Abstract:
BACKGROUND:The aim of this study was to evaluate the efficacy of sustained release of vancomycin and teicoplanin from a resorbable gelatin glycerol sponge, in order to establish a new delivery system for local anti-infective therapy. MATERIALS AND METHODS:60 plasticized glycerol gelatin sponges containing either 10 or 20% gelatin (w/v) were incubated in vancomycin or teicoplanin solution at 20 degrees C for either 1 or 24 h. In vitro release properties of the sponges were investigated over a period of 1 week by determining the levels of vancomycin and teicoplanin eluted in plasma using fluorescent polarization immunoassay. The rate constant and the half-life for the antibiotic release of each group were calculated by linear regression assuming first order kinetics. RESULTS:Presoaking for 24 h was associated with a significant increase in the total antibiotic release in all groups opposed to 1 h of incubation, except for the 10% sponges presoaked in teicoplanin. Doubling the gelatin content of the sponges from 10 to 20% significantly increased the total release of antibiotic load only in teicoplanin-containing sponges after 24 h incubation. In all corresponding groups investigated, release of vancomycin was more prolonged compared to teicoplanin, which allowed a gradual release beyond 5 days. The half-life (h +/- SEM) of both types of vancomycin-containing sponges was significantly prolonged by 24 h incubation in comparison to 1 h incubation (29.1 +/- 5.9 vs 5.9 +/- 1.0; p < 0.001, 30.0 +/- 2.1 vs 11.1 +/- 1.9; p < 0.001). However, neither doubling the gelatin content of the sponges nor a prolonged incubation was associated with a significantly prolonged delivery of teicoplanin. CONCLUSION:This study demonstrated a better diffusion-controlled release of vancomycin-impregnated glycerol gelatin sponges compared to those pretreated with teicoplanin. The plasticized glycerol gelatin sponge may be a promising carrier for the application of vancomycin to infected wounds for local anti-infective therapy.
journal_name
Infectionjournal_title
Infectionauthors
Drognitz O,Thorn D,Krüger T,Gatermann SG,Iven H,Bruch HP,Muhl Edoi
10.1007/s15010-006-1067-1keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
29-34issue
1eissn
0300-8126issn
1439-0973journal_volume
34pub_type
杂志文章相关文献
INFECTION文献大全abstract::Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies increasingly reported in patients with HIV infection. However, characteristic features of thrombotic microangiopathies associated with HIV disease have not been defined yet. The typical courses of HUS and T...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF02565164
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Optimal antimicrobial treatment duration for Gram-negative bloodstream infection (BSI) remains unclear. This retrospective cohort study examined effectiveness of short (7-10 days) and long (>10 days) courses of antimicrobial therapy for uncomplicated Gram-negative BSI. METHODS:Hospitalized adults with uncompli...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1020-5
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:This study aims to describe the occurrence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections and the relation between endemic and epidemic nosocomial MRSA infections in intensive care units (ICUs) in Germany. METHODS:The ICU component within the German national nosocomial infection...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2043-z
更新日期:2002-08-01 00:00:00
abstract::The kinetics of human cytomegalovirus (HCMV)-specific immunoglobulin E (IgE), M (IgM), A (IgA) and G (IgG) were studied in 421 sera obtained from 19 renal allograft recipients by enzyme-linked immunosorbent assay (ELISA). Cytomegalic inclusion disease (CID) occurred in 11 (57.9%) patients. HCMV infection was diagnosed...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710536
更新日期:1993-05-01 00:00:00
abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709952
更新日期:1992-01-01 00:00:00
abstract::In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100050036
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Screening for staphylococci among various patient populations has become important for appropriate therapeutic management and for control of nosocomial infections. The purpose of this study is to evaluate the in vitro sensitivity and specificity of a chromogenic agar medium, S. aureus ID (bioMérieux, France)...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-5094-8
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION:Influenza continues to be a considerable health problem in Europe. Vaccination is the only preventive measure, reducing mortality and morbidity of influenza in all age groups OBJECTIVES:The objective of this survey was to assess and compare the level of influenza vaccination coverage during three consecut...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6218-5
更新日期:2007-10-01 00:00:00
abstract::Preliminary data from the U.S. regarding the safety and efficacy of ofloxacin in the treatment of urinary tract infections are presented. Treatment of uncomplicated urinary tract infections with either 200 mg or 300 mg ofloxacin b.i.d. was as effective as treatment with a standard therapy, co-trimoxazole. In another s...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01661300
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most impo...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-018-1222-5
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-5013-z
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...
journal_title:Infection
pub_type: 杂志文章,meta分析
doi:10.1007/s15010-020-01502-8
更新日期:2020-12-01 00:00:00
abstract::A prospective study was designed to evaluate the efficacy and effects on pulmonary function tests of weekly 600 mg aerosolised pentamidine as prophylaxis against Pneumocystis carinii pneumonia (PCP) amongst two groups of patients infected with the human immunodeficiency virus. Group 1 (primary prophylaxis) consisted o...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01704600
更新日期:1992-05-01 00:00:00
abstract::The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hyd...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01647497
更新日期:1986-01-01 00:00:00
abstract::A 12-year-old girl with a 2-month history of fever and abdominal pain was admitted to our hospital. Ultrasound and CT scans of the abdomen showed multiple hypoechoic lesions of liver and spleen. Screening for zoonosis revealed high positive titers to Bartonella henselae. T-cell deficiency was demonstrated and remained...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s150100050059
更新日期:2000-03-01 00:00:00
abstract::The influence of cefodizime (CDZ) on CD4 and CD8 lymphocytes was investigated in patients with lower respiratory tract infection and underlying respiratory diseases. Ten men and one woman were treated with CDZ 1 g i.m. b.i.d. for ten days. The infecting organisms were Haemophilus influenzae (5), Streptococcus pneumoni...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709955
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Loxoscelism is an envenomation due to a bite by spiders of the genus Loxosceles, very well known on the American continent but unrecognized in Europe. CASE REPORT:We report the case of a 36-year-old woman, without any medical history or treatment, who went to a University Hospital in the South of France, fo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0869-4
更新日期:2016-06-01 00:00:00
abstract::In order to determine the infection rate of Chlamydia trachomatis in young males in Austria an epidemiological study was performed on 335 male Austrian soldiers attending the military hospital for a health check-up procedure. Three hundred twenty-nine (98.2%) of the screened males were clinically asymptomatic. Chlamyd...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644946
更新日期:1991-07-01 00:00:00
abstract::Although Enterococcus faecalis is a relatively common cause of infective endocarditis, it rarely causes meningitis. A case of Enterococcus faecalis endocarditis presenting as meningitis in a 74-year-old diabetic man on chronic hemodialysis is reported. A review of the literature showed that the association of enteroco...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02962253
更新日期:1998-09-01 00:00:00
abstract::The ability of clavulanic acid to inactivate beta-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci, Escherichia coli, Klebsiella and Proteus mirabilis became fully amoxicillin-sensitive. This effect of clavulanic acid was in mo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641472
更新日期:1980-01-01 00:00:00
abstract::Infection is an important cause of death in patients receiving cytostatic drugs or with any other impairment of host resistance. Such infections are frequently due to opportunist micro-organisms usually belonging to the endogenous flora of the patient. It is often difficult to obtain an exact diagnosis of the cause an...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642766
更新日期:1975-01-01 00:00:00
abstract::The activity of clarithromycin in combination with ethambutol and rifampicin was tested at concentrations achievable in serum against 20 strains of Mycobacterium avium complex. The combination of clarithromycin plus rifampicin showed inhibition of 11 of the strains and bactericidal synergism against seven of the strai...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645362
更新日期:1991-09-01 00:00:00
abstract::The clinical tolrance of 350 mg pivampicillin tablets was evaluated in 470 hospitalized patients in Denmark, Norway and Iceland. The tablets were given to 229 fasting patients and to 241 non-fasting patients at mealtime. Side-effects were reported in 44 patients (9.4%). Upper gastro intestinal disturbances occurred in...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01639105
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:SARS-COV-2 infection can develop into a multi-organ disease. Although pathophysiological mechanisms of COVID-19-associated myocardial injury have been studied throughout the pandemic course in 2019, its morphological characterisation is still unclear. With this study, we aimed to characterise echocardiographic ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01572-8
更新日期:2021-01-30 00:00:00
abstract::In this article the cooperating partners of the ClinSurv HIV cohort were not listed in the acknowledgements. The correct paragraph appears below. ...
journal_title:Infection
pub_type: 杂志文章,已发布勘误
doi:10.1007/s15010-019-01281-x
更新日期:2019-04-01 00:00:00
abstract::A 17-year-old boy presented with a severe form of an acute disseminated encephalomyelitis (ADEM) with hemiparesis and coma after initial symptoms of a flu-like febrile infection 1 week previously. Titers against Mycoplasma pneumoniae were significantly increased in serum and cerebrospinal fluid (CSF). Detection of M. ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1173-z
更新日期:2001-08-01 00:00:00
abstract:PURPOSE:SARS-CoV-2 is a recently emerged ß-coronavirus. Here we present the current knowledge on its epidemiologic features. METHODS:Non-systematic review. RESULTS:SARS-CoV-2 replicates in the upper and lower respiratory tract. It is mainly transmitted by droplets and aerosols from asymptomatic and symptomatic infect...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-020-01531-3
更新日期:2020-10-08 00:00:00
abstract::We are presenting a new case of meningitis due to the Micrococcus luteus species. This germ was isolated twice in eight days from the CSF of a 57-year old woman. The patient had a ventriculoperitoneal shunt implanted for hydrocephalus following a meningeal haemorrhage. Antibiotic therapy was efficient but the patient ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645439
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:To prevent transmission of MRSA, eradication by antiseptic washings and nasal ointment is recommended. There are few studies, which investigated the success of eradication of MRSA carriage during everyday clinical working conditions and results are controversial. We wanted to assess the effectiveness of MRSA...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6273-y
更新日期:2007-06-01 00:00:00
abstract::We describe two splenectomized patients admitted with pneumonia. The course in one was complicated by overwhelming multiorgan failure when the only indicative laboratory result was seropositivity for Legionella hackeliae and Legionella longbeachae. He was initially treated with ceftriaxone and roxithromycin, followed ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-004-3005-4
更新日期:2004-06-01 00:00:00