Duration of posaconazole therapy for Aspergillus fumigatus osteomyelitis dictated by serial monitoring of 1,3-beta-D glucan.

Abstract:

:Here, we present a case of an immunocompetent 37-year old male who developed Aspergillus fumigatus osteomyelitis 16 years after extensive chest wall reconstructive surgery for Ewing sarcoma. His treatment course was complicated by a severe adverse drug reaction to voriconazole, requiring the use of oral posaconazole therapy. Serum 1,3-beta-D glucan assay was utilized to dictate the duration of posaconazole therapy. The patient successfully completed 9 months of oral posaconazole therapy and has not had clinical recurrence for 9 months off antifungal therapy.

journal_name

Infection

journal_title

Infection

authors

Doub JB,Mathur P

doi

10.1007/s15010-020-01489-2

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

959-963

issue

6

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-020-01489-2

journal_volume

48

pub_type

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