Efficacy of penicillin treatment in purulent maxillary sinusitis. A European multicenter trial.

Abstract:

:Three hundred and one patients with maxillary sinusitis participated in a double-blind, randomized study at 11 ENT-clinics in Europe. Sinusitis was diagnosed by the presence of at least two signs and symptoms and sinus X-ray showing more than 6 mm swelling of the maxillary mucosa. A microbiological specimen was obtained by intrasinusal aspiration. The patients were randomly assigned to treatment either with bacampillin 800 mg b. i. d. or with amoxicillin 500 mg t. i. d. for ten days. The most frequently isolated bacteria were Haemophilus influenzae (94 strains), Streptococcus pneumoniae (66 strains) and Branhamella catarrhalis (12 strains). In 96 of the patients, no microorganisms could be isolated. Beta-lactamase production was found in one H. influenzae strain and in three B. catarrhalis strains. Two hundred and seventy-one patients could be evaluated for efficacy at the follow-up visit day 8-25. The overall clinical outcome was the same in both treatment groups. Adverse events such as skin reactions and upper and lower gastrointestinal reactions occurred in 17.4% of the amoxicillin treated patients and in 10.8% of the bacampicillin treated patients (p = 0.101).

journal_name

Infection

journal_title

Infection

authors

Nord CE

doi

10.1007/BF01650753

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

209-14

issue

4

eissn

0300-8126

issn

1439-0973

journal_volume

16

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Risk factors for bacteriuria with carbapenem-resistant Klebsiella pneumoniae and its impact on mortality: a case-control study.

    abstract:BACKGROUND:The objective of this study was to evaluate the mortality of and risk factors for bacteriuria due to carbapenem-resistant Klebsiella pneumoniae (CRKp) versus carbapenem-susceptible K. pneumoniae (CSKp) producing extended spectrum β lactamase (ESBL). METHODS:This was a retrospective case-control study in whi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0380-0

    authors: Shilo S,Assous MV,Lachish T,Kopuit P,Bdolah-Abram T,Yinnon AM,Wiener-Well Y

    更新日期:2013-04-01 00:00:00

  • Low C-reactive protein values at admission predict mortality in patients with severe community-acquired pneumonia caused by Streptococcus pneumoniae that require intensive care management.

    abstract:PURPOSE:To identify risk factors associated with mortality in patients with severe community-acquired pneumonia (CAP) caused by S. pneumoniae who require intensive care unit (ICU) management, and to assess the prognostic values of these risk factors at the time of admission. METHODS:Retrospective analysis of all conse...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0755-0

    authors: Que YA,Virgini V,Lozeron ED,Paratte G,Prod'hom G,Revelly JP,Pagani JL,Charbonney E,Eggimann P

    更新日期:2015-04-01 00:00:00

  • Passive immunization against cytomegalovirus in allograft recipients. The Rotterdam Heart Transplant Program experience.

    abstract::We analyzed the results of passive immunization against CMV in 146 heart transplant recipients. The 65 seronegative recipients were prophylactically treated with anti-CMV immunoglobulins during and after the operation. Twenty-nine of these 65 patients received a seropositive donor heart. CMV infection occurred in 21/6...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01728886

    authors: Balk AH,Weimar W,Rothbarth PH,Meeter K,Metselaar HJ,Mochtar B,Simoons ML

    更新日期:1993-07-01 00:00:00

  • The integrity of latex gloves in clinical dental practice.

    abstract:BACKGROUND:The aim of the study was to assess the integrity of non-sterile latex gloves (Biogel Diagnostic (A), Biogel Dental (B), Gentle Skin (C) and Manufix (D)) in clinical dental practice. MATERIALS AND METHODS:After use, the gloves were collected and examined for perforations using the water inflation test accord...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100070011

    authors: Pitten FA,Herdemann G,Kramer A

    更新日期:2000-11-01 00:00:00

  • Staphylococcus lugdunensis early prosthetic valve endocarditis in a young HIV positive patient.

    abstract::Staphylococcus lugdunensis is a coagulase-negative Staphylococcus that causes skin and soft tissue infections and occasionally life threatening endocarditis of native valves. Prosthetic valve infection due to this pathogen is very rare and has not been described in HIV infected individuals. We report on the first case...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6029-8

    authors: Kourbeti IS,Alegakis DE,Roditakis GE,Samonis G

    更新日期:2007-02-01 00:00:00

  • Transintestinal elimination of ciprofloxacin in humans--concomitant assessment of its metabolites in serum, ileum and colon.

    abstract::Ciprofloxacin (200 mg) was infused to seven patients at the beginning of elective colorectal surgery. Thirty minutes after the end of infusion (i.e. 60 min after the start of the operation) ciprofloxacin reached concentrations of 1.60 mg/l in serum and of 3.42-6.07 mg/kg fresh weight in the ileum and colon. During the...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710676

    authors: Viell B,Krause B,Vestweber KH,Schaaf S,Scholl H

    更新日期:1992-11-01 00:00:00

  • Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases.

    abstract:INTRODUCTION:In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0885-z

    authors: de With K,Allerberger F,Amann S,Apfalter P,Brodt HR,Eckmanns T,Fellhauer M,Geiss HK,Janata O,Krause R,Lemmen S,Meyer E,Mittermayer H,Porsche U,Presterl E,Reuter S,Sinha B,Strauß R,Wechsler-Fördös A,Wenisch C,Kern

    更新日期:2016-06-01 00:00:00

  • Clinical significance of Bacteroidaceae.

    abstract::Material from 50 patients with purulent otitis media was investigated. All patients had undergone surgical operation. The results indicate that anaerobic non spore-forming bacteria, especially gram-negative rods of the family Bacteroidaceae, may play an important role in the aetiology of purulent otitis media. In a fu...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639899

    authors: Hudác A

    更新日期:1980-01-01 00:00:00

  • Soft-tissue infection secondary to cellulitis killed St. John of the Cross (1542-1591).

    abstract:PURPOSE:St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Here, an alternative diagnosis is proposed....

    journal_title:Infection

    pub_type: 历史文章,杂志文章

    doi:10.1007/s15010-017-1089-x

    authors: Bianucci R,Appenzeller O,Evans P,Charlier P,Perciaccante A

    更新日期:2018-04-01 00:00:00

  • Experiences on the efficacy and safety of nalidixic acid, oxolinic acid, cinoxacin and norfloxacin in the treatment of urinary tract infections (UTI).

    abstract::The purpose of this study was to determine the effectiveness and tolerability of norfloxacin, cinoxacin and oxolinic acid in the treatment of urinary tract infections (UTI) in comparison to nalidixic acid. 125 patients were given the drugs in the appropriate doses for 10-14 days and 30 patients were treated for six we...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01645218

    authors: Sabbour MS,El Bokl MA,Osman LM

    更新日期:1984-11-01 00:00:00

  • Susceptibility to HIV/AIDS: an individual characteristic we can measure?

    abstract::Susceptibility to HIV-1 infections is, beside other factors, determined by individual host genetic variants like HLA class I alleles, CCR5 and CCR2 variants and levels of CCR5 binding chemokines. A new approach to determine the individual risk of acquiring an HIV infection or to estimate the disease progression could ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-005-6305-4

    authors: Jülg B,Goebel FD

    更新日期:2005-06-01 00:00:00

  • Actinobacillus actinomycetem-comitans endocarditis in a child with a prosthetic heart valve.

    abstract::The first case of Actinobacillus actinomycetem-comitans endocarditis in a child with a prosthetic cardiac valve is reported. Endocarditis was possibly caused by dental work done without antibiotic prophylaxis four weeks prior to admission. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645955

    authors: Felius A,Fleer A,Moulaert A

    更新日期:1984-07-01 00:00:00

  • Thyroiditis due to Brucella melitensis--report of two cases.

    abstract::Two cases of thyroiditis due to Brucella melitensis are reported. Both occurred in foreigners working in Switzerland and presented with characteristic symptoms of thyroiditis which masked those of brucellosis. Cultures were diagnostic. One patient had concomitant thyroid malignancy. Both showed normal thyroid function...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642110

    authors: von Graevenitz A,Colla F

    更新日期:1990-05-01 00:00:00

  • Clinical experience with ofloxacin in urinary tract infection.

    abstract::Preliminary data from the U.S. regarding the safety and efficacy of ofloxacin in the treatment of urinary tract infections are presented. Treatment of uncomplicated urinary tract infections with either 200 mg or 300 mg ofloxacin b.i.d. was as effective as treatment with a standard therapy, co-trimoxazole. In another s...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01661300

    authors: Cox CE,Callery SV,Tack KJ

    更新日期:1986-01-01 00:00:00

  • Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review.

    abstract:PURPOSE:There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS:We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment opt...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-1070-8

    authors: Chibabhai V,Nana T,Bosman N,Thomas T,Lowman W

    更新日期:2018-02-01 00:00:00

  • Mortality risk factors with nosocomial Staphylococcus aureus infections in intensive care units: results from the German Nosocomial Infection Surveillance System (KISS).

    abstract:INTRODUCTION:As the number of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections in German intensive care units increases, the problem of MRSA infection as such is becoming ever more serious. The aim of this study was to investigate whether mortality rates from nosocomial MRSA pneumonia and primar...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-3186-5

    authors: Gastmeier P,Sohr D,Geffers C,Behnke M,Daschner F,Rüden H

    更新日期:2005-04-01 00:00:00

  • Comparative study of the binding of acylureidopenicillins and carbenicillin to human serum proteins.

    abstract::The binding of the acylureidopenicillins azlocillin and mezlocillin to serum proteins was investigated by means of equilibrium dialysis and ultracentrifugation. The penicillin concentrations were determined by the agar diffusion test and by circular dichroism. The degree of binding is dependent on the penicillin conce...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641306

    authors: Rosenkranz H,Förster D

    更新日期:1979-01-01 00:00:00

  • [Microbiological diagnosis of septicemia].

    abstract::To detect microorganisms in the blood it is necessary not only that the microbiologist uses reliable methods, but also that the clinician takes a sufficient number of blood samples at the right point in time using a correct method for drawing the blood. The best results are obtained if the blood sample is transferred ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639113

    authors: Rotter M

    更新日期:1977-03-01 00:00:00

  • Hepatitis agents with enteric transmission--an epidemiological analysis.

    abstract:BACKGROUND:Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jau...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2123-0

    authors: Yayli G,Kiliç S,Ormeci AR

    更新日期:2002-12-01 00:00:00

  • Guidelines for medical research in children.

    abstract::Nearly everyone agrees that violations in research occur. Nobody knows how often. But if Pediatrics is to progress children must be the subjects of research carried out in an acceptable way. The following guidelines should be followed in childhood experimentation: (1) Research should not be done on children if the sam...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01645562

    authors: Papadatos CJ

    更新日期:1989-11-01 00:00:00

  • HAART-prolonged life of HIV-infected patients should not be shortened by hepatitis C.

    abstract::As highly active antiretroviral treatment (HAART) prolongs the life of HIV-infected individuals and reduces mortality associated with opportunistic infections, liver diseases have become a major challenge in the management of these patients. up to 45% of deaths of persons with HIV are related to endstage liver disease...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-6604-1

    authors: Horster S,Goebel FD

    更新日期:2004-12-01 00:00:00

  • Femoral osteomyelitis due to Aspergillus nidulans in a patient with chronic granulomatous disease.

    abstract::13 cases of osteomyelitis caused by Aspergillus nidulans have been previously reported in patients with chronic granulomatous disease (CGD). All of them have been associated with simultaneous pulmonary infection and have had an extremely poor outcome. We report an unusual case of femoral osteomyelitis due to A. nidula...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2167-1

    authors: Dotis J,Panagopoulou P,Filioti J,Winn R,Toptsis C,Panteliadis C,Roilides E

    更新日期:2003-03-01 00:00:00

  • A before-after study of multi-resistance and cost of selective decontamination of the digestive tract.

    abstract:BACKGROUND:We compared standard antibiotic use with an antibiotic policy based on selective decontamination of the digestive tract (SDD) for cost and microbiology. PATIENTS AND METHODS:A 2-year before-after observational study was performed in an 11-bed, mixed medical and surgical intensive care unit (ICU). We include...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-3170-5

    authors: van der Voort PH,van Roon EN,Kampinga GA,Boerma EC,Gerritsen RT,Egbers PH,Kuiper MA

    更新日期:2004-10-01 00:00:00

  • Five cases of Plasmodium vivax malaria treated with artemisinin derivatives: the advantages of a unified approach to treatment.

    abstract:OBJECTIVES:In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01286-6

    authors: Corpolongo A,Pisapia R,Oliva A,Giancola ML,Mencarini P,Bevilacqua N,Ghirga P,Mariano A,Vulcano A,Paglia MG,Nicastri E

    更新日期:2019-08-01 00:00:00

  • In-vitro susceptibility of cefoperazone-susceptible and -resistant gram-negative rods to cefoperazone plus sulbactam, other beta-lactams, aminoglycosides and quinolone.

    abstract::We compared the in-vitro activity of cefoperazone-sulbactam (2:1), other beta-lactams, amino-glycosides and ciprofloxacin against cefoperazone-susceptible and -resistant nosocomial gram-negative bacilli. Resistant isolates including Pseudomonas aeruginosa were susceptible to cefoperazone-sulbactam; the susceptible iso...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643761

    authors: Chandrasekar PH,Sluchak JA

    更新日期:1991-01-01 00:00:00

  • In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.

    abstract::The ability of clavulanic acid to inactivate beta-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci, Escherichia coli, Klebsiella and Proteus mirabilis became fully amoxicillin-sensitive. This effect of clavulanic acid was in mo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641472

    authors: Peters G,Pulverer G,Neugebauer M

    更新日期:1980-01-01 00:00:00

  • Thrombogenicity testing of central venous catheters in vitro.

    abstract::To date there have been no standard methods for assessing the thrombogenicity of central venous catheters. A procedure for testing the thrombogenicity of intravenous lines such as the silver-impregnated catheter by continuous blood flow in vitro was therefore developed. For this test, fresh blood was drawn from health...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02561614

    authors: Böswald M,Lugauer S,Bechert T,Greil J,Regenfus A,Guggenbichler JP

    更新日期:1999-01-01 00:00:00

  • Diagnosis and treatment of chlamydial venereal disease.

    abstract::We examined patients attending an STD clinic (Department of Dermatology, Lasarettet, Lund). Chlamydia trachomatis was demonstrated in 26% of 2021 male patients by culture from the urethra (using cyclo-heximide-treated McCoy cells). The corresponding figure for Neisseria gonorrhoeae was 15%. Both organisms were found i...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640715

    authors: Thelin I

    更新日期:1982-01-01 00:00:00

  • Socioeconomic impact on device-associated infections in limited-resource neonatal intensive care units: findings of the INICC.

    abstract:PURPOSE:To evaluate the impact of country socioeconomic status and hospital type on device-associated healthcare-associated infections (DA-HAIs) in neonatal intensive care units (NICUs). METHODS:Data were collected on DA-HAIs from September 2003 to February 2010 on 13,251 patients in 30 NICUs in 15 countries. DA-HAIs ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0136-2

    authors: Rosenthal VD,Lynch P,Jarvis WR,Khader IA,Richtmann R,Jaballah NB,Aygun C,Villamil-Gómez W,Dueñas L,Atencio-Espinoza T,Navoa-Ng JA,Pawar M,Sobreyra-Oropeza M,Barkat A,Mejía N,Yuet-Meng C,Apisarnthanarak A,International N

    更新日期:2011-10-01 00:00:00

  • Andrologic studies and sexual potency in chronic human brucellosis.

    abstract::A 100 male patients aged from 20 to 45 years were treated for chronic brucellosis. Sixty-eight complained of impaired sexual potency. The percentage of patients with sexual disorders increased parallel to the duration of the disease. Andrologic investigations comprised a study sexual history, physical examination of t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641469

    authors: Kassur B,Dziubek Z

    更新日期:1980-01-01 00:00:00