Susceptibility to HIV/AIDS: an individual characteristic we can measure?

Abstract:

:Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could now be possible. In a recent study, a significant interindividual and interpopulation difference in the copy number of a segmental duplication encompassing the gene encoding CCL3L1, a potent human immunodeficiency virus-1 (HIV- 1)-suppressive chemokine was found. Possession of a CCL3L1 copy number lower than the population average was associated with markedly enhanced HIV/acquired immunodeficiency syndrome (AIDS) susceptibility. This could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/ AIDS, potentially enabling clinicians to adapt treatment regimens. Also, this is particularly important for assessment of the efficacy of a protective vaccine.

journal_name

Infection

journal_title

Infection

authors

Jülg B,Goebel FD

doi

10.1007/s15010-005-6305-4

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

160-2

issue

3

eissn

0300-8126

issn

1439-0973

journal_volume

33

pub_type

杂志文章,评审
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    doi:10.1007/BF02770846

    authors: Adeyemi-Doro FA,Hui AC,Ho FN,Ip M

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    doi:10.1007/BF01645968

    authors: Siegel JP,Rook AH,Djeu JY,Quinnan GV Jr

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    authors: Müller D,Szucs TD

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    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01645218

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    更新日期:1984-11-01 00:00:00

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    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

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    authors: Hofbauer H,Naber KG,Kinzig-Schippers M,Sörgel F,Rustige-Wiedemann C,Wiedemann B,Reiz A,Kresken M

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    abstract::The natural decline of passively acquired maternal antibody titers and the influence of these antibodies on the efficacy of live, further attenuated measles vaccine were studied in 7 to 12 month old infants. Hemagglutination-inhibition (HI) antibody titers were determined in the pre- and postvaccination sera. HI antib...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642310

    authors: Stewien KE,Barbosa V,de Lima OS,Osiro K

    更新日期:1978-01-01 00:00:00

  • [Bactericidal activity of enoxacin and ciprofloxacin in body fluids].

    abstract::Until present studies are lacking which investigate the bactericidal activity of new quinolones in body fluids. Therefore, we determined bactericidal titers of enoxacin (en) and ciprofloxacin (cip) against a typical pathogen in urinary tract infections (Escherichia coli) in urine and against a typical pathogen in resp...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01643629

    authors: Roos R,Jäger A,Kraeft H,Adam D

    更新日期:1989-01-01 00:00:00

  • [Ceftazidime versus cefotaxime in the therapy of severe infections in intensive care patients].

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    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01645865

    authors: Müller E,Heinkelein J

    更新日期:1987-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF01639742

    authors: Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FH

    更新日期:1988-01-01 00:00:00

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02561614

    authors: Böswald M,Lugauer S,Bechert T,Greil J,Regenfus A,Guggenbichler JP

    更新日期:1999-01-01 00:00:00

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0928-5

    authors: Lee J,Yoo SS,Lee SY,Cha SI,Park JY,Kim CH

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641022

    authors: Kaiser W,von der Lieth H,Potel J,Heymann H

    更新日期:1984-01-01 00:00:00

  • Diagnosis and treatment of chlamydial venereal disease.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640715

    authors: Thelin I

    更新日期:1982-01-01 00:00:00

  • Short courses of intravenous empirical antibiotic treatment in selected febrile neutropenic children with cancer.

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    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/s15010-002-2094-1

    authors: Lehrnbecher T,Stanescu A,Kühl J

    更新日期:2002-01-01 00:00:00

  • Operative management of intraabdominal infection.

    abstract::Surgical principles in the management of intraabdominal infection have remained constant. Rather, it is the application of these principles in selected cases that has varied. Judgement, therefore, becomes paramount for the surgeon. In selected cases multiple planned relaparotomies may be the most effective means of cl...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01726464

    authors: Aprahamian C,Wittmann DH

    更新日期:1991-11-01 00:00:00

  • Risk factors for undervaccination against measles in a large sample of preschool children from rural Bavaria.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-3122-0

    authors: Zucs AP,Crispin A,Eckl E,Weitkunat R,Schlipköter U

    更新日期:2004-06-01 00:00:00

  • Correction to: Time‑trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change of antibiotic prophylaxis guidelines.

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    journal_title:Infection

    pub_type: 已发布勘误

    doi:10.1007/s15010-020-01490-9

    authors: Knirsch W,Schuler SK,Christmann M,Weber R

    更新日期:2020-10-01 00:00:00

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    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01713160

    authors: Wildfeuer A,Mallwitz J,Gotthardt H,Hille E,Gruber H,Dahmen G,Pfaff G,Göbel C

    更新日期:1997-07-01 00:00:00

  • Interobserver agreement on signs and symptoms of patients with acute febrile illness.

    abstract:PURPOSE:To assess the interobserver agreement on clinical history and physical examination when using a semi-structured questionnaire to evaluate patients with an acute febrile illness (AFI). METHODS:A cross-sectional study was conducted with outpatients aged 12 years and over, presenting with an AFI defined as fever ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0101-0

    authors: Daumas RP,Brasil P,Bressan CS,Oliveira RV,Carvalho BB,Carneiro DV,Passos SR

    更新日期:2011-04-01 00:00:00

  • A prognostic score for postherpetic neuralgia in ambulatory patients.

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    pub_type: 杂志文章

    doi:10.1007/BF02770836

    authors: Meister W,Neiss A,Gross G,Doerr HW,Höbel W,Malin JP,von Essen J,Reimann BY,Witke C,Wutzler P

    更新日期:1998-11-01 00:00:00

  • Lymphocyte apoptosis, caspase activation and inflammatory response in septic shock.

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    journal_title:Infection

    pub_type: 信件

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    更新日期:2008-10-01 00:00:00

  • [In vitro effect of acylureido penicillins and mezlocillin on anaerobic sporeless gram-negative rods of genus Bacteroides].

    abstract::313 anaerobic gram-negative rods of the Bacteroides genus isolated from 295 clinical specimens were tested for their sensitivity to azlocillin and mezlocillin using the dilution method with agar plates. 25 mg/l of azlocillin inhibited 80.2% of the strains and the same concentration of mezlocillin inhibited 86.9%. The ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640681

    authors: Höhne C

    更新日期:1982-01-01 00:00:00

  • Cefotaxime in pneumococcal meningitis.

    abstract::Forty-six consecutive patients with pneumococcal meningitis were treated with cefotaxime (CTX). Ages ranged from 1-79 years: 29 adults, six adolescents, six children and five infants. Underlying diseases were found in 38 patients (82.6%). Twenty-six patients (56.5%) were admitted in coma. All isolates were sensitive t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644223

    authors: Lecour H,Seara A,Miranda AM,Cordeiro J

    更新日期:1985-01-01 00:00:00

  • Oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA), a hidden resistant mechanism among clinically significant isolates in the Wessex region/UK.

    abstract:PURPOSE:Methicillin-resistant Staphylococcus aureus (MRSA) is defined as S. aureus genetically having the mecA or mecC genes or phenotypically showing minimum inhibitory concentration (MIC) of oxacillin higher than 2 mg/L. However, recently, cefoxitin/oxacillin-susceptible mecA-positive S. aureus (OS-MRSA) has been rep...

    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-014-0641-1

    authors: Saeed K,Ahmad N,Dryden M,Cortes N,Marsh P,Sitjar A,Wyllie S,Bourne S,Hemming J,Jeppesen C,Green S

    更新日期:2014-10-01 00:00:00

  • New fluoroquinolones in lower respiratory tract infections and emerging patterns of pneumococcal resistance.

    abstract::The increasing resistance of Streptococcus pneumoniae, the most important community respiratory pathogen, to beta-lactams and other first-line antimicrobial agents usually employed for the empirical treatment of lower respiratory tract infections has led to the inclusion, in several current guidelines, of a fluoroquin...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-005-4102-8

    authors: Ferrara AM

    更新日期:2005-06-01 00:00:00

  • HHV6 meningoencephalitis sequelae in previously healthy children.

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    journal_title:Infection

    pub_type: 杂志文章

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    authors: Bozzola E,Krzysztofiak A,Bozzola M,Calcaterra V,Quondamcarlo A,Lancella L,Villani A

    更新日期:2012-10-01 00:00:00

  • Anaerobic microbiology in the NASA space program.

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    pub_type: 杂志文章

    doi:10.1007/BF01639903

    authors: Brewer JH

    更新日期:1980-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF02561526

    authors: Biselli R,Fortini M,Matricardi PM,Stroffolini T,D'Amelio R

    更新日期:1999-05-01 00:00:00