Development of sulphonamide-trimethoprim combinations for urinary tract infections. Part 2: Comparative pharmacokinetics of five sulphonamides.

Abstract:

:The pharmacokinetics and renal excretion of the sulphonamides sulphachloropyridazine, sulphadiazine, sulphaisodimidine, sulphamerazine, and sulphamethoxazole were investigated in a cross-over study with doses of 800 mg each. The serum half-life, urine levels, distribution volume, protein binding and potential antibacterial activity in the urine renders sulphadiazine the preferred component in a combination tablet together with trimethoprim for the treatment of urinary tract infections.

journal_name

Infection

journal_title

Infection

authors

Ortengren B,Fellner H,Bergan T

doi

10.1007/BF01639015

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

S367-70

eissn

0300-8126

issn

1439-0973

journal_volume

7 Suppl 4

pub_type

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