Thrombotic microangiopathies and HIV infection: report of two typical cases, features of HUS and TTP, and review of the literature.

Abstract:

:Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies increasingly reported in patients with HIV infection. However, characteristic features of thrombotic microangiopathies associated with HIV disease have not been defined yet. The typical courses of HUS and TTP in two patients are presented. The data as well as the analysis of cases published in the literature demonstrate the association of thrombotic microangiopathies with late-stage HIV disease. Moreover, differences between HUS and TTP can be detected. Patients with HUS present with more severe immunologic deterioration. Although clinical symptoms are fewer, HUS implicates a very poor prognosis. Life expectancy rarely exceeded 1 year after diagnosis. HUS and TTP should therefore be added to the international AIDS classification.

journal_name

Infection

journal_title

Infection

authors

Sutor GC,Schmidt RE,Albrecht H

doi

10.1007/BF02565164

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

12-5

issue

1

eissn

0300-8126

issn

1439-0973

journal_volume

27

pub_type

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