A review on anti-adhesion therapies of bacterial diseases.


BACKGROUND:Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies. METHODS:All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines. RESULTS:Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases. CONCLUSION:Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.






Asadi A,Razavi S,Talebi M,Gholami M




Has Abstract


2019-02-01 00:00:00














  • Benefit and advantage to clinicians of a computer-assisted microbiological diagnosis and database system.

    abstract::Computer-assisted diagnostic systems may accelerate transmission of microbiological reports and facilitate evaluation of the epidemiological situation and thus improve the collaboration between microbiologists and clinicians. This possible benefit is demonstrated by four examples. It became evident that incidences of ...


    pub_type: 杂志文章


    authors: Manncke K,Heizmann W

    更新日期:1988-01-01 00:00:00

  • Vitamin K supplementation during prophylactic use of cefoperazone in urologic surgery.

    abstract::Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of bleeding, co-administration of vitamin K has been advised. We reassessed the need for vitamin K use in a retrospective analysis of 50 patients undergoing urologic pro...


    pub_type: 杂志文章


    authors: Rockoff SD,Blumenfrucht MJ,Irwin RJ Jr,Eng RH

    更新日期:1992-05-01 00:00:00

  • Thrombogenicity testing of central venous catheters in vitro.

    abstract::To date there have been no standard methods for assessing the thrombogenicity of central venous catheters. A procedure for testing the thrombogenicity of intravenous lines such as the silver-impregnated catheter by continuous blood flow in vitro was therefore developed. For this test, fresh blood was drawn from health...


    pub_type: 杂志文章


    authors: Böswald M,Lugauer S,Bechert T,Greil J,Regenfus A,Guggenbichler JP

    更新日期:1999-01-01 00:00:00

  • The influence of flucloxacillin and amoxicillin with clavulanic acid on the aerobic flora of the alimentary tract.

    abstract::In a randomized study, 42 patients undergoing extensive maxillo-facial surgery (correction of the position of the mandible or maxilla by using autologous bone transplants) received prophylactically ten-day courses of either flucloxacillin or amoxicillin with clavulanic acid. Patients were comparable with regard to age...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vlaspolder F,de Zeeuw G,Rozenberg-Arska M,Egyedi P,Verhoef J

    更新日期:1987-07-01 00:00:00

  • Clindamycin-induced hypersensitivity reaction.

    abstract::Drug-induced anaphylaxis is an unpredictable adverse reaction. Although it may occur with any medication, antibiotics induce more cases of anaphylaxis than any other medication class with most cases being induced by β-lactam antibiotics. Clindamycin is an antibiotic with good gram-positive and anaerobe coverage which ...


    pub_type: 杂志文章


    authors: Bulloch MN,Baccas JT,Arnold S

    更新日期:2016-06-01 00:00:00

  • Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis.

    abstract::A total of 208 patients underwent brain biopsy for presumptive herpes simplex encephalitis and were randomized to receive either vidarabine, vira-A, at 15 mg/kg/day, or acyclovir, at 30 mg/kg/day for ten days. 69 patients (33%) had biopsy-proven disease; 37 received vira-A and 32 acyclovir. With the exception of age, ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Whitley RJ,Alford CA,Hirsch MS,Schooley RT,Luby JP,Aoki FY,Hanley D,Nahmias AJ,Soong SJ

    更新日期:1987-01-01 00:00:00

  • Costal BCG osteomyelitis presenting as a tumor.

    abstract::We present the case of an 11-month-old male infant who had been BCG vaccinated as a neonate. At the age of nine months, he developed a localized tumor above his right mamilla. The tumor destroyed the fourth rib and infiltrated the surrounding soft tissue. X-ray and CT scan suggested a malignant neoplasm. Histology, ho...


    pub_type: 杂志文章


    authors: Hoppe JE,Orlikowsky T,Klingebiel T,Niethammer D

    更新日期:1992-03-01 00:00:00

  • Prevalence rates of viral hepatitis infections in refugee Kurds from Iraq and Turkey.

    abstract:BACKGROUND:Since little is known about the burden of viral hepatitis in Kurds, the prevalence of infection with hepatitis A virus (HAV), hepatitis E virus (HEV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a sample of refugee Kurds from Iraq and Turkey. PATIENTS AND METHODS:A cross-sectiona...


    pub_type: 杂志文章


    authors: Chironna M,Germinario C,Lopalco PL,Carrozzini F,Barbuti S,Quarto M

    更新日期:2003-03-01 00:00:00

  • Incidence of Helicobacter pylori infection in a cohort of Italian military students.

    abstract::Prevalence and incidence of Helicobacter pylori infection among 250 Italian military students were studied using specific IgG antibodies. Subjects susceptible at enrollment were evaluated during a 10-month follow-up period, when two serum samples were collected after 5 and 10 months, respectively. Samples were also an...


    pub_type: 杂志文章


    authors: Biselli R,Fortini M,Matricardi PM,Stroffolini T,D'Amelio R

    更新日期:1999-05-01 00:00:00

  • Native vertebral osteomyelitis in aged patients: distinctive features. An observational cohort study.

    abstract:PURPOSE:To describe the demographic, clinical, and microbiological profile of native vertebral osteomyelitis (NVO) in aged patients as compared to that of younger patients, to identify differences that could motivate changes in clinical management. METHODS:Retrospective, observational cohort study (1990-2015) includin...


    pub_type: 杂志文章


    authors: Aguilar-Company J,Pigrau C,Fernández-Hidalgo N,Rodríguez-Pardo D,Falcó V,Lung M,Pellisé F,Almirante B

    更新日期:2018-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Eigel P,Tschirkov A,Satter P,Knothe H

    更新日期:1978-01-01 00:00:00

  • Transitory ventricular tachycardia associated with influenza A infection of cardiac conduction tissue.

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    pub_type: 杂志文章


    authors: Frustaci A,Petrosillo N,Ippolito G,Chimenti C

    更新日期:2016-06-01 00:00:00

  • Neglected tropical diseases in Europe: rare diseases and orphan drugs?

    abstract::Neglected tropical diseases are becoming more and more frequent in Europe due to the increasing immigration from endemic areas. Nonetheless specific treatments are scarcely available in many European countries, since they are neither officially licensed nor marketed. Only a few referral health centres can afford to ac...


    pub_type: 社论


    authors: Calleri G,Angheben A,Albonico M

    更新日期:2019-02-01 00:00:00

  • Pleural fluid adenosine deaminase/serum C-reactive protein ratio for the differentiation of tuberculous and parapneumonic effusions with neutrophilic predominance and high adenosine deaminase levels.

    abstract:PURPOSE:Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are usually distinguished by cellular predominance and pleural fluid adenosine deaminase (ADA) levels. However, both diseases may occasionally show similar neutrophilic predominance and high ADA levels. In such cases, the differential diagnosis...


    pub_type: 杂志文章


    authors: Lee J,Yoo SS,Lee SY,Cha SI,Park JY,Kim CH

    更新日期:2017-02-01 00:00:00

  • Comparative antibacterial activity of azlocillin, mezlocillin, carbenicillin and ticarcillin and relative stability to beta-lactamases of pseudomonas aeruginosa and klebsiella aerogenes.

    abstract::The antibacterial activities of two ureidopenicillins, azlocillin and mezlocillin, were compared with those of the alpha-carboxypenicillins, carbenicillin and ticarcillin, against a large number of gram-positive and gram-negative bacteria. All four penicillins were active against a wide range of bacteria including Pse...


    pub_type: 杂志文章


    authors: Basker MJ,Edmondson RA,Sutherland R

    更新日期:1979-01-01 00:00:00

  • Assessment of immunomodulating activity of ofloxacin and three other quinolones in human plasma.

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    pub_type: 杂志文章


    authors: De Simone C,Vullo V,Grassi M,Di Fabio S,Baldinelli L,Sorice F

    更新日期:1986-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Almomani BA,Hayajneh WA,Ayoub AM,Ababneh MA,Al Momani MA

    更新日期:2018-08-01 00:00:00

  • [Altered bacterial periurethral flora in young girls with chronic, recurrent urinary tract infections? (author's transl)].

    abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...


    pub_type: 杂志文章


    authors: Hofmann K,Marget W,Belohradsky B

    更新日期:1981-01-01 00:00:00

  • Serum immunoglobulin levels in hepatitis non-A, non-B: a comparison with hepatitis A and B.

    abstract::The serum levels of IgA, IgG and IgM were determined by the single radial immunodiffusion method in 86 patients with acute viral hepatitis serologically differentiated by radioimmunoassays. The levels of IgA and IgG were similar in patients with hepatitis A, B and non-A, non-B, while differences in IgM levels were obs...


    pub_type: 杂志文章


    authors: Norkrans G,Nilsson LA,Frösner G,Wahl M,Iwarson S

    更新日期:1980-01-01 00:00:00

  • [A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)].

    abstract::The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity...


    pub_type: 杂志文章


    authors: Wahlig H

    更新日期:1977-01-01 00:00:00

  • Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in 11 adult intensive care units from 10 cities of Turkey: findings of the International Nosocomial Infection Control Consortium (INICC).

    abstract:PURPOSE:To evaluate the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach on the reduction of ventilator-associated pneumonia (VAP) in adult patients hospitalized in 11 intensive care units (ICUs), from 10 hospitals, members of the INICC, in 10 cities of Turkey. METH...


    pub_type: 杂志文章,多中心研究


    authors: Leblebicioglu H,Yalcin AN,Rosenthal VD,Koksal I,Sirmatel F,Unal S,Turgut H,Ozdemir D,Ersoz G,Uzun C,Ulusoy S,Esen S,Ulger F,Dilek A,Yilmaz H,Turhan O,Gunay N,Gumus E,Dursun O,Yýlmaz G,Kaya S,Ulusoy H,Cengiz M

    更新日期:2013-04-01 00:00:00

  • Cefetamet pivoxil: bacteriostatic and bactericidal activity of the free acid against 355 gram-negative rods.

    abstract::The in vitro activity of the free acid of cefetamet pivoxil (Ro 15-8075) was tested against 355 clinical isolates, namely enteropathogenic bacteria, glucose non-fermentative gram-negative rods (excluding Pseudomonas aeruginosa) and Legionella pneumophila. Ceftriaxone was included in the study as reference compound. Al...


    pub_type: 杂志文章


    authors: Hohl P,von Graevenitz A,Zollinger-Iten J

    更新日期:1988-05-01 00:00:00

  • [Pseudomonas aeruginosa immunoglobulin in experimental pneumonia].

    abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...


    pub_type: 杂志文章


    authors: Pennington JE,Pier GB

    更新日期:1987-01-01 00:00:00

  • Acute disseminated encephalomyelitis (ADEM) due to Mycoplasma pneumoniae infection in an adolescent.

    abstract::A 17-year-old boy presented with a severe form of an acute disseminated encephalomyelitis (ADEM) with hemiparesis and coma after initial symptoms of a flu-like febrile infection 1 week previously. Titers against Mycoplasma pneumoniae were significantly increased in serum and cerebrospinal fluid (CSF). Detection of M. ...


    pub_type: 杂志文章


    authors: Riedel K,Kempf VA,Bechtold A,Klimmer M

    更新日期:2001-08-01 00:00:00

  • Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms.

    abstract:PURPOSE:To evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival secretions from patients without ocular symptoms. METHODS:Conjunctival swabs were prospectively collected from laboratory-confirmed Coronavirus disease 2019 (COVID-19) patients without ocular symptoms for r...


    pub_type: 杂志文章


    authors: Li X,Chan JF,Li KK,Tso EY,Yip CC,Sridhar S,Chung TW,Chiu KH,Hung DL,Wu AK,Chau SK,Liu R,Lung KC,Tam AR,Cheng VC,To KK,Chan KH,Hung IF,Yuen KY

    更新日期:2020-09-17 00:00:00

  • Quantitative antibiotic use in hospitals: comparison of measurements, literature review, and recommendations for a standard of reporting.

    abstract:BACKGROUND:Reports on antibiotic use often lack complete definitions of the units of measurement, hampering the comparison of data between hospitals or hospital units. PATIENTS AND METHODS:To compare methods of measures of in-hospital antimicrobial use, we determined aggregate in-hospital consumption data at a tertiar...


    pub_type: 杂志文章,评审


    authors: Kuster SP,Ruef C,Ledergerber B,Hintermann A,Deplazes C,Neuber L,Weber R

    更新日期:2008-12-01 00:00:00

  • Correction to: Clinical management of ageing people living with HIV in Europe: the view of the care providers.

    abstract::The original version of this article unfortunately contained a mistake. ...


    pub_type: 已发布勘误


    authors: Boffito M,Ryom L,Spinner C,Martinez E,Behrens G,Rockstroh J,Hohenauer J,Lacombe K,Psichogyiou M,Voith N,Mallon P,Branco T,Svedhem V,dÁrminio Monforte A

    更新日期:2020-08-01 00:00:00

  • Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

    abstract:PURPOSE:Data on the systemic dissemination in Staphylococcus aureus bloodstream infection (SAB) remain sparse. We investigated the timing and the sequence of clinical symptoms, diagnostic confirmation, and occurrence of multiple infective foci in relation to three major infective foci. METHODS:From 2006 to 2011, all a...


    pub_type: 杂志文章


    authors: Smit J,Rieg SR,Wendel AF,Kern WV,Seifert H,Schønheyder HC,Kaasch AJ

    更新日期:2018-10-01 00:00:00

  • A novel duplex real-time PCR permits simultaneous detection and differentiation of Borrelia miyamotoi and Borrelia burgdorferi sensu lato.

    abstract:PURPOSE:For simultaneous detection of Borrelia miyamotoi (relapsing fever spirochete) and Borrelia burgdorferi sensu lato, we have developed a duplex real-time PCR targeting the flagellin gene (flaB; p41), a locus frequently used in routine diagnostic PCR for B. burgdorferi s.l. detection. METHODS:Primers and probes w...


    pub_type: 杂志文章


    authors: Venczel R,Knoke L,Pavlovic M,Dzaferovic E,Vaculova T,Silaghi C,Overzier E,Konrad R,Kolenčík S,Derdakova M,Sing A,Schaub GA,Margos G,Fingerle V

    更新日期:2016-02-01 00:00:00

  • A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis.

    abstract:PURPOSE:The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. METHODS:From Ja...


    pub_type: 杂志文章


    authors: Smids C,Kouijzer IJ,Vos FJ,Sprong T,Hosman AJ,de Rooy JW,Aarntzen EH,de Geus-Oei LF,Oyen WJ,Bleeker-Rovers CP

    更新日期:2017-02-01 00:00:00