Abstract:
:The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hydroxylapatite (imbution), however, its antimicrobial activity is lost. The mean serum concentration in 12 patients (mean age 77 years) with normal renal and hepatic function 15 minutes after the beginning of the infusion was 93.1 mg/l imipenem. The mean serum half life t (1/2 beta) was 1.32 hours, the total body clearance 108.6 1/h, and the volume of distribution during the beta phase V(beta) 12.4 1.
journal_name
Infectionjournal_title
Infectionauthors
Wittmann DH,Kuipers TH,Fock R,Höll M,Bauernfeind Adoi
10.1007/BF01647497subject
Has Abstractpub_date
1986-01-01 00:00:00pages
S130-7eissn
0300-8126issn
1439-0973journal_volume
14 Suppl 2pub_type
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