Guidelines for medical research in children.

Abstract:

:Nearly everyone agrees that violations in research occur. Nobody knows how often. But if Pediatrics is to progress children must be the subjects of research carried out in an acceptable way. The following guidelines should be followed in childhood experimentation: (1) Research should not be done on children if the same investigation can be done in adults. (2) All research projects must be evaluated by ethics committees having as members lay people and investigators possessing the qualities of competence and judgement. (3) The degree of benefit from a research procedure should be assessed against the risk of disturbance, discomfort or pain. (4) Statements regarding consent are meaningless and consent is still only partially informed. Although a parental signature does not mean that consent is informed, nevertheless parental consent must still remain as a key requirement in childhood experimentation.

journal_name

Infection

journal_title

Infection

authors

Papadatos CJ

doi

10.1007/BF01645562

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

411-7

issue

6

eissn

0300-8126

issn

1439-0973

journal_volume

17

pub_type

杂志文章,评审
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    abstract::Prevalence and incidence of Helicobacter pylori infection among 250 Italian military students were studied using specific IgG antibodies. Subjects susceptible at enrollment were evaluated during a 10-month follow-up period, when two serum samples were collected after 5 and 10 months, respectively. Samples were also an...

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    doi:10.1007/BF02561526

    authors: Biselli R,Fortini M,Matricardi PM,Stroffolini T,D'Amelio R

    更新日期:1999-05-01 00:00:00

  • Socioeconomic impact on device-associated infections in limited-resource neonatal intensive care units: findings of the INICC.

    abstract:PURPOSE:To evaluate the impact of country socioeconomic status and hospital type on device-associated healthcare-associated infections (DA-HAIs) in neonatal intensive care units (NICUs). METHODS:Data were collected on DA-HAIs from September 2003 to February 2010 on 13,251 patients in 30 NICUs in 15 countries. DA-HAIs ...

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    doi:10.1007/s15010-011-0136-2

    authors: Rosenthal VD,Lynch P,Jarvis WR,Khader IA,Richtmann R,Jaballah NB,Aygun C,Villamil-Gómez W,Dueñas L,Atencio-Espinoza T,Navoa-Ng JA,Pawar M,Sobreyra-Oropeza M,Barkat A,Mejía N,Yuet-Meng C,Apisarnthanarak A,International N

    更新日期:2011-10-01 00:00:00

  • IL-6 and TNF alpha release in association with neutrophil activation after cardiopulmonary bypass surgery.

    abstract::The serum IL-6 and TNF alpha response to cardiopulmonary bypass surgery was studied in 12 patients. Human neutrophil elastase was also measured in order to detect the presence of neutrophil activation. Peripheral venous blood samples were obtained before, during, and 1, 2, 3 and 6 days after surgery. Intra-operative s...

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    pub_type: 杂志文章

    doi:10.1007/BF01780764

    authors: Holzheimer RG,Molloy RG,Görlach H,Wilkert S,Hehrlein F

    更新日期:1994-01-01 00:00:00

  • Duration of posaconazole therapy for Aspergillus fumigatus osteomyelitis dictated by serial monitoring of 1,3-beta-D glucan.

    abstract::Here, we present a case of an immunocompetent 37-year old male who developed Aspergillus fumigatus osteomyelitis 16 years after extensive chest wall reconstructive surgery for Ewing sarcoma. His treatment course was complicated by a severe adverse drug reaction to voriconazole, requiring the use of oral posaconazole t...

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    doi:10.1007/s15010-020-01489-2

    authors: Doub JB,Mathur P

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  • Pharmacokinetics of ampicillin, sulbactam and cefotiam in patients undergoing orthopedic surgery.

    abstract::As perioperative prophylaxis for major orthopedic operations 81 patients were given the fixed combination of ampicillin (1 g)/sulbactam (0.5 g) or cefotiam (2 g) as short infusions. The three beta-lactams were rapidly distributed into the different tissues and their pharmacokinetic profiles were found to be very simil...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01713160

    authors: Wildfeuer A,Mallwitz J,Gotthardt H,Hille E,Gruber H,Dahmen G,Pfaff G,Göbel C

    更新日期:1997-07-01 00:00:00

  • Sporopachydermia cereana fungaemia in refractory leukaemia presenting as breakthrough infection during micafungin therapy.

    abstract::The Sporopachydermia cereana species lives in decaying stems of cactus and is exceptionally rare as a human pathogen. A 57-year-old man with therapy-refractory acute promyelocytic leukaemia developed severe neutropaenia. After about 3 weeks of micafungin used as prophylaxis, he developed high fever, multiple pulmonary...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0402-y

    authors: Chan TS,Hwang YY,To KK,Kwong YL

    更新日期:2013-06-01 00:00:00

  • Clindamycin-induced hypersensitivity reaction.

    abstract::Drug-induced anaphylaxis is an unpredictable adverse reaction. Although it may occur with any medication, antibiotics induce more cases of anaphylaxis than any other medication class with most cases being induced by β-lactam antibiotics. Clindamycin is an antibiotic with good gram-positive and anaerobe coverage which ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0826-2

    authors: Bulloch MN,Baccas JT,Arnold S

    更新日期:2016-06-01 00:00:00

  • Intestinal microsporidiosis in patients with acquired immunodeficiency syndrome--report of three more German cases.

    abstract::Intestinal microsporidiosis with Enterocytozoon bieneusi was diagnosed in three of 18 HIV-infected patients with chronic diarrhoea. In two cases all known stages of the life cycle of E. bieneusi (merogonial plasmodia, sporogonial plasmodia, sporoblasts, spores) were found in duodenal biopsies by electron microscopical...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01715501

    authors: Franzen C,Fätkenheuer G,Salzberger B,Müller A,Mahrle G,Diehl V,Schrappe M

    更新日期:1994-11-01 00:00:00

  • Correction to: Occult HBV infection in the oncohematological setting.

    abstract::The original version of this article unfortunately contained a mistake. ...

    journal_title:Infection

    pub_type: 已发布勘误

    doi:10.1007/s15010-020-01465-w

    authors: Sagnelli C,Macera M,Pisaturo M,Zampino R,Coppola N,Sagnelli E

    更新日期:2020-08-01 00:00:00

  • Low transmission rate of 2009 H1N1 Influenza during a long-distance bus trip.

    abstract:BACKGROUND:Current data on the risk of transmission of 2009 H1N1 Influenza in public transportation systems (e.g., public trains, busses, airplanes) are conflicting. The main transmission route of this virus is thought to be via droplets, but airborne transmission has not been completely ruled out. METHODS:This is a c...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0084-x

    authors: Piso RJ,Albrecht Y,Handschin P,Bassetti S

    更新日期:2011-04-01 00:00:00

  • A stringent preemptive protocol reduces cytomegalovirus disease in the first 6 months after kidney transplantation.

    abstract:BACKGROUND:The optimal strategy to prevent cytomegalovirus (CMV) disease after kidney transplantation continues to be open to debate. The preemptive approach requires regular determination of CMV viremia and prompt initiation of therapy. METHODS:We retrospectively compared the incidence of CMV disease during two perio...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0343-5

    authors: Greiner M,Cusini A,Ruesch M,Schiesser M,Ledergerber B,Fehr T,Mueller NJ

    更新日期:2012-12-01 00:00:00

  • The effects of ciprofloxacin on human chondrocytes in cell culture.

    abstract::Ciprofloxacin is a highly potent antibacterial agent that is used extensively in bone and joint infections. Because of reports of potential chondro-toxicity in animals, the effects of this drug on cells derived from human cartilage were tested in liquid micromass and agarose gel cultures. An inhibition of cell prolife...

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    pub_type: 杂志文章

    doi:10.1007/BF01713325

    authors: Mont MA,Mathur SK,Frondoza CG,Hungerford DS

    更新日期:1996-03-01 00:00:00

  • A comparison of the diagnostic value of MRI and 18F-FDG-PET/CT in suspected spondylodiscitis.

    abstract:PURPOSE:The purpose of this study was to evaluate the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing spondylodiscitis and its complications, such as epidural and paraspinal abscesses. METHODS:From Ja...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0914-y

    authors: Smids C,Kouijzer IJ,Vos FJ,Sprong T,Hosman AJ,de Rooy JW,Aarntzen EH,de Geus-Oei LF,Oyen WJ,Bleeker-Rovers CP

    更新日期:2017-02-01 00:00:00

  • Single and multiple dose pharmacokinetics of intravenous cefpirome (HR 810), a novel cephalosporin derivative.

    abstract::After intravenous injection of single doses of 1.0 g of cefpirome (HR 810) and multiple doses of 1.0 g b.i.d. for five days to the same ten healthy male volunteers in an open design, concentrations of unchanged drug were estimated at various times in serum and urine, over 24 h and 48 h, respectively. Cefpirome concent...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646053

    authors: Malerczyk V,Maass L,Verho M,Hajdú P,Klesel N,Rangoonwala R

    更新日期:1987-05-01 00:00:00

  • Using the kinetics of C-reactive protein response to improve the differential diagnosis between acute bacterial and viral infections.

    abstract:PURPOSE:Differential diagnosis between acute viral and bacterial infection is an emerging common challenge for a physician in the emergency department. Serum C-reactive protein (CRP) is used to support diagnosis of bacterial infection, but in patients admitted with low CRP, its ability to discriminate between viral and...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01383-6

    authors: Coster D,Wasserman A,Fisher E,Rogowski O,Zeltser D,Shapira I,Bernstein D,Meilik A,Raykhshtat E,Halpern P,Berliner S,Shenhar-Tsarfaty S,Shamir R

    更新日期:2020-04-01 00:00:00

  • Five cases of Plasmodium vivax malaria treated with artemisinin derivatives: the advantages of a unified approach to treatment.

    abstract:OBJECTIVES:In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01286-6

    authors: Corpolongo A,Pisapia R,Oliva A,Giancola ML,Mencarini P,Bevilacqua N,Ghirga P,Mariano A,Vulcano A,Paglia MG,Nicastri E

    更新日期:2019-08-01 00:00:00

  • Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease.

    abstract::Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filam...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0724-7

    authors: Shigemura T,Nakazawa Y,Amano Y,Sudo A,Watanabe M,Kobayashi M,Kobayashi N,Koike K,Agematsu K,Nishimura K

    更新日期:2015-06-01 00:00:00

  • Long-term seropositivity against Echinococcus multilocularis in an epidemiological follow-up study in southwestern Germany (Römerstein).

    abstract:BACKGROUND:Out of 2,560 participants in an epidemiological survey of alveolar echinococcosis (AE) performed in 1996 in southwestern Germany, 47 participants had tested seropositive in one of two crude antigen screening ELISAs and were inconspicuous on hepatic ultrasound. PATIENTS AND METHODS:Out of these 47 seroreacto...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1153-3

    authors: Jensen B,Reuter S,Kratzer W,Naser K,Kächele V,Kimmig P,Kern P

    更新日期:2001-12-01 00:00:00

  • Improvement of serological diagnosis of human cytomegalovirus infection in renal transplant recipients by testing for specific immunoglobulin E by ELISA.

    abstract::The kinetics of human cytomegalovirus (HCMV)-specific immunoglobulin E (IgE), M (IgM), A (IgA) and G (IgG) were studied in 421 sera obtained from 19 renal allograft recipients by enzyme-linked immunosorbent assay (ELISA). Cytomegalic inclusion disease (CID) occurred in 11 (57.9%) patients. HCMV infection was diagnosed...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710536

    authors: Weber B,Stemmler A,Ernst W,Scheuerman EH,Braun W,Doerr HW

    更新日期:1993-05-01 00:00:00

  • Serum immunoglobulin levels in hepatitis non-A, non-B: a comparison with hepatitis A and B.

    abstract::The serum levels of IgA, IgG and IgM were determined by the single radial immunodiffusion method in 86 patients with acute viral hepatitis serologically differentiated by radioimmunoassays. The levels of IgA and IgG were similar in patients with hepatitis A, B and non-A, non-B, while differences in IgM levels were obs...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641470

    authors: Norkrans G,Nilsson LA,Frösner G,Wahl M,Iwarson S

    更新日期:1980-01-01 00:00:00

  • New aspects on the pathophysiology of wound infection and wound healing--the problem of lowered oxygen pressure in the tissue.

    abstract::There is a correlation between tissue oxygen tension, incidence of infection and disturbance of wound healing. Scientific investigations in recent years have documented that infection and tissue repair are processes consuming oxygen. Animal experiments have shown that oxygenation of the tissue is essential for the eli...

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    pub_type: 杂志文章

    doi:10.1007/BF01660413

    authors: Kühne HH,Ullmann U,Kühne FW

    更新日期:1985-03-01 00:00:00

  • Studies on serum and cerebrospinal fluid levels of cephacetrile in neonates.

    abstract::The serum half-life of cephacetrile and its penetration from the serum into the cerebrospinal fluid (CSF) was determined in 33 premature and full-term neonates. On an average the serum half-life was 3.6 hours in children with a birth weight above 1,500 g; in children with a birth weight below 1,500 g it was 5.1 hours....

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640789

    authors: Windorfer A,Gasteiger U

    更新日期:1977-01-01 00:00:00

  • Safety and immunogenicity of early vaccination with two doses of tetravalent measles-mumps-rubella-varicella (MMRV) vaccine in healthy children from 9 months of age.

    abstract:BACKGROUND:This open, randomized, controlled study [208136/018] assessed the safety and immunogenicity of early vaccination with an experimental tetravalent measles-mumps-rubella-varicella (MMRV) vaccine (GlaxoSmithKline Biologicals) compared to concomitant administration of separate licensed MMR (Priorix) and varicell...

    journal_title:Infection

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s15010-007-6337-z

    authors: Goh P,Lim FS,Han HH,Willems P

    更新日期:2007-10-01 00:00:00

  • Late-onset cytomegalovirus infection complicated by Guillain-Barre syndrome in a kidney transplant recipient: case report and review of the literature.

    abstract::Cytomegalovirus (CMV) infection remains a common infection after solid-organ transplantation. In the general population CMV disease is associated with Guillain-Barre syndrome (GBS), an autoimmune disease leading to an acute peripheral neuropathy, in 1 of 1000 cases. Interestingly, GBS is a rarely observed complication...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-015-0819-1

    authors: Shaban E,Gohh R,Knoll BM

    更新日期:2016-04-01 00:00:00

  • Cervical lymphadenitis--a rare case of focal listeriosis.

    abstract::Cervical lymphadenopathy is a condition with a broad differential diagnosis. Malignant tumors, allergic reactions, autoimmune diseases as well as various infectious agents can be the cause. We report the case of a 75-year-old man who had a cervical lymphadenopathy without symptoms of infection. The draining lymph node...

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    pub_type: 杂志文章

    doi:10.1007/s15010-001-1098-6

    authors: Rosenthal R,Vogelbach P,Gasser M,Zimmerli W

    更新日期:2001-05-01 00:00:00

  • [Humoral and cell-mediated immune reactions in chronic posttraumatic osteomyelitis (author's transl)].

    abstract::The humoral and cell mediated immune response was investigated in 90 patients suffering from chronic posttraumatic osteomyelitis. In 10-20% of the patients the serum IgG and IgM was increased, in 5-10% the levels were decreased. The values were compared with those of a control group of 35 normal healthy volunteers. Of...

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    pub_type: 杂志文章

    doi:10.1007/BF01638722

    authors: Ring J,Seifert J,Zinn K,Stickl H,Probst J,Brendel W

    更新日期:1976-01-01 00:00:00

  • Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin.

    abstract:INTRODUCTION:Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking. CASE REPORT:We...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1168-7

    authors: Biliotti E,Franchi C,Spaziante M,Garbuglia AR,Volpicelli L,Palazzo D,De Angelis M,Esvan R,Taliani G

    更新日期:2018-10-01 00:00:00

  • Diagnosis and treatment of chlamydial venereal disease.

    abstract::We examined patients attending an STD clinic (Department of Dermatology, Lasarettet, Lund). Chlamydia trachomatis was demonstrated in 26% of 2021 male patients by culture from the urethra (using cyclo-heximide-treated McCoy cells). The corresponding figure for Neisseria gonorrhoeae was 15%. Both organisms were found i...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640715

    authors: Thelin I

    更新日期:1982-01-01 00:00:00

  • Influence of aminopenicillins on bacterial growth kinetics in vitro in comparison with the antibacterial effect in vivo.

    abstract::To quantify the relative antibacterial efficacy of beta-lactam antibiotics in vitro, a mathematical description of bacterial growth was developed. Curves of growth in the presence of the antibiotic are expressed as quadratic functions of time, with initial growth rate (ko) and rate of change of growth (a) as concentra...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01659765

    authors: Mattie H,van der Voet GB

    更新日期:1979-01-01 00:00:00

  • Screening for Chlamydia trachomatis in military personnel by urine testing.

    abstract::In order to determine the infection rate of Chlamydia trachomatis in young males in Austria an epidemiological study was performed on 335 male Austrian soldiers attending the military hospital for a health check-up procedure. Three hundred twenty-nine (98.2%) of the screened males were clinically asymptomatic. Chlamyd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644946

    authors: Stary A,Steyrer K,Heller-Vitouch C,Müller I,Mårdh PA

    更新日期:1991-07-01 00:00:00