Abstract:
:At present, there is no definitive antiviral treatment for coronavirus disease 2019 (COVID-19). We describe our early experience with remdesivir in four critically ill COVID-19 patients. Patients received a 200 mg loading dose, followed by 100 mg daily intravenously for up to 10 days. All patients had been previously treated with other antivirals before remdesivir initiation. One patient experienced a torsade de pointes requiring cardiac resuscitation and one died due to multiple organ failure. Three patients showed biochemical signs of liver injury. Lymphocyte count increased in all patients soon after remdesivir initiation. Nasal swab SARS-CoV-2 RNA became negative in three of four patients after 3 days of therapy. We observed an in vivo virological effect of remdesivir in four critically ill, COVID-19 patients, coupled with a significant burden of adverse events. Although limited by the low number of subjects studied, our preliminary experience may be relevant for clinicians treating COVID-19.
journal_name
Infectionjournal_title
Infectionauthors
Durante-Mangoni E,Andini R,Bertolino L,Mele F,Florio LL,Murino P,Corcione A,Zampino Rdoi
10.1007/s15010-020-01448-xsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
779-782issue
5eissn
0300-8126issn
1439-0973pii
10.1007/s15010-020-01448-xjournal_volume
48pub_type
杂志文章相关文献
INFECTION文献大全abstract:BACKGROUND:The objective of this study was to evaluate the mortality of and risk factors for bacteriuria due to carbapenem-resistant Klebsiella pneumoniae (CRKp) versus carbapenem-susceptible K. pneumoniae (CSKp) producing extended spectrum β lactamase (ESBL). METHODS:This was a retrospective case-control study in whi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-012-0380-0
更新日期:2013-04-01 00:00:00
abstract::Twenty-four homosexual adult patients suffering from LAS or AIDS were investigated for immunoglobulin class- and IgG subclass-specific antibodies to human immunodeficiency virus (HIV) by the indirect ELISA and Western blot using monoclonal tracer antibodies. All patients revealed HIV-specific serum antibodies of IgG s...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01647729
更新日期:1987-01-01 00:00:00
abstract::Both aciclovir and brivudin are effective in the treatment of immunocompromised children with varicella-zoster virus infection. To determine which drug is preferable, a prospective randomized trial aciclovir vs. brivudin was conducted. Forty-three immunocompromised children were randomly assigned to receive aciclovir ...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01726449
更新日期:1991-11-01 00:00:00
abstract::Mycobacterium kansasii infection is a recognized complication of AIDS and a broad spectrum of extrapulmonary manifestations has been reported. However, AIDS-related M. kansasii pericarditis is an extremely rare disease. We report the first European case of this infection, that presented some different clinical finding...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-0061-x
更新日期:2001-01-01 00:00:00
abstract::To date there have been no standard methods for assessing the thrombogenicity of central venous catheters. A procedure for testing the thrombogenicity of intravenous lines such as the silver-impregnated catheter by continuous blood flow in vitro was therefore developed. For this test, fresh blood was drawn from health...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02561614
更新日期:1999-01-01 00:00:00
abstract::The distribution of mannose-resistant (MRHA) and mannose-sensitive (MSHA) fimbrial haemagglutinins was examined in 482 strains of Escherichia coli isolated from 390 adult women and 45 pregnant mothers with a variety of urinary tract infections (UTI), and from 47 healthy controls. The proportion of MRHA strains was sig...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01641080
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:There are conflicting results concerning an association between Chlamydia pneumoniae and MS (multiple sclerosis). In the present study, we investigated a possible therapeutic option with antibiotics. PATIENTS AND METHODS:In our randomized, placebo-controlled double-blind study, 28 patients with the confirme...
journal_title:Infection
pub_type: 杂志文章,随机对照试验
doi:10.1007/s15010-006-5114-8
更新日期:2006-12-01 00:00:00
abstract::Cydnidae bug (also termed the burrowing bug) are arthropods of the order Hemiptera, that are recognized by their morphological adaptations for digging. They release an odorous substance from special glands that serve as self-defense, causing pigmented macules when in contact with human skin, especially during the rain...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01481-w
更新日期:2020-07-11 00:00:00
abstract:PURPOSE:To test a new assay based on an ex vivo cytokine release from whole blood for the monitoring of immune changes in human immunodeficiency virus (HIV)-infected patients. METHODS:A pilot study of outpatients with HIV infection (n = 9) at a large academic hospital who were divided into three groups: HIV-infected p...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-013-0445-8
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:Staphylococcus aureus frequently causes infections in outpatient and hospital settings and can present as a highly variable entity. Typical manifestations are endocarditis, osteoarticular infections or infection of implanted prostheses, intravascular devices or foreign bodies. A thorough diagnostic evaluat...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1221-6
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:In recent years, the role of pro- and antiinflammatory cytokines in the development of Lyme arthritis (LA) has been widely discussed. The purpose of the present study was to determine the concentration of interleukin-18 (IL-18), interleukin-1beta (IL-beta) and its soluble receptor sIL-1RII in serum of patien...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-5013-z
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Tuberculous pleural effusion (TPE) and parapneumonic effusion (PPE) are usually distinguished by cellular predominance and pleural fluid adenosine deaminase (ADA) levels. However, both diseases may occasionally show similar neutrophilic predominance and high ADA levels. In such cases, the differential diagnosis...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0928-5
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Risk factors for nosocomial candidemia, severity of sepsis, treatment, and outcome were compared between patients admitted to medicine wards and those to surgical and intensive care units (ICUs). METHODS:Data were retrospectively collected from patients belonging to six referral hospitals in Italy between Janu...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-016-0924-9
更新日期:2016-12-01 00:00:00
abstract::Cefodizime was evaluated for its effect on a number of parameters of leukocyte function in humans. Four healthy volunteers received 2 g i.v. b.i.d. for seven days. Leukocyte activity was measured before, during and after treatment. Using opsonized zymosan as a stimulant, no effect on the respiratory burst of granulocy...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01709952
更新日期:1992-01-01 00:00:00
abstract::Erythromycin ethylsuccinate was given orally (30-60 mg/kg/day) to 72 otherwise healthy children for different intervals before adenoidectomy. The concentration of erythromycin was assessed in homogenized tissue, in whole blood and in plasma, making it possible to calculate blood-free tissue levels. The tissue levels (...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640866
更新日期:1982-01-01 00:00:00
abstract::Intestinal microsporidiosis with Enterocytozoon bieneusi was diagnosed in three of 18 HIV-infected patients with chronic diarrhoea. In two cases all known stages of the life cycle of E. bieneusi (merogonial plasmodia, sporogonial plasmodia, sporoblasts, spores) were found in duodenal biopsies by electron microscopical...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01715501
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS:We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-004-2036-1
更新日期:2004-04-01 00:00:00
abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640729
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:Peripheral facial nerve palsy (FP) is the most common single nerve affection. Most cases are idiopathic, but a relevant fraction is caused by potentially treatable aetiologies including infections. Not all current diagnosis and treatment guidelines recommend routine cerebrospinal fluid (CSF) analysis in the dia...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-016-0933-8
更新日期:2017-04-01 00:00:00
abstract::Computer-assisted diagnostic systems may accelerate transmission of microbiological reports and facilitate evaluation of the epidemiological situation and thus improve the collaboration between microbiologists and clinicians. This possible benefit is demonstrated by four examples. It became evident that incidences of ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01646938
更新日期:1988-01-01 00:00:00
abstract::Influenza viruses type A and B can cause a wide spectrum of illness, and they are responsible for considerable mortality and morbidity. With the new neuraminidase inhibitors, of which zanamivir was the first drug to be licensed, the physician has antivirals at his disposal which are safe and effective against both inf...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s150100070016
更新日期:2000-09-01 00:00:00
abstract::This report concerns a case of congenital rubella syndrome (CRS) with atypical immune response affecting an infant whose mother had repeated evidence of immunity before pregnancy. Laboratory diagnosis of CRS could only clearly be achieved by virus isolation after the second month of life despite typical clinical featu...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710747
更新日期:1993-03-01 00:00:00
abstract::The great majority of individuals with human immunodeficiency virus type 1 (HIV-1) infection presents with no signs or symptoms, or only lymphadenopathy. To initiate prophylactic measures in time it is necessary to establish risk criteria. CD4+ cell counts are significant predictors. Supplementary methods to improve t...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01644476
更新日期:1991-01-01 00:00:00
abstract::A case of repeated episodes of Pseudomonas vesicularis bacteraemia, in a 54-year-old woman with a past history including systemic lupus erythematosus and chronic active autoimmune hepatitis is reported. She was treated with tobramycin and ceftazidime but bacteraemia persisted until surgical resection of the infected t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710687
更新日期:1992-11-01 00:00:00
abstract::We compared the in-vitro activity of cefoperazone-sulbactam (2:1), other beta-lactams, amino-glycosides and ciprofloxacin against cefoperazone-susceptible and -resistant nosocomial gram-negative bacilli. Resistant isolates including Pseudomonas aeruginosa were susceptible to cefoperazone-sulbactam; the susceptible iso...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643761
更新日期:1991-01-01 00:00:00
abstract::40 patients were given a single, short intravenous infusion of 4 g fosfomycin over a period of five to ten minutes. In 23 patients, the contents of the gall bladder were removed intra-operatively 30-105 minutes after the fosfomycin infusion. In 17 patients who had undergone cholecystectomy eight to ten days earlier, b...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01640831
更新日期:1982-01-01 00:00:00
abstract::To quantify the relative antibacterial efficacy of beta-lactam antibiotics in vitro, a mathematical description of bacterial growth was developed. Curves of growth in the presence of the antibiotic are expressed as quadratic functions of time, with initial growth rate (ko) and rate of change of growth (a) as concentra...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659765
更新日期:1979-01-01 00:00:00
abstract::A 12-year-old girl with a 2-month history of fever and abdominal pain was admitted to our hospital. Ultrasound and CT scans of the abdomen showed multiple hypoechoic lesions of liver and spleen. Screening for zoonosis revealed high positive titers to Bartonella henselae. T-cell deficiency was demonstrated and remained...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s150100050059
更新日期:2000-03-01 00:00:00
abstract::The case of a 13-year-old girl with CVI is presented who required steroid treatment for myositis. After three weeks of treatment, the serum IgM level increased about ten-fold. Specific antibodies to vaccination antigens, which despite adequate vaccination were absent prior to any kind of treatment, could be synthesize...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643615
更新日期:1985-01-01 00:00:00
abstract::Antibiotic activity against common respiratory pathogens can be affected by the pH of the medium (in vitro) or the bodily fluid (in vivo) in which bacteria are present. The ionized fraction of an antibiotic is not able to efficiently penetrate bacterial or mammalian membranes, reducing the quantity of molecules able t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-005-8206-y
更新日期:2005-12-01 00:00:00