Abstract:
INTRODUCTION:As the number of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections in German intensive care units increases, the problem of MRSA infection as such is becoming ever more serious. The aim of this study was to investigate whether mortality rates from nosocomial MRSA pneumonia and primary bloodstream infections (BSI) differ significantly from those of nosocomial pneumonia and primary BSI caused by methicillin-susceptible S. aureus (MSSA). METHODS:For the analysis data from the ICU component of the German nosocomial infection surveillance system (KISS) were used (January 1997 to June 2002). To identify mortality risk factors a logistic regression analysis with step-wise variable selection was conducted including all cases of nosocomial S. aureus pneumonia and primary BSI. The possible risk factors that were evaluated were age > median, male gender, time in the ICU before infection > median, type of ICU, type and size of hospital, intubation, CVC use, total parenteral nutrition, year of investigation, infection caused by MRSA. RESULTS:Data from 274 ICUs and 505,487 ICU patients were recorded and a total of 6,888 cases of nosocomial pneumonia and 2,357 cases of primary BSI identified, of which 1,851 cases of S. aureus pneumonia and 378 cases of S. aureus primary BSI were considered for analysis. 59 of the 349 patients with MRSA pneumonia (16.9%) and 105 of the 1,502 patients with MSSA pneumonia (7.0%) died. 16 of the 95 patients with primary MRSA BSI (16.8%) and 17 of the 283 patients with primary MSSA BSI died (6.0%). Four factors were significantly associated with mortality from S. aureus pneumonia, one of them being pneumonia caused by MRSA (OR = 2.62; CI95 1.69-4.02). Only MRSA was significantly associated with death from S. aureus primary BSI (OR = 3.84; CI95 1.51-10.2). CONCLUSION:Nosocomial pneumonia and primary BSI from MRSA may be associated with death, but the cause-effect relationship of severity of illness and MRSA remains to be determined due to the limitations of surveillance data.
journal_name
Infectionjournal_title
Infectionauthors
Gastmeier P,Sohr D,Geffers C,Behnke M,Daschner F,Rüden Hdoi
10.1007/s15010-005-3186-5keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
50-5issue
2eissn
0300-8126issn
1439-0973journal_volume
33pub_type
杂志文章相关文献
INFECTION文献大全abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-005-4118-0
更新日期:2005-08-01 00:00:00
abstract::The clinical tolrance of 350 mg pivampicillin tablets was evaluated in 470 hospitalized patients in Denmark, Norway and Iceland. The tablets were given to 229 fasting patients and to 241 non-fasting patients at mealtime. Side-effects were reported in 44 patients (9.4%). Upper gastro intestinal disturbances occurred in...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01639105
更新日期:1977-01-01 00:00:00
abstract::Campylobacter jejuni (previously called "related vibrio") has recently become recognized as an important cause of acute diarrhoeal disease in many countries. As with other intestinal pathogens, the clinical picture of C. jejuni infection varies from symptomless excretion to severe disease. The incubation period averag...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640857
更新日期:1982-01-01 00:00:00
abstract::In this article the cooperating partners of the ClinSurv HIV cohort were not listed in the acknowledgements. The correct paragraph appears below. ...
journal_title:Infection
pub_type: 杂志文章,已发布勘误
doi:10.1007/s15010-019-01281-x
更新日期:2019-04-01 00:00:00
abstract::Bacteria-specific antibody responses in expressed prostatic secretions (EPS) were investigated by use of an indirect immunoperoxidase method. Positive responses were observed in all 12 patients with acute bacterial prostatis due to gram-negative rods. However, in 41 patients with chromic prostatitis, antibody response...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01704389
更新日期:1992-01-01 00:00:00
abstract::Intestinal microsporidiosis with Enterocytozoon bieneusi was diagnosed in three of 18 HIV-infected patients with chronic diarrhoea. In two cases all known stages of the life cycle of E. bieneusi (merogonial plasmodia, sporogonial plasmodia, sporoblasts, spores) were found in duodenal biopsies by electron microscopical...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01715501
更新日期:1994-11-01 00:00:00
abstract::Cefotaxime is an effective antibiotic in lower respiratory tract infection caused by streptococci and staphylococci. There is a limited tendency to superinfections with Pseudomonas aeruginosa (1.5%) and there is a low incidence of side-effects. It is questionable whether there is really an urgent need for cefotaxime i...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644213
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Due to insufficient vaccination rates, measles outbreaks still pose a threat to public health in Germany. The purpose of this study was to identify risk factors for undervaccination against measles. PATIENTS AND METHODS:Datasets from two cross-sectional surveys were analyzed by logistic regression models. T...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-004-3122-0
更新日期:2004-06-01 00:00:00
abstract::A 24-year-old man presented with vague abdominal fullness and a mild epigastric dull pain for about 3 months was found to have a pancreatic head tumor at a medical center 2 months ago. He came to our hospital for further treatment. Ultrasonography, endoscopic retrograde cholangiopancreatography (ERCP) and abdominal co...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01739920
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:An observational prospective cohort study was carried out on complication rates and time kinetics of phlebitis caused by short peripheral intravenous catheters (PIVCs) in inpatients on 15 hospital wards in four hospitals in Cologne, Germany. PATIENTS AND METHODS:We observed 1,582 patients with 2,495 PIVCs d...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-004-1037-4
更新日期:2004-02-01 00:00:00
abstract::Cydnidae bug (also termed the burrowing bug) are arthropods of the order Hemiptera, that are recognized by their morphological adaptations for digging. They release an odorous substance from special glands that serve as self-defense, causing pigmented macules when in contact with human skin, especially during the rain...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01481-w
更新日期:2020-07-11 00:00:00
abstract::Aztreonam was given intravenously at a dose of 1 g at induction of anaesthesia, followed by subsequent doses of 1 g at eight hour intervals during 48 hours to 20 patients undergoing colorectal surgery. A series of serum and faecal specimens were taken for analysis of aztreonam concentrations. Tissue samples from the g...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642868
更新日期:1985-05-01 00:00:00
abstract::As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very simil...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713160
更新日期:1997-07-01 00:00:00
abstract::Ciprofloxacin is a highly potent antibacterial agent that is used extensively in bone and joint infections. Because of reports of potential chondro-toxicity in animals, the effects of this drug on cells derived from human cartilage were tested in liquid micromass and agarose gel cultures. An inhibition of cell prolife...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01713325
更新日期:1996-03-01 00:00:00
abstract::Pulmonary edema is a recognized complication of Plasmodium falciparum malaria but is uncommon with Plasmodium vivax infection. We report the case of a non-immune adult with imported P. vivax malaria who developed pulmonary edema during treatment. The case was further complicated by a recurrent malaria episode after fa...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6108-x
更新日期:2007-10-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) is an autoimmune disease that can be triggered by different infectious agents. Here we report the case of a 26-year-old Algerian woman who developed GBS associated with a Mycobacterium bovis cervical lymphadenitis. Following intravenous immunoglobulin therapy, the patient's neurologic sta...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0762-1
更新日期:2015-10-01 00:00:00
abstract::We are presenting a new case of meningitis due to the Micrococcus luteus species. This germ was isolated twice in eight days from the CSF of a 57-year old woman. The patient had a ventriculoperitoneal shunt implanted for hydrocephalus following a meningeal haemorrhage. Antibiotic therapy was efficient but the patient ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645439
更新日期:1985-11-01 00:00:00
abstract::A Haemophilus influenzae multicenter antimicrobial susceptibility surveillance was carried out. An overall beta-lactamase production rate of 25.7% was found, with significant differences between hospitals ranging between 7.9 and 47.9%. Presumable intrinsic resistance was found in 4.6% of strains. No differences in sus...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s150100050026
更新日期:1999-01-01 00:00:00
abstract::Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could ...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-005-6305-4
更新日期:2005-06-01 00:00:00
abstract::Surgical principles in the management of intraabdominal infection have remained constant. Rather, it is the application of these principles in selected cases that has varied. Judgement, therefore, becomes paramount for the surgeon. In selected cases multiple planned relaparotomies may be the most effective means of cl...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01726464
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:The aim of the study was to assess the integrity of non-sterile latex gloves (Biogel Diagnostic (A), Biogel Dental (B), Gentle Skin (C) and Manufix (D)) in clinical dental practice. MATERIALS AND METHODS:After use, the gloves were collected and examined for perforations using the water inflation test accord...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100070011
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:The aim of the study was to evaluate the efficacy and safety of combined treatment with natural leukocyte interferon alpha (Alfaferone) plus ribavirin in patients with HCV-related cirrhosis. PATIENTS AND METHODS:Twenty-three patients (15 women, 8 men) aged 17-68 years hospitalized in 2005-2008 were included...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0135-3
更新日期:2011-10-01 00:00:00
abstract::Cervical lymphadenopathy is a condition with a broad differential diagnosis. Malignant tumors, allergic reactions, autoimmune diseases as well as various infectious agents can be the cause. We report the case of a 75-year-old man who had a cervical lymphadenopathy without symptoms of infection. The draining lymph node...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1098-6
更新日期:2001-05-01 00:00:00
abstract::The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641100
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:Giving advice about antibiotic prescription through dedicated consultations is a cornerstone of antibiotic stewardship programmes. Our objective was to explore practices, organisation, and regulatory requirements related to antibiotic advising. METHODS:We performed an international, exploratory, Internet-based...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-019-01298-2
更新日期:2019-10-01 00:00:00
abstract::The use of covered stents in an infected field is controversial. It is generally recommended that infected aneurysms be treated using autografts or allografts. We report a case of infected brachial pseudoaneurysms that developed after medical debridement of a methicillin-resistant Staphylococcus aureus (MRSA)-infected...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-3046-5
更新日期:2003-06-01 00:00:00
abstract::A study on prevention of borreliosis in humans bitten by infected ticks was performed in 1992-1994 in the Perm' region of Russia. Adult Ixodes persulcatus ticks were removed from the study subjects, and live preparations made from the material obtained from the gut of each tick were microscopically analyzed (up to 250...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713337
更新日期:1996-03-01 00:00:00
abstract::Drug-induced anaphylaxis is an unpredictable adverse reaction. Although it may occur with any medication, antibiotics induce more cases of anaphylaxis than any other medication class with most cases being induced by β-lactam antibiotics. Clindamycin is an antibiotic with good gram-positive and anaerobe coverage which ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0826-2
更新日期:2016-06-01 00:00:00
abstract::The spelling of the name "Ali Bazarbachi" was incorrect. ...
journal_title:Infection
pub_type: 杂志文章,已发布勘误
doi:10.1007/s15010-018-1203-8
更新日期:2018-12-01 00:00:00
abstract::Mycobacterium immunogenum is a member of the rapidly growing non-tuberculous mycobacteria and is a relatively new species identified within this group. An 81-year-old immune-competent male was diagnosed with M. immunogenum infection of his peritoneal dialysis catheter exit site and surrounding soft tissue. To our know...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1199-0
更新日期:2018-12-01 00:00:00