Guillain-Barré syndrome associated with Mycobacterium bovis lymphadenitis.

Abstract:

:Guillain-Barré syndrome (GBS) is an autoimmune disease that can be triggered by different infectious agents. Here we report the case of a 26-year-old Algerian woman who developed GBS associated with a Mycobacterium bovis cervical lymphadenitis. Following intravenous immunoglobulin therapy, the patient's neurologic state returned to normal after 3 months. The lymphadenitis responded more slowly to the antituberculous treatment and an excision of necrotic cervical lymph nodes had to be performed four times. Antibiotics were administered for 16 months: ethambutol was stopped after 2 months, and rifampicin and isoniazid pursued for 14 months. An extensive etiological investigation showed that, in this case, the only likely infectious trigger GBS was the concomitant M. bovis infection. To our knowledge, this is the first report of GBS triggered by M. bovis. We performed a literature review revealing that the association between tuberculosis and Guillain-Barré syndrome is very rare (only seven cases previously reported) but is not coincidental. Physicians should be aware that tuberculosis can be a cause of GBS.

journal_name

Infection

journal_title

Infection

authors

Vergnon-Miszczycha D,Suy F,Robert F,Carricajo A,Fresard A,Cazorla C,Guglielminotti C,Lucht F,Botelho-Nevers E

doi

10.1007/s15010-015-0762-1

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

603-8

issue

5

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-015-0762-1

journal_volume

43

pub_type

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