A review on anti-adhesion therapies of bacterial diseases.


BACKGROUND:Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies. METHODS:All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines. RESULTS:Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases. CONCLUSION:Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.






Asadi A,Razavi S,Talebi M,Gholami M




Has Abstract


2019-02-01 00:00:00














  • Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review.

    abstract:PURPOSE:There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS:We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment opt...


    pub_type: 杂志文章,评审


    authors: Chibabhai V,Nana T,Bosman N,Thomas T,Lowman W

    更新日期:2018-02-01 00:00:00

  • Prolonged antibiotic prophylaxis after thoracoabdominal esophagectomy does not reduce the risk of pneumonia in the first 30 days: a retrospective before-and-after analysis.

    abstract:PURPOSE:Thoracoabdominal esophageal resection for malignant disease is frequently associated with pulmonary infection. Whether prolonged antibiotic prophylaxis beyond a single perioperative dose is advantageous in preventing pulmonary infection after thoracoabdominal esophagectomy remains unclear. METHODS:In this retr...


    pub_type: 杂志文章


    authors: Hochreiter M,Uhling M,Sisic L,Bruckner T,Heininger A,Hohn A,Ott K,Schmidt T,Berger MM,Richter DC,Büchler M,Weigand MA,Busch CJ

    更新日期:2018-10-01 00:00:00

  • In vitro activity of clarithromycin and its 14-hydroxy-metabolite against 203 strains of Haemophilus influenzae.

    abstract::The in vitro activity of clarithromycin alone and in combination with its primary human metabolite, 14-hydroxy-clarithromycin, was determined against 203 strains of Haemophilus influenzae. Microdilution broth MICs and MBCs of both clarithromycin and 14-hydroxy-clarithromycin were determined. The clarithromycin MIC50 w...


    pub_type: 杂志文章


    authors: Bergeron MG,Bernier M,L'Ecuyer J

    更新日期:1992-05-01 00:00:00

  • Neopterin and beta 2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection.

    abstract::The great majority of individuals with human immunodeficiency virus type 1 (HIV-1) infection presents with no signs or symptoms, or only lymphadenopathy. To initiate prophylactic measures in time it is necessary to establish risk criteria. CD4+ cell counts are significant predictors. Supplementary methods to improve t...


    pub_type: 杂志文章,评审


    authors: Fuchs D,Krämer A,Reibnegger G,Werner ER,Dierich MP,Goedert JJ,Wachter H

    更新日期:1991-01-01 00:00:00

  • The elimination of gentamicin-resistant gram-negative bacteria in a newborn intensive care unit.

    abstract::The aminoglycosides play a central role in the treatment of infectious diseases caused by gram-negative bacteria. During the period of January to June 1984, 45 clinical specimens collected in our neonatal intensive care unit grew Enterobacter cloacae; 41 of them were gentamicin resistant. One neonate developed septice...


    pub_type: 杂志文章


    authors: Raz R,Sharir R,Shmilowitz L,Kenes I,Ephros M

    更新日期:1987-01-01 00:00:00

  • Cefodizime given once daily for the treatment of upper urinary tract infections and complicated lower urinary tract infections.

    abstract::The efficacy of cefodizime (CDZ) in upper urinary tract infections (UUTI) and complicated lower urinary tract infections (LUTI) was assessed by analysis of the combined results of five clinical trials. Doses of CDZ 1 g i.m. daily, 1 x 2 g i.v. or i.m. and 2 x 2 g i.v. were investigated; comparative agents were cefurox...


    pub_type: 杂志文章


    authors: Hofstetter AG

    更新日期:1992-01-01 00:00:00

  • The optimal management of lower urinary tract infections.

    abstract::Lower urinary tract infection is a common problem for women, and tends to be recurrent. It is not associated with significant long term morbidity. Optimal management for symptomatic infection is short course antimicrobial therapy. For women with frequent, symptomatic, recurrent infection a number of therapeutic option...


    pub_type: 杂志文章,评审


    authors: Nicolle LE

    更新日期:1990-01-01 00:00:00

  • Serum and sputum antibiotic levels after ampicillin, amoxycillin and bacampicillin chronic bronchitis patients.

    abstract::Serum and sputum concentrations of ampicillin or amoxycillin were measured in patients admitted to hospital for acute exacerbations of chronic bronchitis with purulent sputum. Mean peak serum levels of nearly 12 mg/l were found after 1600 mg bacampicillin (mean peak level in sputum 0.85 mg/l). The serum and sputum con...


    pub_type: 杂志文章


    authors: Davies B,Maesen F

    更新日期:1979-01-01 00:00:00

  • Using the kinetics of C-reactive protein response to improve the differential diagnosis between acute bacterial and viral infections.

    abstract:PURPOSE:Differential diagnosis between acute viral and bacterial infection is an emerging common challenge for a physician in the emergency department. Serum C-reactive protein (CRP) is used to support diagnosis of bacterial infection, but in patients admitted with low CRP, its ability to discriminate between viral and...


    pub_type: 杂志文章


    authors: Coster D,Wasserman A,Fisher E,Rogowski O,Zeltser D,Shapira I,Bernstein D,Meilik A,Raykhshtat E,Halpern P,Berliner S,Shenhar-Tsarfaty S,Shamir R

    更新日期:2020-04-01 00:00:00

  • Non-typeable Haemophilus influenzae-associated early pregnancy loss: an emerging neonatal and maternal pathogen.

    abstract:OBJECTIVES:There is increasing evidence indicating an association between invasive non-typeable Haemophilus influenzae (NTHi) infection in pregnancy and early pregnancy loss. As the diagnosis relies on microbiological investigation of post-mortem placental and foetal samples, a significant proportion of NTHi-related pr...


    pub_type: 杂志文章


    authors: Cevik M,Moncayo-Nieto OL,Evans MJ

    更新日期:2020-04-01 00:00:00

  • Women facing HIV. Key question on women with HIV infection: Italian consensus workshop.

    abstract::A panel of leading Italian specialists in infectious diseases, obstetrics and gynaecology met in a national consensus workshop on women facing HIV to review critical aspects and discuss recommendations for selected key questions on four issues: (1) women and highly active antiretroviral therapy (HAART): access to care...


    pub_type: 共识发展会议,杂志文章


    authors: Carosi G,Nasta P,Fiore S,Matteelli A,Cauda R,Ferrazzi E,Tamburrini E,Savasi V,Bini T,Ravizza M,Bucceri A,Vichi F,Murri R,Mazzotta F,d'Arminio Monforte A,Italian Working Group for the Women with HIV Management Guidelines.

    更新日期:2009-04-01 00:00:00

  • Nosocomial infections in HIV-positive patients: an overview.

    abstract::Nosocomial infections (NIs) constitute a significant public health problem and contribute to prolonged hospitalization, additional healthcare costs and excess morbidity and mortality. NIs appear to be more common in patients with acquired immunodeficiency syndrome (AIDS) as a result of some degree of immunosuppression...


    pub_type: 杂志文章,评审


    authors: Petrosillo N,Pagani L,Ippolito G,Gruppo HIV e Infezioni Ospedaliere.

    更新日期:2003-12-01 00:00:00

  • The penetration of erythromycin into Waldeyer's ring--tonsil and adenoid tissue.

    abstract::Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (...


    pub_type: 杂志文章


    authors: Sundberg L,Edén T,Ernstson S

    更新日期:1982-01-01 00:00:00

  • Interaction between levothyroxine and indinavir in a patient with HIV infection.

    abstract::Drug interactions are an important and emerging problem in the treatment of HIV-infected patients. Protease inhibitors, like nonnucleoside reverse transcriptase inhibitors, are metabolized by the cytochrome P-450 enzyme system and each of these antiretroviral agents may interact with other drugs metabolized by this sy...


    pub_type: 信件


    authors: Lanzafame M,Trevenzoli M,Faggian F,Marcati P,Gatti F,Carolo G,Concia E

    更新日期:2002-01-01 00:00:00

  • Practices, organisation, and regulatory aspects in advising on antibiotic prescription: the international ESCMID AntibioLegalMap survey.

    abstract:PURPOSE:Giving advice about antibiotic prescription through dedicated consultations is a cornerstone of antibiotic stewardship programmes. Our objective was to explore practices, organisation, and regulatory requirements related to antibiotic advising. METHODS:We performed an international, exploratory, Internet-based...


    pub_type: 杂志文章


    authors: Tebano G,Dyar OJ,Beovic B,Claudot F,Béraud G,Thilly N,Pulcini C,European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Antimicrobial stewardshiP (ESGAP).

    更新日期:2019-10-01 00:00:00

  • Urine bactericidal activity of pefloxacin versus norfloxacin in healthy female volunteers after a single 800-mg oral dose.

    abstract::In an open randomised crossover study the antibacterial activity of pefloxacin and norfloxacin was assessed in the urine after a single 800-mg oral dose in 14 healthy female volunteers. Pefloxacin demonstrated lower peak concentrations in the urine than norfloxacin (mean, 217.2 mg/l versus 492.9 mg/l as determined by ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hofbauer H,Naber KG,Kinzig-Schippers M,Sörgel F,Rustige-Wiedemann C,Wiedemann B,Reiz A,Kresken M

    更新日期:1997-03-01 00:00:00

  • Early experience with remdesivir in SARS-CoV-2 pneumonia.

    abstract::At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200 mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously ...


    pub_type: 杂志文章


    authors: Durante-Mangoni E,Andini R,Bertolino L,Mele F,Florio LL,Murino P,Corcione A,Zampino R

    更新日期:2020-10-01 00:00:00

  • Ventriculitis caused by Klebsiella pneumoniae successfully treated with pefloxacin in a neonate.

    abstract::Pefloxacin was applied to a newborn suffering from ventriculitis caused by Klebsiella pneumoniae after failure of routine antibiotics. Treatment was successful. Blood and CSF levels were high, thus documenting good CSF penetration. In addition to this case report, a review of the literature regarding seven neonates wi...


    pub_type: 杂志文章,评审


    authors: Linder N,Dagan R,Kuint J,Keler N,Keren G,Reichman B

    更新日期:1994-05-01 00:00:00

  • Treatment of recurrent Clostridium difficile infection: a systematic review.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) recurs in nearly one-third of patients who develop an initial infection. Recurrent CDI (RCDI) is associated with considerable morbidity, mortality, and cost. Treatment for RCDI has not been not well examined. METHODS:A systematic review. RESULTS:Sixty-four articles wer...


    pub_type: 杂志文章,评审


    authors: O'Horo JC,Jindai K,Kunzer B,Safdar N

    更新日期:2014-02-01 00:00:00

  • Late-onset cytomegalovirus infection complicated by Guillain-Barre syndrome in a kidney transplant recipient: case report and review of the literature.

    abstract::Cytomegalovirus (CMV) infection remains a common infection after solid-organ transplantation. In the general population CMV disease is associated with Guillain-Barre syndrome (GBS), an autoimmune disease leading to an acute peripheral neuropathy, in 1 of 1000 cases. Interestingly, GBS is a rarely observed complication...


    pub_type: 杂志文章,评审


    authors: Shaban E,Gohh R,Knoll BM

    更新日期:2016-04-01 00:00:00

  • Serum levels of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), its soluble receptor sIL-1RII and C-reactive protein (CRP) in patients with Lyme arthritis.

    abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...


    pub_type: 杂志文章


    authors: Pietruczuk A,Swierzbińska R,Pancewicz S,Pietruczuk M,Hermanowska-Szpakowicz T

    更新日期:2006-06-01 00:00:00

  • An outbreak of rubella aboard a ship of the German Navy.

    abstract:BACKGROUND:During May and June 1996, an outbreak of rubella occurred offshore aboard a ship of the German Navy. The outbreak spread among 330 crew members over a period of 9 weeks, ending 2 days after the ship's return. This is the first detailed epidemiological investigation of a rubella outbreak on a ship, describing...


    pub_type: 杂志文章


    authors: Ziebold C,Hassenpflug B,Wegner-Bröse H,Wegner K,Schmitt HJ

    更新日期:2003-06-01 00:00:00

  • Candidemia in intensive care unit patients: risk factors for mortality.

    abstract::Aim of this study was to evaluate whether risk factors which predict the development of candidemia may also predict death in ICU patients with candidemia. During an 8-year-period all ICU patients whose blood cultures yielded Candida species (n = 40) were retrospectively evaluated in a case-control fashion. The average...


    pub_type: 杂志文章


    authors: Voss A,le Noble JL,Verduyn Lunel FM,Foudraine NA,Meis JF

    更新日期:1997-01-01 00:00:00

  • Bacterial meningitis in infants and children.

    abstract::Bacterial meningitis of infants and children exact a major toll worldwide. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis continue to be the major causes, and efforts to reduce the incidence of this disease have had limited success. Major advances in rapid diagnosis, such as antigen detect...


    pub_type: 杂志文章,评审


    authors: Marks MI

    更新日期:1984-01-01 00:00:00

  • Prevalence of anti-HCV and risk factors for hepatitis C virus infection in healthy pregnant women.

    abstract::The prevalence of anti-HCV antibodies and the risk factors for HCV infection were assessed in 5,672 pregnant women living in North Italy. All reactive sera were confirmed by RIBA-2 test. Anti-HCV positive pregnant women together with an anti-HCV negative control group, were interviewed by standardised questionnaire to...


    pub_type: 杂志文章


    authors: Marranconi F,Fabris P,Stecca C,Zampieri L,Bettini MC,Di Fabrizio N,de Lalla F

    更新日期:1994-09-01 00:00:00

  • Release of TNF alpha and IL6 from human monocytes infected with Mycobacterium kansasii: a comparison to Mycobacterium avium.

    abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of B-lymphocytes. Mycobacterium avium has been shown to stimulate the release of TNF alpha and IL6 fro...


    pub_type: 杂志文章


    authors: Stauffer F,Petrow EP,Burgmann H,Graninger W,Georgopoulos A

    更新日期:1994-09-01 00:00:00

  • Controversies in the therapeutic approach to congenital cytomegalovirus infection.

    abstract::Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these child...


    pub_type: 杂志文章


    authors: Garrido-Barbero M,Arnaez J,Garcia-Alix A

    更新日期:2020-06-01 00:00:00

  • The significance of the HBeAg/anti-HBe system in hemodialysis patients. A multicenter study.

    abstract::The HBeAg/anti-HBe system was studied as a marker of infectivity and chronic progressive liver disease in 460 hemodialysis patients. The importance of HBeAg as an index of infectivity was confirmed in that it was present simultaneously with specific DNA polymerase (31 patients) and by the presence of widely diffuse co...


    pub_type: 杂志文章


    authors: Fiaccadori F,David S,Faggion G,Feriani N,Ferrari C,Franco V,Giuberti T,Grutta D'Auria C,La Greca G,Magnani G

    更新日期:1984-01-01 00:00:00

  • Hepatitis agents with enteric transmission--an epidemiological analysis.

    abstract:BACKGROUND:Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jau...


    pub_type: 杂志文章


    authors: Yayli G,Kiliç S,Ormeci AR

    更新日期:2002-12-01 00:00:00

  • Management of a Mycobacterium immunogenum infection of a peritoneal dialysis catheter site.

    abstract::Mycobacterium immunogenum is a member of the rapidly growing non-tuberculous mycobacteria and is a relatively new species identified within this group. An 81-year-old immune-competent male was diagnosed with M. immunogenum infection of his peritoneal dialysis catheter exit site and surrounding soft tissue. To our know...


    pub_type: 杂志文章


    authors: Shenoy A,El-Nahal W,Walker M,Chopra T,Townsend G,Heysell S,Eby J

    更新日期:2018-12-01 00:00:00