[Bone concentrations of imipenem after a dose of imipenem/cilastatin].

Abstract:

:The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hydroxylapatite (imbution), however, its antimicrobial activity is lost. The mean serum concentration in 12 patients (mean age 77 years) with normal renal and hepatic function 15 minutes after the beginning of the infusion was 93.1 mg/l imipenem. The mean serum half life t (1/2 beta) was 1.32 hours, the total body clearance 108.6 1/h, and the volume of distribution during the beta phase V(beta) 12.4 1.

journal_name

Infection

journal_title

Infection

authors

Wittmann DH,Kuipers TH,Fock R,Höll M,Bauernfeind A

doi

10.1007/BF01647497

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

S130-7

eissn

0300-8126

issn

1439-0973

journal_volume

14 Suppl 2

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:10.1007/BF01644971

    authors: Dirksen M,Focht J,Boerema J

    更新日期:1991-07-01 00:00:00

  • Acinetobacter septicemia: a threat to neonates? Special aspects in a neonatal intensive care unit.

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    pub_type: 杂志文章

    doi:10.1007/BF01728921

    authors: Regev R,Dolfin T,Zelig I,Givoni S,Wolach B

    更新日期:1993-11-01 00:00:00

  • Chlamydial antigen detection in urine samples by immunofluorescence tests.

    abstract::To investigate the diagnostic value of a direct immunofluorescence test (DIF-test), urethral samples and first catch urine (FCU) from 153 male patients attending an outpatient clinic for sexually transmitted diseases (STD) were studied. Of the male patients, 40 (26.1%) had a positive urethral culture, 39 (25.5%) had a...

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    pub_type: 杂志文章

    doi:10.1007/BF01711077

    authors: Stary A,Genç M,Heller-Vitouch C,Mårdh PA

    更新日期:1992-03-01 00:00:00

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    authors: Diederen BM,van Leest CM,van Duijn I,Willemse P,van Keulen PH,Kluytmans JA

    更新日期:2006-04-01 00:00:00

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    pub_type: 杂志文章

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    authors: Almomani BA,Hayajneh WA,Ayoub AM,Ababneh MA,Al Momani MA

    更新日期:2018-08-01 00:00:00

  • [A cross-over study on the effectiveness of ofloxacin and ciprofloxacin administered orally].

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    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01645207

    authors: Kurz CC,Marget W,Harms K,Bertele RM

    更新日期:1986-01-01 00:00:00

  • Open, randomized comparison of pefloxacin and cefotaxime in the treatment of complicated urinary tract infections.

    abstract::In an open, randomized study, the effect of pefloxacin (400 mg b.i.d.) was compared with that of cefotaxime (1 g t.i.d.) in the treatment of complicated urinary tract infections. In total 87 patients entered the study under the clinical diagnosis of complicated urinary tract infection, of whom 49 were eligible for eva...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01704892

    authors: Timmerman C,Hoepelman I,de Hond J,Boon T,Schreinemachers L,Mensink H,Verhoef J

    更新日期:1992-01-01 00:00:00

  • Pancreatic tuberculosis mimicking pancreatic head carcinoma: a case report and review of the literature.

    abstract::A 24-year-old man presented with vague abdominal fullness and a mild epigastric dull pain for about 3 months was found to have a pancreatic head tumor at a medical center 2 months ago. He came to our hospital for further treatment. Ultrasonography, endoscopic retrograde cholangiopancreatography (ERCP) and abdominal co...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01739920

    authors: Wu CS,Wang SH,Kuo TT

    更新日期:1994-07-01 00:00:00

  • Thrombocytosis associated with acute osteomyelitis.

    abstract::Thrombocytosis is rarely observed during infection. We are describing a patient with acute osteomyelitis and bacteremia who developed thrombocytosis. In the patient described the platelet count paralleled the activity of the infection and the response to therapy. The causes of thrombocytosis and its implications are b...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645220

    authors: Robey C,Chmel H

    更新日期:1984-11-01 00:00:00

  • Bactericidal activity of ciprofloxacin, norfloxacin and ofloxacin in serum and urine after oral administration to healthy volunteers.

    abstract::A 200 mg oral dose of ciprofloxacin, norfloxacin or ofloxacin was administered to six healthy male volunteers in a three way cross-over study in order to examine the kinetics in humans in relation to the bactericidal activity in serum and urine. Serum concentrations for ciprofloxacin were similar to norfloxacin and lo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650502

    authors: Zeiler HJ,Beermann D,Wingender W,Förster D,Schacht P

    更新日期:1988-01-01 00:00:00

  • Screening for Chlamydia trachomatis in military personnel by urine testing.

    abstract::In order to determine the infection rate of Chlamydia trachomatis in young males in Austria an epidemiological study was performed on 335 male Austrian soldiers attending the military hospital for a health check-up procedure. Three hundred twenty-nine (98.2%) of the screened males were clinically asymptomatic. Chlamyd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644946

    authors: Stary A,Steyrer K,Heller-Vitouch C,Müller I,Mårdh PA

    更新日期:1991-07-01 00:00:00

  • Partial in vivo response to corticosteroid treatment in common variable immune deficiency.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643615

    authors: Wahn V,Grosse-Wilde H,Rosin H,Carls C,Göbel U

    更新日期:1985-01-01 00:00:00

  • Clinical features of liver involvement in adult patients with listeriosis. Review of the literature.

    abstract::Clinical features of liver involvement due to Listeria monocytogenes infection in adults are rarely reported in literature. This is surprising, regarding the current opinion that the portal system is extensively involved in the first stages of pathogenesis in invasive L. monocytogenes disease. A literature search in t...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-007-6006-2

    authors: Scholing M,Schneeberger PM,van den Dries P,Drenth JP

    更新日期:2007-06-01 00:00:00

  • Disseminated zoster in an elderly patient.

    abstract::A 97-year-old lady was hospitalized for left leg cellulitis. Comorbidity included hypertension and congestive heart failure. While in hospital, she developed a painless vesicular rash localized to the territory of the left trigeminal nerve (third branch), which evolved to pustules and crusts (Figure 1). A chickenpox-l...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-8287-5

    authors: Capron J,Steichen O

    更新日期:2009-04-01 00:00:00

  • Passive immunization against cytomegalovirus in allograft recipients. The Rotterdam Heart Transplant Program experience.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01728886

    authors: Balk AH,Weimar W,Rothbarth PH,Meeter K,Metselaar HJ,Mochtar B,Simoons ML

    更新日期:1993-07-01 00:00:00

  • Comparison in a laboratory model between the performance of a urinary closed system bag with double non-return valve and that of a single valve system.

    abstract:BACKGROUND:Catheter-associated urinary tract infection is the most common nosocomial infection in clinical settings. For bacteria ascending to the bladder the most common route is the extraluminal, but the intraluminal route also plays a role. For this reason, we compared two urinary closed system bags (CSB), one with ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-5626-2

    authors: Wenzler-Röttele S,Dettenkofer M,Schmidt-Eisenlohr E,Gregersen A,Schulte-Mönting J,Tvede M

    更新日期:2006-08-01 00:00:00

  • Acute disseminated encephalomyelitis (ADEM) due to Mycoplasma pneumoniae infection in an adolescent.

    abstract::A 17-year-old boy presented with a severe form of an acute disseminated encephalomyelitis (ADEM) with hemiparesis and coma after initial symptoms of a flu-like febrile infection 1 week previously. Titers against Mycoplasma pneumoniae were significantly increased in serum and cerebrospinal fluid (CSF). Detection of M. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1173-z

    authors: Riedel K,Kempf VA,Bechtold A,Klimmer M

    更新日期:2001-08-01 00:00:00

  • High prevalence of latent tuberculosis infection in patients in end-stage renal disease on hemodialysis: Comparison of QuantiFERON-TB GOLD, ELISPOT, and tuberculin skin test.

    abstract:BACKGROUND:Individuals with end-stage renal disease (ESRD) are 10- to 25-fold more likely than immunocompetent people to develop active tuberculosis (TB) and are candidates for being treated for latent TB infection (LTBI). However, diagnosis using the tuberculin skin test (TST) is doubly difficult due to cutaneous aner...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-8082-3

    authors: Lee SS,Chou KJ,Su IJ,Chen YS,Fang HC,Huang TS,Tsai HC,Wann SR,Lin HH,Liu YC

    更新日期:2009-04-01 00:00:00

  • Infant tuberculosis in Austria--trend reversal since 1990?

    abstract::Since 1990 a relatively high number of cases of childhood tuberculosis has been observed in Austria, mainly occurring in the age-group of 0-4 years. Within this group most cases were registered in 1995. Since the beginning of 1995 the establishment of a lab-supported nationwide data collection system enables a more de...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02768752

    authors: Makristathis A,Stauffer F,Klein JP,Rotter ML,Wewalka G,Hirschl AM

    更新日期:1998-01-01 00:00:00

  • Qualitative and quantitative microbiological analysis of sputa of 102 patients with cystic fibrosis.

    abstract::A microbiological analysis of 102 patients suffering from cystic fibrosis was conducted over a 22 month period. 20 microbial species with the following incidence were identified: Pseudomonas aeruginosa: 83.4%; Candida albicans: 29.4%; Staphylococcus aureus: 24.5%; Staphylococcus epidermidis: 11.8%; Haemophilus influen...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644137

    authors: Bauernfeind A,Bertele RM,Harms K,Hörl G,Jungwirth R,Petermüller C,Przyklenk B,Weisslein-Pfister C

    更新日期:1987-07-01 00:00:00

  • The "Choosing Wisely" initiative in infectious diseases.

    abstract:OBJECTIVE:"Choosing Wisely" is a growing international campaign aiming at practice changes to improve patient health and safety by both, conduct of essential and avoidance of unnecessary diagnostic, preventive and therapeutic procedures. The goal is to create an easily recognizable and distributable list ("Choosing Wis...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-0997-0

    authors: Lehmann C,Berner R,Bogner JR,Cornely OA,de With K,Herold S,Kern WV,Lemmen S,Pletz MW,Ruf B,Salzberger B,Stellbrink HJ,Suttorp N,Ullmann AJ,Fätkenheuer G,Jung N

    更新日期:2017-06-01 00:00:00

  • Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review.

    abstract:PURPOSE:There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS:We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment opt...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-1070-8

    authors: Chibabhai V,Nana T,Bosman N,Thomas T,Lowman W

    更新日期:2018-02-01 00:00:00

  • Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry.

    abstract:BACKGROUND:The PROGRESS Registry (Promoting Global Research Excellence in Severe Sepsis) was designed to provide comparative data reflecting everyday clinical practice, thereby allowing participating institutions to explore and benchmark medical interventions in severe sepsis. MATERIALS AND METHODS:PROGRESS was an int...

    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-008-8203-z

    authors: Beale R,Reinhart K,Brunkhorst FM,Dobb G,Levy M,Martin G,Martin C,Ramsey G,Silva E,Vallet B,Vincent JL,Janes JM,Sarwat S,Williams MD,PROGRESS Advisory Board.

    更新日期:2009-06-01 00:00:00

  • [A microbiological method for the rapid determination of antibiotic concentrations during therapy].

    abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62° C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the te...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642093

    authors: Wahlig H

    更新日期:1977-06-01 00:00:00

  • Assays of cephalosporin antibiotics administered prophylactically in open heart surgery. Determination of serum and tissue levels before, during and after cardiopulmonary bypass.

    abstract::Twenty-eight patients who underwent open-heart surgery were divided into three groups, each of which received a different antibiotic from the cephalosporin series (cephalotin, cefazolin or cefamandole) in order to prevent infection. All antibiotics were given via intravenous infusion in a dosage of 2 g prior to surger...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641087

    authors: Eigel P,Tschirkov A,Satter P,Knothe H

    更新日期:1978-01-01 00:00:00

  • Prevalence of antibodies to human herpesviruses and hepatitis B virus in patients at different stages of human immunodeficiency virus (HIV) infection.

    abstract::The results of antibody assays for viruses of the herpes group (HSV, EBV, VZV and CMV) and for hepatitis B virus (HBV) were retrospectively evaluated in 439 HIV-seropositive patients classified into different stages of HIV infection. The prevalence of specific IgG, IgM and IgA antibodies in these groups was compared w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643233

    authors: Enzensberger R,Braun W,July C,Helm EB,Doerr HW

    更新日期:1991-05-01 00:00:00

  • Actinobacillus actinomycetem-comitans endocarditis in a child with a prosthetic heart valve.

    abstract::The first case of Actinobacillus actinomycetem-comitans endocarditis in a child with a prosthetic cardiac valve is reported. Endocarditis was possibly caused by dental work done without antibiotic prophylaxis four weeks prior to admission. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645955

    authors: Felius A,Fleer A,Moulaert A

    更新日期:1984-07-01 00:00:00

  • Clinical characteristics of Raoultella ornithinolytica bacteremia.

    abstract:PURPOSE:Raoultella ornithinolytica is not well known as a clinical pathogen. We performed a retrospective review of R. ornithinolytica bacteremia to investigate its clinical features, antimicrobial susceptibility, and overall patient outcomes. METHODS:R. ornithinolytica bacteremia cases were collected from an electron...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0696-z

    authors: Chun S,Yun JW,Huh HJ,Lee NY

    更新日期:2015-02-01 00:00:00

  • Practices, organisation, and regulatory aspects in advising on antibiotic prescription: the international ESCMID AntibioLegalMap survey.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01298-2

    authors: Tebano G,Dyar OJ,Beovic B,Claudot F,Béraud G,Thilly N,Pulcini C,European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Antimicrobial stewardshiP (ESGAP).

    更新日期:2019-10-01 00:00:00

  • Oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA), a hidden resistant mechanism among clinically significant isolates in the Wessex region/UK.

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    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-014-0641-1

    authors: Saeed K,Ahmad N,Dryden M,Cortes N,Marsh P,Sitjar A,Wyllie S,Bourne S,Hemming J,Jeppesen C,Green S

    更新日期:2014-10-01 00:00:00