Effect of aztreonam on the colon microflora in patients undergoing colorectal surgery.

Abstract:

:Aztreonam was given intravenously at a dose of 1 g at induction of anaesthesia, followed by subsequent doses of 1 g at eight hour intervals during 48 hours to 20 patients undergoing colorectal surgery. A series of serum and faecal specimens were taken for analysis of aztreonam concentrations. Tissue samples from the gut wall were taken at surgery. The maximum serum concentrations (mean value 114.7 mg/l) during surgery were reached 15 minutes after aztreonam administration. The aztreonam concentration in the tissue samples varied from 4.1-28.3 mg/kg and the concentration in the faecal samples from 0.4-34.4 mg/kg. Faecal samples were also collected during the investigation period for cultivation of aerobic and anaerobic bacteria. Enterobacteria were suppressed significantly during the prophylaxis period and there was a significant increase of staphylococci in ten of the patients. Three of these patients developed postoperative wound infections with staphylococci. Among the anaerobic bacteria, only minor changes were observed during the same period. After two weeks, the microflora was normalized in all patients. Five postoperative infections including an anastomose dehiscence in one patient occurred.

journal_name

Infection

journal_title

Infection

authors

Kager L,Brismar B,Malmborg AS,Nord CE

doi

10.1007/BF01642868

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

111-4

issue

3

eissn

0300-8126

issn

1439-0973

journal_volume

13

pub_type

杂志文章
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    doi:10.1007/BF01641744

    authors: Marks MI

    更新日期:1984-01-01 00:00:00

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    authors: Naqvi B,Dorsky D,Ali SA,Feingold JM,Edwards RL,Bona RD,Clive J,Tutschka PJ,Bilgrami S

    更新日期:2001-08-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/s15010-012-0250-9

    authors: Chan JF,Wong SS,Leung SS,Fan RY,Ngan AH,To KK,Lau SK,Yuen KY,Woo PC

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2185-z

    authors: Erensoy S,Sayiner AA,Türkoğlu S,Canatan D,Akarca US,Sertöz R,Ozacar T,Batur Y,Badur S,Bilgiç A

    更新日期:2002-10-01 00:00:00

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647501

    authors: Voeckl J,Fischer M

    更新日期:1986-01-01 00:00:00

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-5094-8

    authors: Diederen BM,van Leest CM,van Duijn I,Willemse P,van Keulen PH,Kluytmans JA

    更新日期:2006-04-01 00:00:00

  • Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis.

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    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01650104

    authors: Whitley RJ,Alford CA,Hirsch MS,Schooley RT,Luby JP,Aoki FY,Hanley D,Nahmias AJ,Soong SJ

    更新日期:1987-01-01 00:00:00

  • Studies on serum and cerebrospinal fluid levels of cephacetrile in neonates.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640789

    authors: Windorfer A,Gasteiger U

    更新日期:1977-01-01 00:00:00

  • [Experimental study of the local application of silver sulfadiazine, cefsulodin and povidone-iodine in burns].

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641022

    authors: Kaiser W,von der Lieth H,Potel J,Heymann H

    更新日期:1984-01-01 00:00:00

  • Do antibody-coated bacteria prove bacterial prostatitis?

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643684

    authors: Riedasch G,Möhring K,Ritz E

    更新日期:1991-01-01 00:00:00

  • The role of GM-CSF in infection.

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    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01705024

    authors: Freund M,Kleine HD

    更新日期:1992-01-01 00:00:00

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    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-008-8203-z

    authors: Beale R,Reinhart K,Brunkhorst FM,Dobb G,Levy M,Martin G,Martin C,Ramsey G,Silva E,Vallet B,Vincent JL,Janes JM,Sarwat S,Williams MD,PROGRESS Advisory Board.

    更新日期:2009-06-01 00:00:00

  • Emergence of SCCmec type IV as the most common type of methicillin-resistant Staphylococcus aureus in a university hospital.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-7430-7

    authors: Strandén AM,Frei R,Adler H,Flückiger U,Widmer AF

    更新日期:2009-02-01 00:00:00

  • Low C-reactive protein values at admission predict mortality in patients with severe community-acquired pneumonia caused by Streptococcus pneumoniae that require intensive care management.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0755-0

    authors: Que YA,Virgini V,Lozeron ED,Paratte G,Prod'hom G,Revelly JP,Pagani JL,Charbonney E,Eggimann P

    更新日期:2015-04-01 00:00:00

  • Pharmacokinetics of quinolone derivatives in the prostate.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643687

    authors: Madsen PO,Aagaard J

    更新日期:1991-01-01 00:00:00

  • Single and multiple dose pharmacokinetics of intravenous cefpirome (HR 810), a novel cephalosporin derivative.

    abstract::After intravenous injection of single doses of 1.0 g of cefpirome (HR 810) and multiple doses of 1.0 g b.i.d. for five days to the same ten healthy male volunteers in an open design, concentrations of unchanged drug were estimated at various times in serum and urine, over 24 h and 48 h, respectively. Cefpirome concent...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646053

    authors: Malerczyk V,Maass L,Verho M,Hajdú P,Klesel N,Rangoonwala R

    更新日期:1987-05-01 00:00:00

  • Prophylactic chemotherapy with fosfomycin trometamol during transurethral surgery and urological manoeuvres. Results of a multicentre study.

    abstract::The aim of the present open prospective study is to evaluate the efficacy and safety profile of fosfomycin trometamol in the chemoprophylaxis of urinary tract infections following transurethral diagnostic and/or therapeutic manoeuvres. 712 patients were enrolled in 72 urological surgical centres. All the enrolled pati...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF01643436

    authors: di Silverio F,Ferrone G,Carati L

    更新日期:1990-01-01 00:00:00

  • Serological biomarkers of candidemia: a retrospective evaluation of three assays.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1224-3

    authors: Dichtl K,Seybold U,Wagener J

    更新日期:2019-04-01 00:00:00

  • Eikenella corrodens brain abscess after repeated periodontal manipulations cured with imipenem and neurosurgery.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2004-6

    authors: Asensi V,Alvarez M,Carton JA,Lago M,Maradona JA,Asensi JM,Arribas JM

    更新日期:2002-08-01 00:00:00

  • Release of vancomycin and teicoplanin from a plasticized and resorbable gelatin sponge: in vitro investigation of a new antibiotic delivery system with glycopeptides.

    abstract:BACKGROUND:The aim of this study was to evaluate the efficacy of sustained release of vancomycin and teicoplanin from a resorbable gelatin glycerol sponge, in order to establish a new delivery system for local anti-infective therapy. MATERIALS AND METHODS:60 plasticized glycerol gelatin sponges containing either 10 or...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-006-1067-1

    authors: Drognitz O,Thorn D,Krüger T,Gatermann SG,Iven H,Bruch HP,Muhl E

    更新日期:2006-02-01 00:00:00

  • Spectrum of opportunistic infections and profile of CD4+ counts among AIDS patients in North India.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-003-3198-y

    authors: Vajpayee M,Kanswal S,Seth P,Wig N

    更新日期:2003-10-01 00:00:00

  • Mortality risk factors with nosocomial Staphylococcus aureus infections in intensive care units: results from the German Nosocomial Infection Surveillance System (KISS).

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-3186-5

    authors: Gastmeier P,Sohr D,Geffers C,Behnke M,Daschner F,Rüden H

    更新日期:2005-04-01 00:00:00

  • Non-typeable Haemophilus influenzae-associated early pregnancy loss: an emerging neonatal and maternal pathogen.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01359-6

    authors: Cevik M,Moncayo-Nieto OL,Evans MJ

    更新日期:2020-04-01 00:00:00

  • Mycobacterium kansasii pericarditis as a presentation of AIDS.

    abstract::Mycobacterium kansasii infection is a recognized complication of AIDS and a broad spectrum of extrapulmonary manifestations has been reported. However, AIDS-related M. kansasii pericarditis is an extremely rare disease. We report the first European case of this infection, that presented some different clinical finding...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-0061-x

    authors: Pintado V,Fortún J,Casado JL,Gómez-Mampaso E

    更新日期:2001-01-01 00:00:00

  • Hepatitis with fibrin-ring granulomas.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6365-8

    authors: Khanlari B,Bodmer M,Terracciano L,Heim MH,Fluckiger U,Weisser M

    更新日期:2008-08-01 00:00:00

  • Phlebitis rate and time kinetics of short peripheral intravenous catheters.

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    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-004-1037-4

    authors: Grüne F,Schrappe M,Basten J,Wenchel HM,Tual E,Stützer H,Cologne Quality Control Network.

    更新日期:2004-02-01 00:00:00

  • Prevalence of hepatitis B virus infection in out-patient alcoholics.

    abstract::Sera from 192 out-patient alcoholics attending a clinic for the treatment of alcoholism were tested for hepatitis B surface antigen (HBsAg) and for antibodies to HBsAg and to hepatitis B core antigen (HBcAg). Three sera (1.5%) were positive for HBsAg. Of the remaining 189 alcoholics, 29 (15%) were positive for one or ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641674

    authors: Gluud C,Gluud B,Aldershvile J,Jacobsen A,Dietrichson O

    更新日期:1984-03-01 00:00:00

  • Using the kinetics of C-reactive protein response to improve the differential diagnosis between acute bacterial and viral infections.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01383-6

    authors: Coster D,Wasserman A,Fisher E,Rogowski O,Zeltser D,Shapira I,Bernstein D,Meilik A,Raykhshtat E,Halpern P,Berliner S,Shenhar-Tsarfaty S,Shamir R

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  • [Erythromycin determination in organ tissues (author's transl)].

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641124

    authors: Dette GA,Finke U

    更新日期:1979-01-01 00:00:00

  • The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis.

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    journal_title:Infection

    pub_type: 杂志文章,meta分析

    doi:10.1007/s15010-020-01502-8

    authors: Mahumud RA,Kamara JK,Renzaho AMN

    更新日期:2020-12-01 00:00:00