Abstract:
:In this open study the efficacy and tolerability of rufloxacin in a single dose of 400 mg the first day and 200 mg the nine consecutive days was studied in 26 patients with an acute exacerbation of chronic bronchitis. Twenty-two patients were evaluable for efficacy. Four patients stopped treatment prematurely after five days because of clinical cure. At the enrollment visit a pathogen was isolated in the sputum sample in 19 of 22 evaluable patients. The predominant pathogens were Streptococcus pneumoniae and Moraxella catarrhalis. In 17 of these 19 bacteriologically evaluable patients the initial infecting organism was eradicated from specimens obtained within 48 hours after the end of therapy. There was one case of persistent infection caused by S. pneumoniae (MIC 4 mg/l), one patient had a superinfection with Serratia marcescens (MIC 1 mg/l) susceptible to rufloxacin and therapy was stopped after five days due to clinical failure. One week after the end of therapy, 15 patients remained free from infection whilst one patient experienced reinfection with Klebsiella pneumoniae (MIC 0.5 mg/l). Clinical cure or improvement was observed in 21 of 22 patients. Mild adverse events were reported by two of 26 enrolled patients. In one patient, complaining of headache and dizziness, the adverse events were considered possibly study drug related. No abnormal laboratory findings were reported. Nadir plasma levels of rufloxacin were measured and no accumulation in plasma was observed during treatment. A ten day course of an oral single dose of rufloxacin proved efficacious and was well tolerated in patients with an acute exacerbation of chronic bronchitis.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Infectionjournal_title
Infectionauthors
Dirksen M,Focht J,Boerema Jdoi
10.1007/BF01644971subject
Has Abstractpub_date
1991-07-01 00:00:00pages
297-300issue
4eissn
0300-8126issn
1439-0973journal_volume
19pub_type
杂志文章相关文献
INFECTION文献大全abstract::After the cytology and the chemistry of the CSF had returned to normal, the concentration of ceftizoxime was determined in the CSF and in the serum of 27 patients who had suffered from purulent or serous meningitis. The patients were divided into four groups. The concentration in the CSF was mean = 0.87 mg/l two hours...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01816728
更新日期:1982-01-01 00:00:00
abstract::The MICs and MBCs of mecillinam, ticarcillin, mezlocillin, azlocillin and piperacillin were determined by the microdilution method in liquid medium using 700 strains of gram-negative bacilli and enterococci isolated from pathological sources and classified as a function of their sensitivity to ampicillin and carbenici...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640683
更新日期:1982-01-01 00:00:00
abstract::The efficacy of cefodizime (CDZ) in upper urinary tract infections (UUTI) and complicated lower urinary tract infections (LUTI) was assessed by analysis of the combined results of five clinical trials. Doses of CDZ 1 g i.m. daily, 1 x 2 g i.v. or i.m. and 2 x 2 g i.v. were investigated; comparative agents were cefurox...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709945
更新日期:1992-01-01 00:00:00
abstract::In an open randomised crossover study the antibacterial activity of pefloxacin and norfloxacin was assessed in the urine after a single 800-mg oral dose in 14 healthy female volunteers. Pefloxacin demonstrated lower peak concentrations in the urine than norfloxacin (mean, 217.2 mg/l versus 492.9 mg/l as determined by ...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02113592
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:We analyzed the clinical manifestations and therapeutic outcomes of Klebsiella brain abscesses. PATIENTS AND METHODS:The clinical data of 15 patients with Klebsiella brain abscesses, retrospectively collected over a 14-year period, were studied. RESULTS:The 15 patients included 13 cases of Klebsiella pneum...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-0069-2
更新日期:2001-03-01 00:00:00
abstract::The epidemiological survey was carried out in a Calabrian population in order to ascertain the incidence of antibodies to Mycoplasma pneumoniae. In the past it has been felt that this infection does not occur in Southern Italy. We have found an incidence in our survey equal to that of the other countries. It was impos...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01638421
更新日期:1976-01-01 00:00:00
abstract::Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could ...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-005-6305-4
更新日期:2005-06-01 00:00:00
abstract::The effect of 17 beta-estradiol on in vitro adherence of six strains of uropathic Escherichia coli to human endometrial stromal cells was examined. In contrast to the findings of earlier investigations using murine urogenital cells and malignant human urogenital cell lines, our studies showed no significant effect of ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01646885
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Rotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged < 5 years die from rotavirus-related diarrhoeal diseases. Though these infections are vaccine-preventable, the vast majority of children in low-income countries suffer from the infect...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-017-1082-4
更新日期:2018-02-01 00:00:00
abstract::We present the case of an 11-month-old male infant who had been BCG vaccinated as a neonate. At the age of nine months, he developed a localized tumor above his right mamilla. The tumor destroyed the fourth rib and infiltrated the surrounding soft tissue. X-ray and CT scan suggested a malignant neoplasm. Histology, ho...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01711073
更新日期:1992-03-01 00:00:00
abstract::To quantify the relative antibacterial efficacy of beta-lactam antibiotics in vitro, a mathematical description of bacterial growth was developed. Curves of growth in the presence of the antibiotic are expressed as quadratic functions of time, with initial growth rate (ko) and rate of change of growth (a) as concentra...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659765
更新日期:1979-01-01 00:00:00
abstract::A 38-year-old Omani woman, seven months pregnant, developed extensive zygomycosis involving maxillary and temporal bones. No evidence of any underlying immune deficiency was detected except that which may be attributed to pregnancy. After delivery the patient was treated with repeated courses of amphotericin B, which ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02033066
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:In a previous controlled study, we investigated the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants (sudden infant death syndrome, SIDS). In this present study, we investigated further the respiratory pathology in a subset of infants in the original stud...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0164-y
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the efficacy of sustained release of vancomycin and teicoplanin from a resorbable gelatin glycerol sponge, in order to establish a new delivery system for local anti-infective therapy. MATERIALS AND METHODS:60 plasticized glycerol gelatin sponges containing either 10 or...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-1067-1
更新日期:2006-02-01 00:00:00
abstract::A Haemophilus influenzae multicenter antimicrobial susceptibility surveillance was carried out. An overall beta-lactamase production rate of 25.7% was found, with significant differences between hospitals ranging between 7.9 and 47.9%. Presumable intrinsic resistance was found in 4.6% of strains. No differences in sus...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s150100050026
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Since May 2016, WHO recommended a 9-12 month short-treatment regimen for multidrug-resistant tuberculosis (MDR-TB) treatment known as the 'Bangladesh Regimen'. However, limited data exist on the appropriateness thereof, and its implementation in low- and middle-income countries (LMIC). We report here on the pil...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-019-01314-5
更新日期:2019-10-01 00:00:00
abstract::During the course of chronic hepatitis B virus (HBV) infection, a patient seropositive for hepatitis B e antigen experienced four episodes of acute hepatic necroinflammation. Serum HBV-DNA concentration elevated immediately before the first and third exacerbations, whereas serum hepatitis C virus (HCV) RNA was detecte...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1195-6
更新日期:2001-12-01 00:00:00
abstract::The question of whether ampicillin and sulbactam are able to penetrate sufficiently into costal cartilage tissue was investigated in 21 children undergoing surgery for funnel chest malformations. The concentrations of both compounds were determined in the core and mantle pieces of samples taken 45 min or 120 min after...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01739028
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:Limited data are available on immunologic responses to primary pandemic H1N1 (2009) vaccination in recipients of allogeneic hematopoietic stem cell transplantation (HSCT) recipients. In 2009 serologic responses to either pandemic H1N1 (2009) vaccine (n = 36) or pandemic H1N1 (2009) infection (n = 2) were studie...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0206-5
更新日期:2012-04-01 00:00:00
abstract::The in vitro activity of lomefloxacin, a new difluorinated quinolone, was compared to that of ciprofloxacin, ofloxacin, norfloxacin and other relevant antibacterial agents. Lomefloxacin and norfloxacin shared similar activity, whereas ofloxacin and in particular ciprofloxacin showed superior activity. Most gram-negati...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644019
更新日期:1989-05-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. METHODS:From Ja...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0914-y
更新日期:2017-02-01 00:00:00
abstract::The serum half-life of cephacetrile and its penetration from the serum into the cerebrospinal fluid (CSF) was determined in 33 premature and full-term neonates. On an average the serum half-life was 3.6 hours in children with a birth weight above 1,500 g; in children with a birth weight below 1,500 g it was 5.1 hours....
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640789
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:An observational prospective cohort study was carried out on complication rates and time kinetics of phlebitis caused by short peripheral intravenous catheters (PIVCs) in inpatients on 15 hospital wards in four hospitals in Cologne, Germany. PATIENTS AND METHODS:We observed 1,582 patients with 2,495 PIVCs d...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-004-1037-4
更新日期:2004-02-01 00:00:00
abstract::Cydnidae bug (also termed the burrowing bug) are arthropods of the order Hemiptera, that are recognized by their morphological adaptations for digging. They release an odorous substance from special glands that serve as self-defense, causing pigmented macules when in contact with human skin, especially during the rain...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01481-w
更新日期:2020-07-11 00:00:00
abstract::Aminoglycosides are widely used antibacterial agents, particularly for serious infections. They have a narrow therapeutic margin of efficacy over toxicity relative to many other agents, a disadvantage which can be obviated to some extent by precise dosing regulated by blood concentration monitoring. The relationships ...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01639603
更新日期:1980-01-01 00:00:00
abstract::Recently, important advances have been made in the immunodiagnosis of tuberculosis. New T cell interferon-gamma release assays (TIGRA) are more specific and more sensitive than the tuberculin skin test (TST) for the diagnosis of Mycobacterium tuberculosis (MTB) infection. However, like the TST, TIGRA are unable to dis...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-008-8089-9
更新日期:2008-12-01 00:00:00
abstract::The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearan...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641291
更新日期:1983-05-01 00:00:00
abstract::Tuberculous epididymitis is a rare entity associated with minor complications. We present two cases of tuberculous epididymitis associated with serious complications (bilateral psoas abscesses and Addison's disease with psoas abscess). A review of the literature disclosed six additional cases associated with serious c...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s150100050080
更新日期:2000-05-01 00:00:00
abstract::The minimum duration of continuous amphotericin B irrigation (50 mg/liter/day) required to clear the candida colonizing the urinary bladder was investigated. Eleven in vitro experiments revealed a consistent candidicidal effect within 48 hours with 25 and 5 mg/l of amphotericin B concentrations attainable in the bladd...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01647004
更新日期:1990-09-01 00:00:00
abstract::Between 1 November 1993 and 31 October 1996, admissions to paediatric departments for Bordetella pertussis complications were reported to a nationwide, hospital-based active surveillance system. The case definition included pertussis complicated by pneumonia, apnoea requiring assisted ventilation, seizures, encephalop...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02962368
更新日期:1998-07-01 00:00:00