Abstract:
:We describe a 66-year-old woman hospitalized with fever, fatigue and hepatopathy. In her medical history arterial hypertension (treated with propranolol and lisinopril), diabetes mellitus type 2 (no treatment before admission) and a gout arthropathy were noted wherefore a therapy with allopurinol 300 mg per day has been started 4 months before. Liver biopsy revealed fibrin-ring granulomas, compatible with allopurinol-induced hepatitis. Because of persistence of high fever after stopping allopurinol, steroids (1 mg/kg) were started. Under this treatment, she developed pancytopenia and fever. The bone marrow aspiration revealed Leishmania infantum. A second liver biopsy showed amastigotes and a disappearance of the granulomas. The history revealed a travel to Malta 2 years earlier. Despite adequate treatment with liposomal amphotericin B the patient deteriorated and finally died in septic shock.
journal_name
Infectionjournal_title
Infectionauthors
Khanlari B,Bodmer M,Terracciano L,Heim MH,Fluckiger U,Weisser Mdoi
10.1007/s15010-007-6365-8subject
Has Abstractpub_date
2008-08-01 00:00:00pages
381-3issue
4eissn
0300-8126issn
1439-0973journal_volume
36pub_type
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