Abstract:
PURPOSE:Methicillin-resistant Staphylococcus aureus (MRSA) is defined as S. aureus genetically having the mecA or mecC genes or phenotypically showing minimum inhibitory concentration (MIC) of oxacillin higher than 2 mg/L. However, recently, cefoxitin/oxacillin-susceptible mecA-positive S. aureus (OS-MRSA) has been reported worldwide. Little is known about the prevalence and virulence of these strains among clinically significant isolates in the UK. The aims were to (1) investigate the prevalence of OS-MRSA in seven major hospitals in the Wessex region/UK from a cohort of 500 clinically significant phenotypically identified MSSA isolates, (2) genetically characterise OS-MRSA strains by pulsed-field gel electrophoresis (PFGE) and compare these to common UK epidemic strains; and (3) to determine Panton-Valentine leukocidin (PVL; lukFS) gene carriage rates among these isolates. RESULTS:OS-MRSA was found in six isolates (1.2 %) of phenotypically identified and reported MSSA isolates by conventional methods. PFGE showed OS-MRSA strains to be genetically diverse and distinct from the common UK epidemic strains EMRSA-15 and EMRSA-16. None of these OS-MRSA stains carried the genes encoding PVL; however, overall positivity rate for PVL was 4.4 %, much higher than the nationally reported rates of 2 % in the UK. CONCLUSION:There are still many unknowns regarding phenotypic and/or genetic characterization of the emerging OS-MRSA isolates in the UK and worldwide. Data regarding their epidemiology and optimal therapy for infection are limited and need further investigation not only in the UK, but also worldwide, as it is likely to have an impact on the empirical treatment of S. aureus infections.
journal_name
Infectionjournal_title
Infectionauthors
Saeed K,Ahmad N,Dryden M,Cortes N,Marsh P,Sitjar A,Wyllie S,Bourne S,Hemming J,Jeppesen C,Green Sdoi
10.1007/s15010-014-0641-1subject
Has Abstractpub_date
2014-10-01 00:00:00pages
843-7issue
5eissn
0300-8126issn
1439-0973journal_volume
42pub_type
杂志文章,多中心研究相关文献
INFECTION文献大全abstract:: ...
journal_title:Infection
pub_type: 社论
doi:10.1007/s15010-018-1228-z
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...
journal_title:Infection
pub_type: 杂志文章,meta分析
doi:10.1007/s15010-020-01502-8
更新日期:2020-12-01 00:00:00
abstract::Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filam...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0724-7
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking. CASE REPORT:We...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1168-7
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:For simultaneous detection of Borrelia miyamotoi (relapsing fever spirochete) and Borrelia burgdorferi sensu lato, we have developed a duplex real-time PCR targeting the flagellin gene (flaB; p41), a locus frequently used in routine diagnostic PCR for B. burgdorferi s.l. detection. METHODS:Primers and probes w...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0820-8
更新日期:2016-02-01 00:00:00
abstract::Neglected tropical diseases are becoming more and more frequent in Europe due to the increasing immigration from endemic areas. Nonetheless specific treatments are scarcely available in many European countries, since they are neither officially licensed nor marketed. Only a few referral health centres can afford to ac...
journal_title:Infection
pub_type: 社论
doi:10.1007/s15010-018-1241-2
更新日期:2019-02-01 00:00:00
abstract::A rare case of spontaneous spondylodiscitis caused by Klebsiella pneumoniae in a 55-year-old man who presented with thoracolumbar pain is described. Increased erythrocyte sedimentation rate and C-reactive protein level were pertinent laboratory findings. Computed tomography revealed a paravertebral mass and destructio...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100050046
更新日期:1999-11-01 00:00:00
abstract::Cytomegalovirus (CMV) infection remains a common infection after solid-organ transplantation. In the general population CMV disease is associated with Guillain-Barre syndrome (GBS), an autoimmune disease leading to an acute peripheral neuropathy, in 1 of 1000 cases. Interestingly, GBS is a rarely observed complication...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-015-0819-1
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Cryptococcal meningitis is a potentially fatal fungal infection associated with a significant attributable morbidity and mortality, especially among HIV/AIDS patients. The first-line therapy for the treatment of this clinical entity is the combinatory therapy of amphotericin B plus flucytosine. However, the hig...
journal_title:Infection
pub_type: 杂志文章,随机对照试验
doi:10.1007/s15010-017-1059-3
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Investigation of the injecting drug users (IDUs) population is becoming extremely critical and timely in light of the recent evidence that IDUs now act as the core of hepatitis C virus (HCV) epidemics in developed countries. The purpose of this article, therefore, is not only to review the epidemiology of HCV i...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-011-0236-z
更新日期:2012-02-01 00:00:00
abstract::A 100 male patients aged from 20 to 45 years were treated for chronic brucellosis. Sixty-eight complained of impaired sexual potency. The percentage of patients with sexual disorders increased parallel to the duration of the disease. Andrologic investigations comprised a study sexual history, physical examination of t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641469
更新日期:1980-01-01 00:00:00
abstract::A case of meningitis due to an unusual organism, Haemophilus aphrophilus in an adult is described. In spite of rapid clearance of the organism from the cerebrospinal fluid with intravenous cefotaxime, fever persisted over 8 days of therapy and infection was complicated by hydrocephalus. H. aphrophilus meningitis is un...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02770846
更新日期:1998-11-01 00:00:00
abstract::We compared the in-vitro activity of cefoperazone-sulbactam (2:1), other beta-lactams, amino-glycosides and ciprofloxacin against cefoperazone-susceptible and -resistant nosocomial gram-negative bacilli. Resistant isolates including Pseudomonas aeruginosa were susceptible to cefoperazone-sulbactam; the susceptible iso...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643761
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Cardiac involvement in dengue fever is underdiagnosed due to low index of clinical suspicion and its contribution to hemodynamic instability in severe dengue is not well known. METHODS:A prospective observational study was conducted among admitted patients ≥ 14 years of age having confirmed dengue fever. Patie...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01500-w
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To assess incidence rate, risk factors and susceptibility patterns associated with extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli or Klebsiella pneumoniae in community-acquired urinary tract infections (CA-UTIs). METHODS:A prospective, case-control study was conducted at a tertiary teaching...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1148-y
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey. MATERIALS AND MET...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2185-z
更新日期:2002-10-01 00:00:00
abstract::Thrombocytosis is rarely observed during infection. We are describing a patient with acute osteomyelitis and bacteremia who developed thrombocytosis. In the patient described the platelet count paralleled the activity of the infection and the response to therapy. The causes of thrombocytosis and its implications are b...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645220
更新日期:1984-11-01 00:00:00
abstract::A study on prevention of borreliosis in humans bitten by infected ticks was performed in 1992-1994 in the Perm' region of Russia. Adult Ixodes persulcatus ticks were removed from the study subjects, and live preparations made from the material obtained from the gut of each tick were microscopically analyzed (up to 250...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713337
更新日期:1996-03-01 00:00:00
abstract::A case of repeated episodes of Pseudomonas vesicularis bacteraemia, in a 54-year-old woman with a past history including systemic lupus erythematosus and chronic active autoimmune hepatitis is reported. She was treated with tobramycin and ceftazidime but bacteraemia persisted until surgical resection of the infected t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710687
更新日期:1992-11-01 00:00:00
abstract::A prospective study was designed to evaluate the efficacy and effects on pulmonary function tests of weekly 600 mg aerosolised pentamidine as prophylaxis against Pneumocystis carinii pneumonia (PCP) amongst two groups of patients infected with the human immunodeficiency virus. Group 1 (primary prophylaxis) consisted o...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01704600
更新日期:1992-05-01 00:00:00
abstract::Raoultella ornithinolytica is increasingly being isolated as a causative organism in human infections. Most of the infections caused by R. ornithinolytica are hospital acquired and occur in patients who are immunocompromised, had invasive procedures or have indwelling catheters. This is a first report of early onset n...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1098-9
更新日期:2018-04-01 00:00:00
abstract::Lower urinary tract infection is a common problem for women, and tends to be recurrent. It is not associated with significant long term morbidity. Optimal management for symptomatic infection is short course antimicrobial therapy. For women with frequent, symptomatic, recurrent infection a number of therapeutic option...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01643426
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Tuberculosis is still a major cause of serious illness in developing countries. The objective of this study was to assess the clinical, laboratory, radiological and prognostic features of tuberculous meningitis (TBM) in immuncompetent adult patients. PATIENTS AND METHODS:Sixty-one patients with confirmed or...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-003-3179-1
更新日期:2003-12-01 00:00:00
abstract::Eikenella corrodens is a facultatively anaerobic gram-negative rod that colonizes the oral cavity and very rarely produces central nervous system (CNS) infections. Frontal lobe abscesses are occasionally associated with a dental source of infection. We report a case of an adult man with overzealous dental cleaning hab...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2004-6
更新日期:2002-08-01 00:00:00
abstract:INTRODUCTION:As the number of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections in German intensive care units increases, the problem of MRSA infection as such is becoming ever more serious. The aim of this study was to investigate whether mortality rates from nosocomial MRSA pneumonia and primar...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-005-3186-5
更新日期:2005-04-01 00:00:00
abstract:PURPOSE:No reports have been published on synchronous multifocal necrotizing fasciitis (SMNF), a multifocal presence of necrotizing fasciitis in different extremities. We evaluated the clinical characteristics and outcomes of SMNF. METHODS:Eighteen patients (14 men, 4 women; mean age: 59 years) diagnosed with SMNF of ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0932-9
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:In a previous controlled study, we investigated the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants (sudden infant death syndrome, SIDS). In this present study, we investigated further the respiratory pathology in a subset of infants in the original stud...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0164-y
更新日期:2011-12-01 00:00:00
abstract::The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearan...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641291
更新日期:1983-05-01 00:00:00
abstract:PURPOSE:This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS:After a literature review, five authors determined the barriers and facilitators to...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-018-1250-1
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The optimal strategy to prevent cytomegalovirus (CMV) disease after kidney transplantation continues to be open to debate. The preemptive approach requires regular determination of CMV viremia and prompt initiation of therapy. METHODS:We retrospectively compared the incidence of CMV disease during two perio...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-012-0343-5
更新日期:2012-12-01 00:00:00