Abstract:
PURPOSE:To evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival secretions from patients without ocular symptoms. METHODS:Conjunctival swabs were prospectively collected from laboratory-confirmed Coronavirus disease 2019 (COVID-19) patients without ocular symptoms for reverse transcription-polymerase chain reaction (RT-PCR) and viral culture. RESULTS:A total of 158 conjunctival swabs were obtained from 49 laboratory-confirmed COVID-19 patients. The median duration of illness when the first conjunctival swab was obtained was 10 days (range 2-27 days). Four conjunctival swabs from four different patients (4/49, 8.2%) were positive for SARS-CoV-2 RNA by RT-PCR. The Ct values ranged from 32.7 to 37.7 (mean 35.4). Viral cultures were negative for all four RT-PCR-positive conjunctival swabs. CONCLUSION:Conjunctival secretions of a minority of COVID-19 patients without ocular symptoms may contain relatively low levels of SARS-CoV-2 RNA, but their infectiousness remains undetermined. Appropriate infection control measures should be implemented during ophthalmological assessment of COVID-19 patients to prevent potential nosocomial transmission of SARS-CoV-2.
journal_name
Infectionjournal_title
Infectionauthors
Li X,Chan JF,Li KK,Tso EY,Yip CC,Sridhar S,Chung TW,Chiu KH,Hung DL,Wu AK,Chau SK,Liu R,Lung KC,Tam AR,Cheng VC,To KK,Chan KH,Hung IF,Yuen KYdoi
10.1007/s15010-020-01524-2subject
Has Abstractpub_date
2020-09-17 00:00:00eissn
0300-8126issn
1439-0973pii
10.1007/s15010-020-01524-2pub_type
杂志文章相关文献
INFECTION文献大全abstract::Thirty patients suffering from bacteriogenic skin diseases were given cefaclor, in most cases simultaneously with classical external dermatological therapy. The results of therapy were satisfactory in 29 of the 30 patients. Only in one relatively severe case of erysipelas did the disease continue to spread despite the...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659751
更新日期:1979-01-01 00:00:00
abstract::A 97-year-old lady was hospitalized for left leg cellulitis. Comorbidity included hypertension and congestive heart failure. While in hospital, she developed a painless vesicular rash localized to the territory of the left trigeminal nerve (third branch), which evolved to pustules and crusts (Figure 1). A chickenpox-l...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-008-8287-5
更新日期:2009-04-01 00:00:00
abstract::Alternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and effi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01527-z
更新日期:2020-09-29 00:00:00
abstract::Aztreonam was given intravenously at a dose of 1 g at induction of anaesthesia, followed by subsequent doses of 1 g at eight hour intervals during 48 hours to 20 patients undergoing colorectal surgery. A series of serum and faecal specimens were taken for analysis of aztreonam concentrations. Tissue samples from the g...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01642868
更新日期:1985-05-01 00:00:00
abstract::Surgical principles in the management of intraabdominal infection have remained constant. Rather, it is the application of these principles in selected cases that has varied. Judgement, therefore, becomes paramount for the surgeon. In selected cases multiple planned relaparotomies may be the most effective means of cl...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01726464
更新日期:1991-11-01 00:00:00
abstract::We report the case of a patient who presented with a thrombus of the aortic arch complicated with splenic, renal and peroneal artery embolisms, associated with transient lupus anticoagulant, during a Mycoplasma pneumoniae infection. The outcome was good under antibiotic and anticoagulant treatment. We also review the ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0475-2
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The rise in the standard of living of the Israeli population during recent decades has been accompanied by a significant decline in the prevalence of various viral diseases including hepatitis A (HAV). This trend is not reflected in the seroprevalence of herpes simplex (HSV) infection, which has remained sta...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100070042
更新日期:2000-07-01 00:00:00
abstract::The in vitro activity of the free acid of cefetamet pivoxil (Ro 15-8075) was tested against 355 clinical isolates, namely enteropathogenic bacteria, glucose non-fermentative gram-negative rods (excluding Pseudomonas aeruginosa) and Legionella pneumophila. Ceftriaxone was included in the study as reference compound. Al...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644102
更新日期:1988-05-01 00:00:00
abstract::Polymerase chain reaction (PCR) analysis with primers for the pp65, a-sequence, glycoprotein B, and major immediate early genes of human cytomegalovirus (CMV) was used to study five congenitally-infected infants and their CMV-infected family members. Family members excreting CMV included three mothers and two siblings...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02113601
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:The PROGRESS Registry (Promoting Global Research Excellence in Severe Sepsis) was designed to provide comparative data reflecting everyday clinical practice, thereby allowing participating institutions to explore and benchmark medical interventions in severe sepsis. MATERIALS AND METHODS:PROGRESS was an int...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-008-8203-z
更新日期:2009-06-01 00:00:00
abstract::The penicillins, the tetracyclines and the sulfonamides have often been used in the last few decades in spite of their well-known side effects. Hypersensitivity reactions to penicillins are among the most important adverse reactions in these antibiotics; in every case a careful medical history has to be taken before a...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01644730
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:For simultaneous detection of Borrelia miyamotoi (relapsing fever spirochete) and Borrelia burgdorferi sensu lato, we have developed a duplex real-time PCR targeting the flagellin gene (flaB; p41), a locus frequently used in routine diagnostic PCR for B. burgdorferi s.l. detection. METHODS:Primers and probes w...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0820-8
更新日期:2016-02-01 00:00:00
abstract::The recovery rates of erythromycin after in vitro and in vivo administration were studied comparatively in liver, lung, and kidney. Using buffer standards the recovery rate in homogenates of in vitro administered erythromycin decreased with increasing protein concentration. At constant protein concentration the erythr...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641124
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:There are conflicting results concerning an association between Chlamydia pneumoniae and MS (multiple sclerosis). In the present study, we investigated a possible therapeutic option with antibiotics. PATIENTS AND METHODS:In our randomized, placebo-controlled double-blind study, 28 patients with the confirme...
journal_title:Infection
pub_type: 杂志文章,随机对照试验
doi:10.1007/s15010-006-5114-8
更新日期:2006-12-01 00:00:00
abstract::Thrombocytosis is rarely observed during infection. We are describing a patient with acute osteomyelitis and bacteremia who developed thrombocytosis. In the patient described the platelet count paralleled the activity of the infection and the response to therapy. The causes of thrombocytosis and its implications are b...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645220
更新日期:1984-11-01 00:00:00
abstract::The incidence of fulminant hepatitis in Taiwan was studied in a series of consecutive 523 patients with acute viral hepatitis including 11 with acute hepatitis A, 67 with acute hepatitis B, 124 with acute hepatitis NANB and 321 acute hepatitis in HBsAg carriers (patients who were HBsAg positive but anti-HBc IgM negati...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643385
更新日期:1990-07-01 00:00:00
abstract::The incidence of urinary tract infections (UTI) in 299 renal graft transplantations (281 patients) was analyzed. UTI episodes were demonstrated in 185 grafts (62%), most frequently in the first month after transplantation. The infectious episodes were mostly recurrent. Persistent infection, detected in 11% of grafts, ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01667212
更新日期:1985-09-01 00:00:00
abstract::The antiviral effects of interferon-alpha (IFN-alpha) are well documented for the treatment of hepatitis B or C infections, whereas antiretroviral effects for treatment of HIV-1 infection have been investigated up to now only in small-sized preclinical studies. New preclinical and clinical data on IFN-alpha for HIV, H...
journal_title:Infection
pub_type:
doi:
更新日期:2003-03-01 00:00:00
abstract::During the course of chronic hepatitis B virus (HBV) infection, a patient seropositive for hepatitis B e antigen experienced four episodes of acute hepatic necroinflammation. Serum HBV-DNA concentration elevated immediately before the first and third exacerbations, whereas serum hepatitis C virus (HCV) RNA was detecte...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1195-6
更新日期:2001-12-01 00:00:00
abstract::The activity of ten different 4-quinolone antibacterial agents against Escherichia coli KL16 was investigated at four pH values between 5.6 and 8.3, which is the pH range of urine. It was found that pH affected the minimum inhibitory concentrations of all the drugs, but the nature of the substituent at the C7 position...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01645195
更新日期:1986-01-01 00:00:00
abstract::We have reviewed 38 patients with brucellosis who were admitted to the Chaim Sheba Medical Center between 1955 and 1977, i.e. during a 23-year period. The clinical manifestations varied greatly. Diagnosis was easy when brucellosis was suspected, as in cases presenting with fever of unknown origin. In nine of the 38 ca...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641353
更新日期:1983-11-01 00:00:00
abstract::Recently, important advances have been made in the immunodiagnosis of tuberculosis. New T cell interferon-gamma release assays (TIGRA) are more specific and more sensitive than the tuberculin skin test (TST) for the diagnosis of Mycobacterium tuberculosis (MTB) infection. However, like the TST, TIGRA are unable to dis...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-008-8089-9
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The aim of the study was to evaluate the efficacy and safety of combined treatment with natural leukocyte interferon alpha (Alfaferone) plus ribavirin in patients with HCV-related cirrhosis. PATIENTS AND METHODS:Twenty-three patients (15 women, 8 men) aged 17-68 years hospitalized in 2005-2008 were included...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0135-3
更新日期:2011-10-01 00:00:00
abstract::The outer membrane proteins, F, H2 and I, from PA12 strain of Pseudomonas aeruginosa, were purified and used successfully for immunization of Balb/c mice. The immunized mice were protected against challenge with a 2-26 fold LD50 of all known 19 serogroups of P. aeruginosa. ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01647755
更新日期:1987-01-01 00:00:00
abstract::A 200 mg oral dose of ciprofloxacin, norfloxacin or ofloxacin was administered to six healthy male volunteers in a three way cross-over study in order to examine the kinetics in humans in relation to the bactericidal activity in serum and urine. Serum concentrations for ciprofloxacin were similar to norfloxacin and lo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01650502
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:In recent years, several reports have suggested, but never definitely demonstrated that dental units (DU) could be potential sources of viral cross-infections sustained by viral agents including HBV, HCV and HIV. This work aims at assessing the risk of HCV cross-infection by dental unit water lines (DUWLs). ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-008-7246-5
更新日期:2008-10-01 00:00:00
abstract:PURPOSE:Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are usually distinguished by cellular predominance and pleural fluid adenosine deaminase (ADA) levels. However, both diseases may occasionally show similar neutrophilic predominance and high ADA levels. In such cases, the differential diagnosis...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0928-5
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:To test a new assay based on an ex vivo cytokine release from whole blood for the monitoring of immune changes in human immunodeficiency virus (HIV)-infected patients. METHODS:A pilot study of outpatients with HIV infection (n = 9) at a large academic hospital who were divided into three groups: HIV-infected p...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0445-8
更新日期:2013-06-01 00:00:00
abstract::Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filam...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0724-7
更新日期:2015-06-01 00:00:00
abstract::Antibiotic activity against common respiratory pathogens can be affected by the pH of the medium (in vitro) or the bodily fluid (in vivo) in which bacteria are present. The ionized fraction of an antibiotic is not able to efficiently penetrate bacterial or mammalian membranes, reducing the quantity of molecules able t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-005-8206-y
更新日期:2005-12-01 00:00:00