[Efficacy and tolerance of imipenem/cilastatin in the treatment of surgical infections with and without bone involvement].

Abstract:

:Imipenem/cilastatin in a doses of 1.5/day was used to treat 31 moderate to severe infections, predominantly soft tissue infections with bone involvement, in 30 surgical patients. A clinical success was achieved in 93% of the patients. In one patient with diabetic gangrene of the foot, imipenem/cilastatin treatment performed as a last resort was not able to prevent amputation. One patient died from his underlying disease while on therapy. All isolates except one Pseudomonas diminuta strain regarded as contaminant were initially sensitive to imipenem. Two Pseudomonas aeruginosa strains developed resistance by the end of therapy. Staphylococcus aureus and coagulase-negative staphylococci were the most common aetiologic agents. Only few clinical and biochemical side-effects were observed: in two cases an allergic rash appeared following several days' treatment. Four patients developed thrombocytopenia, which, however, was completely reversible after the end of therapy.

journal_name

Infection

journal_title

Infection

authors

Voeckl J,Fischer M

doi

10.1007/BF01647501

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

S154-9

eissn

0300-8126

issn

1439-0973

journal_volume

14 Suppl 2

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:10.1007/s15010-001-1098-6

    authors: Rosenthal R,Vogelbach P,Gasser M,Zimmerli W

    更新日期:2001-05-01 00:00:00

  • Alpha-hemolytic streptococci: a major pathogen of iatrogenic meningitis following lumbar puncture. Case reports and a review of the literature.

    abstract::Iatrogenic meningitis following lumbar puncture is a rare complication of myelography, spinal anesthesia, intrathecal chemotherapy, and epidural anesthesia. Sporadic cases and clusters of iatrogenic meningitis have been reported after intrathecal therapy, but most incidental cases are reported after myelography. Four ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01780647

    authors: Schneeberger PM,Janssen M,Voss A

    更新日期:1996-01-01 00:00:00

  • Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

    abstract:BACKGROUND:Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS:We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-2036-1

    authors: Anderson DJ,Murdoch DR,Sexton DJ,Reller LB,Stout JE,Cabell CH,Corey GR

    更新日期:2004-04-01 00:00:00

  • Chlamydia trachomatis in andrologic patients--direct and indirect detection.

    abstract:BACKGROUND:Chlamydia trachomatis is considered to be the most common sexually transmitted disease in Germany. It is currently unclear whether chlamydial infection causes pathological conditions of the male accessory glands with consequences for male infertility. PATIENTS AND METHODS:Within the framework of several pro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-0088-z

    authors: Bollmann R,Engel S,Petzoldt R,Göbel UB

    更新日期:2001-05-01 00:00:00

  • In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.

    abstract::The ability of clavulanic acid to inactivate beta-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci, Escherichia coli, Klebsiella and Proteus mirabilis became fully amoxicillin-sensitive. This effect of clavulanic acid was in mo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641472

    authors: Peters G,Pulverer G,Neugebauer M

    更新日期:1980-01-01 00:00:00

  • Comparative in vitro activity of cefpodoxime against anaerobes other than Bacteroides fragilis.

    abstract::To assess the in vitro activity of cefpodoxime against anaerobic respiratory tract and oropharyngeal pathogens 77 strains belonging to 18 gram-negative and 7 gram-positive species were studied by means of agar dilution tests. For comparison cefuroxime, amoxicillin, amoxicillin + clavulanic acid and clindamycin were al...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645372

    authors: Werner H,Heizmann WR,Höflsauer M

    更新日期:1991-09-01 00:00:00

  • The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis.

    abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...

    journal_title:Infection

    pub_type: 杂志文章,meta分析

    doi:10.1007/s15010-020-01502-8

    authors: Mahumud RA,Kamara JK,Renzaho AMN

    更新日期:2020-12-01 00:00:00

  • [In vitro effect of acylureido penicillins and mezlocillin on anaerobic sporeless gram-negative rods of genus Bacteroides].

    abstract::313 anaerobic gram-negative rods of the Bacteroides genus isolated from 295 clinical specimens were tested for their sensitivity to azlocillin and mezlocillin using the dilution method with agar plates. 25 mg/l of azlocillin inhibited 80.2% of the strains and the same concentration of mezlocillin inhibited 86.9%. The ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640681

    authors: Höhne C

    更新日期:1982-01-01 00:00:00

  • Influenza vaccination coverage rates in 5 European countries: a population-based cross-sectional analysis of the seasons 02/03, 03/04 and 04/05.

    abstract:INTRODUCTION:Influenza continues to be a considerable health problem in Europe. Vaccination is the only preventive measure, reducing mortality and morbidity of influenza in all age groups OBJECTIVES:The objective of this survey was to assess and compare the level of influenza vaccination coverage during three consecut...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6218-5

    authors: Müller D,Szucs TD

    更新日期:2007-10-01 00:00:00

  • Disseminated zoster in an elderly patient.

    abstract::A 97-year-old lady was hospitalized for left leg cellulitis. Comorbidity included hypertension and congestive heart failure. While in hospital, she developed a painless vesicular rash localized to the territory of the left trigeminal nerve (third branch), which evolved to pustules and crusts (Figure 1). A chickenpox-l...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-8287-5

    authors: Capron J,Steichen O

    更新日期:2009-04-01 00:00:00

  • Nosocomial infections in HIV-positive patients: an overview.

    abstract::Nosocomial infections (NIs) constitute a significant public health problem and contribute to prolonged hospitalization, additional healthcare costs and excess morbidity and mortality. NIs appear to be more common in patients with acquired immunodeficiency syndrome (AIDS) as a result of some degree of immunosuppression...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:

    authors: Petrosillo N,Pagani L,Ippolito G,Gruppo HIV e Infezioni Ospedaliere.

    更新日期:2003-12-01 00:00:00

  • Mycobacterium avium-intracellulare pulmonary infection complicated by cutaneous leukocytoclastic vasculitis in a woman with anorexia nervosa.

    abstract::A 53-year-old Caucasian woman with a history of anorexia nervosa developed a bilateral lower extremity rash comprised of palpable red to violaceous, sub-centimeter papular lesions that increased in quantity rapidly. She also noted a 2-month history of non-productive cough. Imaging modalities revealed a thin-walled cav...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0574-0

    authors: Walsh TL,Baca V,Stalling SS,Natalie AA,Veldkamp PJ

    更新日期:2014-06-01 00:00:00

  • Q fever meningoencephalitis associated with bilateral abducens nerve paralysis, bilateral optic neuritis and abnormal cerebrospinal fluid findings.

    abstract::Q fever is an zoonosis caused by Coxiella burnetti, the clinical features of which are often nonspecific and self-limited. Involvement of the central nervous system is rare and is usually seen as a complication of endocarditis caused by this rickettsial organism in the chronic disease. Specific neurological manifestat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645555

    authors: Shaked Y,Samra Y

    更新日期:1989-11-01 00:00:00

  • Rufloxacin once daily in acute exacerbations of chronic bronchitis.

    abstract::In this open study the efficacy and tolerability of rufloxacin in a single dose of 400 mg the first day and 200 mg the nine consecutive days was studied in 26 patients with an acute exacerbation of chronic bronchitis. Twenty-two patients were evaluable for efficacy. Four patients stopped treatment prematurely after fi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644971

    authors: Dirksen M,Focht J,Boerema J

    更新日期:1991-07-01 00:00:00

  • A novel duplex real-time PCR permits simultaneous detection and differentiation of Borrelia miyamotoi and Borrelia burgdorferi sensu lato.

    abstract:PURPOSE:For simultaneous detection of Borrelia miyamotoi (relapsing fever spirochete) and Borrelia burgdorferi sensu lato, we have developed a duplex real-time PCR targeting the flagellin gene (flaB; p41), a locus frequently used in routine diagnostic PCR for B. burgdorferi s.l. detection. METHODS:Primers and probes w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0820-8

    authors: Venczel R,Knoke L,Pavlovic M,Dzaferovic E,Vaculova T,Silaghi C,Overzier E,Konrad R,Kolenčík S,Derdakova M,Sing A,Schaub GA,Margos G,Fingerle V

    更新日期:2016-02-01 00:00:00

  • Environmental pollution with antimicrobial agents from bulk drug manufacturing industries in Hyderabad, South India, is associated with dissemination of extended-spectrum beta-lactamase and carbapenemase-producing pathogens.

    abstract:PURPOSE:High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-1007-2

    authors: Lübbert C,Baars C,Dayakar A,Lippmann N,Rodloff AC,Kinzig M,Sörgel F

    更新日期:2017-08-01 00:00:00

  • Low rate of clinical consequences derived from results of blood cultures obtained in an internal medicine emergency department.

    abstract:BACKGROUND:Blood cultures detect bacteremia in individual patients and help define local pathogen and resistance spectra. At the same time, the benefits of blood culture results in the management of individual patients -- and therefore their cost-effectiveness -- are disputed. PATIENTS AND METHODS:During 1 calendar ye...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-5065-5

    authors: Ehrenstein BP,Jarry T,Linde HJ,Schölmerich J,Glück T

    更新日期:2005-10-01 00:00:00

  • Phlebitis rate and time kinetics of short peripheral intravenous catheters.

    abstract:BACKGROUND:An observational prospective cohort study was carried out on complication rates and time kinetics of phlebitis caused by short peripheral intravenous catheters (PIVCs) in inpatients on 15 hospital wards in four hospitals in Cologne, Germany. PATIENTS AND METHODS:We observed 1,582 patients with 2,495 PIVCs d...

    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-004-1037-4

    authors: Grüne F,Schrappe M,Basten J,Wenchel HM,Tual E,Stützer H,Cologne Quality Control Network.

    更新日期:2004-02-01 00:00:00

  • Urinary tract infection in renal transplant patients.

    abstract::The incidence of urinary tract infections (UTI) in 299 renal graft transplantations (281 patients) was analyzed. UTI episodes were demonstrated in 185 grafts (62%), most frequently in the first month after transplantation. The infectious episodes were mostly recurrent. Persistent infection, detected in 11% of grafts, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01667212

    authors: Prát V,Horcicková M,Matousovic K,Hatala M,Liska M

    更新日期:1985-09-01 00:00:00

  • A stringent preemptive protocol reduces cytomegalovirus disease in the first 6 months after kidney transplantation.

    abstract:BACKGROUND:The optimal strategy to prevent cytomegalovirus (CMV) disease after kidney transplantation continues to be open to debate. The preemptive approach requires regular determination of CMV viremia and prompt initiation of therapy. METHODS:We retrospectively compared the incidence of CMV disease during two perio...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0343-5

    authors: Greiner M,Cusini A,Ruesch M,Schiesser M,Ledergerber B,Fehr T,Mueller NJ

    更新日期:2012-12-01 00:00:00

  • Correction to: Clinical management of ageing people living with HIV in Europe: the view of the care providers.

    abstract::The original version of this article unfortunately contained a mistake. ...

    journal_title:Infection

    pub_type: 已发布勘误

    doi:10.1007/s15010-020-01463-y

    authors: Boffito M,Ryom L,Spinner C,Martinez E,Behrens G,Rockstroh J,Hohenauer J,Lacombe K,Psichogyiou M,Voith N,Mallon P,Branco T,Svedhem V,dÁrminio Monforte A

    更新日期:2020-08-01 00:00:00

  • Correlation between antibiotic consumption and resistance of bloodstream bacteria in a University Hospital in North Eastern Italy, 2008-2014.

    abstract:PURPOSE:The spread of multidrug-resistant bacteria is a worrisome problem worldwide. This study investigated the correlation between antibiotic consumption and antimicrobial resistance trends of the most important bacteria causing bacteremia at the University hospital of Trieste, Italy, from 2008 to 2014. METHODS:Anti...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-0998-z

    authors: Mascarello M,Simonetti O,Knezevich A,Carniel LI,Monticelli J,Busetti M,Schincariol P,Torelli L,Luzzati R

    更新日期:2017-08-01 00:00:00

  • Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin.

    abstract:INTRODUCTION:Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking. CASE REPORT:We...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1168-7

    authors: Biliotti E,Franchi C,Spaziante M,Garbuglia AR,Volpicelli L,Palazzo D,De Angelis M,Esvan R,Taliani G

    更新日期:2018-10-01 00:00:00

  • A prospective study on infectious mononucleosis in childhood--symptoms, serology, Epstein-Barr-Virus specific leukocyte migration inhibition.

    abstract::The clinical course, serological changes and the development of the specific cell-mediated immune response to Epstein-Barr-Virus (EBV), measured in terms of leukocyte migration inhibition, were followed in 40 children suffering from an EBV infection. The patients were followed for between six and 24 months. Although t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640763

    authors: Timár L,Budai J,Koller M

    更新日期:1982-01-01 00:00:00

  • Legionella bozemanii, an elusive agent of fatal cavitary pneumonia.

    abstract::A 67-year-old patient died of Legionella bozemanii pneumonia with negative urinary antigen and negative serology. Cystic lesions in pneumonia of unknown origin should lead to the differential diagnosis of L. bozemanii infections. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6251-4

    authors: Widmer A,Hohl P,Dirnhofer S,Bassetti S,Marsch S,Frei R

    更新日期:2007-06-01 00:00:00

  • Epidemiology of candidemia in Qatar, the Middle East: performance of MALDI-TOF MS for the identification of Candida species, species distribution, outcome, and susceptibility pattern.

    abstract:INTRODUCTION:Bloodstream infections (BSIs) due to Candida spp. constitute the predominant group of hospital-based fungal infections worldwide. A retrospective study evaluated the performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the identification of BSI Cand...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0570-4

    authors: Taj-Aldeen SJ,Kolecka A,Boesten R,Alolaqi A,Almaslamani M,Chandra P,Meis JF,Boekhout T

    更新日期:2014-04-01 00:00:00

  • Changes in lymphocyte subpopulations in patients treated with cefodizime for acute lower respiratory tract infections.

    abstract::The influence of cefodizime (CDZ) on CD4 and CD8 lymphocytes was investigated in patients with lower respiratory tract infection and underlying respiratory diseases. Ten men and one woman were treated with CDZ 1 g i.m. b.i.d. for ten days. The infecting organisms were Haemophilus influenzae (5), Streptococcus pneumoni...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01709955

    authors: Valcke Y,Van der Straeten M

    更新日期:1992-01-01 00:00:00

  • Hepatitis C virus infection: sexual or non-sexual transmission between spouses? A case report and review of the literature.

    abstract::The most efficient route of transmission of hepatitis C virus (HCV) infection is through contaminated blood. Sexual transmission or other close human contact could play a role in sporadic infections. We describe a case of acute hepatitis C progressing to chronic hepatitis over a follow-up of 4 years in a 44-year-old w...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-007-6188-7

    authors: Orlando R,Lirussi F

    更新日期:2007-12-01 00:00:00

  • Secretory non-pancreatic phopholipase A2 in severe sepsis: relation to endotoxin, cytokines and thromboxane B2.

    abstract::Circulatory secretory non-pancreatic phospholipase A2 (snp-PLA2) was measured prospectively at the onset (day 0) of severe sepsis in 52 patients as well as on day 1 and 2 in 25 patients, in order to answer two questions: 1) does the snp-PLA2 plasma concentration differ according to the type and severity of infection? ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01713312

    authors: Guidet B,Piot O,Masliah J,Barakett V,Maury E,Bereziat G,Offenstadt G

    更新日期:1996-03-01 00:00:00

  • Staphylococcus lugdunensis early prosthetic valve endocarditis in a young HIV positive patient.

    abstract::Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that causes skin and soft tissue infections and occasionally life threatening endocarditis of native valves. Prosthetic valve infection due to this pathogen is very rare and has not been described in HIV infected individuals. We report on the first case...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6029-8

    authors: Kourbeti IS,Alegakis DE,Roditakis GE,Samonis G

    更新日期:2007-02-01 00:00:00