Lymphocyte apoptosis, caspase activation and inflammatory response in septic shock.

Abstract:

BACKGROUND:We examined lymphocyte apoptosis, activity of caspases-1, -3, -8 and -9 and the relationship between those two events and inflammation response in septic shock. MATERIALS AND METHODS:Blood samples were obtained within 24 h after diagnosis of septic shock from 16 patients to measure apoptosis, caspases-3, -8, -9 expression, changes in mitochondrial transmembrane potential and expression of Fas/FasL system of peripheral blood mononuclear cells (PBMCs). Moreover, serum levels of caspase-1 and blood concentrations of IL-6, IL-12, IL-15 and IL-18 were assessed. RESULTS:PBMCs from patients with septic shock compared to control individuals exhibited a greatly increased frequency of apoptosis (39.10 +/- 7.33% vs 4.19 +/- 1.13%; p < 0.001), an over expression of caspases-3, -8, and -9 (p < 0.01, p < 0.05, p < 0.001 for caspases-3, -8 and -9, respectively) as well as of Fas/FasL system (p < 0.05) and significant changes in mitochondrial transmembrane potential. Blood levels of caspase-1 (101.5 +/- 18.2 pg/ml vs 9.09 +/- 2.7 pg/ml, p < 0.001) and of IL-6, IL-12, IL-15 and IL-18 were significantly higher in septic patients vs control (p < 0.0001, p < 0.05, p < 0.05 and p < 0.0001, respectively). Furthermore, a correlation linking IL-6 blood level with both the apoptotic rate (r(2) = 0.75; p = 0.001) and caspase-9 expression (r(2) = 0.92; p = 0.0001) of PBMCs was observed.

journal_name

Infection

journal_title

Infection

authors

Delogu G,Famularo G,Tellan G,Marandola M,Antonucci A,Signore M,Marcellini S,Moretti S

doi

10.1007/s15010-008-7070-y

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

485-7

issue

5

eissn

0300-8126

issn

1439-0973

journal_volume

36

pub_type

信件
  • Single and multiple dose pharmacokinetics of intravenous cefpirome (HR 810), a novel cephalosporin derivative.

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    pub_type: 杂志文章

    doi:10.1007/BF01646053

    authors: Malerczyk V,Maass L,Verho M,Hajdú P,Klesel N,Rangoonwala R

    更新日期:1987-05-01 00:00:00

  • Kinetics and correlation with body temperature of circulating interleukin-6, interleukin-8, tumor necrosis factor alpha and interleukin-1 beta in patients with fever and neutropenia.

    abstract::Interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor alpha (TNF) are important mediators of fever and inflammation, and are involved in the pathogenesis of sepsis. There is only limited data on serum concentrations of these proinflammatory cytokines in patients with feve...

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    pub_type: 杂志文章

    doi:10.1007/BF01716695

    authors: Engel A,Kern WV,Mürdter G,Kern P

    更新日期:1994-05-01 00:00:00

  • Fungal resistance.

    abstract::Fungal resistance is caused by an acquisition of intrinsically resistant species, by selection of resistant strains from a population or by mutation of an initially susceptible strain. According to different classes of antimycotics there are different resistance mechanisms: differences in the uptake mechanisms, drug t...

    journal_title:Infection

    pub_type: 杂志文章,评审

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    authors: Bernhardt H,Zimmermann K,Knoke M

    更新日期:1999-01-01 00:00:00

  • Ciprofloxacin concentrations in tonsils following a single intravenous infusion.

    abstract::Penetration of ciprofloxacin into human tonsils was studied following an intravenous infusion of 200 mg over 15 minutes to adult humans undergoing tonsillectomy. Samples were taken one-and-a-half to four hours after dosing. Generally, tissue levels exceeded corresponding serum concentrations by 50% (range of intraindi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01651152

    authors: Falser N,Dalhoff A,Weuta H

    更新日期:1984-09-01 00:00:00

  • The integrity of latex gloves in clinical dental practice.

    abstract:BACKGROUND:The aim of the study was to assess the integrity of non-sterile latex gloves (Biogel Diagnostic (A), Biogel Dental (B), Gentle Skin (C) and Manufix (D)) in clinical dental practice. MATERIALS AND METHODS:After use, the gloves were collected and examined for perforations using the water inflation test accord...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100070011

    authors: Pitten FA,Herdemann G,Kramer A

    更新日期:2000-11-01 00:00:00

  • Efficacy and local tolerability of povidone iodine and octenidine hydrochloride solution for the antiseptic preparation of the orificium urethrae.

    abstract::In a randomized clinical study, 61 hospitalized men were examined to test the local tolerability and antimicrobial efficacy of antiseptic treatment of the genitals with povidone iodine versus octenidine hydrochloride solution. Antibacterial efficacy was established by comparing the total aerobic bacterial colony count...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02560508

    authors: Rudolph P,Fritze F,Reimer K,Klebingat KJ,Kramer A

    更新日期:1999-03-01 00:00:00

  • Influence of cefodizime on the reagibility of human leukocytes.

    abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...

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    pub_type: 杂志文章

    doi:10.1007/BF01709952

    authors: Limbert M,Müllner H,Shah PM

    更新日期:1992-01-01 00:00:00

  • Treatment of recurrent Clostridium difficile infection: a systematic review.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) recurs in nearly one-third of patients who develop an initial infection. Recurrent CDI (RCDI) is associated with considerable morbidity, mortality, and cost. Treatment for RCDI has not been not well examined. METHODS:A systematic review. RESULTS:Sixty-four articles wer...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-013-0496-x

    authors: O'Horo JC,Jindai K,Kunzer B,Safdar N

    更新日期:2014-02-01 00:00:00

  • Anaerobic microbiology in the NASA space program.

    abstract::After briefly reviewing the earlier methods used to monitor the microbial load of returned lunar material, the author reports the more accurate research on the ability of terrestrial organisms to grow under simulated Martian environments. The possible importance of anaerobic microbiology can readily be seen because of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639903

    authors: Brewer JH

    更新日期:1980-01-01 00:00:00

  • Comparison in a laboratory model between the performance of a urinary closed system bag with double non-return valve and that of a single valve system.

    abstract:BACKGROUND:Catheter-associated urinary tract infection is the most common nosocomial infection in clinical settings. For bacteria ascending to the bladder the most common route is the extraluminal, but the intraluminal route also plays a role. For this reason, we compared two urinary closed system bags (CSB), one with ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-5626-2

    authors: Wenzler-Röttele S,Dettenkofer M,Schmidt-Eisenlohr E,Gregersen A,Schulte-Mönting J,Tvede M

    更新日期:2006-08-01 00:00:00

  • A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.

    abstract::The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0774-x

    authors: Taniguchi R,Koyano S,Suzutani T,Goishi K,Ito Y,Morioka I,Nakamura H,Yamada H,Oka A,Inoue N

    更新日期:2015-06-01 00:00:00

  • Isolation of Chlamydia trachomatis from prostatic tissue of patients undergoing transurethral prostatectomy.

    abstract::Chlamydia trachomatis was isolated from three of 100 prostatic tissue specimens obtained from patients undergoing transurethral resection of the prostate. All examined patients were free from symptoms of urethral or prostatic inflammation. Our findings are in accordance with the high incidence of asymptomatic chlamydi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643241

    authors: Dan M,Samra Z,Siegel YI,Korczak D,Lindner A

    更新日期:1991-05-01 00:00:00

  • [Effectiveness and tolerance of cefixime in bacterial infections in the ENT area].

    abstract::Clinical efficacy and tolerance of cefixime were investigated in an open, uncontrolled trial. 200 mg of cefixime were applied twice daily, duration of therapy was between eight and 14 days (mean value 10.1 days, standard deviation +/- 1.4 days). Ten male patients (mean age 42.7 years) and 19 female patients (mean age ...

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    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01644629

    authors: Theopold M,Benner U,Bauernfeind A

    更新日期:1990-01-01 00:00:00

  • In vitro activity of new cephalosporins against multi-resistant gram-negative bacteria.

    abstract::The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime ...

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    pub_type: 杂志文章

    doi:10.1007/BF01641100

    authors: Fainstein V,Le Blanc B,Bodey GP

    更新日期:1983-01-01 00:00:00

  • [Microbiological diagnosis of septicemia].

    abstract::To detect microorganisms in the blood it is necessary not only that the microbiologist uses reliable methods, but also that the clinician takes a sufficient number of blood samples at the right point in time using a correct method for drawing the blood. The best results are obtained if the blood sample is transferred ...

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    pub_type: 杂志文章

    doi:10.1007/BF01639113

    authors: Rotter M

    更新日期:1977-03-01 00:00:00

  • New fluoroquinolones in lower respiratory tract infections and emerging patterns of pneumococcal resistance.

    abstract::The increasing resistance of Streptococcus pneumoniae, the most important community respiratory pathogen, to beta-lactams and other first-line antimicrobial agents usually employed for the empirical treatment of lower respiratory tract infections has led to the inclusion, in several current guidelines, of a fluoroquin...

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    pub_type: 杂志文章,评审

    doi:10.1007/s15010-005-4102-8

    authors: Ferrara AM

    更新日期:2005-06-01 00:00:00

  • Emergence of SCCmec type IV as the most common type of methicillin-resistant Staphylococcus aureus in a university hospital.

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    doi:10.1007/s15010-008-7430-7

    authors: Strandén AM,Frei R,Adler H,Flückiger U,Widmer AF

    更新日期:2009-02-01 00:00:00

  • The potential impact of biomarker-guided triage decisions for patients with urinary tract infections.

    abstract:OBJECTIVES:Current guidelines provide limited evidence as to which patients with urinary tract infection (UTI) require hospitalisation. We evaluated the currently used triage routine and tested whether a set of criteria including biomarkers like proadrenomedullin (proADM) and urea have the potential to improve triage d...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0423-1

    authors: Litke A,Bossart R,Regez K,Schild U,Guglielmetti M,Conca A,Schäfer P,Reutlinger B,Mueller B,Albrich WC

    更新日期:2013-08-01 00:00:00

  • Documented cutaneous loxoscelism in the south of France: an unrecognized condition causing delay in diagnosis.

    abstract:BACKGROUND:Loxoscelism is an envenomation due to a bite by spiders of the genus Loxosceles, very well known on the American continent but unrecognized in Europe. CASE REPORT:We report the case of a 36-year-old woman, without any medical history or treatment, who went to a University Hospital in the South of France, fo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0869-4

    authors: Rubenstein E,Stoebner PE,Herlin C,Lechiche C,Rollard C,Laureillard D,Sotto A

    更新日期:2016-06-01 00:00:00

  • [Enoxacin concentration in bone tissue].

    abstract::For successful treatment of bacterial osteomyelitis the administered antibiotic must reach sufficiently high concentrations in bone tissues. Therefore concentrations of enoxacin in bone in ten patients requiring hip surgery were measured. To prevent a postoperative infection, 400 mg enoxacin b.i.d. for two days were a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643632

    authors: Adam D,Weismeier K,Sörgel F,Zürcher J

    更新日期:1989-01-01 00:00:00

  • Vitamin K supplementation during prophylactic use of cefoperazone in urologic surgery.

    abstract::Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of bleeding, co-administration of vitamin K has been advised. We reassessed the need for vitamin K use in a retrospective analysis of 50 patients undergoing urologic pro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01704604

    authors: Rockoff SD,Blumenfrucht MJ,Irwin RJ Jr,Eng RH

    更新日期:1992-05-01 00:00:00

  • The frequency of Mycoplasma pneumoniae antibodies in a Calabrian population.

    abstract::The epidemiological survey was carried out in a Calabrian population in order to ascertain the incidence of antibodies to Mycoplasma pneumoniae. In the past it has been felt that this infection does not occur in Southern Italy. We have found an incidence in our survey equal to that of the other countries. It was impos...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01638421

    authors: Calisto ML,Farina W,Picerno I,Ceccarelli G

    更新日期:1976-01-01 00:00:00

  • Correlation between antibiotic consumption and resistance of bloodstream bacteria in a University Hospital in North Eastern Italy, 2008-2014.

    abstract:PURPOSE:The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS:Anti...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-0998-z

    authors: Mascarello M,Simonetti O,Knezevich A,Carniel LI,Monticelli J,Busetti M,Schincariol P,Torelli L,Luzzati R

    更新日期:2017-08-01 00:00:00

  • In vitro activity of second and third generation cephalosporins against ampicillin susceptible and resistant haemophilus influenzae.

    abstract::One hundred seventy-five clinical isolates of Haemophilus influenzae (including 74 beta-lactamase-producing strains) were examined for susceptibility to ampicillin, cefonicid, cefamandole, cefuroxime and cefotaxime. Cefonicid and cefamandole exhibited similar activity against ampicillin-susceptible strains (MIC90 = 0....

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645075

    authors: Burns JL,Wong K,Smith AL

    更新日期:1988-09-01 00:00:00

  • Thrombocytosis associated with acute osteomyelitis.

    abstract::Thrombocytosis is rarely observed during infection. We are describing a patient with acute osteomyelitis and bacteremia who developed thrombocytosis. In the patient described the platelet count paralleled the activity of the infection and the response to therapy. The causes of thrombocytosis and its implications are b...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645220

    authors: Robey C,Chmel H

    更新日期:1984-11-01 00:00:00

  • Epidemiology of SARS-CoV-2.

    abstract:PURPOSE:SARS-CoV-2 is a recently emerged ß-coronavirus. Here we present the current knowledge on its epidemiologic features. METHODS:Non-systematic review. RESULTS:SARS-CoV-2 replicates in the upper and lower respiratory tract. It is mainly transmitted by droplets and aerosols from asymptomatic and symptomatic infect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-020-01531-3

    authors: Salzberger B,Buder F,Lampl B,Ehrenstein B,Hitzenbichler F,Holzmann T,Schmidt B,Hanses F

    更新日期:2020-10-08 00:00:00

  • [Altered bacterial periurethral flora in young girls with chronic, recurrent urinary tract infections? (author's transl)].

    abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640729

    authors: Hofmann K,Marget W,Belohradsky B

    更新日期:1981-01-01 00:00:00

  • A review on anti-adhesion therapies of bacterial diseases.

    abstract:BACKGROUND:Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most impo...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-018-1222-5

    authors: Asadi A,Razavi S,Talebi M,Gholami M

    更新日期:2019-02-01 00:00:00

  • Prevalence rates of viral hepatitis infections in refugee Kurds from Iraq and Turkey.

    abstract:BACKGROUND:Since little is known about the burden of viral hepatitis in Kurds, the prevalence of infection with hepatitis A virus (HAV), hepatitis E virus (HEV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a sample of refugee Kurds from Iraq and Turkey. PATIENTS AND METHODS:A cross-sectiona...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-3100-3

    authors: Chironna M,Germinario C,Lopalco PL,Carrozzini F,Barbuti S,Quarto M

    更新日期:2003-03-01 00:00:00

  • Investigation of Rickettsia conorii antibodies in the Antalya area.

    abstract::Mediterranean spotted fever, caused by Rickettsia conorii, is a tick-borne infection. Serum samples for screening R. conorii antibodies of professionally exposed persons in the Antalya region, on the Mediterranean coast of Turkey, were analyzed. R. conorii IgG antibodies were detected in 13 of 98 (13.3%) serum samples...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02771845

    authors: Vural T,Ergin C,Sayin F

    更新日期:1998-05-01 00:00:00