Efficacy and local tolerability of povidone iodine and octenidine hydrochloride solution for the antiseptic preparation of the orificium urethrae.

Abstract:

:In a randomized clinical study, 61 hospitalized men were examined to test the local tolerability and antimicrobial efficacy of antiseptic treatment of the genitals with povidone iodine versus octenidine hydrochloride solution. Antibacterial efficacy was established by comparing the total aerobic bacterial colony count from standardized swabs from the orificium urethrae externum before, immediately after, and 30 and 60 min after antisepsis. Tolerability was assessed by dermatoscopy, applying a scale to rate the criteria of reddening, erosions and microbleeding. pH-value was taken and the nitracin yellow test carried out at several intervals. Patients assessed sensations (itching, burning, warmth, cold tension) in visual analogue scales. The test for equivalence in efficacy of both antiseptic agents produced no significant result (P = 0.3). The sum score of tolerability produced a better result for povidone iodine. In addition, the drop in the pH value after observed antisepsis with povidone iodine provides an additional protective mechanism against bacterial colonization.

journal_name

Infection

journal_title

Infection

authors

Rudolph P,Fritze F,Reimer K,Klebingat KJ,Kramer A

doi

10.1007/BF02560508

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

108-13

issue

2

eissn

0300-8126

issn

1439-0973

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 已发布勘误

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    pub_type: 杂志文章

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