Pharmacological properties of cephalosporins.

Abstract:

:The cephalosporins differ in the substituents attached at the 3 and/or 7 positions of the molecule. Very schematically, substitution at C3 mainly modifies the overall pharmacokinetic properties whereas substitution at position 7 influences the antibacterial characteristics. When using the more common "generation" system for classification, three generations can be distinguished on the basis of their antibacterial spectrum, potency, and their stability to beta-lactamases. The first generation cephalosporins have similar antibacterial and pharmacokinetic characteristics. C3-esterified cephalosporins (e.g. cephalothin and cephapirin) are significantly metabolized. The so-called second generation cephalosporins exhibit only minor differences with respect to the pharmacokinetic properties in contrast to the third generation cephalosporins. The apparent volumes of distribution of most cephalosporins range between seven and 20 1, indicating that they mainly stay in the extracellular space. Plasma protein binding is variable from compound to compound. Generally, the major route of elimination of most cephalosporins is via the kidney except for cefoperazone and ceftriaxone which are both excreted to a large extent by the biliary route. With the exception of cefonicid, cefotetan and cefriaxone, which have longer elimination half-lives (i.e. 4.5, 3.5 and around eight hours), all other cephalosporins have a half-life ranging from 0.5 to 2.5 hours. The pattern of adverse reactions is comparable for all the cephalosporins although there are slight differences in both the incidence and the type of reactions. The major categories of adverse reactions are gastrointestinal, dermatologic, hypersensitivity, haematologic, hepatic, renal as well as CNS effects. Alcohol intolerance (antabus-like effect) can occur when cephalosporins containing the NMTT moiety are administered concomitantly.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Infection

journal_title

Infection

authors

Christ W

doi

10.1007/BF01645535

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

S244-52

eissn

0300-8126

issn

1439-0973

journal_volume

19 Suppl 5

pub_type

杂志文章,评审
  • Catheter-associated infections in urology: possible use of silver-impregnated catheters and the Erlanger silver catheter.

    abstract::Indwelling urinary catheters play a very important part in urology. However, their use is accompanied by a considerable increase in the risk of nosocomial urinary tract infections. The pathophysiological cause is ascribed to pathogens that adhere to the catheter surface, proliferate and produce a biofilm. In addition ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF02561624

    authors: Rösch W,Lugauer S

    更新日期:1999-01-01 00:00:00

  • Bactericidal activity of ciprofloxacin, norfloxacin and ofloxacin in serum and urine after oral administration to healthy volunteers.

    abstract::A 200 mg oral dose of ciprofloxacin, norfloxacin or ofloxacin was administered to six healthy male volunteers in a three way cross-over study in order to examine the kinetics in humans in relation to the bactericidal activity in serum and urine. Serum concentrations for ciprofloxacin were similar to norfloxacin and lo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650502

    authors: Zeiler HJ,Beermann D,Wingender W,Förster D,Schacht P

    更新日期:1988-01-01 00:00:00

  • Cefotaxime: efficacy and tolerance in lower respiratory tract infections caused by gram-positive cocci.

    abstract::Cefotaxime is an effective antibiotic in lower respiratory tract infection caused by streptococci and staphylococci. There is a limited tendency to superinfections with Pseudomonas aeruginosa (1.5%) and there is a low incidence of side-effects. It is questionable whether there is really an urgent need for cefotaxime i...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644213

    authors: Lode H,Glatzel PD

    更新日期:1985-01-01 00:00:00

  • Clinical significance of changes of flora in the upper digestive tract.

    abstract::Dysbiosis does not necessarily mean disease. Typical clinical picture of disease caused by metabolic activity of dysbiotic microflora is the microbial over-growth syndrome. We studied case histories of 434 patients without consideration of their basic illnesses and correlated them with types of dysbioses of duodenal j...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639535

    authors: Knoke M,Bernhardt H

    更新日期:1989-07-01 00:00:00

  • Urine bactericidal activity of pefloxacin versus norfloxacin in healthy female volunteers after a single 800-mg oral dose.

    abstract::In an open randomised crossover study the antibacterial activity of pefloxacin and norfloxacin was assessed in the urine after a single 800-mg oral dose in 14 healthy female volunteers. Pefloxacin demonstrated lower peak concentrations in the urine than norfloxacin (mean, 217.2 mg/l versus 492.9 mg/l as determined by ...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02113592

    authors: Hofbauer H,Naber KG,Kinzig-Schippers M,Sörgel F,Rustige-Wiedemann C,Wiedemann B,Reiz A,Kresken M

    更新日期:1997-03-01 00:00:00

  • Late-onset cytomegalovirus infection complicated by Guillain-Barre syndrome in a kidney transplant recipient: case report and review of the literature.

    abstract::Cytomegalovirus (CMV) infection remains a common infection after solid-organ transplantation. In the general population CMV disease is associated with Guillain-Barre syndrome (GBS), an autoimmune disease leading to an acute peripheral neuropathy, in 1 of 1000 cases. Interestingly, GBS is a rarely observed complication...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-015-0819-1

    authors: Shaban E,Gohh R,Knoll BM

    更新日期:2016-04-01 00:00:00

  • Hospital at home for the management of COVID-19: preliminary experience with 63 patients.

    abstract::Alternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and effi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01527-z

    authors: Pericàs JM,Cucchiari D,Torrallardona-Murphy O,Calvo J,Serralabós J,Alvés E,Agelet A,Hidalgo J,Alves E,Castells E,Seijas N,Hernández C,Bodro M,Cardozo C,Coloma E,Nicolás D,Hospital Clínic 4H Team (Hospital at Home-Health H

    更新日期:2020-09-29 00:00:00

  • Subacute invasive pulmonary aspergillosis as a rare cause of pneumothorax in immunocompetent patient: brief report.

    abstract::Subacute invasive pulmonary aspergillosis (IPA) represents a form of chronic pulmonary aspergillosis which affects immunocompetent individuals or mildly immunocompromised persons with underlying pulmonary disease. Pneumothorax can be a rare complication of subacute IPA due to a leakage of air from an air-filled lung c...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-0994-3

    authors: Vukicevic TA,Dudvarski-Ilic A,Zugic V,Stevanovic G,Rubino S,Barac A

    更新日期:2017-06-01 00:00:00

  • Effectiveness of a multidimensional approach for prevention of ventilator-associated pneumonia in 11 adult intensive care units from 10 cities of Turkey: findings of the International Nosocomial Infection Control Consortium (INICC).

    abstract:PURPOSE:To evaluate the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach on the reduction of ventilator-associated pneumonia (VAP) in adult patients hospitalized in 11 intensive care units (ICUs), from 10 hospitals, members of the INICC, in 10 cities of Turkey. METH...

    journal_title:Infection

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s15010-013-0407-1

    authors: Leblebicioglu H,Yalcin AN,Rosenthal VD,Koksal I,Sirmatel F,Unal S,Turgut H,Ozdemir D,Ersoz G,Uzun C,Ulusoy S,Esen S,Ulger F,Dilek A,Yilmaz H,Turhan O,Gunay N,Gumus E,Dursun O,Yýlmaz G,Kaya S,Ulusoy H,Cengiz M

    更新日期:2013-04-01 00:00:00

  • Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center.

    abstract:PURPOSE:No reports have been published on synchronous multifocal necrotizing fasciitis (SMNF), a multifocal presence of necrotizing fasciitis in different extremities. We evaluated the clinical characteristics and outcomes of SMNF. METHODS:Eighteen patients (14 men, 4 women; mean age: 59 years) diagnosed with SMNF of ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0932-9

    authors: Lee CY,Li YY,Huang TW,Huang TY,Hsu WH,Tsai YH,Huang JC,Huang KC

    更新日期:2016-12-01 00:00:00

  • Prevalence of hepatitis B virus markers among Polish urban alcoholics.

    abstract::124 consecutive patients (mean age: 41.1 years; range: 20-63 years) attending an outpatient alcoholic clinic were tested for the presence of markers of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), thes...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644546

    authors: Laskus T,Lupa E,Szczutowska E,Babiuch L

    更新日期:1988-01-01 00:00:00

  • In-vitro susceptibility of cefoperazone-susceptible and -resistant gram-negative rods to cefoperazone plus sulbactam, other beta-lactams, aminoglycosides and quinolone.

    abstract::We compared the in-vitro activity of cefoperazone-sulbactam (2:1), other beta-lactams, amino-glycosides and ciprofloxacin against cefoperazone-susceptible and -resistant nosocomial gram-negative bacilli. Resistant isolates including Pseudomonas aeruginosa were susceptible to cefoperazone-sulbactam; the susceptible iso...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643761

    authors: Chandrasekar PH,Sluchak JA

    更新日期:1991-01-01 00:00:00

  • [Mezlocillin in the antibiotic therapy of severe bacterial infections in visceral surgery].

    abstract::Fifty-six patients suffering from severe and very severe bacterial infections received additional antibacterial treatment with mezlocillin following abdominal or chest surgery. There were 18 intestinal-peritoneal infections, 15 pleuropulmonary infections, seven patients with sepsis, six localized abscesses and ten pat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640656

    authors: Amgwerd R,Rauh G,Sonnabend W

    更新日期:1982-01-01 00:00:00

  • Effect of pH on the in vitro activity of and propensity for emergence of resistance to fluoroquinolones, macrolides, and a ketolide.

    abstract::Antibiotic activity against common respiratory pathogens can be affected by the pH of the medium (in vitro) or the bodily fluid (in vivo) in which bacteria are present. The ionized fraction of an antibiotic is not able to efficiently penetrate bacterial or mammalian membranes, reducing the quantity of molecules able t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-8206-y

    authors: Dalhoff A,Schubert S,Ullmann U

    更新日期:2005-12-01 00:00:00

  • Incidence of Helicobacter pylori infection in a cohort of Italian military students.

    abstract::Prevalence and incidence of Helicobacter pylori infection among 250 Italian military students were studied using specific IgG antibodies. Subjects susceptible at enrollment were evaluated during a 10-month follow-up period, when two serum samples were collected after 5 and 10 months, respectively. Samples were also an...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02561526

    authors: Biselli R,Fortini M,Matricardi PM,Stroffolini T,D'Amelio R

    更新日期:1999-05-01 00:00:00

  • Immunoglobulin prophylaxis against hepatitis A among Swedish UN soldiers in an endemic region.

    abstract::Six hundred and fifteen Swedish soldiers (X = 24.9 years) serving with the UN forces in Cyprus were tested for antibody against hepatitis A (anti-HAV) before and after six months' service. Before the service, a high susceptibility to hepatitis A was found, as only 2.3% (14/615) had anti-HAV. In comparison, the prevale...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01648930

    authors: Weiland O,Berg JV,Bäck E,Lundbergh P

    更新日期:1979-01-01 00:00:00

  • Pneumocystis carinii pneumonia in HIV-negative patients with haematologic disease.

    abstract::Since 1990, Pneumocystis carinii pneumonia (PCP) was diagnosed in 15 adult HIV-negative haematologic patients in our hospital. None of them had received PCP prophylaxis. All except one had been treated with prednisone. Symptoms usually started after stopping or tapering. In six patients the diagnosis of PCP was delaye...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02113579

    authors: van der Lelie J,Venema D,Kuijper EJ,van Steenwijk RP,van Oers MH,Thomas LL,von dem Borne AE

    更新日期:1997-03-01 00:00:00

  • Serum immunoglobulin levels in hepatitis non-A, non-B: a comparison with hepatitis A and B.

    abstract::The serum levels of IgA, IgG and IgM were determined by the single radial immunodiffusion method in 86 patients with acute viral hepatitis serologically differentiated by radioimmunoassays. The levels of IgA and IgG were similar in patients with hepatitis A, B and non-A, non-B, while differences in IgM levels were obs...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641470

    authors: Norkrans G,Nilsson LA,Frösner G,Wahl M,Iwarson S

    更新日期:1980-01-01 00:00:00

  • Outpatient parenteral antimicrobial therapy and antibiotic stewardship: opponents or teammates?

    abstract:PURPOSE:This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS:After a literature review, five authors determined the barriers and facilitators to...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-018-1250-1

    authors: Steffens E,Quintens C,Derdelinckx I,Peetermans WE,Van Eldere J,Spriet I,Schuermans A

    更新日期:2019-04-01 00:00:00

  • Automated ribotyping and pulsed-field gel electrophoresis reveal a cluster of group A streptococci in intravenous drug abusers.

    abstract:BACKGROUND:In 1998, an unexpected increase of group A streptococci (GAS) in blood cultures was observed at our institution. MATERIALS AND METHODS:To determine whether they were from unrelated sporadic cases or attributable to a common source, all isolates were analyzed by pulsed-field gel electrophoresis (PFGE) and by...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100070026

    authors: Brunner S,Fleisch F,Ruef C,Altwegg M

    更新日期:2000-09-01 00:00:00

  • Guidelines for medical research in children.

    abstract::Nearly everyone agrees that violations in research occur. Nobody knows how often. But if Pediatrics is to progress children must be the subjects of research carried out in an acceptable way. The following guidelines should be followed in childhood experimentation: (1) Research should not be done on children if the sam...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01645562

    authors: Papadatos CJ

    更新日期:1989-11-01 00:00:00

  • [Microbiological diagnosis of septicemia].

    abstract::To detect microorganisms in the blood it is necessary not only that the microbiologist uses reliable methods, but also that the clinician takes a sufficient number of blood samples at the right point in time using a correct method for drawing the blood. The best results are obtained if the blood sample is transferred ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639113

    authors: Rotter M

    更新日期:1977-03-01 00:00:00

  • Safety and immunogenicity of an inactivated hepatitis A vaccine in children 2 to 5 years old.

    abstract::The reactogenicity and immunogenicity of an inactivated hepatitis A vaccine were assessed. Seventy healthy children aged between 2 and 5 years old, who lacked antibodies against the hepatitis A virus, were enrolled in this study. With a 0-, 1-, and 6-month vaccination schedule, the children received three doses of 360...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01716302

    authors: Arístegui J,Morales JL,Dal-Ré R,González A,Gallego MS,Garrote E

    更新日期:1995-09-01 00:00:00

  • Seroprevalence of Chlamydia pneumoniae antibodies in a young adult population sample living in Verona. European Community Respiratory Health Survey (ECRHS) Verona.

    abstract:UNLABELLED:The aim of the study was to evaluate the prevalence of antibodies to Chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in Verona, Italy. IgG and IgM titers were measured by micro-immunofluorescence. IgG antibodies, greater or equal to 16, were found in 104/177 ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050009

    authors: Ferrari M,Poli A,Olivieri M,Tardivo S,Biasin C,Balestreri F,Dal Molin G,Lo Cascio V,Campello C

    更新日期:2000-01-01 00:00:00

  • Surgical Site Infections after glioblastoma surgery: results of a multicentric retrospective study.

    abstract:BACKGROUND:The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients. METHODS:Data from SSI cases after glioblastoma surgeries between 2009 and...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01534-0

    authors: Salle H,Deluche E,Couvé-Deacon E,Beaujeux AC,Pallud J,Roux A,Dagain A,de Barros A,Voirin J,Seizeur R,Belmabrouk H,Lemnos L,Emery E,Fotso MJ,Engelhardt J,Jecko V,Zemmoura I,Le Van T,Berhouma M,Cebula H,Peyre M,Pr

    更新日期:2020-10-09 00:00:00

  • Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis.

    abstract:BACKGROUND:The diagnostic value of admission serum levels of procalcitonin (PCT) and C-reactive protein (CRP) as indicators of the etiology and prognosis was prospectively investigated. PATIENTS:96 patients, 50-85 years of age, treated in the hospital for community-acquired pneumonia (CAP). RESULTS:On admission, all ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050049

    authors: Hedlund J,Hansson LO

    更新日期:2000-03-01 00:00:00

  • Transintestinal elimination of ciprofloxacin in humans--concomitant assessment of its metabolites in serum, ileum and colon.

    abstract::Ciprofloxacin (200 mg) was infused to seven patients at the beginning of elective colorectal surgery. Thirty minutes after the end of infusion (i.e. 60 min after the start of the operation) ciprofloxacin reached concentrations of 1.60 mg/l in serum and of 3.42-6.07 mg/kg fresh weight in the ileum and colon. During the...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710676

    authors: Viell B,Krause B,Vestweber KH,Schaaf S,Scholl H

    更新日期:1992-11-01 00:00:00

  • Non-fermentative Gram-negative rods bacteremia in children with cancer: a 14-year single-center experience.

    abstract:PURPOSE:Data on non-fermentative Gram-negative rods (NFGNR) bacteremia in children with malignancies are limited. The aim of this study was to present clinical picture, antimicrobial susceptibility pattern, risk factors for resistance and outcome in NFGNR bacteremia in children with cancer. METHODS:All episodes of NFG...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-0988-1

    authors: Averbuch D,Avaky C,Harit M,Stepensky P,Fried I,Ben-Ami T,Temper V,Peled Y,Troen H,Masarwa R,Abu Ahmad W,Weintraub M,Revel-Vilk S,Engelhard D

    更新日期:2017-06-01 00:00:00

  • Neopterin and beta 2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection.

    abstract::The great majority of individuals with human immunodeficiency virus type 1 (HIV-1) infection presents with no signs or symptoms, or only lymphadenopathy. To initiate prophylactic measures in time it is necessary to establish risk criteria. CD4+ cell counts are significant predictors. Supplementary methods to improve t...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01644476

    authors: Fuchs D,Krämer A,Reibnegger G,Werner ER,Dierich MP,Goedert JJ,Wachter H

    更新日期:1991-01-01 00:00:00

  • Pulmonary edema due to Plasmodium vivax malaria in an American missionary.

    abstract::Pulmonary edema is a recognized complication of Plasmodium falciparum malaria but is uncommon with Plasmodium vivax infection. We report the case of a non-immune adult with imported P. vivax malaria who developed pulmonary edema during treatment. The case was further complicated by a recurrent malaria episode after fa...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6108-x

    authors: Illamperuma C,Allen BL

    更新日期:2007-10-01 00:00:00