A review on anti-adhesion therapies of bacterial diseases.

Abstract:

BACKGROUND:Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies. METHODS:All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines. RESULTS:Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases. CONCLUSION:Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.

journal_name

Infection

journal_title

Infection

authors

Asadi A,Razavi S,Talebi M,Gholami M

doi

10.1007/s15010-018-1222-5

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

13-23

issue

1

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-018-1222-5

journal_volume

47

pub_type

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