Abstract:
BACKGROUND:The effects of surgical site infections (SSI) after glioblastoma surgery on patient outcomes are understudied. The aim of this retrospective multicenter study was to evaluate the impact of SSI on the survival of glioblastoma patients. METHODS:Data from SSI cases after glioblastoma surgeries between 2009 and 2016 were collected from 14 French neurosurgical centers. Collected data included patient demographics, previous medical history, risk factors, details of the surgical procedure, radiotherapy/chemotherapy, infection characteristics, and infection management. Similar data were collected from gender- and age-paired control individuals. RESULTS:We used the medical records of 77 SSI patients and 58 control individuals. 13 were excluded. Our analyses included data from 64 SSI cases and 58 non-infected glioblastoma patients. Infections occurred after surgery for primary tumors in 38 cases (group I) and after surgery for a recurrent tumor in 26 cases (group II). Median survival was 381, 633, and 547 days in patients of group I, group II, and the control group, respectively. Patients in group I had significantly shorter survival compared to the other two groups (p < 0.05). The one-year survival rate of patients who developed infections after surgery for primary tumors was 50%. Additionally, we found that SSIs led to postoperative treatment discontinuation in 30% of the patients. DISCUSSION:Our findings highlighted the severity of SSIs after glioblastoma surgery, as they significantly affect patient survival. The establishment of preventive measures, as well as guidelines for the management of SSIs, is of high clinical importance.
journal_name
Infectionjournal_title
Infectionauthors
Salle H,Deluche E,Couvé-Deacon E,Beaujeux AC,Pallud J,Roux A,Dagain A,de Barros A,Voirin J,Seizeur R,Belmabrouk H,Lemnos L,Emery E,Fotso MJ,Engelhardt J,Jecko V,Zemmoura I,Le Van T,Berhouma M,Cebula H,Peyre M,Prdoi
10.1007/s15010-020-01534-0subject
Has Abstractpub_date
2020-10-09 00:00:00eissn
0300-8126issn
1439-0973pii
10.1007/s15010-020-01534-0pub_type
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