case of M. hominis subdural empyema in a woman occurring shortly after delivery. The patient presented with sympt...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0713-2

    authors: Hos NJ,Bauer C,Liebig T,Plum G,Seifert H,Hampl J

    更新日期:2015-04-01 00:00:00

  • Lymphocyte apoptosis, caspase activation and inflammatory response in septic shock.

    abstract:BACKGROUND:We examined lymphocyte apoptosis, activity of caspases-1, -3, -8 and -9 and the relationship between those two events and inflammation response in septic shock. MATERIALS AND METHODS:Blood samples were obtained within 24 h after diagnosis of septic shock from 16 patients to measure apoptosis, caspases-3, -8...

    journal_title:Infection

    pub_type: 信件

    doi:10.1007/s15010-008-7070-y

    authors: Delogu G,Famularo G,Tellan G,Marandola M,Antonucci A,Signore M,Marcellini S,Moretti S

    更新日期:2008-10-01 00:00:00

  • Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis.

    abstract::A total of 208 patients underwent brain biopsy for presumptive herpes simplex encephalitis and were randomized to receive either vidarabine, vira-A, at 15 mg/kg/day, or acyclovir, at 30 mg/kg/day for ten days. 69 patients (33%) had biopsy-proven disease; 37 received vira-A and 32 acyclovir. With the exception of age, ...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01650104

    authors: Whitley RJ,Alford CA,Hirsch MS,Schooley RT,Luby JP,Aoki FY,Hanley D,Nahmias AJ,Soong SJ

    更新日期:1987-01-01 00:00:00

  • The effects of ciprofloxacin on human chondrocytes in cell culture.

    abstract::Ciprofloxacin is a highly potent antibacterial agent that is used extensively in bone and joint infections. Because of reports of potential chondro-toxicity in animals, the effects of this drug on cells derived from human cartilage were tested in liquid micromass and agarose gel cultures. An inhibition of cell prolife...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01713325

    authors: Mont MA,Mathur SK,Frondoza CG,Hungerford DS

    更新日期:1996-03-01 00:00:00

  • Seroprevalence of Chlamydia pneumoniae antibodies in a young adult population sample living in Verona. European Community Respiratory Health Survey (ECRHS) Verona.

    abstract:UNLABELLED:The aim of the study was to evaluate the prevalence of antibodies to Chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in Verona, Italy. IgG and IgM titers were measured by micro-immunofluorescence. IgG antibodies, greater or equal to 16, were found in 104/177 ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050009

    authors: Ferrari M,Poli A,Olivieri M,Tardivo S,Biasin C,Balestreri F,Dal Molin G,Lo Cascio V,Campello C

    更新日期:2000-01-01 00:00:00

  • In vitro activity of clarithromycin and its 14-hydroxy-metabolite against 203 strains of Haemophilus influenzae.

    abstract::The in vitro activity of clarithromycin alone and in combination with its primary human metabolite, 14-hydroxy-clarithromycin, was determined against 203 strains of Haemophilus influenzae. Microdilution broth MICs and MBCs of both clarithromycin and 14-hydroxy-clarithromycin were determined. The clarithromycin MIC50 w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01704612

    authors: Bergeron MG,Bernier M,L'Ecuyer J

    更新日期:1992-05-01 00:00:00

  • Clinical experience with ofloxacin in urinary tract infection.

    abstract::Preliminary data from the U.S. regarding the safety and efficacy of ofloxacin in the treatment of urinary tract infections are presented. Treatment of uncomplicated urinary tract infections with either 200 mg or 300 mg ofloxacin b.i.d. was as effective as treatment with a standard therapy, co-trimoxazole. In another s...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01661300

    authors: Cox CE,Callery SV,Tack KJ

    更新日期:1986-01-01 00:00:00

  • Bactericidal activity of ciprofloxacin, norfloxacin and ofloxacin in serum and urine after oral administration to healthy volunteers.

    abstract::A 200 mg oral dose of ciprofloxacin, norfloxacin or ofloxacin was administered to six healthy male volunteers in a three way cross-over study in order to examine the kinetics in humans in relation to the bactericidal activity in serum and urine. Serum concentrations for ciprofloxacin were similar to norfloxacin and lo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650502

    authors: Zeiler HJ,Beermann D,Wingender W,Förster D,Schacht P

    更新日期:1988-01-01 00:00:00

  • Pancreatic tuberculosis mimicking pancreatic head carcinoma: a case report and review of the literature.

    abstract::A 24-year-old man presented with vague abdominal fullness and a mild epigastric dull pain for about 3 months was found to have a pancreatic head tumor at a medical center 2 months ago. He came to our hospital for further treatment. Ultrasonography, endoscopic retrograde cholangiopancreatography (ERCP) and abdominal co...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01739920

    authors: Wu CS,Wang SH,Kuo TT

    更新日期:1994-07-01 00:00:00

  • Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in 11 adult intensive care units from 10 cities of Turkey: findings of the International Nosocomial Infection Control Consortium (INICC).

    abstract:PURPOSE:To evaluate the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach on the reduction of ventilator-associated pneumonia (VAP) in adult patients hospitalized in 11 intensive care units (ICUs), from 10 hospitals, members of the INICC, in 10 cities of Turkey. METH...

    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-013-0407-1

    authors: Leblebicioglu H,Yalcin AN,Rosenthal VD,Koksal I,Sirmatel F,Unal S,Turgut H,Ozdemir D,Ersoz G,Uzun C,Ulusoy S,Esen S,Ulger F,Dilek A,Yilmaz H,Turhan O,Gunay N,Gumus E,Dursun O,Yýlmaz G,Kaya S,Ulusoy H,Cengiz M

    更新日期:2013-04-01 00:00:00

  • [Bone concentrations of imipenem after a dose of imipenem/cilastatin].

    abstract::The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hyd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647497

    authors: Wittmann DH,Kuipers TH,Fock R,Höll M,Bauernfeind A

    更新日期:1986-01-01 00:00:00