Suttons's law: local immunodiagnosis of tuberculosis.

Abstract:

:Recently, important advances have been made in the immunodiagnosis of tuberculosis. New T cell interferon-gamma release assays (TIGRA) are more specific and more sensitive than the tuberculin skin test (TST) for the diagnosis of Mycobacterium tuberculosis (MTB) infection. However, like the TST, TIGRA are unable to distinguish between active tuberculosis (TB), latent TB infection (LTBI) and treated TB if performed on blood mononuclear cells alone. In active TB, MTB-specific T cells are actively recruited to the site of infection and can rapidly be identified in extrasanguinous fluids, such as pleural effusions, ascites, cerebrospinal fluid, and in bronchoalveolar lavages. This review summarizes recent findings comparing systemic and local immune responses against MTB. Although bacteriological and histological methods have the highest specificity for TB in terms of diagnosing active TB and the number of TB patients in whom extrapulmonary TIGRAs have been evaluated is still limited, a comparison of local and systemic MTB-specific immune responses is a promising technique to rapidly distinguish active TB from latent MTB infection in routine clinical practice.

journal_name

Infection

journal_title

Infection

authors

Jafari C,Lange C

doi

10.1007/s15010-008-8089-9

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

510-4

issue

6

eissn

0300-8126

issn

1439-0973

journal_volume

36

pub_type

杂志文章,评审
  • Aspects of anaerobic infections in animals.

    abstract::The recent literature on clostridial infections of animals and infections due to gram-negative anaerobic rods is reviewed. It is stressed that quite recently the literature is concerned with animal models for the evaluation and study of the chemotherapy, immunity mechanisms and pathogenesis of Fusobacterium and Bacter...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01639869

    authors: Goldberg HS

    更新日期:1980-01-01 00:00:00

  • Escherichia coli isolated from babies delivered by caesarean section and their environment.

    abstract::The sources from which eight Caesarean section babies acquired E. coli are described and the probable routes by which the organisms reached the babies are outlined. Suggestions are made concerning the control of the spread of E. coli in premature nurseries and during outbreaks of E. coli gastroenteritis. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01638940

    authors: Lennox-King SM,O'Farrell SM,Bettelheim KA,Shooter RA

    更新日期:1976-01-01 00:00:00

  • Changes in lymphocyte subpopulations in patients treated with cefodizime for acute lower respiratory tract infections.

    abstract::The influence of cefodizime (CDZ) on CD4 and CD8 lymphocytes was investigated in patients with lower respiratory tract infection and underlying respiratory diseases. Ten men and one woman were treated with CDZ 1 g i.m. b.i.d. for ten days. The infecting organisms were Haemophilus influenzae (5), Streptococcus pneumoni...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01709955

    authors: Valcke Y,Van der Straeten M

    更新日期:1992-01-01 00:00:00

  • Localized pulmonary infection associated with Mycobacterium tilburgii in an HIV-infected patient.

    abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-4118-0

    authors: Kolditz M,Halank M,Spornraft-Ragaller P,Schmidt H,Höffken G

    更新日期:2005-08-01 00:00:00

  • The influence of maternally derived antibody on the efficacy of further attenuated measles vaccine.

    abstract::The natural decline of passively acquired maternal antibody titers and the influence of these antibodies on the efficacy of live, further attenuated measles vaccine were studied in 7 to 12 month old infants. Hemagglutination-inhibition (HI) antibody titers were determined in the pre- and postvaccination sera. HI antib...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01642310

    authors: Stewien KE,Barbosa V,de Lima OS,Osiro K

    更新日期:1978-01-01 00:00:00

  • A before-after study of multi-resistance and cost of selective decontamination of the digestive tract.

    abstract:BACKGROUND:We compared standard antibiotic use with an antibiotic policy based on selective decontamination of the digestive tract (SDD) for cost and microbiology. PATIENTS AND METHODS:A 2-year before-after observational study was performed in an 11-bed, mixed medical and surgical intensive care unit (ICU). We include...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-3170-5

    authors: van der Voort PH,van Roon EN,Kampinga GA,Boerma EC,Gerritsen RT,Egbers PH,Kuiper MA

    更新日期:2004-10-01 00:00:00

  • Occurrence of methicillin-resistant Staphylococcus aureus infections in German intensive care units.

    abstract:BACKGROUND:This study aims to describe the occurrence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections and the relation between endemic and epidemic nosocomial MRSA infections in intensive care units (ICUs) in Germany. METHODS:The ICU component within the German national nosocomial infection...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2043-z

    authors: Gastmeier P,Sohr D,Geffers C,Nassauer A,Dettenkofer M,Rüden H

    更新日期:2002-08-01 00:00:00

  • Congenital rubella syndrome after maternal reinfection.

    abstract::This report concerns a case of congenital rubella syndrome (CRS) with atypical immune response affecting an infant whose mother had repeated evidence of immunity before pregnancy. Laboratory diagnosis of CRS could only clearly be achieved by virus isolation after the second month of life despite typical clinical featu...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710747

    authors: Weber B,Enders G,Schlösser R,Wegerich B,Koenig R,Rabenau H,Doerr HW

    更新日期:1993-03-01 00:00:00

  • Hospital at home for the management of COVID-19: preliminary experience with 63 patients.

    abstract::Alternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and effi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01527-z

    authors: Pericàs JM,Cucchiari D,Torrallardona-Murphy O,Calvo J,Serralabós J,Alvés E,Agelet A,Hidalgo J,Alves E,Castells E,Seijas N,Hernández C,Bodro M,Cardozo C,Coloma E,Nicolás D,Hospital Clínic 4H Team (Hospital at Home-Health H

    更新日期:2020-09-29 00:00:00

  • IFN-alpha: therapeutic options in HIV and HIV/HCV, HIV/HBV dual infection.

    abstract::The antiviral effects of interferon-alpha (IFN-alpha) are well documented for the treatment of hepatitis B or C infections, whereas antiretroviral effects for treatment of HIV-1 infection have been investigated up to now only in small-sized preclinical studies. New preclinical and clinical data on IFN-alpha for HIV, H...

    journal_title:Infection

    pub_type:

    doi:

    authors: Jablonowski H

    更新日期:2003-03-01 00:00:00

  • Release of TNF alpha and IL6 from human monocytes infected with Mycobacterium kansasii: a comparison to Mycobacterium avium.

    abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of B-lymphocytes. Mycobacterium avium has been shown to stimulate the release of TNF alpha and IL6 fro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01715538

    authors: Stauffer F,Petrow EP,Burgmann H,Graninger W,Georgopoulos A

    更新日期:1994-09-01 00:00:00

  • Effect of dexamethasone and pentoxifylline in combination with amoxicillin in the treatment of penicillin-insensitive pneumococcal pneumonia in guinea pigs.

    abstract::A fatal guinea pig model of pneumococcal pneumonia was developed in order to evaluate the efficacy of amoxicillin combined with either pentoxifylline or dexamethasone. Parameters assessed were survival time and lung changes (alterations, bacterial colony counts, inducible nitric oxide synthase [iNOS] and cyclooxygenas...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2098-x

    authors: Parra A,García-Olmos M,Nieto E,García-Calvo G,Ponte C,Soriano F

    更新日期:2002-06-01 00:00:00

  • TT virus infection and genotype distribution in blood donors and a group of patients from Turkey.

    abstract:BACKGROUND:TT virus (TTV) DNA has been found in a large proportion of patients with different forms of non-A-G hepatitis, however the clinical importance is unclear. We aimed to determine the genotypes of TTV isolates found in blood donors and different patient groups from the western part of Turkey. MATERIALS AND MET...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2185-z

    authors: Erensoy S,Sayiner AA,Türkoğlu S,Canatan D,Akarca US,Sertöz R,Ozacar T,Batur Y,Badur S,Bilgiç A

    更新日期:2002-10-01 00:00:00

  • [Experimental study of the local application of silver sulfadiazine, cefsulodin and povidone-iodine in burns].

    abstract::Non-infected standardized burns and those contaminated experimentally with a constant number of organisms of a selected Pseudomonas aeruginosa strain underwent varying forms of treatment with silver sulfadiazine, cefsulodin cream and povidone iodine ointment. Wound healing was controlled by evaluating the wound area. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641022

    authors: Kaiser W,von der Lieth H,Potel J,Heymann H

    更新日期:1984-01-01 00:00:00

  • Meningitis due to Micrococcus luteus.

    abstract::We are presenting a new case of meningitis due to the Micrococcus luteus species. This germ was isolated twice in eight days from the CSF of a 57-year old woman. The patient had a ventriculoperitoneal shunt implanted for hydrocephalus following a meningeal haemorrhage. Antibiotic therapy was efficient but the patient ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645439

    authors: Fosse T,Peloux Y,Granthil C,Toga B,Bertrando J,Sethian M

    更新日期:1985-11-01 00:00:00

  • Immune status against diphtheria among immigrants from the former USSR who arrived in Israel during 1990-1991.

    abstract::Large outbreaks of diphtheria occurred recently in the former USSR. Between 1989 and 1994, a total of about 600,000 Soviet immigrants arrived in Israel. The immune status against diphtheria in a sample of 992 men aged 17-49 and 195 women aged 17-19, who arrived in Israel during 1990-91, was studied in order to evaluat...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02767769

    authors: Low M,Almog R,Green MS,Ashkenazi S,Bercovier H,Katzenelson E,Ashkenazi I,Shemer J,Cohen D

    更新日期:1998-03-01 00:00:00

  • Colistin and trimethoprim-sulfamethoxazole for the prevention of infection in patients with acute non-lymphocytic leukaemia. Decrease in the emergence of resistant bacteria.

    abstract::In a previous study we demonstrated that trimethoprim-sulfamethoxazole decreases the prevalence of infection in patients with severe granulocytopenia. However, treatment was accompanied by a relatively high incidence of multiresistant microorganisms. We therefore conducted this study to determine whether the addition ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641298

    authors: Rozenberg-Arska M,Dekker AW,Verhoef J

    更新日期:1983-05-01 00:00:00

  • Assessment of immunomodulating activity of ofloxacin and three other quinolones in human plasma.

    abstract::A time-dependent degree of immunosuppression or immunostimulation which may be correlated to pharmacokinetic variables was obtained by administering a single dose of ofloxacin, norfloxacin, pipemidic and piromidic acid to healthy volunteers. The plasma samples collected before drug administration and then at various t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01661284

    authors: De Simone C,Vullo V,Grassi M,Di Fabio S,Baldinelli L,Sorice F

    更新日期:1986-01-01 00:00:00

  • A novel duplex real-time PCR permits simultaneous detection and differentiation of Borrelia miyamotoi and Borrelia burgdorferi sensu lato.

    abstract:PURPOSE:For simultaneous detection of Borrelia miyamotoi (relapsing fever spirochete) and Borrelia burgdorferi sensu lato, we have developed a duplex real-time PCR targeting the flagellin gene (flaB; p41), a locus frequently used in routine diagnostic PCR for B. burgdorferi s.l. detection. METHODS:Primers and probes w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0820-8

    authors: Venczel R,Knoke L,Pavlovic M,Dzaferovic E,Vaculova T,Silaghi C,Overzier E,Konrad R,Kolenčík S,Derdakova M,Sing A,Schaub GA,Margos G,Fingerle V

    更新日期:2016-02-01 00:00:00

  • Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases.

    abstract:INTRODUCTION:In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0885-z

    authors: de With K,Allerberger F,Amann S,Apfalter P,Brodt HR,Eckmanns T,Fellhauer M,Geiss HK,Janata O,Krause R,Lemmen S,Meyer E,Mittermayer H,Porsche U,Presterl E,Reuter S,Sinha B,Strauß R,Wechsler-Fördös A,Wenisch C,Kern

    更新日期:2016-06-01 00:00:00

  • Clinical predictors for death in HIV-positive and HIV-negative tuberculosis patients in Guinea-Bissau.

    abstract:OBJECT:To assess easily monitored predictors for tuberculosis mortality. DESIGN:Risk factors for tuberculosis mortality were assessed during the 8-month treatment in 440 men and 269 women diagnosed with confirmed or presumed intrathoracic tuberculosis included prospectively in Guinea-Bissau from May 1996 to April 2001...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6090-3

    authors: Gustafson P,Gomes VF,Vieira CS,Samb B,Nauclér A,Aaby P,Lisse I

    更新日期:2007-04-01 00:00:00

  • Comparative in vitro activity of cefpodoxime against anaerobes other than Bacteroides fragilis.

    abstract::To assess the in vitro activity of cefpodoxime against anaerobic respiratory tract and oropharyngeal pathogens 77 strains belonging to 18 gram-negative and 7 gram-positive species were studied by means of agar dilution tests. For comparison cefuroxime, amoxicillin, amoxicillin + clavulanic acid and clindamycin were al...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645372

    authors: Werner H,Heizmann WR,Höflsauer M

    更新日期:1991-09-01 00:00:00

  • Thrombotic microangiopathies and HIV infection: report of two typical cases, features of HUS and TTP, and review of the literature.

    abstract::Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies increasingly reported in patients with HIV infection. However, characteristic features of thrombotic microangiopathies associated with HIV disease have not been defined yet. The typical courses of HUS and T...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF02565164

    authors: Sutor GC,Schmidt RE,Albrecht H

    更新日期:1999-01-01 00:00:00

  • Low transmission rate of 2009 H1N1 Influenza during a long-distance bus trip.

    abstract:BACKGROUND:Current data on the risk of transmission of 2009 H1N1 Influenza in public transportation systems (e.g., public trains, busses, airplanes) are conflicting. The main transmission route of this virus is thought to be via droplets, but airborne transmission has not been completely ruled out. METHODS:This is a c...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0084-x

    authors: Piso RJ,Albrecht Y,Handschin P,Bassetti S

    更新日期:2011-04-01 00:00:00

  • Do antibody-coated bacteria prove bacterial prostatitis?

    abstract::Using the immunofluorescence technique in 187 patients with bacteriologically proven prostatitis according to the Meares-Stamey test demonstrated a significant amount of antibody-coated bacteria (ACB) in their ejaculates. The ACB test was useful to discriminate between chronic bacterial prostatitis and prostatodynia w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643684

    authors: Riedasch G,Möhring K,Ritz E

    更新日期:1991-01-01 00:00:00

  • First report of neonatal early-onset sepsis caused by multi-drug-resistant Raoultella ornithinolytica.

    abstract::Raoultella ornithinolytica is increasingly being isolated as a causative organism in human infections. Most of the infections caused by R. ornithinolytica are hospital acquired and occur in patients who are immunocompromised, had invasive procedures or have indwelling catheters. This is a first report of early onset n...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-017-1098-9

    authors: Abbas A,Ahmad I

    更新日期:2018-04-01 00:00:00

  • Neuraminidase inhibitors in the treatment of influenza A and B--overview and case reports.

    abstract::Influenza viruses type A and B can cause a wide spectrum of illness, and they are responsible for considerable mortality and morbidity. With the new neuraminidase inhibitors, of which zanamivir was the first drug to be licensed, the physician has antivirals at his disposal which are safe and effective against both inf...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s150100070016

    authors: Wutzler P,Vogel G

    更新日期:2000-09-01 00:00:00

  • A retrospective analysis of weight changes in HIV-positive patients switching from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing treatment regimen in one German university hospital in 2015-2017.

    abstract:PURPOSE:To determine whether changing from a tenofovir disoproxil fumarate (TDF)- to a tenofovir alafenamide fumarate (TAF)-containing regimen is correlated with weight changes in a human immunodeficiency virus (HIV)-positive adult cohort. METHODS:Retrospective analysis was conducted of data gathered from routine care...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1227-0

    authors: Gomez M,Seybold U,Roider J,Härter G,Bogner JR

    更新日期:2019-02-01 00:00:00

  • In vitro activity of clarithromycin and its 14-hydroxy-metabolite against 203 strains of Haemophilus influenzae.

    abstract::The in vitro activity of clarithromycin alone and in combination with its primary human metabolite, 14-hydroxy-clarithromycin, was determined against 203 strains of Haemophilus influenzae. Microdilution broth MICs and MBCs of both clarithromycin and 14-hydroxy-clarithromycin were determined. The clarithromycin MIC50 w...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01704612

    authors: Bergeron MG,Bernier M,L'Ecuyer J

    更新日期:1992-05-01 00:00:00

  • Temporofacial zygomycosis in a pregnant woman.

    abstract::A 38-year-old Omani woman, seven months pregnant, developed extensive zygomycosis involving maxillary and temporal bones. No evidence of any underlying immune deficiency was detected except that which may be attributed to pregnancy. After delivery the patient was treated with repeated courses of amphotericin B, which ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02033066

    authors: Buhl MR,Joseph TP,Snelling BE,Buhl L

    更新日期:1992-07-01 00:00:00