The penetration of erythromycin into Waldeyer's ring--tonsil and adenoid tissue.

Abstract:

:Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (1.5-2.0 mg/l) were the same as the plasma levels. Six patients with chronic tonsillitis were given 1000 mg erythromycin ethylsuccinate via a gastric tube, and tonsillectomy à froid was performed three to five hours later. This unusual mode of administration was chosen to avoid tonsil surface contamination, which might cause artificially high values. The concentration of erythromycin was assessed as described above. The levels of erythromycin in the tonsil tissue were the same as the concomitant plasma levels. Erythromycin has been shown to penetrate into adenoid and tonsil tissue and to attain levels similar to the simultaneous plasma levels. It may be inferred from this study that erythromycin penetrates into other lymphatic localities to the same degree.

journal_name

Infection

journal_title

Infection

authors

Sundberg L,Edén T,Ernstson S

doi

10.1007/BF01640866

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

S105-7

eissn

0300-8126

issn

1439-0973

journal_volume

10 Suppl 2

pub_type

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