Five cases of Plasmodium vivax malaria treated with artemisinin derivatives: the advantages of a unified approach to treatment.

Abstract:

OBJECTIVES:In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, and reduction of recrudescence or reinfection. METHODS:We describe five cases of Plasmodium vivax malaria in returning travelers treated with dihydroartemisinin-piperaquine. RESULTS:All patients showed the early parasite clearance and no side effects. Our preliminary results suggest that the dihydroartemisinin-piperaquine combination is effective and safe even in imported cases. CONCLUSIONS:A unified treatment policy using the artemisinin combination therapy should be adopted even in non-endemic countries and larger studies are underway to support this strategy.

journal_name

Infection

journal_title

Infection

authors

Corpolongo A,Pisapia R,Oliva A,Giancola ML,Mencarini P,Bevilacqua N,Ghirga P,Mariano A,Vulcano A,Paglia MG,Nicastri E

doi

10.1007/s15010-019-01286-6

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

655-659

issue

4

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-019-01286-6

journal_volume

47

pub_type

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