Experiences on the efficacy and safety of nalidixic acid, oxolinic acid, cinoxacin and norfloxacin in the treatment of urinary tract infections (UTI).

Abstract:

:The purpose of this study was to determine the effectiveness and tolerability of norfloxacin, cinoxacin and oxolinic acid in the treatment of urinary tract infections (UTI) in comparison to nalidixic acid. 125 patients were given the drugs in the appropriate doses for 10-14 days and 30 patients were treated for six weeks. Clinical, bacteriological, hematological and chemical checks were made on all patients before and after treatment. It was found that norfloxacin, cinoxacin and oxolinic acid are safe and effective against Escherichia coli, Klebsiella and Proteus, the commonly encountered organisms in urinary tract infections. The cure rate for norfloxacin was 93%, for cinoxacin 83%, for oxolinic acid 80% and for nalidixic acid 70% in the short course. However, these differences were not statistically significant. Oxolinic acid, cinoxacin and norfloxacin have the advantage over nalidixic acid of being administered only twice daily.

journal_name

Infection

journal_title

Infection

authors

Sabbour MS,El Bokl MA,Osman LM

doi

10.1007/BF01645218

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

377-80

issue

6

eissn

0300-8126

issn

1439-0973

journal_volume

12

pub_type

临床试验,杂志文章
  • Interaction between levothyroxine and indinavir in a patient with HIV infection.

    abstract::Drug interactions are an important and emerging problem in the treatment of HIV-infected patients. Protease inhibitors, like nonnucleoside reverse transcriptase inhibitors, are metabolized by the cytochrome P-450 enzyme system and each of these antiretroviral agents may interact with other drugs metabolized by this sy...

    journal_title:Infection

    pub_type: 信件

    doi:10.1007/s15010-002-2092-3

    authors: Lanzafame M,Trevenzoli M,Faggian F,Marcati P,Gatti F,Carolo G,Concia E

    更新日期:2002-01-01 00:00:00

  • Comparative antibacterial activity of azlocillin, mezlocillin, carbenicillin and ticarcillin and relative stability to beta-lactamases of pseudomonas aeruginosa and klebsiella aerogenes.

    abstract::The antibacterial activities of two ureidopenicillins, azlocillin and mezlocillin, were compared with those of the alpha-carboxypenicillins, carbenicillin and ticarcillin, against a large number of gram-positive and gram-negative bacteria. All four penicillins were active against a wide range of bacteria including Pse...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641616

    authors: Basker MJ,Edmondson RA,Sutherland R

    更新日期:1979-01-01 00:00:00

  • The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis.

    abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...

    journal_title:Infection

    pub_type: 杂志文章,meta分析

    doi:10.1007/s15010-020-01502-8

    authors: Mahumud RA,Kamara JK,Renzaho AMN

    更新日期:2020-12-01 00:00:00

  • IL-6 and TNF alpha release in association with neutrophil activation after cardiopulmonary bypass surgery.

    abstract::The serum IL-6 and TNF alpha response to cardiopulmonary bypass surgery was studied in 12 patients. Human neutrophil elastase was also measured in order to detect the presence of neutrophil activation. Peripheral venous blood samples were obtained before, during, and 1, 2, 3 and 6 days after surgery. Intra-operative s...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01780764

    authors: Holzheimer RG,Molloy RG,Görlach H,Wilkert S,Hehrlein F

    更新日期:1994-01-01 00:00:00

  • Natural leukocyte interferon alpha (Alfaferone) combined with ribavirin in the treatment of patients with HCV-related cirrhosis: our experience.

    abstract:BACKGROUND:The aim of the study was to evaluate the efficacy and safety of combined treatment with natural leukocyte interferon alpha (Alfaferone) plus ribavirin in patients with HCV-related cirrhosis. PATIENTS AND METHODS:Twenty-three patients (15 women, 8 men) aged 17-68 years hospitalized in 2005-2008 were included...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0135-3

    authors: Kozielewicz D,Dybowska D,Halota W,Dróżdż W

    更新日期:2011-10-01 00:00:00

  • Investigation of Rickettsia conorii antibodies in the Antalya area.

    abstract::Mediterranean spotted fever, caused by Rickettsia conorii, is a tick-borne infection. Serum samples for screening R. conorii antibodies of professionally exposed persons in the Antalya region, on the Mediterranean coast of Turkey, were analyzed. R. conorii IgG antibodies were detected in 13 of 98 (13.3%) serum samples...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02771845

    authors: Vural T,Ergin C,Sayin F

    更新日期:1998-05-01 00:00:00

  • [Erythromycin determination in organ tissues (author's transl)].

    abstract::The recovery rates of erythromycin after in vitro and in vivo administration were studied comparatively in liver, lung, and kidney. Using buffer standards the recovery rate in homogenates of in vitro administered erythromycin decreased with increasing protein concentration. At constant protein concentration the erythr...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641124

    authors: Dette GA,Finke U

    更新日期:1979-01-01 00:00:00

  • Q fever meningoencephalitis associated with bilateral abducens nerve paralysis, bilateral optic neuritis and abnormal cerebrospinal fluid findings.

    abstract::Q fever is an zoonosis caused by Coxiella burnetti, the clinical features of which are often nonspecific and self-limited. Involvement of the central nervous system is rare and is usually seen as a complication of endocarditis caused by this rickettsial organism in the chronic disease. Specific neurological manifestat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645555

    authors: Shaked Y,Samra Y

    更新日期:1989-11-01 00:00:00

  • Comparison of BacT/Alert blood culture bottles with lytic media for culture of peritoneal dialysis fluid.

    abstract::A comparison was made between the Septi-Chek "Release" system containing saponins, standard BacT/Alert blood culture bottles and FAN BacT/Alert blood culture bottles for culturing CAPD fluids. Seventy-seven CAPD effluent specimens were tested. No differences could be found. Therefore, lytic agents are not necessary wh...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01713570

    authors: Wüst J,von Graevenitz A

    更新日期:1995-11-01 00:00:00

  • Clinical significance of changes of flora in the upper digestive tract.

    abstract::Dysbiosis does not necessarily mean disease. Typical clinical picture of disease caused by metabolic activity of dysbiotic microflora is the microbial over-growth syndrome. We studied case histories of 434 patients without consideration of their basic illnesses and correlated them with types of dysbioses of duodenal j...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639535

    authors: Knoke M,Bernhardt H

    更新日期:1989-07-01 00:00:00

  • Partial in vivo response to corticosteroid treatment in common variable immune deficiency.

    abstract::The case of a 13-year-old girl with CVI is presented who required steroid treatment for myositis. After three weeks of treatment, the serum IgM level increased about ten-fold. Specific antibodies to vaccination antigens, which despite adequate vaccination were absent prior to any kind of treatment, could be synthesize...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643615

    authors: Wahn V,Grosse-Wilde H,Rosin H,Carls C,Göbel U

    更新日期:1985-01-01 00:00:00

  • Infant tuberculosis in Austria--trend reversal since 1990?

    abstract::Since 1990 a relatively high number of cases of childhood tuberculosis has been observed in Austria, mainly occurring in the age-group of 0-4 years. Within this group most cases were registered in 1995. Since the beginning of 1995 the establishment of a lab-supported nationwide data collection system enables a more de...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02768752

    authors: Makristathis A,Stauffer F,Klein JP,Rotter ML,Wewalka G,Hirschl AM

    更新日期:1998-01-01 00:00:00

  • Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

    abstract:BACKGROUND:Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS:We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-2036-1

    authors: Anderson DJ,Murdoch DR,Sexton DJ,Reller LB,Stout JE,Cabell CH,Corey GR

    更新日期:2004-04-01 00:00:00

  • Urinary tract infection in renal transplant patients.

    abstract::The incidence of urinary tract infections (UTI) in 299 renal graft transplantations (281 patients) was analyzed. UTI episodes were demonstrated in 185 grafts (62%), most frequently in the first month after transplantation. The infectious episodes were mostly recurrent. Persistent infection, detected in 11% of grafts, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01667212

    authors: Prát V,Horcicková M,Matousovic K,Hatala M,Liska M

    更新日期:1985-09-01 00:00:00

  • Interobserver agreement on signs and symptoms of patients with acute febrile illness.

    abstract:PURPOSE:To assess the interobserver agreement on clinical history and physical examination when using a semi-structured questionnaire to evaluate patients with an acute febrile illness (AFI). METHODS:A cross-sectional study was conducted with outpatients aged 12 years and over, presenting with an AFI defined as fever ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0101-0

    authors: Daumas RP,Brasil P,Bressan CS,Oliveira RV,Carvalho BB,Carneiro DV,Passos SR

    更新日期:2011-04-01 00:00:00

  • [Pseudomonas aeruginosa immunoglobulin in experimental pneumonia].

    abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644192

    authors: Pennington JE,Pier GB

    更新日期:1987-01-01 00:00:00

  • Chlamydia trachomatis in andrologic patients--direct and indirect detection.

    abstract:BACKGROUND:Chlamydia trachomatis is considered to be the most common sexually transmitted disease in Germany. It is currently unclear whether chlamydial infection causes pathological conditions of the male accessory glands with consequences for male infertility. PATIENTS AND METHODS:Within the framework of several pro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-0088-z

    authors: Bollmann R,Engel S,Petzoldt R,Göbel UB

    更新日期:2001-05-01 00:00:00

  • Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease.

    abstract::Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filam...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0724-7

    authors: Shigemura T,Nakazawa Y,Amano Y,Sudo A,Watanabe M,Kobayashi M,Kobayashi N,Koike K,Agematsu K,Nishimura K

    更新日期:2015-06-01 00:00:00

  • Efficacy of clarithromycin in preventing viridans streptococcal bacteremia following autologous stem cell transplantation.

    abstract:BACKGROUND:In a study involving 200 patients, we previously found that 17.5% of patients developed viridans streptococcal (VS) bacteremia following autologous peripheral blood stem cell transplantation (aPBSCT) when ciprofloxacin or ciprofloxacin plus ampicillin was used for prophylaxis. PATIENTS AND METHODS:A retrosp...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1028-7

    authors: Naqvi B,Dorsky D,Ali SA,Feingold JM,Edwards RL,Bona RD,Clive J,Tutschka PJ,Bilgrami S

    更新日期:2001-08-01 00:00:00

  • The course of cryptococcal capsular polysaccharide antigenemia/human cryptococcal polysaccharide elimination kinetics.

    abstract::The detection of cryptococcal polysaccharides in the serum is diagnostic of cryptococcosis in the absence of rheumatoid factor. The significance of the continued detection of this antigen in the serum during antifungal therapy is not known. Prolonged antigenemia might indicate ongoing active infection, delayed clearan...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641291

    authors: Eng R,Chmel H,Corrado M,Smith SM

    更新日期:1983-05-01 00:00:00

  • HAART-prolonged life of HIV-infected patients should not be shortened by hepatitis C.

    abstract::As highly active antiretroviral treatment (HAART) prolongs the life of HIV-infected individuals and reduces mortality associated with opportunistic infections, liver diseases have become a major challenge in the management of these patients. up to 45% of deaths of persons with HIV are related to endstage liver disease...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-6604-1

    authors: Horster S,Goebel FD

    更新日期:2004-12-01 00:00:00

  • Screening for Chlamydia trachomatis in military personnel by urine testing.

    abstract::In order to determine the infection rate of Chlamydia trachomatis in young males in Austria an epidemiological study was performed on 335 male Austrian soldiers attending the military hospital for a health check-up procedure. Three hundred twenty-nine (98.2%) of the screened males were clinically asymptomatic. Chlamyd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644946

    authors: Stary A,Steyrer K,Heller-Vitouch C,Müller I,Mårdh PA

    更新日期:1991-07-01 00:00:00

  • Serum immunoglobulin levels in hepatitis non-A, non-B: a comparison with hepatitis A and B.

    abstract::The serum levels of IgA, IgG and IgM were determined by the single radial immunodiffusion method in 86 patients with acute viral hepatitis serologically differentiated by radioimmunoassays. The levels of IgA and IgG were similar in patients with hepatitis A, B and non-A, non-B, while differences in IgM levels were obs...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641470

    authors: Norkrans G,Nilsson LA,Frösner G,Wahl M,Iwarson S

    更新日期:1980-01-01 00:00:00

  • Clinical characteristics of Raoultella ornithinolytica bacteremia.

    abstract:PURPOSE:Raoultella ornithinolytica is not well known as a clinical pathogen. We performed a retrospective review of R. ornithinolytica bacteremia to investigate its clinical features, antimicrobial susceptibility, and overall patient outcomes. METHODS:R. ornithinolytica bacteremia cases were collected from an electron...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-014-0696-z

    authors: Chun S,Yun JW,Huh HJ,Lee NY

    更新日期:2015-02-01 00:00:00

  • An outbreak of rubella aboard a ship of the German Navy.

    abstract:BACKGROUND:During May and June 1996, an outbreak of rubella occurred offshore aboard a ship of the German Navy. The outbreak spread among 330 crew members over a period of 9 weeks, ending 2 days after the ship's return. This is the first detailed epidemiological investigation of a rubella outbreak on a ship, describing...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-003-3048-y

    authors: Ziebold C,Hassenpflug B,Wegner-Bröse H,Wegner K,Schmitt HJ

    更新日期:2003-06-01 00:00:00

  • Bacterial meningitis in infants and children.

    abstract::Bacterial meningitis of infants and children exact a major toll worldwide. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis continue to be the major causes, and efforts to reduce the incidence of this disease have had limited success. Major advances in rapid diagnosis, such as antigen detect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01641744

    authors: Marks MI

    更新日期:1984-01-01 00:00:00

  • Localized pulmonary infection associated with Mycobacterium tilburgii in an HIV-infected patient.

    abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-4118-0

    authors: Kolditz M,Halank M,Spornraft-Ragaller P,Schmidt H,Höffken G

    更新日期:2005-08-01 00:00:00

  • Penetration of ampicillin and sulbactam into human costal cartilage.

    abstract::The question of whether ampicillin and sulbactam are able to penetrate sufficiently into costal cartilage tissue was investigated in 21 children undergoing surgery for funnel chest malformations. The concentrations of both compounds were determined in the core and mantle pieces of samples taken 45 min or 120 min after...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01739028

    authors: Meier H,Springsklee M,Wildfeuer A

    更新日期:1994-03-01 00:00:00

  • The significance of the HBeAg/anti-HBe system in hemodialysis patients. A multicenter study.

    abstract::The HBeAg/anti-HBe system was studied as a marker of infectivity and chronic progressive liver disease in 460 hemodialysis patients. The importance of HBeAg as an index of infectivity was confirmed in that it was present simultaneously with specific DNA polymerase (31 patients) and by the presence of widely diffuse co...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641020

    authors: Fiaccadori F,David S,Faggion G,Feriani N,Ferrari C,Franco V,Giuberti T,Grutta D'Auria C,La Greca G,Magnani G

    更新日期:1984-01-01 00:00:00

  • Six different strains of Neisseria meningitidis in a case with meningococcal sepsis and five contact persons in a boys' home.

    abstract:BACKGROUND:It is routine practice to provide chemoprophylaxis for close contacts of a patient infected with meningococci. PATIENTS:When a 17-year-old boy living in a boys' home was admitted to the hospital with septic shock caused by Neisseria meningitidis, we immediately identified contact persons in the boys' home. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050070

    authors: Linde H,Glück T,Metz M,Reng C,Erlmeier S,Lehn N

    更新日期:2000-05-01 00:00:00