Interleukin 2 therapy in infectious diseases: rationale and prospects.

Abstract:

:Clinical trials using interleukin 2 as a therapeutic immunomodulating agent in patients with acquired immunodeficiency syndrome have recently begun. In this article we present data from studies which indicate the ability of interleukin 2 in vitro to augment clinically important cytotoxic immune responses in lymphocytes from these patients. These studies provide both a rationale for the current trials and a model for evaluating the potential for use of interleukin 2 in other infectious diseases. We outline the types of infectious diseases in which interleukin 2 may prove to be useful and the therapeutic strategies in which it may play a role.

journal_name

Infection

journal_title

Infection

authors

Siegel JP,Rook AH,Djeu JY,Quinnan GV Jr

doi

10.1007/BF01645968

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

298-302

issue

4

eissn

0300-8126

issn

1439-0973

journal_volume

12

pub_type

临床试验,杂志文章
  • [Use and risk of antibacterial chemotherapy from the medical point of view].

    abstract::The evaluation of the efficacy and possible intolerance of an antibacterial chemotherapy is based on the exact analysis of patient specific signs and symptoms, pathogenetic factors of the specific bacteria and parameters of the specific substance. One has to differentiate between usefulness of the antibiotics (effect)...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644740

    authors: Lode H

    更新日期:1991-01-01 00:00:00

  • [Ceftazidime versus cefotaxime in the therapy of severe infections in intensive care patients].

    abstract::In a randomized controlled, clinical study the efficacy of ceftazidime at a dosage of 2 g b. i. d. was compared to that of cefotaxime at a dosage of 2 g t. i. d. or more in the treatment of pneumonia or peritonitis in intensive care patients. 61 of 67 assessable cases were evaluable. In the ceftazidime group ten out o...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01645865

    authors: Müller E,Heinkelein J

    更新日期:1987-01-01 00:00:00

  • Criteria for the diagnosis of urinary tract infection and for the assessment of therapeutic effectiveness.

    abstract::Three parameters--urinary symptoms, pyuria, and bacteriuria--can be used independently or in combination to define the presence of urinary tract infection. Using these parameters, several approaches to defining urinary infection in various clinical contexts are discussed. Similarly, approaches to the definition and cl...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01704358

    authors: Stamm WE

    更新日期:1992-01-01 00:00:00

  • Outpatient parenteral antimicrobial therapy and antibiotic stewardship: opponents or teammates?

    abstract:PURPOSE:This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS:After a literature review, five authors determined the barriers and facilitators to...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-018-1250-1

    authors: Steffens E,Quintens C,Derdelinckx I,Peetermans WE,Van Eldere J,Spriet I,Schuermans A

    更新日期:2019-04-01 00:00:00

  • Invasive listeriosis in a patient with several episodes of antibiotic associated colitis presumably due to Clostridium difficile.

    abstract::A 62-year-old man developed a blood stream infection and meningitis due to Listeria monocytogenes, 20 days after an episode of pseudo-membranous colitis. The patient, hospitalized for the first time for transurethral prostatectomy, was readmitted 20 days later with watery diarrhea. Pseudo-membranous colitis was diagno...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-1013-4

    authors: Carannante N,Pagliano P,Rossi M,Attanasio V,Rescigno C,Corte L,Tascini C,Cardinali G

    更新日期:2017-06-01 00:00:00

  • The penetration of erythromycin into Waldeyer's ring--tonsil and adenoid tissue.

    abstract::Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640866

    authors: Sundberg L,Edén T,Ernstson S

    更新日期:1982-01-01 00:00:00

  • Correction to: Time‑trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change of antibiotic prophylaxis guidelines.

    abstract::The original version of this article unfortunately contained a mistake. In the author list, the first and last names were tagged incorrectly. The corrected author list is given above. ...

    journal_title:Infection

    pub_type: 已发布勘误

    doi:10.1007/s15010-020-01490-9

    authors: Knirsch W,Schuler SK,Christmann M,Weber R

    更新日期:2020-10-01 00:00:00

  • Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis.

    abstract:BACKGROUND:The diagnostic value of admission serum levels of procalcitonin (PCT) and C-reactive protein (CRP) as indicators of the etiology and prognosis was prospectively investigated. PATIENTS:96 patients, 50-85 years of age, treated in the hospital for community-acquired pneumonia (CAP). RESULTS:On admission, all ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050049

    authors: Hedlund J,Hansson LO

    更新日期:2000-03-01 00:00:00

  • Anaerobic microbiology in the NASA space program.

    abstract::After briefly reviewing the earlier methods used to monitor the microbial load of returned lunar material, the author reports the more accurate research on the ability of terrestrial organisms to grow under simulated Martian environments. The possible importance of anaerobic microbiology can readily be seen because of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639903

    authors: Brewer JH

    更新日期:1980-01-01 00:00:00

  • Native vertebral osteomyelitis in aged patients: distinctive features. An observational cohort study.

    abstract:PURPOSE:To describe the demographic, clinical, and microbiological profile of native vertebral osteomyelitis (NVO) in aged patients as compared to that of younger patients, to identify differences that could motivate changes in clinical management. METHODS:Retrospective, observational cohort study (1990-2015) includin...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1177-6

    authors: Aguilar-Company J,Pigrau C,Fernández-Hidalgo N,Rodríguez-Pardo D,Falcó V,Lung M,Pellisé F,Almirante B

    更新日期:2018-10-01 00:00:00

  • Congenital rubella syndrome after maternal reinfection.

    abstract::This report concerns a case of congenital rubella syndrome (CRS) with atypical immune response affecting an infant whose mother had repeated evidence of immunity before pregnancy. Laboratory diagnosis of CRS could only clearly be achieved by virus isolation after the second month of life despite typical clinical featu...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710747

    authors: Weber B,Enders G,Schlösser R,Wegerich B,Koenig R,Rabenau H,Doerr HW

    更新日期:1993-03-01 00:00:00

  • Prevalence rates of viral hepatitis infections in refugee Kurds from Iraq and Turkey.

    abstract:BACKGROUND:Since little is known about the burden of viral hepatitis in Kurds, the prevalence of infection with hepatitis A virus (HAV), hepatitis E virus (HEV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a sample of refugee Kurds from Iraq and Turkey. PATIENTS AND METHODS:A cross-sectiona...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-3100-3

    authors: Chironna M,Germinario C,Lopalco PL,Carrozzini F,Barbuti S,Quarto M

    更新日期:2003-03-01 00:00:00

  • [Efficacy and tolerance of imipenem/cilastatin in the treatment of surgical infections with and without bone involvement].

    abstract::Imipenem/cilastatin in a doses of 1.5/day was used to treat 31 moderate to severe infections, predominantly soft tissue infections with bone involvement, in 30 surgical patients. A clinical success was achieved in 93% of the patients. In one patient with diabetic gangrene of the foot, imipenem/cilastatin treatment per...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647501

    authors: Voeckl J,Fischer M

    更新日期:1986-01-01 00:00:00

  • Findings from an outbreak of carbapenem-resistant Klebsiella pneumoniae emphasize the role of antibiotic treatment for cross transmission.

    abstract:PURPOSE:In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition. METHODS:In the present study, the outbreak is described and risk factors fo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-1103-3

    authors: Borgmann S,Pfeifer Y,Becker L,Rieß B,Siegmund R,Sagel U

    更新日期:2018-02-01 00:00:00

  • Seroprevalence of Chlamydia pneumoniae antibodies in a young adult population sample living in Verona. European Community Respiratory Health Survey (ECRHS) Verona.

    abstract:UNLABELLED:The aim of the study was to evaluate the prevalence of antibodies to Chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in Verona, Italy. IgG and IgM titers were measured by micro-immunofluorescence. IgG antibodies, greater or equal to 16, were found in 104/177 ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050009

    authors: Ferrari M,Poli A,Olivieri M,Tardivo S,Biasin C,Balestreri F,Dal Molin G,Lo Cascio V,Campello C

    更新日期:2000-01-01 00:00:00

  • Aortic thrombus and multiple embolisms during a Mycoplasma pneumoniae infection.

    abstract::We report the case of a patient who presented with a thrombus of the aortic arch complicated with splenic, renal and peroneal artery embolisms, associated with transient lupus anticoagulant, during a Mycoplasma pneumoniae infection. The outcome was good under antibiotic and anticoagulant treatment. We also review the ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0475-2

    authors: Flateau C,Asfalou I,Deman AL,Ficko C,Andriamanantena D,Fontan E,Viant E,Bonnevie L,Rapp C

    更新日期:2013-08-01 00:00:00

  • Mycobacterium kansasii pericarditis as a presentation of AIDS.

    abstract::Mycobacterium kansasii infection is a recognized complication of AIDS and a broad spectrum of extrapulmonary manifestations has been reported. However, AIDS-related M. kansasii pericarditis is an extremely rare disease. We report the first European case of this infection, that presented some different clinical finding...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-0061-x

    authors: Pintado V,Fortún J,Casado JL,Gómez-Mampaso E

    更新日期:2001-01-01 00:00:00

  • The effects of pretransplant conditioning, graft-versus-host disease and sepsis on the CRP levels in bone marrow transplantation.

    abstract::To evaluate the diagnostic utility of C-reactive protein (CRP) for the detection of sepsis in bone marrow transplantation, CRP levels were analyzed after pretransplant conditioning and variably combined in septic, focal or viral infections with graft-versus-host disease (GvHD) in 64 bone marrow recipients. The CRP lev...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01740812

    authors: Rintala E,Remes K,Salmi TT,Koskinen P,Nikoskelainen J

    更新日期:1997-11-01 00:00:00

  • Cervical lymphadenitis--a rare case of focal listeriosis.

    abstract::Cervical lymphadenopathy is a condition with a broad differential diagnosis. Malignant tumors, allergic reactions, autoimmune diseases as well as various infectious agents can be the cause. We report the case of a 75-year-old man who had a cervical lymphadenopathy without symptoms of infection. The draining lymph node...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1098-6

    authors: Rosenthal R,Vogelbach P,Gasser M,Zimmerli W

    更新日期:2001-05-01 00:00:00

  • Protective effect of an outer membrane vaccine against Pseudomonas aeruginosa infection.

    abstract::The outer membrane proteins, F, H2 and I, from PA12 strain of Pseudomonas aeruginosa, were purified and used successfully for immunization of Balb/c mice. The immunized mice were protected against challenge with a 2-26 fold LD50 of all known 19 serogroups of P. aeruginosa. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647755

    authors: von Specht BU,Strigl G,Ehret W,Brendel W

    更新日期:1987-01-01 00:00:00

  • Optimal duration of antimicrobial therapy for uncomplicated Gram-negative bloodstream infections.

    abstract:PURPOSE:Optimal antimicrobial treatment duration for Gram-negative bloodstream infection (BSI) remains unclear. This retrospective cohort study examined effectiveness of short (7-10 days) and long (>10 days) courses of antimicrobial therapy for uncomplicated Gram-negative BSI. METHODS:Hospitalized adults with uncompli...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-1020-5

    authors: Nelson AN,Justo JA,Bookstaver PB,Kohn J,Albrecht H,Al-Hasan MN

    更新日期:2017-10-01 00:00:00

  • Prolonged application of closed in-line suction catheters increases microbial colonization of the lower respiratory tract and bacterial growth on catheter surface.

    abstract:BACKGROUND:Microorganisms become attracted to polymer surfaces for a number of reasons including positive charge of biomaterial or concentration of nutrients on the biomaterial surface. Many bacteria additionally possess specific receptors for the interaction with extracellular host protein components that adhere on th...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s15010-002-3066-1

    authors: Freytag CC,Thies FL,König W,Welte T

    更新日期:2003-01-01 00:00:00

  • Spontaneous spondylodiscitis caused by Klebsiella pneumoniae.

    abstract::A rare case of spontaneous spondylodiscitis caused by Klebsiella pneumoniae in a 55-year-old man who presented with thoracolumbar pain is described. Increased erythrocyte sedimentation rate and C-reactive protein level were pertinent laboratory findings. Computed tomography revealed a paravertebral mass and destructio...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050046

    authors: Kouroussis C,Georgoulias V,Souglakos J,Simvoulakis E,Karabekios S,Samonis G

    更新日期:1999-11-01 00:00:00

  • Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

    abstract:PURPOSE:Data on the systemic dissemination in Staphylococcus aureus bloodstream infection (SAB) remain sparse. We investigated the timing and the sequence of clinical symptoms, diagnostic confirmation, and occurrence of multiple infective foci in relation to three major infective foci. METHODS:From 2006 to 2011, all a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1165-x

    authors: Smit J,Rieg SR,Wendel AF,Kern WV,Seifert H,Schønheyder HC,Kaasch AJ

    更新日期:2018-10-01 00:00:00

  • A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis.

    abstract:PURPOSE:The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. METHODS:From Ja...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0914-y

    authors: Smids C,Kouijzer IJ,Vos FJ,Sprong T,Hosman AJ,de Rooy JW,Aarntzen EH,de Geus-Oei LF,Oyen WJ,Bleeker-Rovers CP

    更新日期:2017-02-01 00:00:00

  • Risk for infective endocarditis in bacteremia with Gram positive cocci.

    abstract:PURPOSE:Infective endocarditis (IE) is a serious complication of bacteremia and is most often caused by Gram positive cocci. We investigated the prevalence of IE in patients where echocardiography was encouraged when bacteremia with Gram positive cocci was present. METHODS:The study included patients with Gram positiv...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01504-6

    authors: Andersen MH,Holle SLK,Klein CF,Bruun NE,Arpi M,Bundgaard H,Tønder N,Iversen KK

    更新日期:2020-12-01 00:00:00

  • Autoinfection as a cause of postpartum subdural empyema due to Mycoplasma hominis.

    abstract::Mycoplasma hominis is a commensal of the genitourinary tract, which is infrequently associated with urogenital infections. Extra-urogenital infections due to M. hominis are rare. Here, we report an unusual case of M. hominis subdural empyema in a woman occurring shortly after delivery. The patient presented with sympt...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0713-2

    authors: Hos NJ,Bauer C,Liebig T,Plum G,Seifert H,Hampl J

    更新日期:2015-04-01 00:00:00

  • Myocarditis in admitted patients with dengue fever.

    abstract:PURPOSE:Cardiac involvement in dengue fever is underdiagnosed due to low index of clinical suspicion and its contribution to hemodynamic instability in severe dengue is not well known. METHODS:A prospective observational study was conducted among admitted patients ≥ 14 years of age having confirmed dengue fever. Patie...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01500-w

    authors: Bhatt M,Soneja M,Farooqui FA,Singla P,Vikram NK,Biswas A,Roy A,Wig N

    更新日期:2020-12-01 00:00:00

  • In-vitro susceptibility of cefoperazone-susceptible and -resistant gram-negative rods to cefoperazone plus sulbactam, other beta-lactams, aminoglycosides and quinolone.

    abstract::We compared the in-vitro activity of cefoperazone-sulbactam (2:1), other beta-lactams, amino-glycosides and ciprofloxacin against cefoperazone-susceptible and -resistant nosocomial gram-negative bacilli. Resistant isolates including Pseudomonas aeruginosa were susceptible to cefoperazone-sulbactam; the susceptible iso...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643761

    authors: Chandrasekar PH,Sluchak JA

    更新日期:1991-01-01 00:00:00

  • In vitro activity of second and third generation cephalosporins against ampicillin susceptible and resistant haemophilus influenzae.

    abstract::One hundred seventy-five clinical isolates of Haemophilus influenzae (including 74 beta-lactamase-producing strains) were examined for susceptibility to ampicillin, cefonicid, cefamandole, cefuroxime and cefotaxime. Cefonicid and cefamandole exhibited similar activity against ampicillin-susceptible strains (MIC90 = 0....

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645075

    authors: Burns JL,Wong K,Smith AL

    更新日期:1988-09-01 00:00:00